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P35612 (ADDB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-adducin
Alternative name(s):
Erythrocyte adducin subunit beta
Gene names
Name:ADD2
Synonyms:ADDB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length726 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. Ref.12

Subunit structure

Heterodimer of an alpha and a beta subunit. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with SLC2A1. Ref.12

Subcellular location

Cytoplasmcytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue specificity

Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line. Ref.2

Developmental stage

Fetal kidney expresses isoforms 3, 4, 5, 6 and 7, and fetal liver expresses isoforms 3 and 4. Ref.2

Domain

Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the aldolase class II family. Adducin subfamily.

Sequence caution

The sequence BAD92464.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Cytoskeleton
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandActin-binding
Calmodulin-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processactin cytoskeleton organization

Inferred by curator PubMed 3693401. Source: BHF-UCL

actin filament bundle assembly

Inferred from direct assay PubMed 3693401. Source: BHF-UCL

barbed-end actin filament capping

Inferred from direct assay PubMed 8626479. Source: BHF-UCL

hemopoiesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein binding

Inferred from direct assay PubMed 3693401PubMed 7642559. Source: BHF-UCL

protein complex assembly

Inferred from direct assay Ref.12. Source: UniProtKB

   Cellular_componentF-actin capping protein complex

Inferred from direct assay PubMed 8626479. Source: BHF-UCL

cytoplasmic membrane-bounded vesicle

Inferred from direct assay Ref.12. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionactin binding

Traceable author statement Ref.1. Source: ProtInc

actin filament binding

Inferred from direct assay PubMed 7642559. Source: BHF-UCL

protein heterodimerization activity

Inferred from physical interaction PubMed 7642559. Source: BHF-UCL

protein homodimerization activity

Inferred from physical interaction PubMed 7642559. Source: BHF-UCL

spectrin binding

Inferred from direct assay PubMed 7642559. Source: BHF-UCL

structural molecule activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P35612-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P35612-2)

Also known as: Adducin 63;

The sequence of this isoform differs from the canonical sequence as follows:
     532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
     560-726: Missing.
Isoform 3 (identifier: P35612-3)

Also known as: Beta-4; E;

The sequence of this isoform differs from the canonical sequence as follows:
     581-726: GEKETAPEEP...KSKKKEKVES → ETGQEREPGS...QRRRQRQRAL
Isoform 4 (identifier: P35612-4)

Also known as: Beta-4a;

The sequence of this isoform differs from the canonical sequence as follows:
     581-587: GEKETAP → APGWFSS
     588-726: Missing.
Isoform 5 (identifier: P35612-5)

Also known as: Beta-4b;

The sequence of this isoform differs from the canonical sequence as follows:
     188-493: Missing.
     581-586: GEKETA → ETGQER
     587-726: Missing.
Isoform 6 (identifier: P35612-6)

Also known as: Beta-4c;

The sequence of this isoform differs from the canonical sequence as follows:
     188-493: Missing.
     581-587: GEKETAP → APGWFSS
     588-726: Missing.
Isoform 7 (identifier: P35612-7)

Also known as: Beta-4d;

The sequence of this isoform differs from the canonical sequence as follows:
     78-566: Missing.
     581-587: GEKETAP → APGWFSS
     588-726: Missing.
Isoform 8 (identifier: P35612-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPRRRVPGANCKPTGK
     532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
     560-726: Missing.
Note: No experimental confirmation available.
Isoform 9 (identifier: P35612-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPRRRVPGANCKPTGKM
     532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
     560-726: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 726726Beta-adducin
PRO_0000218533

Regions

Region425 – 44420Interaction with calmodulin Potential
Region704 – 72118Interaction with calmodulin Potential

Amino acid modifications

Modified residue551Phosphothreonine; by PKA Ref.11
Modified residue5301Phosphoserine Ref.14
Modified residue5321Phosphoserine By similarity
Modified residue5351Phosphoserine By similarity
Modified residue5611Phosphothreonine By similarity
Modified residue5921Phosphoserine Ref.14
Modified residue5961Phosphoserine Ref.14
Modified residue6001Phosphoserine Ref.14
Modified residue6041Phosphoserine Ref.14
Modified residue6111Phosphothreonine Ref.14
Modified residue6131Phosphoserine Ref.14
Modified residue6171Phosphoserine Ref.14
Modified residue6931Phosphoserine Ref.14
Modified residue6971Phosphoserine Ref.14
Modified residue7031Phosphoserine; by PKC Ref.11
Modified residue7131Phosphoserine; by PKA and PKC Ref.11

Natural variations

Alternative sequence11M → MPRRRVPGANCKPTGK in isoform 8.
VSP_043625
Alternative sequence11M → MPRRRVPGANCKPTGKM in isoform 9.
VSP_055309
Alternative sequence78 – 566489Missing in isoform 7.
VSP_017241
Alternative sequence188 – 493306Missing in isoform 5 and isoform 6.
VSP_017242
Alternative sequence532 – 55928STESQ…NPFSQ → VEQRLPLTGGETCLPSGSSV PGAGLQDP in isoform 2, isoform 8 and isoform 9.
VSP_000181
Alternative sequence560 – 726167Missing in isoform 2, isoform 8 and isoform 9.
VSP_000182
Alternative sequence581 – 726146GEKET…EKVES → ETGQEREPGSGPAVCEFFSV ALHIWSNILERKKLPQKSLA HLQSLHLLLQCRAQRRRQRQ RAL in isoform 3.
VSP_000183
Alternative sequence581 – 5877GEKETAP → APGWFSS in isoform 4, isoform 6 and isoform 7.
VSP_017244
Alternative sequence581 – 5866GEKETA → ETGQER in isoform 5.
VSP_017243
Alternative sequence587 – 726140Missing in isoform 5.
VSP_017245
Alternative sequence588 – 726139Missing in isoform 4, isoform 6 and isoform 7.
VSP_017246
Natural variant281D → N.
Corresponds to variant rs4986 [ dbSNP | Ensembl ].
VAR_014866
Natural variant981S → C.
Corresponds to variant rs4987 [ dbSNP | Ensembl ].
VAR_048195
Natural variant3351E → D.
Corresponds to variant rs4982 [ dbSNP | Ensembl ].
VAR_014867
Natural variant4391T → A. Ref.8
Corresponds to variant rs17855969 [ dbSNP | Ensembl ].
VAR_025318
Natural variant6631S → R.
Corresponds to variant rs4985 [ dbSNP | Ensembl ].
VAR_014868

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: B07F7303D929DBA4

FASTA72680,854
        10         20         30         40         50         60 
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS 

        70         80         90        100        110        120 
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT 

       130        140        150        160        170        180 
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV 

       190        200        210        220        230        240 
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK 

       250        260        270        280        290        300 
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE 

       310        320        330        340        350        360 
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL 

       370        380        390        400        410        420 
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR 

       430        440        450        460        470        480 
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE 

       490        500        510        520        530        540 
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK 

       550        560        570        580        590        600 
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS 

       610        620        630        640        650        660 
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE 

       670        680        690        700        710        720 
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK 


KEKVES 

« Hide

Isoform 2 (Adducin 63) [UniParc].

Checksum: B62B278AE8F48FD4
Show »

FASTA55962,467
Isoform 3 (Beta-4) (E) [UniParc].

Checksum: 46A10F1D1278E955
Show »

FASTA64372,721
Isoform 4 (Beta-4a) [UniParc].

Checksum: B7ACFE32B2731FB5
Show »

FASTA58766,154
Isoform 5 (Beta-4b) [UniParc].

Checksum: 851E20275B19D246
Show »

FASTA28031,935
Isoform 6 (Beta-4c) [UniParc].

Checksum: 1CF4ACF5875DDF12
Show »

FASTA28131,967
Isoform 7 (Beta-4d) [UniParc].

Checksum: 2FABB44289701D9B
Show »

FASTA9811,625
Isoform 8 [UniParc].

Checksum: 4169DB571ED52F85
Show »

FASTA57464,086
Isoform 9 [UniParc].

Checksum: 99629BA28D32AE6E
Show »

FASTA57564,217

References

« Hide 'large scale' references
[1]"Primary structure and domain organization of human alpha and beta adducin."
Joshi R.L., Gilligan D.M., Otto E., McLaughlin T., Bennett V.D.
J. Cell Biol. 115:665-675(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
Tissue: Reticulocyte.
[2]"Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants."
Citterio L., Tizzoni L., Catalano M., Zerbini G., Bianchi G., Barlassina C.
Biochem. Biophys. Res. Commun. 309:359-367(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6 AND 7), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Fetal kidney and Umbilical vein endothelial cell.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 8 AND 9).
[4]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[5]"Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ALA-439.
Tissue: Eye.
[9]"A novel isoform of beta adducin utilizes an alternatively spliced exon near the C-terminus."
Sinard J.H., Stewart G.W., Argent A.C., Gilligan D.M., Morrow J.S.
Mol. Biol. Cell 6:269-269(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 332-726 (ISOFORM 3).
Tissue: Bone marrow.
[10]"Genomic organisation and chromosomal localisation of the gene encoding human beta adducin."
Tisminetzky S., Devescovi G., Tripodi G., Muro A., Bianchi G., Colombi M., Moro L., Barlati S., Tuteja R., Baralle F.E.
Gene 167:313-316(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 462-559 (ISOFORM 2), ALTERNATIVE SPLICING.
[11]"Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C."
Matsuoka Y., Hughes C.A., Bennett V.
J. Biol. Chem. 271:25157-25166(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT THR-55; SER-703 AND SER-713, PARTIAL PROTEIN SEQUENCE.
[12]"Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1."
Khan A.A., Hanada T., Mohseni M., Jeong J.J., Zeng L., Gaetani M., Li D., Reed B.C., Speicher D.W., Chishti A.H.
J. Biol. Chem. 283:14600-14609(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH DMTN AND SLC2A1, INTERACTION WITH SLC2A1.
[13]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530; SER-592; SER-596; SER-600; SER-604; THR-611; SER-613; SER-617; SER-693 AND SER-697, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58199 mRNA. Translation: CAA41176.1.
AF486420 mRNA. Translation: AAP71863.1.
AF486421 mRNA. Translation: AAP71864.1.
AF486422 mRNA. Translation: AAP71865.1.
AF486423 mRNA. Translation: AAP71866.1.
AK291007 mRNA. Translation: BAF83696.1.
AK297250 mRNA. Translation: BAG59729.1.
AK309773 mRNA. No translation available.
AB209227 mRNA. Translation: BAD92464.1. Different initiation.
AB593080 mRNA. Translation: BAJ84020.1.
AC005234 Genomic DNA. Translation: AAD12715.1.
AC007395 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAW99801.1.
CH471053 Genomic DNA. Translation: EAW99806.1.
CH471053 Genomic DNA. Translation: EAW99807.1.
CH471053 Genomic DNA. Translation: EAW99808.1.
BC041666 mRNA. Translation: AAH41666.1.
BC051882 mRNA. Translation: AAH51882.1.
BC056881 mRNA. Translation: AAH56881.1.
BC065525 mRNA. Translation: AAH65525.1.
U43959 mRNA. Translation: AAA86421.1.
S81079, S81077 Genomic DNA. Translation: AAD14349.1.
CCDSCCDS1906.1. [P35612-1]
CCDS1909.1. [P35612-3]
CCDS46318.1. [P35612-2]
PIRS18208.
RefSeqNP_001171983.1. NM_001185054.1. [P35612-1]
NP_001171984.1. NM_001185055.1.
NP_001608.1. NM_001617.3. [P35612-1]
NP_059516.2. NM_017482.3. [P35612-2]
NP_059522.1. NM_017488.3. [P35612-3]
UniGeneHs.188528.

