P35613 (BASI_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Basigin

Alternative name(s):
5F7
Collagenase stimulatory factor
Extracellular matrix metalloproteinase inducer
Short name=EMMPRIN
Leukocyte activation antigen M6
OK blood group antigen
Tumor cell-derived collagenase stimulatory factor
Short name=TCSF
CD_antigen=CD147

Gene names

Name:	BSG
ORF Names:	UNQ6505/PRO21383

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes By similarity.
Subunit structure	Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM By similarity. Interacts with AJAP1. Ref.10 Ref.22 Ref.28 Ref.29
Subcellular location	Cell membrane; Single-pass type I membrane protein. Melanosome. Note: Colocalizes with SLC16A1 and SLC16A8 By similarity. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.10 Ref.21
Tissue specificity	Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
Induction	Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.
Post-translational modification	N-glycosylated. Ref.19
Sequence similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Ligand	Lectin Mannose-binding
Molecular function	Blood group antigen
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome cell surface receptor signaling pathway Traceable author statement Ref.6. Source: ProtInc decidualization Inferred from electronic annotation. Source: Compara embryo implantation Inferred from electronic annotation. Source: Compara leukocyte migration Traceable author statement. Source: Reactome odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara pyruvate metabolic process Traceable author statement. Source: Reactome response to cAMP Inferred from electronic annotation. Source: Compara response to mercury ion Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi membrane Traceable author statement. Source: Reactome acrosomal membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell membrane raft Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement. Source: Reactome sarcolemma Inferred from electronic annotation. Source: Compara
Molecular_function	mannose binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform 1 (identifier: P35613-1)

Also known as: Long; Basigin-2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P35613-2)

Also known as: Basigin-1;

The sequence of this isoform differs from the canonical sequence as follows:
     24-139: Missing.

Isoform 3 (identifier: P35613-3)

Also known as: Basigin-3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Note: Produced by alternative promoter usage. N-glycosylated.

Isoform 4 (identifier: P35613-4)

Also known as: Basigin-4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MAAALFVLLGF → MKQSDASPQER
     12-191: Missing.

Note: Produced by alternative promoter usage. N-glycosylated.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Ref.16

Chain

22 – 385

364

Basigin

PRO_0000014518

Regions

Topological domain

138 – 323

186

Extracellular Potential

Transmembrane

324 – 344

21

Helical; Potential

Topological domain

345 – 385

41

Cytoplasmic Potential

Domain

138 – 219

82

Ig-like C2-type

Domain

221 – 315

95

Ig-like V-type

Compositional bias

356 – 359

4

Poly-Asp

Amino acid modifications

Modified residue

362

1

Phosphoserine Ref.20 Ref.25 Ref.27

Glycosylation

160

1

N-linked (GlcNAc...) Ref.19 Ref.23 Ref.24

Glycosylation

268

1

N-linked (GlcNAc...) Ref.19 Ref.23 Ref.24

Glycosylation

302

1

N-linked (GlcNAc...) Potential

Disulfide bond

157 ↔ 203

Ref.28 Ref.29

Disulfide bond

242 ↔ 301

Ref.28 Ref.29

Natural variations

Alternative sequence

1 – 209

209

Missing in isoform 3.

VSP_043225

Alternative sequence

1 – 11

11

MAAALFVLLGF → MKQSDASPQER in isoform 4.

VSP_043226

Alternative sequence

12 – 191

180

Missing in isoform 4.

VSP_043227

Alternative sequence

24 – 139

116

Missing in isoform 2.

VSP_011501

Natural variant

208

1

E → K in Ok(A-). Ref.30

VAR_013574

Natural variant

269

1

G → V.
Corresponds to variant rs1803203 [ dbSNP | Ensembl ].

VAR_011720

Experimental info

Sequence conflict

328

1

F → L in BAC76828. Ref.2

Secondary structure

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385

Helix Strand Turn

Details...

