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P35613

- BASI_HUMAN

UniProt

P35613 - BASI_HUMAN

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Protein

Basigin

Gene
BSG, UNQ6505/PRO21383
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.1 Publication

GO - Molecular functioni

  1. mannose binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. cell surface receptor signaling pathway Source: ProtInc
  3. cellular metabolic process Source: Reactome
  4. decidualization Source: Ensembl
  5. embryo implantation Source: Ensembl
  6. extracellular matrix disassembly Source: Reactome
  7. extracellular matrix organization Source: Reactome
  8. leukocyte migration Source: Reactome
  9. odontogenesis of dentin-containing tooth Source: Ensembl
  10. protein targeting to plasma membrane Source: UniProtKB
  11. pyruvate metabolic process Source: Reactome
  12. response to cAMP Source: Ensembl
  13. response to mercury ion Source: Ensembl
  14. response to peptide hormone Source: Ensembl
  15. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen

Keywords - Ligandi

Lectin, Mannose-binding

Enzyme and pathway databases

ReactomeiREACT_118572. Degradation of the extracellular matrix.
REACT_12560. Basigin interactions.
REACT_13552. Integrin cell surface interactions.
REACT_2071. Pyruvate metabolism.

Protein family/group databases

TCDBi8.A.23.1.1. the basigin (basigin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Basigin
Alternative name(s):
5F7
Collagenase stimulatory factor
Extracellular matrix metalloproteinase inducer
Short name:
EMMPRIN
Leukocyte activation antigen M6
OK blood group antigen
Tumor cell-derived collagenase stimulatory factor
Short name:
TCSF
CD_antigen: CD147
Gene namesi
Name:BSG
ORF Names:UNQ6505/PRO21383
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:1116. BSG.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Melanosome
Note: Colocalizes with SLC16A1 and SLC16A8 By similarity. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini138 – 323186Extracellular Reviewed predictionAdd
BLAST
Transmembranei324 – 34421Helical; Reviewed predictionAdd
BLAST
Topological domaini345 – 38541Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. acrosomal membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. Golgi membrane Source: Reactome
  4. integral component of plasma membrane Source: UniProtKB
  5. melanosome Source: UniProtKB-SubCell
  6. membrane raft Source: Ensembl
  7. mitochondrion Source: UniProt
  8. plasma membrane Source: Reactome
  9. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi111380. phenotype.
PharmGKBiPA25433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 385364BasiginPRO_0000014518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi157 ↔ 2032 Publications
Glycosylationi160 – 1601N-linked (GlcNAc...)3 Publications
Disulfide bondi242 ↔ 3012 Publications
Glycosylationi268 – 2681N-linked (GlcNAc...)3 Publications
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Modified residuei362 – 3621Phosphoserine3 Publications
Modified residuei368 – 3681Phosphoserine By similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP35613.
PaxDbiP35613.
PRIDEiP35613.

PTM databases

PhosphoSiteiP35613.

Miscellaneous databases

PMAP-CutDBP35613.

Expressioni

Tissue specificityi

Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Inductioni

Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.

Gene expression databases

ArrayExpressiP35613.
BgeeiP35613.
CleanExiHS_BSG.
GenevestigatoriP35613.

Organism-specific databases

HPAiCAB002427.
HPA036048.

Interactioni

Subunit structurei

Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM By similarity. Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer.5 Publications

Protein-protein interaction databases

BioGridi107147. 33 interactions.
IntActiP35613. 13 interactions.
MINTiMINT-5004205.
STRINGi9606.ENSP00000333769.

Structurei

Secondary structure

1
385
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 274
Beta strandi32 – 354
Beta strandi40 – 478
Beta strandi53 – 6210
Helixi74 – 774
Beta strandi79 – 9517
Helixi100 – 1023
Beta strandi104 – 1118
Beta strandi116 – 1183
Beta strandi128 – 13710
Beta strandi142 – 1498
Beta strandi152 – 1598
Beta strandi166 – 1738
Beta strandi176 – 1816
Beta strandi186 – 1927
Helixi194 – 1963
Beta strandi199 – 2079
Beta strandi210 – 2178
Beta strandi224 – 2263
Beta strandi228 – 2336
Beta strandi238 – 2436
Beta strandi252 – 2576
Beta strandi260 – 2623
Helixi270 – 2723
Beta strandi274 – 2796
Beta strandi282 – 2876
Turni292 – 2943
Beta strandi295 – 30511
Beta strandi308 – 31912

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B5HX-ray2.80A/B/C/D140-321[»]
3I84X-ray2.00A/B13-219[»]
3I85X-ray2.50A/B13-219[»]
3QQNX-ray2.31A/B23-138[»]
3QR2X-ray2.30A/B23-138[»]
ProteinModelPortaliP35613.
SMRiP35613. Positions 23-319.