3D structure databases

DisProtDP00241.
ProteinModelPortalP35612.
SMRP35612. Positions 149-353.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106632. 4 interactions.

PTM databases

PhosphoSiteP35612.

Polymorphism databases

DMDM543774.

Proteomic databases

MaxQBP35612.
PaxDbP35612.
PRIDEP35612.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264436; ENSP00000264436; ENSG00000075340. [P35612-1]
ENST00000355733; ENSP00000347972; ENSG00000075340. [P35612-3]
ENST00000403045; ENSP00000384303; ENSG00000075340. [P35612-1]
ENST00000407644; ENSP00000384677; ENSG00000075340. [P35612-1]
ENST00000413157; ENSP00000388072; ENSG00000075340. [P35612-2]
ENST00000430656; ENSP00000398112; ENSG00000075340.
ENST00000522886; ENSP00000430243; ENSG00000075340. [P35612-5]
ENST00000606038; ENSP00000475223; ENSG00000271760. [P35612-1]
ENST00000606120; ENSP00000476220; ENSG00000271760. [P35612-1]
ENST00000606312; ENSP00000475774; ENSG00000271760. [P35612-5]
ENST00000606698; ENSP00000475993; ENSG00000271760. [P35612-3]
ENST00000607267; ENSP00000475838; ENSG00000271760. [P35612-1]
ENST00000607524; ENSP00000475332; ENSG00000271760. [P35612-2]
ENST00000607677; ENSP00000475595; ENSG00000271760.
GeneID119.
KEGGhsa:119.
UCSCuc002sgy.3. human. [P35612-3]
uc002sgz.3. human. [P35612-1]
uc002shc.2. human. [P35612-2]
uc010fdt.2. human. [P35612-4]

Organism-specific databases

CTD119.
GeneCardsGC02M070800.
HGNCHGNC:244. ADD2.
HPACAB009796.
HPA034509.
HPA034510.
MIM102681. gene.
neXtProtNX_P35612.
PharmGKBPA24566.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0235.
HOVERGENHBG004180.
InParanoidP35612.
OMASGPMSPE.
OrthoDBEOG7HF1HR.
PhylomeDBP35612.
TreeFamTF313003.

Gene expression databases

ArrayExpressP35612.
BgeeP35612.
GenevestigatorP35612.

Family and domain databases

Gene3D3.40.225.10. 1 hit.
InterProIPR027773. ADD2.
IPR001303. Aldolase_II/adducin_N.
[Graphical view]
PANTHERPTHR10672:SF6. PTHR10672:SF6. 1 hit.
PfamPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMSSF53639. SSF53639. 1 hit.
ProtoNetSearch...

Other

GeneWikiADD2.
GenomeRNAi119.
NextBio469.
PROP35612.
SOURCESearch...

Entry information

Entry nameADDB_HUMAN
AccessionPrimary (citable) accession number: P35612
Secondary accession number(s): A8K4P2 expand/collapse secondary AC list , B4DM17, D6W5G7, D6W5G8, Q13482, Q16412, Q59G82, Q5U5P4, Q6P0P2, Q6PGQ4, Q7Z688, Q7Z689, Q7Z690, Q7Z691
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM