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Protein

Protein DVR-1

Gene

dvr1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: GO_Central
  • convergent extension involved in gastrulation Source: ZFIN
  • heart looping Source: ZFIN
  • neuron development Source: ZFIN
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  • regulation of apoptotic process Source: GO_Central
  • regulation of epiboly involved in gastrulation with mouth forming second Source: CACAO
  • regulation of MAPK cascade Source: GO_Central
  • regulation of nodal signaling pathway involved in determination of left/right asymmetry Source: ZFIN
  • SMAD protein signal transduction Source: GO_Central

Keywordsi

Molecular functionGrowth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-DRE-1660661 Sphingolipid de novo biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DVR-1
Gene namesi
Name:dvr1
Synonyms:dvr-1, vg1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-980526-389 gdf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
PropeptideiPRO_000003381616 – 240Sequence analysisAdd BLAST225
ChainiPRO_0000033817241 – 355Protein DVR-1Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi254 ↔ 320By similarity
Disulfide bondi283 ↔ 352By similarity
Disulfide bondi287 ↔ 354By similarity
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi319InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35621

Expressioni

Tissue specificityi

Abundant in ovaries and eggs, and equally distributed among all blastomeres.

Developmental stagei

Concentrated in the streaming cytoplasm in just-fertilized eggs. Evenly partitioned during cleavage among all blastomeres. Absent in the yolk cell during cleavage, blastula and gastrula stages. Distributed homogeneously among all cells of the gastrula.

Gene expression databases

BgeeiENSDARG00000037995
ExpressionAtlasiP35621 baseline

Interactioni

Subunit structurei

Homodimer.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000055378

Structurei

3D structure databases

ProteinModelPortaliP35621
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000249476
HOVERGENiHBG004860
InParanoidiP35621
KOiK05495
OrthoDBiEOG091G0K7Z
TreeFamiTF351789

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLVLLRACL LTLSLCSPAE DDGLVQEKLF LSSMGLWSRP KPSHHAAVPS
60 70 80 90 100
QMWKIFKQAS KQTVNDPCVV SEYGVRGNIV RFMQDQGSLI SAPAVHSFNC
110 120 130 140 150
VRKHLFFNMS VLEEVEQLSL AQLEMKFKQD LLLLGPHVFS VDLYRVLKTT
160 170 180 190 200
LKGVTHESSR KLLQSQTLSP GAHASVLVNL TNLAQSWRKP EKNFGMQLEL
210 220 230 240 250
QVMHLNNMLH DHAYVQIPDI HATLVVVSLN PLQCRSRRKR SASYYLPVTP
260 270 280 290 300
SNVCKPRRLY IDFKDVGWQD WIIAPQGYLA NYCHGECPFP LSESLNGTNH
310 320 330 340 350
AILQTLVHSF DPKGTPQPCC VPIKLSPISM LYYDNNDNVV LRHYEDMVVD

ECGCR
Length:355
Mass (Da):40,202
Last modified:June 1, 1994 - v1
Checksum:i0ED5B9850EBFB222
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00931 mRNA Translation: AAC27347.1
RefSeqiNP_571023.1, NM_130948.1
UniGeneiDr.307

Genome annotation databases

EnsembliENSDART00000055379; ENSDARP00000055378; ENSDARG00000037995
GeneIDi30125
KEGGidre:30125

Similar proteinsi

Entry informationi

Entry nameiDVR1_DANRE
AccessioniPrimary (citable) accession number: P35621
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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