true
1994-06-01
2024-01-24
216
TIMP3_HUMAN
Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.
Uria J.A.
Ferrando A.A.
Velasco G.
Freije J.M.
Lopez-Otin C.
1994
Cancer Res.
54
2091-2094
NUCLEOTIDE SEQUENCE [MRNA]
Mammary carcinoma
Cloning and characterization of human tissue inhibitor of metalloproteinases-3.
Wilde C.G.
Hawkins P.R.
Coleman R.T.
Levine W.B.
Delegeane A.M.
Okamoto P.M.
Ito L.Y.
Scott R.W.
Seilhamer J.J.
doi:10.1089/dna.1994.13.711
1994
DNA Cell Biol.
13
711-718
NUCLEOTIDE SEQUENCE [MRNA]
Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family.
Silbiger S.M.
Jacobsen V.L.
Cupples R.L.
Koski R.A.
doi:10.1016/0378-1119(94)90588-6
1994
Gene
141
293-297
NUCLEOTIDE SEQUENCE [MRNA]
Kidney
A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence.
Wick M.
Buerger C.
Bruesselbach S.
Lucibello F.
Mueller R.
doi:10.1016/s0021-9258(17)32259-7
1994
J. Biol. Chem.
269
18953-18960
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
Genomic organization of the human tissue inhibitor of metalloproteinases-3 (TIMP3).
Stoehr H.
Roomp K.
Felbor U.
Weber B.H.F.
doi:10.1101/gr.5.5.483
1995
Genome Res.
5
483-487
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
TIMP-3 is expressed in the human retinal pigment epithelium.
Ruiz A.C.
Brett P.
Bok D.
doi:10.1006/bbrc.1996.1379
1996
Biochem. Biophys. Res. Commun.
226
467-474
NUCLEOTIDE SEQUENCE [MRNA]
A genome annotation-driven approach to cloning the human ORFeome.
Collins J.E.
Wright C.L.
Edwards C.A.
Davis M.P.
Grinham J.A.
Cole C.G.
Goward M.E.
Aguado B.
Mallya M.
Mokrab Y.
Huckle E.J.
Beare D.M.
Dunham I.
doi:10.1186/gb-2004-5-10-r84
2004
Genome Biol.
5
R84.1-R84.11
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
Kalnine N.
Chen X.
Rolfs A.
Halleck A.
Hines L.
Eisenstein S.
Koundinya M.
Raphael J.
Moreira D.
Kelley T.
LaBaer J.
Lin Y.
Phelan M.
Farmer A.
2003-05
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.
Suzuki Y.
Nishikawa T.
Otsuki T.
Sugiyama T.
Irie R.
Wakamatsu A.
Hayashi K.
Sato H.
Nagai K.
Kimura K.
Makita H.
Sekine M.
Obayashi M.
Nishi T.
Shibahara T.
Tanaka T.
Ishii S.
Yamamoto J.
Saito K.
Kawai Y.
Isono Y.
Nakamura Y.
Nagahari K.
Murakami K.
Yasuda T.
Iwayanagi T.
Wagatsuma M.
Shiratori A.
Sudo H.
Hosoiri T.
Kaku Y.
Kodaira H.
Kondo H.
Sugawara M.
Takahashi M.
Kanda K.
Yokoi T.
Furuya T.
Kikkawa E.
Omura Y.
Abe K.
Kamihara K.
Katsuta N.
Sato K.
Tanikawa M.
Yamazaki M.
Ninomiya K.
Ishibashi T.
Yamashita H.
Murakawa K.
Fujimori K.
Tanai H.
Kimata M.
Watanabe M.
Hiraoka S.
Chiba Y.
Ishida S.
Ono Y.
Takiguchi S.
Watanabe S.
Yosida M.
Hotuta T.
Kusano J.
Kanehori K.
Takahashi-Fujii A.
Hara H.
Tanase T.-O.
Nomura Y.
Togiya S.
Komai F.
Hara R.
Takeuchi K.
Arita M.
Imose N.
Musashino K.
Yuuki H.
Oshima A.
Sasaki N.
Aotsuka S.
Yoshikawa Y.
Matsunawa H.
Ichihara T.
Shiohata N.
Sano S.
Moriya S.
Momiyama H.
Satoh N.
Takami S.
Terashima Y.
Suzuki O.
Nakagawa S.
Senoh A.
Mizoguchi H.
Goto Y.
Shimizu F.
Wakebe H.
Hishigaki H.
Watanabe T.
Sugiyama A.
Takemoto M.
Kawakami B.
Yamazaki M.'
Watanabe K.
Kumagai A.
Itakura S.
Fukuzumi Y.
Fujimori Y.
Komiyama M.
Tashiro H.
Tanigami A.
Fujiwara T.
Ono T.
Yamada K.
Fujii Y.
Ozaki K.
Hirao M.
Ohmori Y.
Kawabata A.
Hikiji T.
Kobatake N.
Inagaki H.
Ikema Y.
Okamoto S.
Okitani R.
Kawakami T.
Noguchi S.
Itoh T.
Shigeta K.
Senba T.
Matsumura K.
Nakajima Y.
Mizuno T.
Morinaga M.
Sasaki M.
Togashi T.
Oyama M.
Hata H.
Watanabe M.'
Komatsu T.
Mizushima-Sugano J.
Satoh T.
Shirai Y.
Takahashi Y.
Nakagawa K.
Okumura K.
Nagase T.
Nomura N.
Kikuchi H.
Masuho Y.
Yamashita R.
Nakai K.
Yada T.
Nakamura Y.'
Ohara O.
Isogai T.
Sugano S.
doi:10.1038/ng1285
2004
Nat. Genet.
36
40-45
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
Placenta
The DNA sequence of human chromosome 22.
Dunham I.
Hunt A.R.
Collins J.E.
Bruskiewich R.
Beare D.M.
Clamp M.
Smink L.J.
Ainscough R.
Almeida J.P.
Babbage A.K.
Bagguley C.
Bailey J.
Barlow K.F.
Bates K.N.
Beasley O.P.
Bird C.P.
Blakey S.E.
Bridgeman A.M.
Buck D.
Burgess J.
Burrill W.D.
Burton J.
Carder C.
Carter N.P.
Chen Y.
Clark G.
Clegg S.M.
Cobley V.E.
Cole C.G.
Collier R.E.
Connor R.
Conroy D.
Corby N.R.
Coville G.J.
Cox A.V.
Davis J.
Dawson E.
Dhami P.D.
Dockree C.
Dodsworth S.J.
Durbin R.M.
Ellington A.G.
Evans K.L.
Fey J.M.
Fleming K.
French L.
Garner A.A.
Gilbert J.G.R.
Goward M.E.
Grafham D.V.
Griffiths M.N.D.
Hall C.
Hall R.E.
Hall-Tamlyn G.
Heathcott R.W.
Ho S.
Holmes S.
Hunt S.E.
Jones M.C.
Kershaw J.
Kimberley A.M.
King A.
Laird G.K.
Langford C.F.
Leversha M.A.
Lloyd C.
Lloyd D.M.
Martyn I.D.
Mashreghi-Mohammadi M.
Matthews L.H.
Mccann O.T.
Mcclay J.
Mclaren S.
McMurray A.A.
Milne S.A.
Mortimore B.J.
Odell C.N.
Pavitt R.
Pearce A.V.
Pearson D.
Phillimore B.J.C.T.
Phillips S.H.
Plumb R.W.
Ramsay H.
Ramsey Y.
Rogers L.
Ross M.T.
Scott C.E.
Sehra H.K.
Skuce C.D.
Smalley S.
Smith M.L.
Soderlund C.
Spragon L.
Steward C.A.
Sulston J.E.
Swann R.M.
Vaudin M.
Wall M.
Wallis J.M.
Whiteley M.N.
Willey D.L.
