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Protein

RNA-binding protein FUS

Gene

FUS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri422 – 453RanBP2-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc
  • transcription coactivator activity Source: CACAO
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089280-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
SIGNORiP35637.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein FUS
Alternative name(s):
75 kDa DNA-pairing protein
Oncogene FUS
Oncogene TLS
POMp75
Translocated in liposarcoma protein
Gene namesi
Name:FUS
Synonyms:TLS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:4010. FUS.

Subcellular locationi

GO - Cellular componenti

  • dendritic spine head Source: Ensembl
  • nucleoplasm Source: HPA
  • nucleus Source: CACAO
  • perikaryon Source: Ensembl
  • perinuclear region of cytoplasm Source: Ensembl
  • polysome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3.

A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG.

Angiomatoid fibrous histiocytoma (AFH)1 Publication
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein.1 Publication
Disease descriptionA distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
See also OMIM:612160
Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia (ALS6)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
See also OMIM:608030
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068918191G → S in ALS6. 1 PublicationCorresponds to variant rs148758737dbSNPEnsembl.1
Natural variantiVAR_068919216R → C in ALS6 and ETM4. 2 PublicationsCorresponds to variant rs267606832dbSNPEnsembl.1
Natural variantiVAR_068920225G → V in ALS6. 1 Publication1
Natural variantiVAR_068921230G → C in ALS6. 1 PublicationCorresponds to variant rs748374535dbSNPEnsembl.1
Natural variantiVAR_068922234R → C in ALS6. 1 PublicationCorresponds to variant rs777819849dbSNPEnsembl.1
Natural variantiVAR_054837244R → C in ALS6. 1 Publication1
Natural variantiVAR_068924507G → D in ALS6. 1 PublicationCorresponds to variant rs267606831dbSNPEnsembl.1
Natural variantiVAR_054838514R → G in ALS6. 1 Publication1
Natural variantiVAR_054839514R → S in ALS6. 1 Publication1
Natural variantiVAR_054840515G → C in ALS6. 1 Publication1
Natural variantiVAR_054842518R → K in ALS6. 1 PublicationCorresponds to variant rs121909669dbSNPEnsembl.1
Natural variantiVAR_054843521R → C in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 3 PublicationsCorresponds to variant rs121909668dbSNPEnsembl.1
Natural variantiVAR_054844521R → G in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 1 PublicationCorresponds to variant rs121909668dbSNPEnsembl.1
Natural variantiVAR_054845521R → H in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 3 PublicationsCorresponds to variant rs121909671dbSNPEnsembl.1
Natural variantiVAR_054846522R → G in ALS6. 1 Publication1
Natural variantiVAR_054847524R → S in ALS6. 1 Publication1
Natural variantiVAR_054848524R → T in ALS6. 1 Publication1
Natural variantiVAR_054849525P → L in ALS6. 1 Publication1
Tremor, hereditary essential 4 (ETM4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
See also OMIM:614782
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068919216R → C in ALS6 and ETM4. 2 PublicationsCorresponds to variant rs267606832dbSNPEnsembl.1
Natural variantiVAR_068923431P → L in ETM4. 1 PublicationCorresponds to variant rs186547381dbSNPEnsembl.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei175Breakpoint for translocation to form chimeric FUS/ATF1 protein1
Sitei266 – 267Breakpoint for translocation to form FUS/TLS-CHOP oncogene2

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration, Proto-oncogene

Organism-specific databases

DisGeNETi2521.
MalaCardsiFUS.
MIMi608030. phenotype.
612160. phenotype.
614782. phenotype.
OpenTargetsiENSG00000089280.
Orphaneti803. Amyotrophic lateral sclerosis.
275872. Frontotemporal dementia with motor neuron disease.
862. Hereditary essential tremor.
300605. Juvenile amyotrophic lateral sclerosis.
79105. Myxofibrosarcoma.
99967. Myxoid/round cell liposarcoma.
PharmGKBiPA28425.

