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Reviewed, UniProtKB/Swiss-Prot P35638 (DDIT3_HUMAN)

Last modified June 16, 2009. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    DNA damage-inducible transcript 3
      Short name=DDIT-3
Alternative name(s):
    Growth arrest and DNA-damage-inducible protein GADD153
    C/EBP-homologous protein
      Short name=CHOP
Gene names
Name: DDIT3
Synonyms: CHOP, GADD153
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA.

Subunit structure

Heterodimer.

Subcellular location

Nucleus.

Involvement in disease

A chromosomal aberration involving DDIT3 is found in a form of malignant myxoid liposarcoma [MIM:126337]. Translocation t(12;16)(q13;p11) with FUS.

Sequence similarities

Belongs to the bZIP family.

Contains 1 bZIP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 169169DNA damage-inducible transcript 3
PRO_0000076642

Regions

Domain134 – 14815Leucine-zipper
Compositional bias93 – 975Poly-Glu

Natural variations

Natural variant1151A → V in a colorectal cancer sample; somatic mutation. Ref.6
VAR_036000

Experimental info

Sequence conflict10 – 145FGTLS → SDTV in AAB22646. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P35638-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 31905293FB1FBBE2

FASTA16919,175
        10         20         30         40         50         60 
MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL 

        70         80         90        100        110        120 
AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM 

       130        140        150        160 
KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA 

« Hide

References

« Hide 'large scale' references
[1]"Isolation, characterization and chromosomal localization of the human GADD153 gene."
Park J.S., Luethy J.D., Wang M.G., Fargnoli J., Fornace A.J. Jr., McBride O.W., Holbrook N.J.
Gene 116:259-267(1992) [PubMed: 1339368] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma."
Crozat A., Aman P., Mandahl N., Ron D.
Nature 363:640-644(1993) [PubMed: 8510758] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma."
Rabbitts T.H., Forster A., Larson R., Nathan P.
Nat. Genet. 4:175-180(1993) [PubMed: 7503811] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH FUS.
[4]NIEHS SNPs program
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-115.
+Additional computationally mapped references.

Cross-references

Sequence databases

S40706 mRNA. Translation: AAB22646.1.
S62138 mRNA. Translation: AAB27103.1. Different initiation.
AY880949 Genomic DNA. Translation: AAW56077.1.
BC003637 mRNA. Translation: AAH03637.1.
IPIIPI00019956.
PIRJC1169.
S33798.
RefSeqNP_004074.2.
UniGeneHs.505777
Hs.690217

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP35638. 5 interactions.

PTM databases

PhosphoSiteP35638.

Genome annotation databases

EnsemblENSG00000175197. Homo sapiens. [Contig view]
GeneID1649.
KEGGhsa:1649.

Organism-specific databases

GeneCardsGC12M056196.
H-InvDBHIX0010762.
HGNCHGNC:2726. DDIT3.
HPACAB008969.
MIM126337. gene+phenotype.
PharmGKBPA27193.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP35638.
HOVERGENP35638.
OMAP35638. WELEAWY.

Enzyme and pathway databases

Pathway_Interaction_DBp38alphabetadownstreampathway. Signaling mediated by p38-alpha and p38-beta.

Gene expression databases

ArrayExpressP35638.
BgeeP35638.
CleanExHS_DDIT3.
GermOnlineENSG00000175197. Homo sapiens.

Family and domain databases

InterProIPR011700. bZIP_2.
IPR016670. DNA_damage_induc_transcript_3.
IPR004827. TF_bZIP.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFPIRSF016571. C/EBPzeta_CHOP_DDIT3. 1 hit.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio6792.
SOURCESearch...

Entry information

Entry nameDDIT3_HUMAN
AccessionPrimary (citable) accession number: P35638
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 16, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents