Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein DVR-1

Gene

dvr1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.

GO - Biological processi

  • growth Source: InterPro
  • heart looping Source: ZFIN
  • neuron development Source: ZFIN
  • positive regulation of cell division Source: UniProtKB-KW
  • regulation of epiboly involved in gastrulation with mouth forming second Source: CACAO
  • regulation of nodal signaling pathway involved in determination of left/right asymmetry Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-DRE-1660661. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DVR-1
Gene namesi
Name:dvr1
Synonyms:dvr-1, vg1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-980526-389. gdf3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Propeptidei16 – 240225Sequence analysisPRO_0000033816Add
BLAST
Chaini241 – 355115Protein DVR-1PRO_0000033817Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi254 ↔ 320By similarity
Disulfide bondi283 ↔ 352By similarity
Disulfide bondi287 ↔ 354By similarity
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence analysis
Disulfide bondi319 – 319InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35621.
PRIDEiP35621.

Expressioni

Tissue specificityi

Abundant in ovaries and eggs, and equally distributed among all blastomeres.

Developmental stagei

Concentrated in the streaming cytoplasm in just-fertilized eggs. Evenly partitioned during cleavage among all blastomeres. Absent in the yolk cell during cleavage, blastula and gastrula stages. Distributed homogeneously among all cells of the gastrula.

Gene expression databases

BgeeiP35621.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi7955.ENSDARP00000055378.

Structurei

3D structure databases

ProteinModelPortaliP35621.
SMRiP35621. Positions 254-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP35621.
KOiK05495.
OMAiKDVGWQD.
OrthoDBiEOG71CFMF.
TreeFamiTF351789.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLVLLRACL LTLSLCSPAE DDGLVQEKLF LSSMGLWSRP KPSHHAAVPS
60 70 80 90 100
QMWKIFKQAS KQTVNDPCVV SEYGVRGNIV RFMQDQGSLI SAPAVHSFNC
110 120 130 140 150
VRKHLFFNMS VLEEVEQLSL AQLEMKFKQD LLLLGPHVFS VDLYRVLKTT
160 170 180 190 200
LKGVTHESSR KLLQSQTLSP GAHASVLVNL TNLAQSWRKP EKNFGMQLEL
210 220 230 240 250
QVMHLNNMLH DHAYVQIPDI HATLVVVSLN PLQCRSRRKR SASYYLPVTP
260 270 280 290 300
SNVCKPRRLY IDFKDVGWQD WIIAPQGYLA NYCHGECPFP LSESLNGTNH
310 320 330 340 350
AILQTLVHSF DPKGTPQPCC VPIKLSPISM LYYDNNDNVV LRHYEDMVVD

ECGCR
Length:355
Mass (Da):40,202
Last modified:June 1, 1994 - v1
Checksum:i0ED5B9850EBFB222
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00931 mRNA. Translation: AAC27347.1.
RefSeqiNP_571023.1. NM_130948.1.
UniGeneiDr.307.

Genome annotation databases

EnsembliENSDART00000055379; ENSDARP00000055378; ENSDARG00000037995.
GeneIDi30125.
KEGGidre:30125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00931 mRNA. Translation: AAC27347.1.
RefSeqiNP_571023.1. NM_130948.1.
UniGeneiDr.307.

3D structure databases

ProteinModelPortaliP35621.
SMRiP35621. Positions 254-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000055378.

Proteomic databases

PaxDbiP35621.
PRIDEiP35621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000055379; ENSDARP00000055378; ENSDARG00000037995.
GeneIDi30125.
KEGGidre:30125.

Organism-specific databases

CTDi9573.
ZFINiZDB-GENE-980526-389. gdf3.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP35621.
KOiK05495.
OMAiKDVGWQD.
OrthoDBiEOG71CFMF.
TreeFamiTF351789.

Enzyme and pathway databases

ReactomeiR-DRE-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

PROiP35621.

Gene expression databases

BgeeiP35621.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DVR-1 (Vg1) transcript of zebrafish is maternally supplied and distributed throughout the embryo."
    Helde K.A., Grunwald D.J.
    Dev. Biol. 159:418-426(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiDVR1_DANRE
AccessioniPrimary (citable) accession number: P35621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.