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P35613

- BASI_HUMAN

UniProt

P35613 - BASI_HUMAN

Protein

Basigin

Gene

BSG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 162 (01 Oct 2014)
      Sequence version 2 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.1 Publication

    GO - Molecular functioni

    1. mannose binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cell surface receptor signaling pathway Source: ProtInc
    3. cellular metabolic process Source: Reactome
    4. decidualization Source: Ensembl
    5. embryo implantation Source: Ensembl
    6. extracellular matrix disassembly Source: Reactome
    7. extracellular matrix organization Source: Reactome
    8. leukocyte migration Source: Reactome
    9. odontogenesis of dentin-containing tooth Source: Ensembl
    10. protein targeting to plasma membrane Source: UniProtKB
    11. pyruvate metabolic process Source: Reactome
    12. response to cAMP Source: Ensembl
    13. response to mercury ion Source: Ensembl
    14. response to peptide hormone Source: Ensembl
    15. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Blood group antigen

    Keywords - Ligandi

    Lectin, Mannose-binding

    Enzyme and pathway databases

    ReactomeiREACT_118572. Degradation of the extracellular matrix.
    REACT_12560. Basigin interactions.
    REACT_13552. Integrin cell surface interactions.
    REACT_2071. Pyruvate metabolism.

    Protein family/group databases

    TCDBi8.A.23.1.1. the basigin (basigin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Basigin
    Alternative name(s):
    5F7
    Collagenase stimulatory factor
    Extracellular matrix metalloproteinase inducer
    Short name:
    EMMPRIN
    Leukocyte activation antigen M6
    OK blood group antigen
    Tumor cell-derived collagenase stimulatory factor
    Short name:
    TCSF
    CD_antigen: CD147
    Gene namesi
    Name:BSG
    ORF Names:UNQ6505/PRO21383
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:1116. BSG.

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein. Melanosome
    Note: Colocalizes with SLC16A1 and SLC16A8 By similarity. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.By similarity

    GO - Cellular componenti

    1. acrosomal membrane Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. Golgi membrane Source: Reactome
    4. integral component of plasma membrane Source: UniProtKB
    5. melanosome Source: UniProtKB-SubCell
    6. membrane Source: UniProtKB
    7. membrane raft Source: Ensembl
    8. mitochondrion Source: UniProt
    9. plasma membrane Source: Reactome
    10. sarcolemma Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi111380. phenotype.
    PharmGKBiPA25433.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 385364BasiginPRO_0000014518Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi157 ↔ 203
    Glycosylationi160 – 1601N-linked (GlcNAc...)3 Publications
    Disulfide bondi242 ↔ 301
    Glycosylationi268 – 2681N-linked (GlcNAc...)3 Publications
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Modified residuei362 – 3621Phosphoserine3 Publications
    Modified residuei368 – 3681PhosphoserineBy similarity

    Post-translational modificationi

    N-glycosylated.3 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP35613.
    PaxDbiP35613.
    PRIDEiP35613.

    PTM databases

    PhosphoSiteiP35613.

    Miscellaneous databases

    PMAP-CutDBP35613.

    Expressioni

    Tissue specificityi

    Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

    Inductioni

    Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.

    Gene expression databases

    ArrayExpressiP35613.
    BgeeiP35613.
    CleanExiHS_BSG.
    GenevestigatoriP35613.

    Organism-specific databases

    HPAiCAB002427.
    HPA036048.

    Interactioni

    Subunit structurei

    Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM By similarity. Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer.By similarity5 Publications

    Protein-protein interaction databases

    BioGridi107147. 33 interactions.
    IntActiP35613. 13 interactions.
    MINTiMINT-5004205.
    STRINGi9606.ENSP00000333769.

    Structurei

    Secondary structure

    1
    385
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi24 – 274
    Beta strandi32 – 354
    Beta strandi40 – 478
    Beta strandi53 – 6210
    Helixi74 – 774
    Beta strandi79 – 9517
    Helixi100 – 1023
    Beta strandi104 – 1118
    Beta strandi116 – 1183
    Beta strandi128 – 13710
    Beta strandi142 – 1498
    Beta strandi152 – 1598
    Beta strandi166 – 1738
    Beta strandi176 – 1816
    Beta strandi186 – 1927
    Helixi194 – 1963
    Beta strandi199 – 2079
    Beta strandi210 – 2178
    Beta strandi224 – 2263
    Beta strandi228 – 2336
    Beta strandi238 – 2436
    Beta strandi252 – 2576
    Beta strandi260 – 2623
    Helixi270 – 2723
    Beta strandi274 – 2796
    Beta strandi282 – 2876
    Turni292 – 2943
    Beta strandi295 – 30511
    Beta strandi308 – 31912

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3B5HX-ray2.80A/B/C/D140-321[»]
    3I84X-ray2.00A/B13-219[»]
    3I85X-ray2.50A/B13-219[»]
    3QQNX-ray2.31A/B23-138[»]
    3QR2X-ray2.30A/B23-138[»]
    ProteinModelPortaliP35613.
    SMRiP35613. Positions 23-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP35613.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini138 – 323186ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini345 – 38541CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei324 – 34421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini138 – 21982Ig-like C2-typeAdd
    BLAST
    Domaini221 – 31595Ig-like V-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi356 – 3594Poly-Asp

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG83713.
    HOGENOMiHOG000263411.
    HOVERGENiHBG008120.
    InParanoidiP35613.
    KOiK06535.
    OMAiDRNHLTR.
    OrthoDBiEOG7V1FQN.
    PhylomeDBiP35613.
    TreeFamiTF326759.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR009151. Basigin.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PANTHERiPTHR10075:SF12. PTHR10075:SF12. 1 hit.
    PfamiPF07679. I-set. 2 hits.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: P35613-1) [UniParc]FASTAAdd to Basket

    Also known as: Long, Basigin-2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP    50
    VPEIQWWFEG QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE 100
    EDTGTYECRA SNDPDRNHLT RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG 150
    SKILLTCSLN DSATEVTGHR WLKGGVVLKE DALPGQKTEF KVDSDDQWGE 200
    YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML VCKSESVPPV 250
    TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR 300
    CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK 350
    PEDVLDDDDA GSAPLKSSGQ HQNDKGKNVR QRNSS 385
    Length:385
    Mass (Da):42,200
    Last modified:August 31, 2004 - v2
    Checksum:iD74C37455BF26685
    GO
    Isoform 2 (identifier: P35613-2) [UniParc]FASTAAdd to Basket

    Also known as: Basigin-1

    The sequence of this isoform differs from the canonical sequence as follows:
         24-139: Missing.

    Show »
    Length:269
    Mass (Da):29,221
    Checksum:i0C9D6BEB966AC258
    GO
    Isoform 3 (identifier: P35613-3) [UniParc]FASTAAdd to Basket

    Also known as: Basigin-3

    The sequence of this isoform differs from the canonical sequence as follows:
         1-209: Missing.

    Note: Produced by alternative promoter usage. N-glycosylated.

    Show »
    Length:176
    Mass (Da):19,438
    Checksum:i1FF03934256AE63E
    GO
    Isoform 4 (identifier: P35613-4) [UniParc]FASTAAdd to Basket

    Also known as: Basigin-4

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: MAAALFVLLGF → MKQSDASPQER
         12-191: Missing.

    Note: Produced by alternative promoter usage. N-glycosylated.

    Show »
    Length:205
    Mass (Da):22,764
    Checksum:i27B3348C16A690BD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti328 – 3281F → L in BAC76828. (PubMed:1783610)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti208 – 2081E → K in Ok(A-). 1 Publication
    VAR_013574
    Natural varianti269 – 2691G → V.
    Corresponds to variant rs1803203 [ dbSNP | Ensembl ].
    VAR_011720

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 209209Missing in isoform 3. 1 PublicationVSP_043225Add
    BLAST
    Alternative sequencei1 – 1111MAAALFVLLGF → MKQSDASPQER in isoform 4. 1 PublicationVSP_043226Add
    BLAST
    Alternative sequencei12 – 191180Missing in isoform 4. 1 PublicationVSP_043227Add
    BLAST
    Alternative sequencei24 – 139116Missing in isoform 2. 3 PublicationsVSP_011501Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64364 mRNA. Translation: CAA45716.1.
    D45131 mRNA. Translation: BAA08109.1.
    L10240 mRNA. Translation: AAA68936.1.
    M87879 mRNA. Translation: AAA91084.1.
    L20471 mRNA. Translation: AAB41120.1.
    AF042854
    , AF042848, AF042849, AF042850, AF042851, AF042852, AF042853 Genomic DNA. Translation: AAD10704.1.
    AB072923 mRNA. Translation: BAB88938.1.
    AB085790 mRNA. Translation: BAC76828.1.
    AF548371 mRNA. Translation: AAN40694.1.
    GU557064 mRNA. Translation: ADD31881.1.
    GU557065 mRNA. Translation: ADD31882.1.
    AY358113 mRNA. Translation: AAQ88480.1.
    AY942196 Genomic DNA. Translation: AAX20110.1.
    AC005559 Genomic DNA. Translation: AAC33279.1.
    CH471242 Genomic DNA. Translation: EAW61181.1.
    CH471242 Genomic DNA. Translation: EAW61185.1.
    BC009040 mRNA. Translation: AAH09040.1.
    CCDSiCCDS12032.1. [P35613-4]
    CCDS12033.1. [P35613-1]
    CCDS12034.1. [P35613-2]
    CCDS58635.1. [P35613-3]
    PIRiA46506.
    RefSeqiNP_001719.2. NM_001728.3. [P35613-1]
    NP_940991.1. NM_198589.2. [P35613-2]
    NP_940992.1. NM_198590.2. [P35613-3]
    NP_940993.1. NM_198591.2. [P35613-4]
    XP_005259676.1. XM_005259619.1. [P35613-2]
    UniGeneiHs.501293.

