Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35612

- ADDB_HUMAN

UniProt

P35612 - ADDB_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Beta-adducin

Gene

ADD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.1 Publication

GO - Molecular functioni

  1. actin binding Source: ProtInc
  2. actin filament binding Source: BHF-UCL
  3. protein heterodimerization activity Source: BHF-UCL
  4. protein homodimerization activity Source: BHF-UCL
  5. spectrin binding Source: BHF-UCL
  6. structural molecule activity Source: Ensembl

GO - Biological processi

  1. actin cytoskeleton organization Source: BHF-UCL
  2. actin filament bundle assembly Source: BHF-UCL
  3. barbed-end actin filament capping Source: BHF-UCL
  4. hemopoiesis Source: Ensembl
  5. positive regulation of protein binding Source: BHF-UCL
  6. protein complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-adducin
Alternative name(s):
Erythrocyte adducin subunit beta
Gene namesi
Name:ADD2
Synonyms:ADDB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:244. ADD2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB
  2. F-actin capping protein complex Source: BHF-UCL
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 726726Beta-adducinPRO_0000218533Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551Phosphothreonine; by PKA1 Publication
Modified residuei530 – 5301Phosphoserine1 Publication
Modified residuei532 – 5321PhosphoserineBy similarity
Modified residuei535 – 5351PhosphoserineBy similarity
Modified residuei561 – 5611PhosphothreonineBy similarity
Modified residuei592 – 5921Phosphoserine1 Publication
Modified residuei596 – 5961Phosphoserine1 Publication
Modified residuei600 – 6001Phosphoserine1 Publication
Modified residuei604 – 6041Phosphoserine1 Publication
Modified residuei611 – 6111Phosphothreonine1 Publication
Modified residuei613 – 6131Phosphoserine1 Publication
Modified residuei617 – 6171Phosphoserine1 Publication
Modified residuei693 – 6931Phosphoserine1 Publication
Modified residuei697 – 6971Phosphoserine1 Publication
Modified residuei703 – 7031Phosphoserine; by PKC1 Publication
Modified residuei713 – 7131Phosphoserine; by PKA and PKC1 Publication

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP35612.
PaxDbiP35612.
PRIDEiP35612.

PTM databases

PhosphoSiteiP35612.

Expressioni

Tissue specificityi

Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.1 Publication

Developmental stagei

Fetal kidney expresses isoforms 3, 4, 5, 6 and 7, and fetal liver expresses isoforms 3 and 4.1 Publication

Gene expression databases

BgeeiP35612.
ExpressionAtlasiP35612. baseline and differential.
GenevestigatoriP35612.

Organism-specific databases

HPAiCAB009796.
HPA034509.
HPA034510.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with SLC2A1.1 Publication

Protein-protein interaction databases

BioGridi106632. 8 interactions.

Structurei

3D structure databases

DisProtiDP00241.
ProteinModelPortaliP35612.
SMRiP35612. Positions 149-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni425 – 44420Interaction with calmodulinSequence AnalysisAdd
BLAST
Regioni704 – 72118Interaction with calmodulinSequence AnalysisAdd
BLAST

