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Protein

Flagellar biosynthesis protein FlhA

Gene

flhA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the export of flagellum proteins.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Bacterial flagellum biogenesis, Bacterial flagellum protein export, Protein transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU16390-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar biosynthesis protein FlhA
Gene namesi
Name:flhA
Ordered Locus Names:BSU16390
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2217HelicalSequence analysisAdd
BLAST
Transmembranei27 – 4317HelicalSequence analysisAdd
BLAST
Transmembranei52 – 6817HelicalSequence analysisAdd
BLAST
Transmembranei104 – 12017HelicalSequence analysisAdd
BLAST
Transmembranei189 – 20517HelicalSequence analysisAdd
BLAST
Transmembranei230 – 24617HelicalSequence analysisAdd
BLAST
Transmembranei275 – 29117HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Flagellar biosynthesis protein FlhAPRO_0000190010Add
BLAST

Proteomic databases

PaxDbiP35620.

Interactioni

Protein-protein interaction databases

DIPiDIP-59539N.
STRINGi224308.Bsubs1_010100009041.

Structurei

Secondary structure

1
677
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi319 – 3268Combined sources
Helixi332 – 3354Combined sources
Helixi336 – 3383Combined sources
Beta strandi343 – 3486Combined sources
Helixi350 – 3523Combined sources
Helixi353 – 3575Combined sources
Beta strandi358 – 3603Combined sources
Helixi364 – 37916Combined sources
Beta strandi387 – 3904Combined sources
Beta strandi398 – 4036Combined sources
Beta strandi406 – 4127Combined sources
Helixi465 – 48420Combined sources
Helixi487 – 50014Combined sources
Helixi502 – 5087Combined sources
Turni509 – 5124Combined sources
Helixi515 – 52713Combined sources
Helixi535 – 54511Combined sources
Turni546 – 5483Combined sources
Helixi552 – 56211Combined sources
Helixi564 – 5718Combined sources
Beta strandi581 – 5833Combined sources
Helixi585 – 59410Combined sources
Helixi608 – 62720Combined sources
Beta strandi634 – 6363Combined sources
Helixi638 – 64811Combined sources
Turni649 – 6513Combined sources
Beta strandi657 – 6593Combined sources
Helixi660 – 6623Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MIXX-ray2.30A303-677[»]
ProteinModelPortaliP35620.
SMRiP35620. Positions 318-676.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35620.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D7B. Bacteria.
COG1298. LUCA.
HOGENOMiHOG000254015.
InParanoidiP35620.
KOiK02400.
OMAiETKELGW.
OrthoDBiEOG6RZB0J.
PhylomeDBiP35620.

Family and domain databases

InterProiIPR025505. FHIPEP_CS.
IPR006301. FlhA.
IPR001712. T3SS_FHIPEP.
[Graphical view]
PfamiPF00771. FHIPEP. 1 hit.
[Graphical view]
PIRSFiPIRSF005419. FlhA. 1 hit.
PRINTSiPR00949. TYPE3IMAPROT.
TIGRFAMsiTIGR01398. FlhA. 1 hit.
PROSITEiPS00994. FHIPEP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35620-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTRDLSVLI SVVLIVAMLV IPFPPWLLSI LIIINISLAL IVLLTTMNMQ
60 70 80 90 100
EALQFSIFPS LLLLLTLFRL GLNVSTTRSI LSHGEGGKVV ETFGNFVVGG
110 120 130 140 150
NVLVGLVVFI ILIIIQFIVI TKGAERVSEV AARFTLDAMP GKQMSIDADL
160 170 180 190 200
NAGMITEQEA KHRREKVARE ADFYGAMDGA SKFVKGDAIA GIIIVMINII
210 220 230 240 250
FGIVIGMLQQ GMSIQEAASH FTMLTVGDGI VSQIPALLIS TATGIVVTRA
260 270 280 290 300
ASEGNLGHDI TGQLFAYPKL LYVAAATIML LGIFTPIGIL LTGPLAGLLA
310 320 330 340 350
FGAYTLSKSG KEKEEVDEIL EEEAEVDELK SPESVVQLLH IDPIEFEFGY
360 370 380 390 400
GLIPLADANQ GGDLLDRIVM IRRQLALELG LVIPVVRIRD NIALQPNEYR
410 420 430 440 450
LKIKGNEVAK GELLLDHYLA MSPTPEDDLI EGIETVEPSF GLPAKWISEA
460 470 480 490 500
VKDEADMLGY TVVDPASVVS THITEKIKQH AHELIGRQET KQLIDHLKES
510 520 530 540 550
YPVLVEEVTP NPLSVGDIQK VLAKLLKEKV SIRNLVTIFE TLADYGKLTT
560 570 580 590 600
DSDLLTEYTR QALAKQITAQ FAKENEVLKV VTCSGRVEKA IADGVQQTEH
610 620 630 640 650
GNYLSLEPDI SESIVRSVAK EAEQLSLRQE TAILLCSPPV RMYVKQLLER
660 670
YFPDLPVLSY NELEANVEVQ SIGVVDI
Length:677
Mass (Da):73,977
Last modified:June 16, 2009 - v2
Checksum:iC7FF66FA886D7203
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 192ML → IV in CAA45225 (PubMed:8097015).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63698 Genomic DNA. Translation: CAA45225.1.
AL009126 Genomic DNA. Translation: CAB13512.2.
PIRiS33664.
RefSeqiNP_389521.2. NC_000964.3.
WP_003231947.1. NZ_JNCM01000035.1.

Genome annotation databases

EnsemblBacteriaiCAB13512; CAB13512; BSU16390.
GeneIDi940029.
KEGGibsu:BSU16390.
PATRICi18975085. VBIBacSub10457_1734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63698 Genomic DNA. Translation: CAA45225.1.
AL009126 Genomic DNA. Translation: CAB13512.2.
PIRiS33664.
RefSeqiNP_389521.2. NC_000964.3.
WP_003231947.1. NZ_JNCM01000035.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MIXX-ray2.30A303-677[»]
ProteinModelPortaliP35620.
SMRiP35620. Positions 318-676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59539N.
STRINGi224308.Bsubs1_010100009041.

Proteomic databases

PaxDbiP35620.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13512; CAB13512; BSU16390.
GeneIDi940029.
KEGGibsu:BSU16390.
PATRICi18975085. VBIBacSub10457_1734.

Phylogenomic databases

eggNOGiENOG4105D7B. Bacteria.
COG1298. LUCA.
HOGENOMiHOG000254015.
InParanoidiP35620.
KOiK02400.
OMAiETKELGW.
OrthoDBiEOG6RZB0J.
PhylomeDBiP35620.

Enzyme and pathway databases

BioCyciBSUB:BSU16390-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP35620.

Family and domain databases

InterProiIPR025505. FHIPEP_CS.
IPR006301. FlhA.
IPR001712. T3SS_FHIPEP.
[Graphical view]
PfamiPF00771. FHIPEP. 1 hit.
[Graphical view]
PIRSFiPIRSF005419. FlhA. 1 hit.
PRINTSiPR00949. TYPE3IMAPROT.
TIGRFAMsiTIGR01398. FlhA. 1 hit.
PROSITEiPS00994. FHIPEP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bacillus subtilis FlhA: a flagellar protein related to a new family of signal-transducing receptors."
    Carpenter P.B., Ordal G.W.
    Mol. Microbiol. 7:735-743(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 18-19.

Entry informationi

Entry nameiFLHA_BACSU
AccessioniPrimary (citable) accession number: P35620
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 16, 2009
Last modified: February 17, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.