Miscellaneous databases

EvolutionaryTraceiP35613.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 21982Ig-like C2-typeAdd
BLAST
Domaini221 – 31595Ig-like V-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi356 – 3594Poly-Asp

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG83713.
HOGENOMiHOG000263411.
HOVERGENiHBG008120.
InParanoidiP35613.
KOiK06535.
OMAiDRNHLTR.
OrthoDBiEOG7V1FQN.
PhylomeDBiP35613.
TreeFamiTF326759.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR009151. Basigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10075:SF12. PTHR10075:SF12. 1 hit.
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: P35613-1) [UniParc]FASTAAdd to Basket

Also known as: Long, Basigin-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP    50
VPEIQWWFEG QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE 100
EDTGTYECRA SNDPDRNHLT RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG 150
SKILLTCSLN DSATEVTGHR WLKGGVVLKE DALPGQKTEF KVDSDDQWGE 200
YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML VCKSESVPPV 250
TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR 300
CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK 350
PEDVLDDDDA GSAPLKSSGQ HQNDKGKNVR QRNSS 385
Length:385
Mass (Da):42,200
Last modified:August 31, 2004 - v2
Checksum:iD74C37455BF26685
GO
Isoform 2 (identifier: P35613-2) [UniParc]FASTAAdd to Basket

Also known as: Basigin-1

The sequence of this isoform differs from the canonical sequence as follows:
     24-139: Missing.

Show »
Length:269
Mass (Da):29,221
Checksum:i0C9D6BEB966AC258
GO
Isoform 3 (identifier: P35613-3) [UniParc]FASTAAdd to Basket

Also known as: Basigin-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Note: Produced by alternative promoter usage. N-glycosylated.

Show »
Length:176
Mass (Da):19,438
Checksum:i1FF03934256AE63E
GO
Isoform 4 (identifier: P35613-4) [UniParc]FASTAAdd to Basket

Also known as: Basigin-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MAAALFVLLGF → MKQSDASPQER
     12-191: Missing.

Note: Produced by alternative promoter usage. N-glycosylated.

Show »
Length:205
Mass (Da):22,764
Checksum:i27B3348C16A690BD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti208 – 2081E → K in Ok(A-). 1 Publication
VAR_013574
Natural varianti269 – 2691G → V.
Corresponds to variant rs1803203 [ dbSNP | Ensembl ].
VAR_011720

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 209209Missing in isoform 3. VSP_043225Add
BLAST
Alternative sequencei1 – 1111MAAALFVLLGF → MKQSDASPQER in isoform 4. VSP_043226Add
BLAST
Alternative sequencei12 – 191180Missing in isoform 4. VSP_043227Add
BLAST
Alternative sequencei24 – 139116Missing in isoform 2. VSP_011501Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti328 – 3281F → L in BAC76828. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64364 mRNA. Translation: CAA45716.1.
D45131 mRNA. Translation: BAA08109.1.
L10240 mRNA. Translation: AAA68936.1.
M87879 mRNA. Translation: AAA91084.1.
L20471 mRNA. Translation: AAB41120.1.
AF042854
, AF042848, AF042849, AF042850, AF042851, AF042852, AF042853 Genomic DNA. Translation: AAD10704.1.
AB072923 mRNA. Translation: BAB88938.1.
AB085790 mRNA. Translation: BAC76828.1.
AF548371 mRNA. Translation: AAN40694.1.
GU557064 mRNA. Translation: ADD31881.1.
GU557065 mRNA. Translation: ADD31882.1.
AY358113 mRNA. Translation: AAQ88480.1.
AY942196 Genomic DNA. Translation: AAX20110.1.
AC005559 Genomic DNA. Translation: AAC33279.1.
CH471242 Genomic DNA. Translation: EAW61181.1.
CH471242 Genomic DNA. Translation: EAW61185.1.
BC009040 mRNA. Translation: AAH09040.1.
CCDSiCCDS12032.1. [P35613-4]
CCDS12033.1. [P35613-1]
CCDS12034.1. [P35613-2]
CCDS58635.1. [P35613-3]
PIRiA46506.
RefSeqiNP_001719.2. NM_001728.3. [P35613-1]
NP_940991.1. NM_198589.2. [P35613-2]
NP_940992.1. NM_198590.2. [P35613-3]
NP_940993.1. NM_198591.2. [P35613-4]
XP_005259676.1. XM_005259619.1. [P35613-2]
UniGeneiHs.501293.

