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Protein

Basigin

Gene

BSG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen

Keywords - Ligandi

Lectin, Mannose-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172270-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.
R-HSA-210991. Basigin interactions.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-433692. Proton-coupled monocarboxylate transport.
R-HSA-70268. Pyruvate metabolism.

Protein family/group databases

TCDBi8.A.23.1.1. the basigin (basigin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Basigin
Alternative name(s):
5F7
Collagenase stimulatory factor
Extracellular matrix metalloproteinase inducer
Short name:
EMMPRIN
Leukocyte activation antigen M6
OK blood group antigen
Tumor cell-derived collagenase stimulatory factor
Short name:
TCSF
CD_antigen: CD147
Gene namesi
Name:BSG
ORF Names:UNQ6505/PRO21383
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1116. BSG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini138 – 323ExtracellularSequence analysisAdd BLAST186
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 385CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

  • acrosomal membrane Source: Ensembl
  • cell-cell adherens junction Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of plasma membrane Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • membrane raft Source: Ensembl
  • mitochondrion Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi327P → A: Loss of interaction with PPIL2. 1 Publication1

Organism-specific databases

DisGeNETi682.
MIMi111380. phenotype.
OpenTargetsiENSG00000172270.
PharmGKBiPA25433.

Chemistry databases

ChEMBLiCHEMBL3580492.

Polymorphism and mutation databases

BioMutaiBSG.
DMDMi51704273.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001451822 – 385BasiginAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi157 ↔ 203Combined sources2 Publications
Glycosylationi160N-linked (GlcNAc...)3 Publications1
Disulfide bondi242 ↔ 301Combined sources1 Publication
Glycosylationi268N-linked (GlcNAc...)3 Publications1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Modified residuei362PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP35613.
MaxQBiP35613.
PaxDbiP35613.
PeptideAtlasiP35613.
PRIDEiP35613.
TopDownProteomicsiP35613-1. [P35613-1]
P35613-2. [P35613-2]
P35613-3. [P35613-3]

PTM databases

iPTMnetiP35613.
PhosphoSitePlusiP35613.
SwissPalmiP35613.

Miscellaneous databases

PMAP-CutDBP35613.

Expressioni

Tissue specificityi

Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Inductioni

Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.

Gene expression databases

BgeeiENSG00000172270.
CleanExiHS_BSG.
ExpressionAtlasiP35613. baseline and differential.
GenevisibleiP35613. HS.

Organism-specific databases

HPAiCAB002427.
HPA036048.

Interactioni

Subunit structurei

Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane.By similarity6 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi107147. 142 interactors.
DIPiDIP-50310N.
IntActiP35613. 32 interactors.
MINTiMINT-5004205.
STRINGi9606.ENSP00000333769.

Structurei

Secondary structure

1385
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 27Combined sources4
Beta strandi32 – 35Combined sources4
Beta strandi40 – 47Combined sources8
Beta strandi53 – 62Combined sources10
Helixi74 – 77Combined sources4
Beta strandi79 – 95Combined sources17
Helixi100 – 102Combined sources3
Beta strandi104 – 111Combined sources8
Beta strandi116 – 118Combined sources3
Beta strandi128 – 137Combined sources10
Beta strandi142 – 149Combined sources8
Beta strandi152 – 159Combined sources8
Beta strandi166 – 173Combined sources8
Beta strandi176 – 181Combined sources6
Beta strandi186 – 192Combined sources7
Helixi194 – 196Combined sources3
Beta strandi199 – 207Combined sources9
Beta strandi210 – 217Combined sources8
Beta strandi224 – 226Combined sources3
Beta strandi228 – 233Combined sources6
Beta strandi238 – 243Combined sources6
Beta strandi252 – 257Combined sources6
Beta strandi260 – 262Combined sources3
Beta strandi264 – 266Combined sources3
Helixi270 – 272Combined sources3
Beta strandi274 – 279Combined sources6
Beta strandi282 – 287Combined sources6
Turni292 – 294Combined sources3
Beta strandi295 – 305Combined sources11
Beta strandi308 – 319Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B5HX-ray2.80A/B/C/D140-321[»]
3I84X-ray2.00A/B13-219[»]
3I85X-ray2.50A/B13-219[»]
3QQNX-ray2.31A/B23-138[»]
3QR2X-ray2.30A/B23-138[»]
4U0QX-ray3.10B/D1-385[»]
ProteinModelPortaliP35613.
SMRiP35613.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35613.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 219Ig-like C2-typeAdd BLAST82
Domaini221 – 315Ig-like V-typeAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi356 – 359Poly-Asp4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJET. Eukaryota.
ENOG4111V1Q. LUCA.
GeneTreeiENSGT00390000010516.
HOGENOMiHOG000263411.
HOVERGENiHBG008120.
InParanoidiP35613.
KOiK06535.
OMAiQANVFVI.
OrthoDBiEOG091G07LY.
PhylomeDBiP35613.
TreeFamiTF326759.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR009151. Basigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10075:SF12. PTHR10075:SF12. 1 hit.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35613-1) [UniParc]FASTAAdd to basket
Also known as: Long, Basigin-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP
60 70 80 90 100
VPEIQWWFEG QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE
110 120 130 140 150
EDTGTYECRA SNDPDRNHLT RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG
160 170 180 190 200
SKILLTCSLN DSATEVTGHR WLKGGVVLKE DALPGQKTEF KVDSDDQWGE
210 220 230 240 250
YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML VCKSESVPPV
260 270 280 290 300
TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR
310 320 330 340 350
CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK
360 370 380
PEDVLDDDDA GSAPLKSSGQ HQNDKGKNVR QRNSS
Length:385
Mass (Da):42,200
Last modified:August 31, 2004 - v2
Checksum:iD74C37455BF26685
GO
Isoform 2 (identifier: P35613-2) [UniParc]FASTAAdd to basket
Also known as: Basigin-1

