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P35613 (BASI_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 160. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Basigin
Alternative name(s):
5F7
Collagenase stimulatory factor
Extracellular matrix metalloproteinase inducer
Short name=EMMPRIN
Leukocyte activation antigen M6
OK blood group antigen
Tumor cell-derived collagenase stimulatory factor
Short name=TCSF
CD_antigen=CD147
Gene names
Name:BSG
ORF Names:UNQ6505/PRO21383
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Ref.22

Subunit structure

Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM By similarity. Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Ref.10 Ref.22 Ref.23 Ref.30 Ref.31

Subcellular location

Cell membrane; Single-pass type I membrane protein. Melanosome. Note: Colocalizes with SLC16A1 and SLC16A8 By similarity. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.10 Ref.21 Ref.22

Tissue specificity

Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Induction

Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.

Post-translational modification

N-glycosylated. Ref.19

Sequence similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative promoter usage
Alternative splicing
Polymorphism
   DomainImmunoglobulin domain
Signal
Transmembrane
Transmembrane helix
   LigandLectin
Mannose-binding
   Molecular functionBlood group antigen
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Traceable author statement. Source: Reactome

cell surface receptor signaling pathway

Traceable author statement Ref.6. Source: ProtInc

cellular metabolic process

Traceable author statement. Source: Reactome

decidualization

Inferred from electronic annotation. Source: Ensembl

embryo implantation

Inferred from electronic annotation. Source: Ensembl

extracellular matrix disassembly

Traceable author statement. Source: Reactome

extracellular matrix organization

Traceable author statement. Source: Reactome

leukocyte migration

Traceable author statement. Source: Reactome

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

protein targeting to plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

pyruvate metabolic process

Traceable author statement. Source: Reactome

response to cAMP

Inferred from electronic annotation. Source: Ensembl

response to mercury ion

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

small molecule metabolic process

Traceable author statement. Source: Reactome

   Cellular_componentGolgi membrane

Traceable author statement. Source: Reactome

acrosomal membrane

Inferred from electronic annotation. Source: Ensembl

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337PubMed 23376485. Source: UniProt

integral component of plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

melanosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane raft

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from direct assay PubMed 20833797. Source: UniProt

plasma membrane

Traceable author statement. Source: Reactome

sarcolemma

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionmannose binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction Ref.22PubMed 22080952. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]
Isoform 1 (identifier: P35613-1)

Also known as: Long; Basigin-2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P35613-2)

Also known as: Basigin-1;

The sequence of this isoform differs from the canonical sequence as follows:
     24-139: Missing.
Isoform 3 (identifier: P35613-3)

Also known as: Basigin-3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
Note: Produced by alternative promoter usage. N-glycosylated.
Isoform 4 (identifier: P35613-4)

Also known as: Basigin-4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MAAALFVLLGF → MKQSDASPQER
     12-191: Missing.
Note: Produced by alternative promoter usage. N-glycosylated.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.16
Chain22 – 385364Basigin
PRO_0000014518

Regions

Topological domain138 – 323186Extracellular Potential
Transmembrane324 – 34421Helical; Potential
Topological domain345 – 38541Cytoplasmic Potential
Domain138 – 21982Ig-like C2-type
Domain221 – 31595Ig-like V-type
Compositional bias356 – 3594Poly-Asp

Amino acid modifications

Modified residue3621Phosphoserine Ref.20 Ref.27 Ref.29
Modified residue3681Phosphoserine By similarity
Glycosylation1601N-linked (GlcNAc...) Ref.19 Ref.25 Ref.26
Glycosylation2681N-linked (GlcNAc...) Ref.19 Ref.25 Ref.26
Glycosylation3021N-linked (GlcNAc...) Potential
Disulfide bond157 ↔ 203 Ref.30 Ref.31
Disulfide bond242 ↔ 301 Ref.30 Ref.31

Natural variations

Alternative sequence1 – 209209Missing in isoform 3.
VSP_043225
Alternative sequence1 – 1111MAAALFVLLGF → MKQSDASPQER in isoform 4.
VSP_043226
Alternative sequence12 – 191180Missing in isoform 4.
VSP_043227
Alternative sequence24 – 139116Missing in isoform 2.
VSP_011501
Natural variant2081E → K in Ok(A-). Ref.32
VAR_013574
Natural variant2691G → V.
Corresponds to variant rs1803203 [ dbSNP | Ensembl ].
VAR_011720

Experimental info

Sequence conflict3281F → L in BAC76828. Ref.2

Secondary structure

.......................................................... 385
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) (Basigin-2) [UniParc].

Last modified August 31, 2004. Version 2.
Checksum: D74C37455BF26685

FASTA38542,200
        10         20         30         40         50         60 
MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP VPEIQWWFEG 

        70         80         90        100        110        120 
QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE EDTGTYECRA SNDPDRNHLT 

       130        140        150        160        170        180 
RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG SKILLTCSLN DSATEVTGHR WLKGGVVLKE 

       190        200        210        220        230        240 
DALPGQKTEF KVDSDDQWGE YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML 

       250        260        270        280        290        300 
VCKSESVPPV TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR 

       310        320        330        340        350        360 
CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK PEDVLDDDDA 

       370        380 
GSAPLKSSGQ HQNDKGKNVR QRNSS 

« Hide

Isoform 2 (Basigin-1) [UniParc].

Checksum: 0C9D6BEB966AC258
Show »

FASTA26929,221
Isoform 3 (Basigin-3) [UniParc].

Checksum: 1FF03934256AE63E
Show »

FASTA17619,438
Isoform 4 (Basigin-4) [UniParc].

Checksum: 27B3348C16A690BD
Show »

FASTA20522,764

References

« Hide 'large scale' references
[1]"Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule."
Kasinrerk W., Fiebiger E., Stefanova I., Baumruker T., Knapp W., Stockinger H.
J. Immunol. 149:847-854(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen."
Miyauchi T., Masuzawa Y., Muramatsu T.
J. Biochem. 110:770-774(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[3]"The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily."
Biswas C., Zhang Y., Decastro R., Guo H., Nakamura T., Kataoka H., Nabeshima K.
Cancer Res. 55:434-439(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]Wakasugi H., Scamps C., Yang G., Vancong N., Bernheim A., Tursz T., Harada N.
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
[5]Decastro R., Zhang Y., Kataoka H., Coon J., Biswas C.
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
[6]"Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases."
Guo H., Majmudar G., Jensen T.C., Biswas C., Toole B.P., Gordon M.K.
Gene 220:99-108(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[7]"Regulation of EMMPRIN/CD147 expression and its function of controlling matrix metalloproteinases production and cell-surface localization in co-culture of human uterine cervical carcinoma SKG-II cells and human uterine cervical fibroblasts."
Sato T., Takita M., Noguchi Y., Hirata M., Sakai T., Ito A.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
[8]Kim D., Kanai Y., Choi H., Shin H., Kim J., Teraoka H., Shigeta Y., Chairoungdua A., Babu E., Anzai N., Iribe Y., Endou H.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
[9]"Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily."
Ochrietor J.D., Moroz T.P., van Ekeris L., Clamp M.F., Jefferson S.C., deCarvalho A.C., Fadool J.M., Wistow G., Muramatsu T., Linser P.J.
Invest. Ophthalmol. Vis. Sci. 44:4086-4096(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
Tissue: Retina.
[10]"Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion."
Liao C.G., Kong L.M., Song F., Xing J.L., Wang L.X., Sun Z.J., Tang H., Yao H., Zhang Y., Wang L., Wang Y., Yang X.M., Li Y., Chen Z.N.
Mol. Cell. Biol. 31:2591-2604(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), SUBUNIT, SUBCELLULAR LOCATION, ALTERNATIVE PROMOTER USAGE.
[11]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[12]SeattleSNPs variation discovery resource
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[13]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[14]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[15]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Eye.
[16]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36 (ISOFORM 1).
[17]"Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor."
Nabeshima K., Lane W.S., Biswas C.
Arch. Biochem. Biophys. 285:90-96(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
[18]"Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion."
Muramatsu T., Miyauchi T.
Histol. Histopathol. 18:981-987(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[19]"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H., Li X.-J., Martin D.B., Aebersold R.
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-160 AND ASN-268.
[20]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[21]"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F.
J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Melanoma.
[22]"The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity."
Manoharan C., Wilson M.C., Sessions R.B., Halestrap A.P.
Mol. Membr. Biol. 23:486-498(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SLC16A1.
[23]"junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147."
Schreiner A., Ruonala M., Jakob V., Suthaus J., Boles E., Wouters F., Starzinski-Powitz A.
Mol. Biol. Cell 18:1272-1281(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AJAP1.
[24]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[25]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268.
Tissue: Liver.
[26]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268.
Tissue: Leukemic T-cell.
[27]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[28]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[29]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[30]"Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion."
Yu X.-L., Hu T., Du J.-M., Ding J.-P., Yang X.-M., Zhang J., Yang B., Shen X., Zhang Z., Zhong W.-D., Wen N., Jiang H., Zhu P., Chen Z.-N.
J. Biol. Chem. 283:18056-18065(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 140-321, SUBUNIT, DISULFIDE BONDS.
[31]"Structure of the EMMPRIN N-terminal domain 1: dimerization via beta-strand swapping."
Luo J., Teplyakov A., Obmolova G., Malia T., Wu S.-J., Beil E., Baker A., Swencki-Underwood B., Zhao Y., Sprenkle J., Dixon K., Sweet R., Gilliland G.L.
Proteins 77:1009-1014(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 13-219, IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, DISULFIDE BONDS.
[32]"The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues."
Spring F.A., Holmes C.H., Simpson K.L., Mawby W.J., Mattes M.J., Okubo Y., Parsons S.F.
Eur. J. Immunol. 27:891-897(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LYS-208.
+Additional computationally mapped references.