Domaini

Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0235.
GeneTreeiENSGT00390000016462.
HOVERGENiHBG004180.
InParanoidiP35612.
OMAiSGPMSPE.
OrthoDBiEOG7HF1HR.
PhylomeDBiP35612.
TreeFamiTF313003.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiIPR027773. ADD2.
IPR001303. Aldolase_II/adducin_N.
[Graphical view]
PANTHERiPTHR10672:SF6. PTHR10672:SF6. 1 hit.
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P35612-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ
60 70 80 90 100
KKRVTMILQS PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA
110 120 130 140 150
VFPTSSMNVS MMTPINDLHT ADSLNLAKGE RLMRCKISSV YRLLDLYGWA
160 170 180 190 200
QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV TASSLIKVNI LGEVVEKGSS
210 220 230 240 250
CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK WGLLPVSHNA
260 270 280 290 300
LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE
310 320 330 340 350
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS
360 370 380 390 400
TFGPMQKSRL GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI
410 420 430 440 450
PATVTAFVFE EDGAPVPALR QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ
460 470 480 490 500
RSMGSPRPKT TWMKADEVEK SSSGMPIRIE NPNQFVPLYT DPQEVLEMRN
510 520 530 540 550
KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK GDEDTKDDSE
560 570 580 590 600
ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS
610 620 630 640 650
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN
660 670 680 690 700
GREEEQTAEE ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK
710 720
SPSKKKKKFR TPSFLKKSKK KEKVES
Length:726
Mass (Da):80,854
Last modified:January 23, 2007 - v3
Checksum:iB07F7303D929DBA4
GO
Isoform 2 (identifier: P35612-2) [UniParc]FASTAAdd to Basket

Also known as: Adducin 63

The sequence of this isoform differs from the canonical sequence as follows:
     532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
     560-726: Missing.

Show »
Length:559
Mass (Da):62,467
Checksum:iB62B278AE8F48FD4
GO
Isoform 3 (identifier: P35612-3) [UniParc]FASTAAdd to Basket

Also known as: Beta-4, E

The sequence of this isoform differs from the canonical sequence as follows:
     581-726: GEKETAPEEP...KSKKKEKVES → ETGQEREPGS...QRRRQRQRAL

Show »
Length:643
Mass (Da):72,721
Checksum:i46A10F1D1278E955
GO
Isoform 4 (identifier: P35612-4) [UniParc]FASTAAdd to Basket

Also known as: Beta-4a

The sequence of this isoform differs from the canonical sequence as follows:
     581-587: GEKETAP → APGWFSS
     588-726: Missing.

Show »
Length:587
Mass (Da):66,154
Checksum:iB7ACFE32B2731FB5
GO
Isoform 5 (identifier: P35612-5) [UniParc]FASTAAdd to Basket

Also known as: Beta-4b

The sequence of this isoform differs from the canonical sequence as follows:
     188-493: Missing.
     581-586: GEKETA → ETGQER
     587-726: Missing.

Show »
Length:280
Mass (Da):31,935
Checksum:i851E20275B19D246
GO
Isoform 6 (identifier: P35612-6) [UniParc]FASTAAdd to Basket

Also known as: Beta-4c

The sequence of this isoform differs from the canonical sequence as follows:
     188-493: Missing.
     581-587: GEKETAP → APGWFSS
     588-726: Missing.

Show »
Length:281
Mass (Da):31,967
Checksum:i1CF4ACF5875DDF12
GO
Isoform 7 (identifier: P35612-7) [UniParc]FASTAAdd to Basket

Also known as: Beta-4d

The sequence of this isoform differs from the canonical sequence as follows:
     78-566: Missing.
     581-587: GEKETAP → APGWFSS
     588-726: Missing.

Show »
Length:98
Mass (Da):11,625
Checksum:i2FABB44289701D9B
GO
Isoform 8 (identifier: P35612-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPRRRVPGANCKPTGK
     532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
     560-726: Missing.

Note: No experimental confirmation available.

Show »
Length:574
Mass (Da):64,086
Checksum:i4169DB571ED52F85
GO
Isoform 9 (identifier: P35612-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPRRRVPGANCKPTGKM
     532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
     560-726: Missing.

Note: No experimental confirmation available.