Genome annotation databases

EnsembliENST00000333511; ENSP00000333769; ENSG00000172270. [P35613-1]
ENST00000346916; ENSP00000344707; ENSG00000172270. [P35613-4]
ENST00000353555; ENSP00000343809; ENSG00000172270. [P35613-2]
ENST00000545507; ENSP00000473664; ENSG00000172270. [P35613-3]
GeneIDi682.
KEGGihsa:682.
UCSCiuc002loy.4. human. [P35613-4]
uc002loz.4. human. [P35613-1]
uc021ulx.2. human. [P35613-3]

Polymorphism databases

DMDMi51704273.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64364 mRNA. Translation: CAA45716.1 .
D45131 mRNA. Translation: BAA08109.1 .
L10240 mRNA. Translation: AAA68936.1 .
M87879 mRNA. Translation: AAA91084.1 .
L20471 mRNA. Translation: AAB41120.1 .
AF042854
, AF042848 , AF042849 , AF042850 , AF042851 , AF042852 , AF042853 Genomic DNA. Translation: AAD10704.1 .
AB072923 mRNA. Translation: BAB88938.1 .
AB085790 mRNA. Translation: BAC76828.1 .
AF548371 mRNA. Translation: AAN40694.1 .
GU557064 mRNA. Translation: ADD31881.1 .
GU557065 mRNA. Translation: ADD31882.1 .
AY358113 mRNA. Translation: AAQ88480.1 .
AY942196 Genomic DNA. Translation: AAX20110.1 .
AC005559 Genomic DNA. Translation: AAC33279.1 .
CH471242 Genomic DNA. Translation: EAW61181.1 .
CH471242 Genomic DNA. Translation: EAW61185.1 .
BC009040 mRNA. Translation: AAH09040.1 .
CCDSi CCDS12032.1. [P35613-4 ]
CCDS12033.1. [P35613-1 ]
CCDS12034.1. [P35613-2 ]
CCDS58635.1. [P35613-3 ]
PIRi A46506.
RefSeqi NP_001719.2. NM_001728.3. [P35613-1 ]
NP_940991.1. NM_198589.2. [P35613-2 ]
NP_940992.1. NM_198590.2. [P35613-3 ]
NP_940993.1. NM_198591.2. [P35613-4 ]
XP_005259676.1. XM_005259619.1. [P35613-2 ]
UniGenei Hs.501293.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3B5H X-ray 2.80 A/B/C/D 140-321 [» ]
3I84 X-ray 2.00 A/B 13-219 [» ]
3I85 X-ray 2.50 A/B 13-219 [» ]
3QQN X-ray 2.31 A/B 23-138 [» ]
3QR2 X-ray 2.30 A/B 23-138 [» ]
ProteinModelPortali P35613.
SMRi P35613. Positions 23-319.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107147. 33 interactions.
IntActi P35613. 13 interactions.
MINTi MINT-5004205.
STRINGi 9606.ENSP00000333769.

Protein family/group databases

TCDBi 8.A.23.1.1. the basigin (basigin) family.

PTM databases

PhosphoSitei P35613.

Polymorphism databases

DMDMi 51704273.

Proteomic databases

MaxQBi P35613.
PaxDbi P35613.
PRIDEi P35613.

Protocols and materials databases

DNASUi 682.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333511 ; ENSP00000333769 ; ENSG00000172270 . [P35613-1 ]
ENST00000346916 ; ENSP00000344707 ; ENSG00000172270 . [P35613-4 ]
ENST00000353555 ; ENSP00000343809 ; ENSG00000172270 . [P35613-2 ]
ENST00000545507 ; ENSP00000473664 ; ENSG00000172270 . [P35613-3 ]
GeneIDi 682.
KEGGi hsa:682.
UCSCi uc002loy.4. human. [P35613-4 ]
uc002loz.4. human. [P35613-1 ]
uc021ulx.2. human. [P35613-3 ]

Organism-specific databases

CTDi 682.
GeneCardsi GC19P000571.
HGNCi HGNC:1116. BSG.
HPAi CAB002427.
HPA036048.
MIMi 109480. gene.
111380. phenotype.
neXtProti NX_P35613.
PharmGKBi PA25433.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83713.
HOGENOMi HOG000263411.
HOVERGENi HBG008120.
InParanoidi P35613.
KOi K06535.
OMAi DRNHLTR.
OrthoDBi EOG7V1FQN.
PhylomeDBi P35613.
TreeFami TF326759.