Polymorphism and mutation databases

BioMutaiFUS.
DMDMi544357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815911 – 526RNA-binding protein FUSAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei216Omega-N-methylarginine; alternateCombined sources1
Modified residuei218Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei218Omega-N-methylarginine; alternateCombined sources1
Modified residuei221PhosphoserineCombined sources1
Modified residuei242Asymmetric dimethylarginine1 Publication1
Modified residuei244Asymmetric dimethylarginine1 Publication1
Modified residuei248Asymmetric dimethylarginine1 Publication1
Modified residuei251Asymmetric dimethylarginine1 Publication1
Modified residuei259Asymmetric dimethylarginine1 Publication1
Modified residuei277PhosphoserineCombined sources1
Modified residuei286PhosphothreonineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei377Asymmetric dimethylarginine1 Publication1
Modified residuei383Asymmetric dimethylarginine1 Publication1
Modified residuei386Asymmetric dimethylarginine1 Publication1
Modified residuei388Asymmetric dimethylarginine1 Publication1
Modified residuei394Asymmetric dimethylarginine1 Publication1
Modified residuei407Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei407Omega-N-methylarginine; alternateBy similarity1
Modified residuei473Asymmetric dimethylarginine1 Publication1
Modified residuei476Asymmetric dimethylarginine1 Publication1
Modified residuei481Asymmetric dimethylarginine1 Publication1
Modified residuei485Asymmetric dimethylarginine1 Publication1
Modified residuei487Asymmetric dimethylarginine1 Publication1
Modified residuei491Asymmetric dimethylarginine1 Publication1
Modified residuei495Asymmetric dimethylarginine1 Publication1
Modified residuei498Asymmetric dimethylarginine1 Publication1
Modified residuei503Asymmetric dimethylarginine; alternate1 Publication1
Modified residuei503Omega-N-methylarginine; alternateCombined sources1

Post-translational modificationi

Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP35637.
PaxDbiP35637.
PeptideAtlasiP35637.
PRIDEiP35637.
TopDownProteomicsiP35637-1. [P35637-1]
P35637-2. [P35637-2]

PTM databases

iPTMnetiP35637.
PhosphoSitePlusiP35637.
SwissPalmiP35637.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000089280.
CleanExiHS_FUS.
ExpressionAtlasiP35637. baseline and differential.
GenevisibleiP35637. HS.

Organism-specific databases

HPAiCAB033036.
CAB058691.
HPA008784.

Interactioni

Subunit structurei

Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-400434,EBI-400434
DROSHAQ9NRR42EBI-400434,EBI-528367
EWSR1Q018445EBI-400434,EBI-739737
PLECQ151494EBI-400434,EBI-297903
TAF15Q928045EBI-400434,EBI-2255091
TP63Q9H3D42EBI-400434,EBI-2337775

Protein-protein interaction databases

BioGridi108797. 335 interactors.
DIPiDIP-29857N.
IntActiP35637. 59 interactors.
MINTiMINT-5005976.
STRINGi9606.ENSP00000254108.

Structurei

Secondary structure

1526
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi285 – 290Combined sources6
Helixi298 – 305Combined sources8
Turni306 – 308Combined sources3
Turni315 – 318Combined sources4
Beta strandi319 – 326Combined sources8
Turni328 – 330Combined sources3
Beta strandi332 – 343Combined sources12
Helixi344 – 354Combined sources11
Beta strandi358 – 363Combined sources6
Beta strandi365 – 368Combined sources4
Beta strandi379 – 381Combined sources3
Helixi514 – 521Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LA6NMR-A282-370[»]
2LCWNMR-A278-385[»]
4FDDX-ray2.30B498-526[»]
4FQ3X-ray3.00B495-526[»]
ProteinModelPortaliP35637.
SMRiP35637.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 371RRMPROSITE-ProRule annotationAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 165Gln/Gly/Ser/Tyr-richAdd BLAST165
Compositional biasi166 – 267Gly-richAdd BLAST102
Compositional biasi371 – 526Arg/Gly-richAdd BLAST156