Show »
Length:575
Mass (Da):64,217
Checksum:i99629BA28D32AE6E
GO

Sequence cautioni

The sequence BAD92464.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281D → N.
Corresponds to variant rs4986 [ dbSNP | Ensembl ].
VAR_014866
Natural varianti98 – 981S → C.
Corresponds to variant rs4987 [ dbSNP | Ensembl ].
VAR_048195
Natural varianti335 – 3351E → D.
Corresponds to variant rs4982 [ dbSNP | Ensembl ].
VAR_014867
Natural varianti439 – 4391T → A.1 Publication
Corresponds to variant rs17855969 [ dbSNP | Ensembl ].
VAR_025318
Natural varianti663 – 6631S → R.
Corresponds to variant rs4985 [ dbSNP | Ensembl ].
VAR_014868

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MPRRRVPGANCKPTGK in isoform 8. 1 PublicationVSP_043625
Alternative sequencei1 – 11M → MPRRRVPGANCKPTGKM in isoform 9. 1 PublicationVSP_055309
Alternative sequencei78 – 566489Missing in isoform 7. 1 PublicationVSP_017241Add
BLAST
Alternative sequencei188 – 493306Missing in isoform 5 and isoform 6. 1 PublicationVSP_017242Add
BLAST
Alternative sequencei532 – 55928STESQ…NPFSQ → VEQRLPLTGGETCLPSGSSV PGAGLQDP in isoform 2, isoform 8 and isoform 9. 2 PublicationsVSP_000181Add
BLAST
Alternative sequencei560 – 726167Missing in isoform 2, isoform 8 and isoform 9. 2 PublicationsVSP_000182Add
BLAST
Alternative sequencei581 – 726146GEKET…EKVES → ETGQEREPGSGPAVCEFFSV ALHIWSNILERKKLPQKSLA HLQSLHLLLQCRAQRRRQRQ RAL in isoform 3. 2 PublicationsVSP_000183Add
BLAST
Alternative sequencei581 – 5877GEKETAP → APGWFSS in isoform 4, isoform 6 and isoform 7. 1 PublicationVSP_017244
Alternative sequencei581 – 5866GEKETA → ETGQER in isoform 5. 1 PublicationVSP_017243
Alternative sequencei587 – 726140Missing in isoform 5. 1 PublicationVSP_017245Add
BLAST
Alternative sequencei588 – 726139Missing in isoform 4, isoform 6 and isoform 7. 1 PublicationVSP_017246Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58199 mRNA. Translation: CAA41176.1.
AF486420 mRNA. Translation: AAP71863.1.
AF486421 mRNA. Translation: AAP71864.1.
AF486422 mRNA. Translation: AAP71865.1.
AF486423 mRNA. Translation: AAP71866.1.
AK291007 mRNA. Translation: BAF83696.1.
AK297250 mRNA. Translation: BAG59729.1.
AK309773 mRNA. No translation available.
AB209227 mRNA. Translation: BAD92464.1. Different initiation.
AB593080 mRNA. Translation: BAJ84020.1.
AC005234 Genomic DNA. Translation: AAD12715.1.
AC007395 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAW99801.1.
CH471053 Genomic DNA. Translation: EAW99806.1.
CH471053 Genomic DNA. Translation: EAW99807.1.
CH471053 Genomic DNA. Translation: EAW99808.1.
BC041666 mRNA. Translation: AAH41666.1.
BC051882 mRNA. Translation: AAH51882.1.
BC056881 mRNA. Translation: AAH56881.1.
BC065525 mRNA. Translation: AAH65525.1.
U43959 mRNA. Translation: AAA86421.1.
S81079, S81077 Genomic DNA. Translation: AAD14349.1.
CCDSiCCDS1906.1. [P35612-1]
CCDS1909.1. [P35612-3]
CCDS46318.1. [P35612-2]
CCDS54365.1. [P35612-9]
PIRiS18208.
RefSeqiNP_001171983.1. NM_001185054.1. [P35612-1]
NP_001171984.1. NM_001185055.1. [P35612-9]
NP_001608.1. NM_001617.3. [P35612-1]
NP_059516.2. NM_017482.3. [P35612-2]
NP_059522.1. NM_017488.3. [P35612-3]
UniGeneiHs.188528.

Genome annotation databases

EnsembliENST00000264436; ENSP00000264436; ENSG00000075340. [P35612-1]
ENST00000355733; ENSP00000347972; ENSG00000075340. [P35612-3]
ENST00000403045; ENSP00000384303; ENSG00000075340. [P35612-1]
ENST00000407644; ENSP00000384677; ENSG00000075340. [P35612-1]
ENST00000413157; ENSP00000388072; ENSG00000075340. [P35612-2]
ENST00000430656; ENSP00000398112; ENSG00000075340. [P35612-9]
ENST00000522886; ENSP00000430243; ENSG00000075340. [P35612-5]
GeneIDi119.
KEGGihsa:119.
UCSCiuc002sgy.3. human. [P35612-3]
uc002sgz.3. human. [P35612-1]
uc002shc.2. human. [P35612-2]
uc010fdt.2. human. [P35612-4]

Polymorphism databases

DMDMi543774.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58199 mRNA. Translation: CAA41176.1 .
AF486420 mRNA. Translation: AAP71863.1 .
AF486421 mRNA. Translation: AAP71864.1 .
AF486422 mRNA. Translation: AAP71865.1 .
AF486423 mRNA. Translation: AAP71866.1 .
AK291007 mRNA. Translation: BAF83696.1 .
AK297250 mRNA. Translation: BAG59729.1 .
AK309773 mRNA. No translation available.
AB209227 mRNA. Translation: BAD92464.1 . Different initiation.
AB593080 mRNA. Translation: BAJ84020.1 .
AC005234 Genomic DNA. Translation: AAD12715.1 .
AC007395 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAW99801.1 .
CH471053 Genomic DNA. Translation: EAW99806.1 .
CH471053 Genomic DNA. Translation: EAW99807.1 .
CH471053 Genomic DNA. Translation: EAW99808.1 .
BC041666 mRNA. Translation: AAH41666.1 .
BC051882 mRNA. Translation: AAH51882.1 .
BC056881 mRNA. Translation: AAH56881.1 .
BC065525 mRNA. Translation: AAH65525.1 .
U43959 mRNA. Translation: AAA86421.1 .
S81079 , S81077 Genomic DNA. Translation: AAD14349.1 .
CCDSi CCDS1906.1. [P35612-1 ]
CCDS1909.1. [P35612-3 ]
CCDS46318.1. [P35612-2 ]
CCDS54365.1. [P35612-9 ]
PIRi S18208.
RefSeqi NP_001171983.1. NM_001185054.1. [P35612-1 ]
NP_001171984.1. NM_001185055.1. [P35612-9 ]
NP_001608.1. NM_001617.3. [P35612-1 ]
NP_059516.2. NM_017482.3. [P35612-2 ]
NP_059522.1. NM_017488.3. [P35612-3 ]
UniGenei Hs.188528.

3D structure databases

DisProti DP00241.
ProteinModelPortali P35612.
SMRi P35612. Positions 149-353.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106632. 8 interactions.

PTM databases

PhosphoSitei P35612.

Polymorphism databases

DMDMi 543774.

Proteomic databases

MaxQBi P35612.
PaxDbi P35612.
PRIDEi P35612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264436 ; ENSP00000264436 ; ENSG00000075340 . [P35612-1 ]
ENST00000355733 ; ENSP00000347972 ; ENSG00000075340 . [P35612-3 ]
ENST00000403045 ; ENSP00000384303 ; ENSG00000075340 . [P35612-1 ]
ENST00000407644 ; ENSP00000384677 ; ENSG00000075340 . [P35612-1 ]
ENST00000413157 ; ENSP00000388072 ; ENSG00000075340 . [P35612-2 ]
ENST00000430656 ; ENSP00000398112 ; ENSG00000075340 . [P35612-9 ]
ENST00000522886 ; ENSP00000430243 ; ENSG00000075340 . [P35612-5 ]
GeneIDi 119.
KEGGi hsa:119.
UCSCi uc002sgy.3. human. [P35612-3 ]
uc002sgz.3. human. [P35612-1 ]
uc002shc.2. human. [P35612-2 ]
uc010fdt.2. human. [P35612-4 ]