The sequence of this isoform differs from the canonical sequence as follows:
     24-139: Missing.

Show »
Length:269
Mass (Da):29,221
Checksum:i0C9D6BEB966AC258
GO
Isoform 3 (identifier: P35613-3) [UniParc]FASTAAdd to basket
Also known as: Basigin-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Note: Produced by alternative promoter usage. N-glycosylated.
Show »
Length:176
Mass (Da):19,438
Checksum:i1FF03934256AE63E
GO
Isoform 4 (identifier: P35613-4) [UniParc]FASTAAdd to basket
Also known as: Basigin-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MAAALFVLLGF → MKQSDASPQER
     12-191: Missing.

Note: Produced by alternative promoter usage. N-glycosylated.
Show »
Length:205
Mass (Da):22,764
Checksum:i27B3348C16A690BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328F → L in BAC76828 (PubMed:1783610).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013574208E → K in Ok(A-). 1 PublicationCorresponds to variant rs104894669dbSNPEnsembl.1
Natural variantiVAR_011720269G → V.Corresponds to variant rs1803203dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0432251 – 209Missing in isoform 3. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_0432261 – 11MAAALFVLLGF → MKQSDASPQER in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_04322712 – 191Missing in isoform 4. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_01150124 – 139Missing in isoform 2. 3 PublicationsAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64364 mRNA. Translation: CAA45716.1.
D45131 mRNA. Translation: BAA08109.1.
L10240 mRNA. Translation: AAA68936.1.
M87879 mRNA. Translation: AAA91084.1.
L20471 mRNA. Translation: AAB41120.1.
AF042854
, AF042848, AF042849, AF042850, AF042851, AF042852, AF042853 Genomic DNA. Translation: AAD10704.1.
AB072923 mRNA. Translation: BAB88938.1.
AB085790 mRNA. Translation: BAC76828.1.
AF548371 mRNA. Translation: AAN40694.1.
GU557064 mRNA. Translation: ADD31881.1.
GU557065 mRNA. Translation: ADD31882.1.
AY358113 mRNA. Translation: AAQ88480.1.
AY942196 Genomic DNA. Translation: AAX20110.1.
AC005559 Genomic DNA. Translation: AAC33279.1.
CH471242 Genomic DNA. Translation: EAW61181.1.
CH471242 Genomic DNA. Translation: EAW61185.1.
BC009040 mRNA. Translation: AAH09040.1.
CCDSiCCDS12032.1. [P35613-4]
CCDS12033.1. [P35613-1]
CCDS12034.1. [P35613-2]
CCDS58635.1. [P35613-3]
PIRiA46506.
RefSeqiNP_001309172.1. NM_001322243.1. [P35613-2]
NP_001719.2. NM_001728.3. [P35613-1]
NP_940991.1. NM_198589.2. [P35613-2]
NP_940992.1. NM_198590.2. [P35613-3]
NP_940993.1. NM_198591.2. [P35613-4]
XP_016882662.1. XM_017027173.1. [P35613-1]
UniGeneiHs.501293.