Web resources

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64364 mRNA. Translation: CAA45716.1.
D45131 mRNA. Translation: BAA08109.1.
L10240 mRNA. Translation: AAA68936.1.
M87879 mRNA. Translation: AAA91084.1.
L20471 mRNA. Translation: AAB41120.1.
AF042854 expand/collapse EMBL AC list , AF042848, AF042849, AF042850, AF042851, AF042852, AF042853 Genomic DNA. Translation: AAD10704.1.
AB072923 mRNA. Translation: BAB88938.1.
AB085790 mRNA. Translation: BAC76828.1.
AF548371 mRNA. Translation: AAN40694.1.
GU557064 mRNA. Translation: ADD31881.1.
GU557065 mRNA. Translation: ADD31882.1.
AY358113 mRNA. Translation: AAQ88480.1.
AY942196 Genomic DNA. Translation: AAX20110.1.
AC005559 Genomic DNA. Translation: AAC33279.1.
CH471242 Genomic DNA. Translation: EAW61181.1.
CH471242 Genomic DNA. Translation: EAW61185.1.
BC009040 mRNA. Translation: AAH09040.1.
CCDSCCDS12032.1. [P35613-4]
CCDS12033.1. [P35613-1]
CCDS12034.1. [P35613-2]
CCDS58635.1. [P35613-3]
PIRA46506.
RefSeqNP_001719.2. NM_001728.3. [P35613-1]
NP_940991.1. NM_198589.2. [P35613-2]
NP_940992.1. NM_198590.2. [P35613-3]
NP_940993.1. NM_198591.2. [P35613-4]
XP_005259676.1. XM_005259619.1. [P35613-2]
UniGeneHs.501293.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3B5HX-ray2.80A/B/C/D140-321[»]
3I84X-ray2.00A/B13-219[»]
3I85X-ray2.50A/B13-219[»]
3QQNX-ray2.31A/B23-138[»]
3QR2X-ray2.30A/B23-138[»]
ProteinModelPortalP35613.
SMRP35613. Positions 23-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107147. 34 interactions.
IntActP35613. 13 interactions.
MINTMINT-5004205.
STRING9606.ENSP00000333769.

Protein family/group databases

TCDB8.A.23.1.1. the basigin (basigin) family.

PTM databases

PhosphoSiteP35613.

Polymorphism databases

DMDM51704273.

Proteomic databases

MaxQBP35613.
PaxDbP35613.
PRIDEP35613.

Protocols and materials databases

DNASU682.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333511; ENSP00000333769; ENSG00000172270. [P35613-1]
ENST00000346916; ENSP00000344707; ENSG00000172270. [P35613-4]
ENST00000353555; ENSP00000343809; ENSG00000172270. [P35613-2]
ENST00000545507; ENSP00000473664; ENSG00000172270. [P35613-3]
GeneID682.
KEGGhsa:682.
UCSCuc002loy.4. human. [P35613-4]
uc002loz.4. human. [P35613-1]
uc021ulx.2. human. [P35613-3]

Organism-specific databases

CTD682.
GeneCardsGC19P000571.
HGNCHGNC:1116. BSG.
HPACAB002427.
HPA036048.
MIM109480. gene.
111380. phenotype.
neXtProtNX_P35613.
PharmGKBPA25433.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG83713.
HOGENOMHOG000263411.
HOVERGENHBG008120.
InParanoidP35613.
KOK06535.
OMADRNHLTR.
OrthoDBEOG7V1FQN.
PhylomeDBP35613.
TreeFamTF326759.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_118779. Extracellular matrix organization.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpressP35613.
BgeeP35613.
CleanExHS_BSG.
GenevestigatorP35613.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR009151. Basigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERPTHR10075:SF12. PTHR10075:SF12. 1 hit.
PfamPF07679. I-set. 2 hits.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBSG. human.
EvolutionaryTraceP35613.
GeneWikiBasigin.
GenomeRNAi682.
NextBio2802.
PMAP-CutDBP35613.
PROP35613.
SOURCESearch...

Entry information

Entry nameBASI_HUMAN
AccessionPrimary (citable) accession number: P35613
Secondary accession number(s): A6NJW1 expand/collapse secondary AC list , D3YLG5, Q7Z796, Q8IZL7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 31, 2004
Last modified: July 9, 2014
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Blood group antigen proteins

Nomenclature of blood group antigens and list of entries