Enzyme and pathway databases

Reactomei REACT_118572. Degradation of the extracellular matrix.
REACT_12560. Basigin interactions.
REACT_13552. Integrin cell surface interactions.
REACT_2071. Pyruvate metabolism.

Miscellaneous databases

ChiTaRSi BSG. human.
EvolutionaryTracei P35613.
GeneWikii Basigin.
GenomeRNAii 682.
NextBioi 2802.
PMAP-CutDB P35613.
PROi P35613.
SOURCEi Search...

Gene expression databases

ArrayExpressi P35613.
Bgeei P35613.
CleanExi HS_BSG.
Genevestigatori P35613.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR009151. Basigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
PANTHERi PTHR10075:SF12. PTHR10075:SF12. 1 hit.
Pfami PF07679. I-set. 2 hits.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule."
    Kasinrerk W., Fiebiger E., Stefanova I., Baumruker T., Knapp W., Stockinger H.
    J. Immunol. 149:847-854(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen."
    Miyauchi T., Masuzawa Y., Muramatsu T.
    J. Biochem. 110:770-774(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
  3. "The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily."
    Biswas C., Zhang Y., Decastro R., Guo H., Nakamura T., Kataoka H., Nabeshima K.
    Cancer Res. 55:434-439(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. Wakasugi H., Scamps C., Yang G., Vancong N., Bernheim A., Tursz T., Harada N.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
  5. Decastro R., Zhang Y., Kataoka H., Coon J., Biswas C.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
  6. "Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases."
    Guo H., Majmudar G., Jensen T.C., Biswas C., Toole B.P., Gordon M.K.
    Gene 220:99-108(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
  7. "Regulation of EMMPRIN/CD147 expression and its function of controlling matrix metalloproteinases production and cell-surface localization in co-culture of human uterine cervical carcinoma SKG-II cells and human uterine cervical fibroblasts."
    Sato T., Takita M., Noguchi Y., Hirata M., Sakai T., Ito A.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
  8. Kim D., Kanai Y., Choi H., Shin H., Kim J., Teraoka H., Shigeta Y., Chairoungdua A., Babu E., Anzai N., Iribe Y., Endou H.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
  9. Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    Tissue: Retina.
  10. "Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion."
    Liao C.G., Kong L.M., Song F., Xing J.L., Wang L.X., Sun Z.J., Tang H., Yao H., Zhang Y., Wang L., Wang Y., Yang X.M., Li Y., Chen Z.N.
    Mol. Cell. Biol. 31:2591-2604(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), SUBUNIT, SUBCELLULAR LOCATION, ALTERNATIVE PROMOTER USAGE.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  12. SeattleSNPs variation discovery resource
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  13. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  15. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.
  16. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36 (ISOFORM 1).
  17. "Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor."
    Nabeshima K., Lane W.S., Biswas C.
    Arch. Biochem. Biophys. 285:90-96(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
  18. "Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion."
    Muramatsu T., Miyauchi T.
    Histol. Histopathol. 18:981-987(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  19. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-160 AND ASN-268.
  20. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  21. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  22. "The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity."
    Manoharan C., Wilson M.C., Sessions R.B., Halestrap A.P.
    Mol. Membr. Biol. 23:486-498(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SLC16A1.
  23. "junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147."
    Schreiner A., Ruonala M., Jakob V., Suthaus J., Boles E., Wouters F., Starzinski-Powitz A.
    Mol. Biol. Cell 18:1272-1281(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AJAP1.
  24. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268.
    Tissue: Liver.
  26. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268.
    Tissue: Leukemic T-cell.
  27. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  28. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  29. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  30. "Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion."
    Yu X.-L., Hu T., Du J.-M., Ding J.-P., Yang X.-M., Zhang J., Yang B., Shen X., Zhang Z., Zhong W.-D., Wen N., Jiang H., Zhu P., Chen Z.-N.
    J. Biol. Chem. 283:18056-18065(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 140-321, SUBUNIT, DISULFIDE BONDS.
  31. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 13-219, IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, DISULFIDE BONDS.
  32. "The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues."
    Spring F.A., Holmes C.H., Simpson K.L., Mawby W.J., Mattes M.J., Okubo Y., Parsons S.F.
    Eur. J. Immunol. 27:891-897(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LYS-208.

Entry informationi

Entry nameiBASI_HUMAN
AccessioniPrimary (citable) accession number: P35613
Secondary accession number(s): A6NJW1
, D3YLG5, Q7Z796, Q8IZL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 31, 2004
Last modified: September 3, 2014
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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