Sequence similaritiesi

Belongs to the RRM TET family.Curated
Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri422 – 453RanBP2-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IP58. Eukaryota.
ENOG4111GEG. LUCA.
GeneTreeiENSGT00530000063105.
HOGENOMiHOG000038010.
HOVERGENiHBG095056.
InParanoidiP35637.
KOiK13098.
PhylomeDBiP35637.
TreeFamiTF322599.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF90209. SSF90209. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P35637-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY
60 70 80 90 100
GQSSYSSYGQ SQNTGYGTQS TPQGYGSTGG YGSSQSSQSS YGQQSSYPGY
110 120 130 140 150
GQQPAPSSTS GSYGSSSQSS SYGQPQSGSY SQQPSYGGQQ QSYGQQQSYN
160 170 180 190 200
PPQGYGQQNQ YNSSSGGGGG GGGGGNYGQD QSSMSSGGGS GGGYGNQDQS
210 220 230 240 250
GGGGSGGYGQ QDRGGRGRGG SGGGGGGGGG GYNRSSGGYE PRGRGGGRGG
260 270 280 290 300
RGGMGGSDRG GFNKFGGPRD QGSRHDSEQD NSDNNTIFVQ GLGENVTIES
310 320 330 340 350
VADYFKQIGI IKTNKKTGQP MINLYTDRET GKLKGEATVS FDDPPSAKAA
360 370 380 390 400
IDWFDGKEFS GNPIKVSFAT RRADFNRGGG NGRGGRGRGG PMGRGGYGGG
410 420 430 440 450
GSGGGGRGGF PSGGGGGGGQ QRAGDWKCPN PTCENMNFSW RNECNQCKAP
460 470 480 490 500
KPDGPGGGPG GSHMGGNYGD DRRGGRGGYD RGGYRGRGGD RGGFRGGRGG
510 520
GDRGGFGPGK MDSRGEHRQD RRERPY
Length:526
Mass (Da):53,426
Last modified:June 1, 1994 - v1
Checksum:i88C8E263B7905549
GO
Isoform Short (identifier: P35637-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-65: TG → S

Show »
Length:525
Mass (Da):53,355
Checksum:i949558C718B4C19B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti338T → N AA sequence (PubMed:10567410).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068918191G → S in ALS6. 1 PublicationCorresponds to variant rs148758737dbSNPEnsembl.1
Natural variantiVAR_068919216R → C in ALS6 and ETM4. 2 PublicationsCorresponds to variant rs267606832dbSNPEnsembl.1
Natural variantiVAR_068920225G → V in ALS6. 1 Publication1
Natural variantiVAR_068921230G → C in ALS6. 1 PublicationCorresponds to variant rs748374535dbSNPEnsembl.1
Natural variantiVAR_068922234R → C in ALS6. 1 PublicationCorresponds to variant rs777819849dbSNPEnsembl.1
Natural variantiVAR_054837244R → C in ALS6. 1 Publication1
Natural variantiVAR_065229254M → V Found in a patient with frontotemporal lobar degeneration. 1 PublicationCorresponds to variant rs752076094dbSNPEnsembl.1
Natural variantiVAR_035481312K → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_068923431P → L in ETM4. 1 PublicationCorresponds to variant rs186547381dbSNPEnsembl.1
Natural variantiVAR_068924507G → D in ALS6. 1 PublicationCorresponds to variant rs267606831dbSNPEnsembl.1
Natural variantiVAR_054838514R → G in ALS6. 1 Publication1
Natural variantiVAR_054839514R → S in ALS6. 1 Publication1
Natural variantiVAR_054840515G → C in ALS6. 1 Publication1
Natural variantiVAR_054841517H → Q Does not affect protein nuclear localization. 1 PublicationCorresponds to variant rs121909667dbSNPEnsembl.1
Natural variantiVAR_054842518R → K in ALS6. 1 PublicationCorresponds to variant rs121909669dbSNPEnsembl.1
Natural variantiVAR_054843521R → C in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 3 PublicationsCorresponds to variant rs121909668dbSNPEnsembl.1
Natural variantiVAR_054844521R → G in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 1 PublicationCorresponds to variant rs121909668dbSNPEnsembl.1
Natural variantiVAR_054845521R → H in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 3 PublicationsCorresponds to variant rs121909671dbSNPEnsembl.1
Natural variantiVAR_054846522R → G in ALS6. 1 Publication1
Natural variantiVAR_054847524R → S in ALS6. 1 Publication1
Natural variantiVAR_054848524R → T in ALS6. 1 Publication1
Natural variantiVAR_054849525P → L in ALS6. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00579864 – 65TG → S in isoform Short. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62140 mRNA. Translation: AAB27102.1.
S62138 mRNA. Translation: AAB27103.1. Sequence problems.
X71427 mRNA. Translation: CAA50558.1. Sequence problems.
X71428 mRNA. Translation: CAA50559.1. Sequence problems.
AF071213 Genomic DNA. Translation: AAC35285.1.
AF071213 Genomic DNA. Translation: AAC35284.1.
AC009088 Genomic DNA. No translation available.
BC000402 mRNA. Translation: AAH00402.1.
BC002459 mRNA. Translation: AAH02459.1.
AJ295163 mRNA. Translation: CAC15058.1. Different termination.
CCDSiCCDS10707.1. [P35637-1]
CCDS58454.1. [P35637-2]
PIRiS33798.
S33799.
RefSeqiNP_001164105.1. NM_001170634.1. [P35637-2]
NP_004951.1. NM_004960.3. [P35637-1]
UniGeneiHs.46894.

Genome annotation databases

EnsembliENST00000254108; ENSP00000254108; ENSG00000089280. [P35637-1]
ENST00000380244; ENSP00000369594; ENSG00000089280. [P35637-2]
GeneIDi2521.
KEGGihsa:2521.
UCSCiuc002ebh.4. human. [P35637-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62140 mRNA. Translation: AAB27102.1.
S62138 mRNA. Translation: AAB27103.1. Sequence problems.
X71427 mRNA. Translation: CAA50558.1. Sequence problems.
X71428 mRNA. Translation: CAA50559.1. Sequence problems.
AF071213 Genomic DNA. Translation: AAC35285.1.
AF071213 Genomic DNA. Translation: AAC35284.1.
AC009088 Genomic DNA. No translation available.
BC000402 mRNA. Translation: AAH00402.1.
BC002459 mRNA. Translation: AAH02459.1.
AJ295163 mRNA. Translation: CAC15058.1. Different termination.
CCDSiCCDS10707.1. [P35637-1]
CCDS58454.1. [P35637-2]
PIRiS33798.
S33799.
RefSeqiNP_001164105.1. NM_001170634.1. [P35637-2]
NP_004951.1. NM_004960.3. [P35637-1]
UniGeneiHs.46894.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LA6NMR-A282-370[»]
2LCWNMR-A278-385[»]
4FDDX-ray2.30B498-526[»]
4FQ3X-ray3.00B495-526[»]
ProteinModelPortaliP35637.
SMRiP35637.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108797. 335 interactors.
DIPiDIP-29857N.
IntActiP35637. 59 interactors.
MINTiMINT-5005976.
STRINGi9606.ENSP00000254108.

PTM databases

iPTMnetiP35637.
PhosphoSitePlusiP35637.
SwissPalmiP35637.

Polymorphism and mutation databases

BioMutaiFUS.
DMDMi544357.

Proteomic databases

EPDiP35637.
PaxDbiP35637.
PeptideAtlasiP35637.
PRIDEiP35637.
TopDownProteomicsiP35637-1. [P35637-1]
P35637-2. [P35637-2]

Protocols and materials databases

DNASUi2521.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254108; ENSP00000254108; ENSG00000089280. [P35637-1]
ENST00000380244; ENSP00000369594; ENSG00000089280. [P35637-2]
GeneIDi2521.
KEGGihsa:2521.
UCSCiuc002ebh.4. human. [P35637-1]

Organism-specific databases

CTDi2521.
DisGeNETi2521.
GeneCardsiFUS.
GeneReviewsiFUS.
HGNCiHGNC:4010. FUS.
HPAiCAB033036.
CAB058691.
HPA008784.
MalaCardsiFUS.
MIMi137070. gene.
608030. phenotype.
612160. phenotype.
614782. phenotype.
neXtProtiNX_P35637.
OpenTargetsiENSG00000089280.
Orphaneti803. Amyotrophic lateral sclerosis.
275872. Frontotemporal dementia with motor neuron disease.
862. Hereditary essential tremor.
300605. Juvenile amyotrophic lateral sclerosis.
79105. Myxofibrosarcoma.
99967. Myxoid/round cell liposarcoma.
PharmGKBiPA28425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP58. Eukaryota.
ENOG4111GEG. LUCA.
GeneTreeiENSGT00530000063105.
HOGENOMiHOG000038010.
HOVERGENiHBG095056.
InParanoidiP35637.
KOiK13098.
PhylomeDBiP35637.
TreeFamiTF322599.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089280-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
SIGNORiP35637.

Miscellaneous databases

ChiTaRSiFUS. human.
GeneWikiiFUS.
GenomeRNAii2521.
PROiP35637.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089280.
CleanExiHS_FUS.
ExpressionAtlasiP35637. baseline and differential.
GenevisibleiP35637. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF90209. SSF90209. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUS_HUMAN
AccessioniPrimary (citable) accession number: P35637
Secondary accession number(s): Q9H4A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 188 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.