Organism-specific databases

CTDi 119.
GeneCardsi GC02M070800.
HGNCi HGNC:244. ADD2.
HPAi CAB009796.
HPA034509.
HPA034510.
MIMi 102681. gene.
neXtProti NX_P35612.
PharmGKBi PA24566.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0235.
GeneTreei ENSGT00390000016462.
HOVERGENi HBG004180.
InParanoidi P35612.
OMAi SGPMSPE.
OrthoDBi EOG7HF1HR.
PhylomeDBi P35612.
TreeFami TF313003.

Miscellaneous databases

GeneWikii ADD2.
GenomeRNAii 119.
NextBioi 469.
PROi P35612.
SOURCEi Search...

Gene expression databases

Bgeei P35612.
ExpressionAtlasi P35612. baseline and differential.
Genevestigatori P35612.

Family and domain databases

Gene3Di 3.40.225.10. 1 hit.
InterProi IPR027773. ADD2.
IPR001303. Aldolase_II/adducin_N.
[Graphical view ]
PANTHERi PTHR10672:SF6. PTHR10672:SF6. 1 hit.
Pfami PF00596. Aldolase_II. 1 hit.
[Graphical view ]
SMARTi SM01007. Aldolase_II. 1 hit.
[Graphical view ]
SUPFAMi SSF53639. SSF53639. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and domain organization of human alpha and beta adducin."
    Joshi R.L., Gilligan D.M., Otto E., McLaughlin T., Bennett V.D.
    J. Cell Biol. 115:665-675(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
    Tissue: Reticulocyte.
  2. "Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants."
    Citterio L., Tizzoni L., Catalano M., Zerbini G., Bianchi G., Barlassina C.
    Biochem. Biophys. Res. Commun. 309:359-367(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6 AND 7), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Fetal kidney and Umbilical vein endothelial cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 8 AND 9).
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
    Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
    Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ALA-439.
    Tissue: Eye.
  9. "A novel isoform of beta adducin utilizes an alternatively spliced exon near the C-terminus."
    Sinard J.H., Stewart G.W., Argent A.C., Gilligan D.M., Morrow J.S.
    Mol. Biol. Cell 6:269-269(1995)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 332-726 (ISOFORM 3).
    Tissue: Bone marrow.
  10. "Genomic organisation and chromosomal localisation of the gene encoding human beta adducin."
    Tisminetzky S., Devescovi G., Tripodi G., Muro A., Bianchi G., Colombi M., Moro L., Barlati S., Tuteja R., Baralle F.E.
    Gene 167:313-316(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 462-559 (ISOFORM 2), ALTERNATIVE SPLICING.
  11. "Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C."
    Matsuoka Y., Hughes C.A., Bennett V.
    J. Biol. Chem. 271:25157-25166(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-55; SER-703 AND SER-713, PARTIAL PROTEIN SEQUENCE.
  12. "Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1."
    Khan A.A., Hanada T., Mohseni M., Jeong J.J., Zeng L., Gaetani M., Li D., Reed B.C., Speicher D.W., Chishti A.H.
    J. Biol. Chem. 283:14600-14609(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH DMTN AND SLC2A1, INTERACTION WITH SLC2A1.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530; SER-592; SER-596; SER-600; SER-604; THR-611; SER-613; SER-617; SER-693 AND SER-697, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADDB_HUMAN
AccessioniPrimary (citable) accession number: P35612
Secondary accession number(s): A8K4P2
, B4DM17, D6W5G7, D6W5G8, Q13482, Q16412, Q59G82, Q5U5P4, Q6P0P2, Q6PGQ4, Q7Z688, Q7Z689, Q7Z690, Q7Z691
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3