    Genome annotation databases

    EnsembliENST00000333511; ENSP00000333769; ENSG00000172270. [P35613-1]
    ENST00000346916; ENSP00000344707; ENSG00000172270. [P35613-4]
    ENST00000353555; ENSP00000343809; ENSG00000172270. [P35613-2]
    ENST00000545507; ENSP00000473664; ENSG00000172270. [P35613-3]
    GeneIDi682.
    KEGGihsa:682.
    UCSCiuc002loy.4. human. [P35613-4]
    uc002loz.4. human. [P35613-1]
    uc021ulx.2. human. [P35613-3]

    Polymorphism databases

    DMDMi51704273.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64364 mRNA. Translation: CAA45716.1 .
    D45131 mRNA. Translation: BAA08109.1 .
    L10240 mRNA. Translation: AAA68936.1 .
    M87879 mRNA. Translation: AAA91084.1 .
    L20471 mRNA. Translation: AAB41120.1 .
    AF042854
    , AF042848 , AF042849 , AF042850 , AF042851 , AF042852 , AF042853 Genomic DNA. Translation: AAD10704.1 .
    AB072923 mRNA. Translation: BAB88938.1 .
    AB085790 mRNA. Translation: BAC76828.1 .
    AF548371 mRNA. Translation: AAN40694.1 .
    GU557064 mRNA. Translation: ADD31881.1 .
    GU557065 mRNA. Translation: ADD31882.1 .
    AY358113 mRNA. Translation: AAQ88480.1 .
    AY942196 Genomic DNA. Translation: AAX20110.1 .
    AC005559 Genomic DNA. Translation: AAC33279.1 .
    CH471242 Genomic DNA. Translation: EAW61181.1 .
    CH471242 Genomic DNA. Translation: EAW61185.1 .
    BC009040 mRNA. Translation: AAH09040.1 .
    CCDSi CCDS12032.1. [P35613-4 ]
    CCDS12033.1. [P35613-1 ]
    CCDS12034.1. [P35613-2 ]
    CCDS58635.1. [P35613-3 ]
    PIRi A46506.
    RefSeqi NP_001719.2. NM_001728.3. [P35613-1 ]
    NP_940991.1. NM_198589.2. [P35613-2 ]
    NP_940992.1. NM_198590.2. [P35613-3 ]
    NP_940993.1. NM_198591.2. [P35613-4 ]
    XP_005259676.1. XM_005259619.1. [P35613-2 ]
    UniGenei Hs.501293.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3B5H X-ray 2.80 A/B/C/D 140-321 [» ]
    3I84 X-ray 2.00 A/B 13-219 [» ]
    3I85 X-ray 2.50 A/B 13-219 [» ]
    3QQN X-ray 2.31 A/B 23-138 [» ]
    3QR2 X-ray 2.30 A/B 23-138 [» ]
    ProteinModelPortali P35613.
    SMRi P35613. Positions 23-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107147. 33 interactions.
    IntActi P35613. 13 interactions.
    MINTi MINT-5004205.
    STRINGi 9606.ENSP00000333769.

    Protein family/group databases

    TCDBi 8.A.23.1.1. the basigin (basigin) family.

    PTM databases

    PhosphoSitei P35613.

    Polymorphism databases

    DMDMi 51704273.

    Proteomic databases

    MaxQBi P35613.
    PaxDbi P35613.
    PRIDEi P35613.

    Protocols and materials databases

    DNASUi 682.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333511 ; ENSP00000333769 ; ENSG00000172270 . [P35613-1 ]
    ENST00000346916 ; ENSP00000344707 ; ENSG00000172270 . [P35613-4 ]
    ENST00000353555 ; ENSP00000343809 ; ENSG00000172270 . [P35613-2 ]
    ENST00000545507 ; ENSP00000473664 ; ENSG00000172270 . [P35613-3 ]
    GeneIDi 682.
    KEGGi hsa:682.
    UCSCi uc002loy.4. human. [P35613-4 ]
    uc002loz.4. human. [P35613-1 ]
    uc021ulx.2. human. [P35613-3 ]

    Organism-specific databases

    CTDi 682.
    GeneCardsi GC19P000571.
    HGNCi HGNC:1116. BSG.
    HPAi CAB002427.
    HPA036048.
    MIMi 109480. gene.
    111380. phenotype.
    neXtProti NX_P35613.
    PharmGKBi PA25433.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83713.
    HOGENOMi HOG000263411.
    HOVERGENi HBG008120.
    InParanoidi P35613.
    KOi K06535.
    OMAi DRNHLTR.
    OrthoDBi EOG7V1FQN.
    PhylomeDBi P35613.
    TreeFami TF326759.

    Enzyme and pathway databases

    Reactomei REACT_118572. Degradation of the extracellular matrix.
    REACT_12560. Basigin interactions.
    REACT_13552. Integrin cell surface interactions.
    REACT_2071. Pyruvate metabolism.

    Miscellaneous databases

    ChiTaRSi BSG. human.
    EvolutionaryTracei P35613.
    GeneWikii Basigin.
    GenomeRNAii 682.
    NextBioi 2802.
    PMAP-CutDB P35613.
    PROi P35613.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35613.
    Bgeei P35613.
    CleanExi HS_BSG.
    Genevestigatori P35613.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR009151. Basigin.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    PANTHERi PTHR10075:SF12. PTHR10075:SF12. 1 hit.
    Pfami PF07679. I-set. 2 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule."
      Kasinrerk W., Fiebiger E., Stefanova I., Baumruker T., Knapp W., Stockinger H.
      J. Immunol. 149:847-854(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen."
      Miyauchi T., Masuzawa Y., Muramatsu T.
      J. Biochem. 110:770-774(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
    3. "The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily."
      Biswas C., Zhang Y., Decastro R., Guo H., Nakamura T., Kataoka H., Nabeshima K.
      Cancer Res. 55:434-439(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. Wakasugi H., Scamps C., Yang G., Vancong N., Bernheim A., Tursz T., Harada N.
      Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
    5. Decastro R., Zhang Y., Kataoka H., Coon J., Biswas C.
      Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
    6. "Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases."
      Guo H., Majmudar G., Jensen T.C., Biswas C., Toole B.P., Gordon M.K.
      Gene 220:99-108(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
    7. "Regulation of EMMPRIN/CD147 expression and its function of controlling matrix metalloproteinases production and cell-surface localization in co-culture of human uterine cervical carcinoma SKG-II cells and human uterine cervical fibroblasts."
      Sato T., Takita M., Noguchi Y., Hirata M., Sakai T., Ito A.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
    8. Kim D., Kanai Y., Choi H., Shin H., Kim J., Teraoka H., Shigeta Y., Chairoungdua A., Babu E., Anzai N., Iribe Y., Endou H.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
    9. Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
      Tissue: Retina.
    10. "Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion."
      Liao C.G., Kong L.M., Song F., Xing J.L., Wang L.X., Sun Z.J., Tang H., Yao H., Zhang Y., Wang L., Wang Y., Yang X.M., Li Y., Chen Z.N.
      Mol. Cell. Biol. 31:2591-2604(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), SUBUNIT, SUBCELLULAR LOCATION, ALTERNATIVE PROMOTER USAGE.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    12. SeattleSNPs variation discovery resource
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    13. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    15. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Eye.
    16. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36 (ISOFORM 1).
    17. "Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor."
      Nabeshima K., Lane W.S., Biswas C.
      Arch. Biochem. Biophys. 285:90-96(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    18. "Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion."
      Muramatsu T., Miyauchi T.
      Histol. Histopathol. 18:981-987(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    19. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-160 AND ASN-268.
    20. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    21. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    22. "The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity."
      Manoharan C., Wilson M.C., Sessions R.B., Halestrap A.P.
      Mol. Membr. Biol. 23:486-498(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SLC16A1.
    23. "junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147."
      Schreiner A., Ruonala M., Jakob V., Suthaus J., Boles E., Wouters F., Starzinski-Powitz A.
      Mol. Biol. Cell 18:1272-1281(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AJAP1.
    24. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    25. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268.
      Tissue: Liver.
    26. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268.
      Tissue: Leukemic T-cell.
    27. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    28. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    29. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    30. "Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion."
      Yu X.-L., Hu T., Du J.-M., Ding J.-P., Yang X.-M., Zhang J., Yang B., Shen X., Zhang Z., Zhong W.-D., Wen N., Jiang H., Zhu P., Chen Z.-N.
      J. Biol. Chem. 283:18056-18065(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 140-321, SUBUNIT, DISULFIDE BONDS.
    31. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 13-219, IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, DISULFIDE BONDS.
    32. "The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues."
      Spring F.A., Holmes C.H., Simpson K.L., Mawby W.J., Mattes M.J., Okubo Y., Parsons S.F.
      Eur. J. Immunol. 27:891-897(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LYS-208.

    Entry informationi

    Entry nameiBASI_HUMAN
    AccessioniPrimary (citable) accession number: P35613
    Secondary accession number(s): A6NJW1
    , D3YLG5, Q7Z796, Q8IZL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 162 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    8. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3