Genome annotation databases

EnsembliENST00000333511; ENSP00000333769; ENSG00000172270. [P35613-1]
ENST00000346916; ENSP00000344707; ENSG00000172270. [P35613-4]
ENST00000353555; ENSP00000343809; ENSG00000172270. [P35613-2]
ENST00000545507; ENSP00000473664; ENSG00000172270. [P35613-3]
GeneIDi682.
KEGGihsa:682.
UCSCiuc002loy.5. human. [P35613-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64364 mRNA. Translation: CAA45716.1.
D45131 mRNA. Translation: BAA08109.1.
L10240 mRNA. Translation: AAA68936.1.
M87879 mRNA. Translation: AAA91084.1.
L20471 mRNA. Translation: AAB41120.1.
AF042854
, AF042848, AF042849, AF042850, AF042851, AF042852, AF042853 Genomic DNA. Translation: AAD10704.1.
AB072923 mRNA. Translation: BAB88938.1.
AB085790 mRNA. Translation: BAC76828.1.
AF548371 mRNA. Translation: AAN40694.1.
GU557064 mRNA. Translation: ADD31881.1.
GU557065 mRNA. Translation: ADD31882.1.
AY358113 mRNA. Translation: AAQ88480.1.
AY942196 Genomic DNA. Translation: AAX20110.1.
AC005559 Genomic DNA. Translation: AAC33279.1.
CH471242 Genomic DNA. Translation: EAW61181.1.
CH471242 Genomic DNA. Translation: EAW61185.1.
BC009040 mRNA. Translation: AAH09040.1.
CCDSiCCDS12032.1. [P35613-4]
CCDS12033.1. [P35613-1]
CCDS12034.1. [P35613-2]
CCDS58635.1. [P35613-3]
PIRiA46506.
RefSeqiNP_001309172.1. NM_001322243.1. [P35613-2]
NP_001719.2. NM_001728.3. [P35613-1]
NP_940991.1. NM_198589.2. [P35613-2]
NP_940992.1. NM_198590.2. [P35613-3]
NP_940993.1. NM_198591.2. [P35613-4]
XP_016882662.1. XM_017027173.1. [P35613-1]
UniGeneiHs.501293.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B5HX-ray2.80A/B/C/D140-321[»]
3I84X-ray2.00A/B13-219[»]
3I85X-ray2.50A/B13-219[»]
3QQNX-ray2.31A/B23-138[»]
3QR2X-ray2.30A/B23-138[»]
4U0QX-ray3.10B/D1-385[»]
ProteinModelPortaliP35613.
SMRiP35613.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107147. 142 interactors.
DIPiDIP-50310N.
IntActiP35613. 32 interactors.
MINTiMINT-5004205.
STRINGi9606.ENSP00000333769.

Chemistry databases

ChEMBLiCHEMBL3580492.

Protein family/group databases

TCDBi8.A.23.1.1. the basigin (basigin) family.

PTM databases

iPTMnetiP35613.
PhosphoSitePlusiP35613.
SwissPalmiP35613.

Polymorphism and mutation databases

BioMutaiBSG.
DMDMi51704273.

Proteomic databases

EPDiP35613.
MaxQBiP35613.
PaxDbiP35613.
PeptideAtlasiP35613.
PRIDEiP35613.
TopDownProteomicsiP35613-1. [P35613-1]
P35613-2. [P35613-2]
P35613-3. [P35613-3]

Protocols and materials databases

DNASUi682.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333511; ENSP00000333769; ENSG00000172270. [P35613-1]
ENST00000346916; ENSP00000344707; ENSG00000172270. [P35613-4]
ENST00000353555; ENSP00000343809; ENSG00000172270. [P35613-2]
ENST00000545507; ENSP00000473664; ENSG00000172270. [P35613-3]
GeneIDi682.
KEGGihsa:682.
UCSCiuc002loy.5. human. [P35613-1]

Organism-specific databases

CTDi682.
DisGeNETi682.
GeneCardsiBSG.
HGNCiHGNC:1116. BSG.
HPAiCAB002427.
HPA036048.
MIMi109480. gene.
111380. phenotype.
neXtProtiNX_P35613.
OpenTargetsiENSG00000172270.
PharmGKBiPA25433.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJET. Eukaryota.
ENOG4111V1Q. LUCA.
GeneTreeiENSGT00390000010516.
HOGENOMiHOG000263411.
HOVERGENiHBG008120.
InParanoidiP35613.
KOiK06535.
OMAiQANVFVI.
OrthoDBiEOG091G07LY.
PhylomeDBiP35613.
TreeFamiTF326759.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172270-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.
R-HSA-210991. Basigin interactions.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-433692. Proton-coupled monocarboxylate transport.
R-HSA-70268. Pyruvate metabolism.

Miscellaneous databases

ChiTaRSiBSG. human.
EvolutionaryTraceiP35613.
GeneWikiiBasigin.
GenomeRNAii682.
PMAP-CutDBP35613.
PROiP35613.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172270.
CleanExiHS_BSG.
ExpressionAtlasiP35613. baseline and differential.
GenevisibleiP35613. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR009151. Basigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10075:SF12. PTHR10075:SF12. 1 hit.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBASI_HUMAN
AccessioniPrimary (citable) accession number: P35613
Secondary accession number(s): A6NJW1
, D3YLG5, Q7Z796, Q8IZL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 31, 2004
Last modified: November 30, 2016
This is version 185 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.