Beta strand

24 – 27

4

Beta strand

32 – 35

4

Beta strand

40 – 47

8

Beta strand

53 – 62

10

Helix

74 – 77

4

Beta strand

79 – 95

17

Helix

100 – 102

3

Beta strand

104 – 111

8

Beta strand

116 – 118

3

Beta strand

128 – 137

10

Beta strand

142 – 149

8

Beta strand

152 – 159

8

Beta strand

166 – 173

8

Beta strand

176 – 181

6

Beta strand

186 – 192

7

Helix

194 – 196

3

Beta strand

199 – 207

9

Beta strand

210 – 217

8

Beta strand

224 – 226

3

Beta strand

228 – 233

6

Beta strand

238 – 243

6

Beta strand

252 – 257

6

Beta strand

260 – 262

3

Helix

270 – 272

3

Beta strand

274 – 279

6

Beta strand

282 – 287

6

Turn

292 – 294

3

Beta strand

295 – 305

11

Beta strand

308 – 319

12

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) (Basigin-2) [UniParc]. Last modified August 31, 2004. Version 2. Checksum: D74C37455BF26685	FASTA	385	42,200
	10 20 30 40 50 60 MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP VPEIQWWFEG 70 80 90 100 110 120 QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE EDTGTYECRA SNDPDRNHLT 130 140 150 160 170 180 RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG SKILLTCSLN DSATEVTGHR WLKGGVVLKE 190 200 210 220 230 240 DALPGQKTEF KVDSDDQWGE YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML 250 260 270 280 290 300 VCKSESVPPV TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR 310 320 330 340 350 360 CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK PEDVLDDDDA 370 380 GSAPLKSSGQ HQNDKGKNVR QRNSS
	Isoform 2 (Basigin-1) [UniParc]. Checksum: 0C9D6BEB966AC258	FASTA	269	29,221
	10 20 30 40 50 60 MAAALFVLLG FALLGTHGAS GAAGTVFTTV EDLGSKILLT CSLNDSATEV TGHRWLKGGV 70 80 90 100 110 120 VLKEDALPGQ KTEFKVDSDD QWGEYSCVFL PEPMGTANIQ LHGPPRVKAV KSSEHINEGE 130 140 150 160 170 180 TAMLVCKSES VPPVTDWAWY KITDSEDKAL MNGSESRFFV SSSQGRSELH IENLNMEADP 190 200 210 220 230 240 GQYRCNGTSS KGSDQAIITL RVRSHLAALW PFLGIVAEVL VLVTIIFIYE KRRKPEDVLD 250 260 DDDAGSAPLK SSGQHQNDKG KNVRQRNSS
	Isoform 3 (Basigin-3) [UniParc]. Checksum: 1FF03934256AE63E	FASTA	176	19,438
	10 20 30 40 50 60 MGTANIQLHG PPRVKAVKSS EHINEGETAM LVCKSESVPP VTDWAWYKIT DSEDKALMNG 70 80 90 100 110 120 SESRFFVSSS QGRSELHIEN LNMEADPGQY RCNGTSSKGS DQAIITLRVR SHLAALWPFL 130 140 150 160 170 GIVAEVLVLV TIIFIYEKRR KPEDVLDDDD AGSAPLKSSG QHQNDKGKNV RQRNSS
	Isoform 4 (Basigin-4) [UniParc]. Checksum: 27B3348C16A690BD	FASTA	205	22,764
	10 20 30 40 50 60 MKQSDASPQE RVDSDDQWGE YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML 70 80 90 100 110 120 VCKSESVPPV TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR 130 140 150 160 170 180 CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK PEDVLDDDDA 190 200 GSAPLKSSGQ HQNDKGKNVR QRNSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule." Kasinrerk W., Fiebiger E., Stefanova I., Baumruker T., Knapp W., Stockinger H. J. Immunol. 149:847-854(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen." Miyauchi T., Masuzawa Y., Muramatsu T. J. Biochem. 110:770-774(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[3]	"The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily." Biswas C., Zhang Y., Decastro R., Guo H., Nakamura T., Kataoka H., Nabeshima K. Cancer Res. 55:434-439(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]	Wakasugi H., Scamps C., Yang G., Vancong N., Bernheim A., Tursz T., Harada N. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
[5]	Decastro R., Zhang Y., Kataoka H., Coon J., Biswas C. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
[6]	"Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases." Guo H., Majmudar G., Jensen T.C., Biswas C., Toole B.P., Gordon M.K. Gene 220:99-108(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[7]	"Regulation of EMMPRIN/CD147 expression and its function of controlling matrix metalloproteinases production and cell-surface localization in co-culture of human uterine cervical carcinoma SKG-II cells and human uterine cervical fibroblasts." Sato T., Takita M., Noguchi Y., Hirata M., Sakai T., Ito A. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
[8]	Kim D., Kanai Y., Choi H., Shin H., Kim J., Teraoka H., Shigeta Y., Chairoungdua A., Babu E., Anzai N., Iribe Y., Endou H. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
[9]	"Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily." Ochrietor J.D., Moroz T.P., van Ekeris L., Clamp M.F., Jefferson S.C., deCarvalho A.C., Fadool J.M., Wistow G., Muramatsu T., Linser P.J. Invest. Ophthalmol. Vis. Sci. 44:4086-4096(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1). Tissue: Retina.
[10]	"Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion." Liao C.G., Kong L.M., Song F., Xing J.L., Wang L.X., Sun Z.J., Tang H., Yao H., Zhang Y., Wang L., Wang Y., Yang X.M., Li Y., Chen Z.N. Mol. Cell. Biol. 31:2591-2604(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), SUBUNIT, SUBCELLULAR LOCATION, ALTERNATIVE PROMOTER USAGE.
[11]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[12]	SeattleSNPs variation discovery resource Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[13]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[14]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[15]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.
[16]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-36 (ISOFORM 1).
[17]	"Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor." Nabeshima K., Lane W.S., Biswas C. Arch. Biochem. Biophys. 285:90-96(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
[18]	"Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion." Muramatsu T., Miyauchi T. Histol. Histopathol. 18:981-987(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[19]	"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." Zhang H., Li X.-J., Martin D.B., Aebersold R. Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-160 AND ASN-268.
[20]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[21]	"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F. J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Melanoma.
[22]	"junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147." Schreiner A., Ruonala M., Jakob V., Suthaus J., Boles E., Wouters F., Starzinski-Powitz A. Mol. Biol. Cell 18:1272-1281(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AJAP1.
[23]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268, MASS SPECTROMETRY. Tissue: Liver.
[24]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[25]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[26]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[27]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, MASS SPECTROMETRY.
[28]	"Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion." Yu X.-L., Hu T., Du J.-M., Ding J.-P., Yang X.-M., Zhang J., Yang B., Shen X., Zhang Z., Zhong W.-D., Wen N., Jiang H., Zhu P., Chen Z.-N. J. Biol. Chem. 283:18056-18065(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 140-321, SUBUNIT, DISULFIDE BONDS.
[29]	"Structure of the EMMPRIN N-terminal domain 1: dimerization via beta-strand swapping." Luo J., Teplyakov A., Obmolova G., Malia T., Wu S.-J., Beil E., Baker A., Swencki-Underwood B., Zhao Y., Sprenkle J., Dixon K., Sweet R., Gilliland G.L. Proteins 77:1009-1014(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 13-219, MASS SPECTROMETRY, SUBUNIT, DISULFIDE BONDS.
[30]	"The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues." Spring F.A., Holmes C.H., Simpson K.L., Mawby W.J., Mattes M.J., Okubo Y., Parsons S.F. Eur. J. Immunol. 27:891-897(1997) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LYS-208.
+	Additional computationally mapped references.

