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Protein

Bacteriocin sakacin-P

Gene

sakP

Organism
Lactobacillus sakei
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Bactericidal activity; inhibits closely related Lactobacilli, Listeria monocytogenes and ivanovvi, Enterococcus faecalis, Carnobacterium sp and Brocothrix thermosphacta.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriocin

Protein family/group databases

TCDBi1.C.24.1.2. the pediocin (pediocin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacteriocin sakacin-P
Alternative name(s):
Sakacin 674
Gene namesi
Name:sakP
Synonyms:sakR, sppA
OrganismiLactobacillus sakei
Taxonomic identifieri1599 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000027511 – 182 PublicationsAdd BLAST18
ChainiPRO_000000275219 – 61Bacteriocin sakacin-PAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 321 Publication

Keywords - PTMi

Disulfide bond

Miscellaneous databases

PMAP-CutDBP35618.

Structurei

Secondary structure

161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi20 – 22Combined sources3
Beta strandi28 – 30Combined sources3
Helixi37 – 50Combined sources14
Turni53 – 59Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OG7NMR-A19-61[»]
1OHMNMR-A19-61[»]
1OHNNMR-A19-61[»]
ProteinModelPortaliP35618.
SMRiP35618.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35618.

Family & Domainsi

Sequence similaritiesi

Belongs to the bacteriocin class IIA/YGNGV family.Curated

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKFIELSLK EVTAITGGKY YGNGVHCGKH SCTVDWGTAI GNIGNNAAAN
60
WATGGNAGWN K
Length:61
Mass (Da):6,385
Last modified:August 29, 2001 - v2
Checksum:iB7BF14DCDD28A73D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75081 Genomic DNA. Translation: CAA52974.1.
Z25816 Genomic DNA. Translation: CAA81064.1.
Z48542 Genomic DNA. Translation: CAA88428.1.
AF002276 Genomic DNA. Translation: AAB93970.1.
PIRiS57911. S38508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75081 Genomic DNA. Translation: CAA52974.1.
Z25816 Genomic DNA. Translation: CAA81064.1.
Z48542 Genomic DNA. Translation: CAA88428.1.
AF002276 Genomic DNA. Translation: AAB93970.1.
PIRiS57911. S38508.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OG7NMR-A19-61[»]
1OHMNMR-A19-61[»]
1OHNNMR-A19-61[»]
ProteinModelPortaliP35618.
SMRiP35618.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.24.1.2. the pediocin (pediocin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP35618.
PMAP-CutDBP35618.

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAKP_LACSK
AccessioniPrimary (citable) accession number: P35618
Secondary accession number(s): Q57121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 29, 2001
Last modified: November 2, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.