Williams L.
Williams S.A.
Williamson H.
Wilmer T.E.
Wilming L.
Wright C.L.
Hubbard T.
Bentley D.R.
Beck S.
Rogers J.
Shimizu N.
Minoshima S.
Kawasaki K.
Sasaki T.
Asakawa S.
Kudoh J.
Shintani A.
Shibuya K.
Yoshizaki Y.
Aoki N.
Mitsuyama S.
Roe B.A.
Chen F.
Chu L.
Crabtree J.
Deschamps S.
Do A.
Do T.
Dorman A.
Fang F.
Fu Y.
Hu P.
Hua A.
Kenton S.
Lai H.
Lao H.I.
Lewis J.
Lewis S.
Lin S.-P.
Loh P.
Malaj E.
Nguyen T.
Pan H.
Phan S.
Qi S.
Qian Y.
Ray L.
Ren Q.
Shaull S.
Sloan D.
Song L.
Wang Q.
Wang Y.
Wang Z.
White J.
Willingham D.
Wu H.
Yao Z.
Zhan M.
Zhang G.
Chissoe S.
Murray J.
Miller N.
Minx P.
Fulton R.
Johnson D.
Bemis G.
Bentley D.
Bradshaw H.
Bourne S.
Cordes M.
Du Z.
Fulton L.
Goela D.
Graves T.
Hawkins J.
Hinds K.
Kemp K.
Latreille P.
Layman D.
Ozersky P.
Rohlfing T.
Scheet P.
Walker C.
Wamsley A.
Wohldmann P.
Pepin K.
Nelson J.
Korf I.
Bedell J.A.
Hillier L.W.
Mardis E.
Waterston R.
Wilson R.
Emanuel B.S.
Shaikh T.
Kurahashi H.
Saitta S.
Budarf M.L.
McDermid H.E.
Johnson A.
Wong A.C.C.
Morrow B.E.
Edelmann L.
Kim U.J.
Shizuya H.
Simon M.I.
Dumanski J.P.
Peyrard M.
Kedra D.
Seroussi E.
Fransson I.
Tapia I.
Bruder C.E.
O'Brien K.P.
Wilkinson P.
Bodenteich A.
Hartman K.
Hu X.
Khan A.S.
Lane L.
Tilahun Y.
Wright H.
doi:10.1038/990031
1999
Nature
402
489-495
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Mural R.J.
Istrail S.
Sutton G.G.
Florea L.
Halpern A.L.
Mobarry C.M.
Lippert R.
Walenz B.
Shatkay H.
Dew I.
Miller J.R.
Flanigan M.J.
Edwards N.J.
Bolanos R.
Fasulo D.
Halldorsson B.V.
Hannenhalli S.
Turner R.
Yooseph S.
Lu F.
Nusskern D.R.
Shue B.C.
Zheng X.H.
Zhong F.
Delcher A.L.
Huson D.H.
Kravitz S.A.
Mouchard L.
Reinert K.
Remington K.A.
Clark A.G.
Waterman M.S.
Eichler E.E.
Adams M.D.
Hunkapiller M.W.
Myers E.W.
Venter J.C.
2005-07
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
Pancreas
Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22.
Apte S.S.
Mattei M.-G.
Olsen B.R.
doi:10.1006/geno.1994.1016
1994
Genomics
19
86-90
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-211
Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix.
Kishnani N.S.
Staskus P.W.
Yang T.-T.
Masiarz F.R.
Hawkes S.P.
doi:10.1016/0945-053x(95)90005-5
1995
Matrix Biol.
14
479-488
PROTEIN SEQUENCE OF 24-41
Cloning and partial structure of the gene encoding human tissue inhibitor of metalloproteinases-3.
Hammani K.
Henriet P.M.
Silbiger S.M.
DeClerck Y.A.
doi:10.1016/0378-1119(95)00864-0
1996
Gene
170
287-288
NUCLEOTIDE SEQUENCE [MRNA] OF 42-211
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations.
Klenotic P.A.
Munier F.L.
Marmorstein L.Y.
Anand-Apte B.
doi:10.1074/jbc.m403026200
2004
J. Biol. Chem.
279
30469-30473
INTERACTION WITH EFEMP1
Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.
Wisniewska M.
Goettig P.
Maskos K.
Belouski E.
Winters D.
Hecht R.
Black R.
Bode W.
doi:10.1016/j.jmb.2008.06.088
2008
J. Mol. Biol.
381
1307-1319
X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 24-144 IN COMPLEX WITH TACE
DISULFIDE BONDS
Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy.
Weber B.H.F.
Vogt G.
Pruett R.C.
Stoehr H.
Felbor U.
doi:10.1038/ng1294-352
1994
Nat. Genet.
8
352-356
VARIANTS SFD CYS-191 AND CYS-204
A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features.
Felbor U.
Stoehr H.
Amann T.
Schoenherr U.
Weber B.H.F.
doi:10.1093/hmg/4.12.2415
1995
Hum. Mol. Genet.
4
2415-2416
VARIANT SFD CYS-179
Night blindness in Sorsby's fundus dystrophy reversed by vitamin A.
Jacobson S.G.
Cideciyan A.V.
Regunath G.
Rodriguez F.J.
Vandenburgh K.
Sheffield V.C.
Stone E.M.
doi:10.1038/ng0995-27
1995
Nat. Genet.
11
27-32
VARIANT SFD CYS-190
A second independent Tyr168Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy.
Felbor U.
Stoehr H.
Amann T.
Schoenherr U.
Apfelstedt-Sylla E.
Weber B.H.F.
doi:10.1136/jmg.33.3.233
1996
J. Med. Genet.
33
233-236
VARIANT SFD CYS-191
Autosomal recessive Sorsby fundus dystrophy revisited: molecular evidence for dominant inheritance.
Felbor U.
Suvanto E.A.
Forsius H.R.
Eriksson A.W.
Weber B.H.
1997
Am. J. Hum. Genet.
60
57-62
VARIANT SFD CYS-189
Mutations of the TIMP3 gene; Retina International's Scientific Newsletter
2.30
B=24-144
91
24
Pimagedine
818 antibodies from 41 providers
human
TIMP3
Low tissue specificity
phenotype
gene
Sorsby pseudoinflammatory fundus dystrophy
Eukaryota
Platelet degranulation
11 hits in 1157 CRISPR screens
human
Tbio
Protein
Expressed in synovial joint and 217 other cell types or tissues
NTR_TIMP
Tissue inhibitor of metalloproteinase-1. Chain B, domain 1
Netrin_domain
TIMP
TIMP-like_OB-fold
TIMP_C
TIMP_CS
METALLOPROTEASE INHIBITOR
METALLOPROTEINASE INHIBITOR 3
TIMP
NTR
TIMP-like
NTR
TIMP
HS
Metalloproteinase inhibitor 3
Protein MIG-5
Tissue inhibitor of metalloproteinases 3
TIMP-3
TIMP3
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Interacts with EFEMP1.
The disease is caused by variants affecting the gene represented in this entry.
Belongs to the protease inhibitor I35 (TIMP) family.
1
23
Metalloproteinase inhibitor 3
21690
24
211
NTR
143
Involved in metalloproteinase-binding
27
Involved in metalloproteinase-binding
88
89
Mediates interaction with EFEMP1
105
188
Involved in metalloproteinase-binding
85
91
26
118
36
145
192
150
155
163
184
In SFD.
C
179
In SFD.
C
189
In SFD.
C
190
In SFD.
C
191
In SFD.
C
204
WGTGAPR
16
R
21
22
31
37
39
42
45
52
55
57
59
65
69
71
73
75
76
78
81
86
90
102
108
124
126
129
136
137
140
ligand shared with metalloproteinase partner
false
7
AGTR2
1995-02-01
2
true
24145
42483f29f3f0ba7806c38e12b7309ee6
MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true