Web resources

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X64364 mRNA. Translation: CAA45716.1.
D45131 mRNA. Translation: BAA08109.1.
L10240 mRNA. Translation: AAA68936.1.
M87879 mRNA. Translation: AAA91084.1.
L20471 mRNA. Translation: AAB41120.1.
AF042854 , AF042848, AF042849, AF042850, AF042851, AF042852, AF042853 Genomic DNA. Translation: AAD10704.1.
AB072923 mRNA. Translation: BAB88938.1.
AB085790 mRNA. Translation: BAC76828.1.
AF548371 mRNA. Translation: AAN40694.1.
GU557064 mRNA. Translation: ADD31881.1.
GU557065 mRNA. Translation: ADD31882.1.
AY358113 mRNA. Translation: AAQ88480.1.
AY942196 Genomic DNA. Translation: AAX20110.1.
AC005559 Genomic DNA. Translation: AAC33279.1.
CH471242 Genomic DNA. Translation: EAW61181.1.
CH471242 Genomic DNA. Translation: EAW61185.1.
BC009040 mRNA. Translation: AAH09040.1.

IPI

IPI00019906.
IPI00218019.
IPI00394877.
IPI01010766.

PIR

A46506.

RefSeq

NP_001719.2. NM_001728.3.
NP_940991.1. NM_198589.2.
NP_940992.1. NM_198590.2.
NP_940993.1. NM_198591.2.

UniGene

Hs.501293.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3B5H	X-ray	2.80	A/B/C/D	140-321	[»]
3I84	X-ray	2.00	A/B	13-219	[»]
3I85	X-ray	2.50	A/B	13-219	[»]
3QQN	X-ray	2.31	A/B	23-138	[»]
3QR2	X-ray	2.30	A/B	23-138	[»]

ProteinModelPortal

P35613.

ModBase

Search...

Protein-protein interaction databases

IntAct

P35613. 13 interactions.

MINT

MINT-5004205.

STRING

9606.ENSP00000333769.

Protein family/group databases

TCDB

8.A.23.1.1. basigin family.

PTM databases

PhosphoSite

P35613.

Polymorphism databases

DMDM

51704273.

Proteomic databases

PaxDb

P35613.

PRIDE

P35613.

Protocols and materials databases

DNASU

682.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000333511; ENSP00000333769; ENSG00000172270.
ENST00000346916; ENSP00000344707; ENSG00000172270.
ENST00000353555; ENSP00000343809; ENSG00000172270.

GeneID

682.

KEGG

hsa:682.

UCSC

uc002loz.3. human.

Organism-specific databases

CTD

682.

GeneCards

GC19P000571.

HGNC

HGNC:1116. BSG.

HPA

CAB002427.

MIM

109480. gene.
111380. phenotype.

neXtProt

NX_P35613.

PharmGKB

PA25433.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG83713.

HOGENOM

HOG000263411.

HOVERGEN

HBG008120.

InParanoid

P35613.

KO

K06535.

OMA

DRNHLTR.

Enzyme and pathway databases

Pathway_Interaction_DB

syndecan_1_pathway. Syndecan-1-mediated signaling events.

Reactome

REACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpress

P35613.

Bgee

P35613.

CleanEx

HS_BSG.

Genevestigator

P35613.

GermOnline

ENSG00000172270. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 2 hits.

InterPro

IPR009151. Basigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]

PANTHER

PTHR10075:SF6. PTHR10075:SF6. 1 hit.

Pfam

PF07679. I-set. 2 hits.
[Graphical view]

SMART

SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

BSG. human.

EvolutionaryTrace

P35613.

GenomeRNAi

682.

NextBio

2802.

PMAP-CutDB

P35613.

SOURCE

Search...

Entry information

Entry name

BASI_HUMAN

Accession

Primary (citable) accession number: P35613
Secondary accession number(s): A6NJW1 , D3YLG5, Q7Z796, Q8IZL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	August 31, 2004
Last modified:	May 1, 2013
This is version 147 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.