Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35612

- ADDB_HUMAN

UniProt

P35612 - ADDB_HUMAN

Protein

Beta-adducin

Gene

ADD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.1 Publication

    GO - Molecular functioni

    1. actin binding Source: ProtInc
    2. actin filament binding Source: BHF-UCL
    3. protein heterodimerization activity Source: BHF-UCL
    4. protein homodimerization activity Source: BHF-UCL
    5. spectrin binding Source: BHF-UCL
    6. structural molecule activity Source: Ensembl

    GO - Biological processi

    1. actin cytoskeleton organization Source: BHF-UCL
    2. actin filament bundle assembly Source: BHF-UCL
    3. barbed-end actin filament capping Source: BHF-UCL
    4. hemopoiesis Source: Ensembl
    5. positive regulation of protein binding Source: BHF-UCL
    6. protein complex assembly Source: UniProtKB

    Keywords - Ligandi

    Actin-binding, Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-adducin
    Alternative name(s):
    Erythrocyte adducin subunit beta
    Gene namesi
    Name:ADD2
    Synonyms:ADDB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:244. ADD2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB
    2. F-actin capping protein complex Source: BHF-UCL
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24566.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 726726Beta-adducinPRO_0000218533Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei55 – 551Phosphothreonine; by PKA1 Publication
    Modified residuei530 – 5301Phosphoserine1 Publication
    Modified residuei532 – 5321PhosphoserineBy similarity
    Modified residuei535 – 5351PhosphoserineBy similarity
    Modified residuei561 – 5611PhosphothreonineBy similarity
    Modified residuei592 – 5921Phosphoserine1 Publication
    Modified residuei596 – 5961Phosphoserine1 Publication
    Modified residuei600 – 6001Phosphoserine1 Publication
    Modified residuei604 – 6041Phosphoserine1 Publication
    Modified residuei611 – 6111Phosphothreonine1 Publication
    Modified residuei613 – 6131Phosphoserine1 Publication
    Modified residuei617 – 6171Phosphoserine1 Publication
    Modified residuei693 – 6931Phosphoserine1 Publication
    Modified residuei697 – 6971Phosphoserine1 Publication
    Modified residuei703 – 7031Phosphoserine; by PKC1 Publication
    Modified residuei713 – 7131Phosphoserine; by PKA and PKC1 Publication

    Post-translational modificationi

    The N-terminus is blocked.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP35612.
    PaxDbiP35612.
    PRIDEiP35612.

    PTM databases

    PhosphoSiteiP35612.

    Expressioni

    Tissue specificityi

    Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.1 Publication

    Developmental stagei

    Fetal kidney expresses isoforms 3, 4, 5, 6 and 7, and fetal liver expresses isoforms 3 and 4.1 Publication

    Gene expression databases

    ArrayExpressiP35612.
    BgeeiP35612.
    GenevestigatoriP35612.

    Organism-specific databases

    HPAiCAB009796.
    HPA034509.
    HPA034510.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with SLC2A1.1 Publication

    Protein-protein interaction databases

    BioGridi106632. 4 interactions.

    Structurei

    3D structure databases

    DisProtiDP00241.
    ProteinModelPortaliP35612.
    SMRiP35612. Positions 149-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni425 – 44420Interaction with calmodulinSequence AnalysisAdd
    BLAST
    Regioni704 – 72118Interaction with calmodulinSequence AnalysisAdd
    BLAST

    Domaini

    Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0235.
    HOVERGENiHBG004180.
    InParanoidiP35612.
    OMAiSGPMSPE.
    OrthoDBiEOG7HF1HR.
    PhylomeDBiP35612.
    TreeFamiTF313003.

    Family and domain databases

    Gene3Di3.40.225.10. 1 hit.
    InterProiIPR027773. ADD2.
    IPR001303. Aldolase_II/adducin_N.
    [Graphical view]
    PANTHERiPTHR10672:SF6. PTHR10672:SF6. 1 hit.
    PfamiPF00596. Aldolase_II. 1 hit.
    [Graphical view]
    SMARTiSM01007. Aldolase_II. 1 hit.
    [Graphical view]
    SUPFAMiSSF53639. SSF53639. 1 hit.

    Sequences (9)i

    Sequence statusi: Complete.

    This entry describes 9 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P35612-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ    50
    KKRVTMILQS PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA 100
    VFPTSSMNVS MMTPINDLHT ADSLNLAKGE RLMRCKISSV YRLLDLYGWA 150
    QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV TASSLIKVNI LGEVVEKGSS 200
    CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK WGLLPVSHNA 250
    LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE 300
    EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS 350
    TFGPMQKSRL GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI 400
    PATVTAFVFE EDGAPVPALR QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ 450
    RSMGSPRPKT TWMKADEVEK SSSGMPIRIE NPNQFVPLYT DPQEVLEMRN 500
    KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK GDEDTKDDSE 550
    ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS 600
    PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN 650
    GREEEQTAEE ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK 700
    SPSKKKKKFR TPSFLKKSKK KEKVES 726
    Length:726
    Mass (Da):80,854
    Last modified:January 23, 2007 - v3
    Checksum:iB07F7303D929DBA4
    GO
    Isoform 2 (identifier: P35612-2) [UniParc]FASTAAdd to Basket

    Also known as: Adducin 63

    The sequence of this isoform differs from the canonical sequence as follows:
         532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
         560-726: Missing.

    Show »
    Length:559
    Mass (Da):62,467
    Checksum:iB62B278AE8F48FD4
    GO
    Isoform 3 (identifier: P35612-3) [UniParc]FASTAAdd to Basket

    Also known as: Beta-4, E

    The sequence of this isoform differs from the canonical sequence as follows:
         581-726: GEKETAPEEP...KSKKKEKVES → ETGQEREPGS...QRRRQRQRAL

    Show »
    Length:643
    Mass (Da):72,721
    Checksum:i46A10F1D1278E955
    GO
    Isoform 4 (identifier: P35612-4) [UniParc]FASTAAdd to Basket

    Also known as: Beta-4a

    The sequence of this isoform differs from the canonical sequence as follows:
         581-587: GEKETAP → APGWFSS
         588-726: Missing.

    Show »
    Length:587
    Mass (Da):66,154
    Checksum:iB7ACFE32B2731FB5
    GO
    Isoform 5 (identifier: P35612-5) [UniParc]FASTAAdd to Basket

    Also known as: Beta-4b

    The sequence of this isoform differs from the canonical sequence as follows:
         188-493: Missing.
         581-586: GEKETA → ETGQER
         587-726: Missing.

    Show »
    Length:280
    Mass (Da):31,935
    Checksum:i851E20275B19D246
    GO
    Isoform 6 (identifier: P35612-6) [UniParc]FASTAAdd to Basket

    Also known as: Beta-4c

    The sequence of this isoform differs from the canonical sequence as follows:
         188-493: Missing.
         581-587: GEKETAP → APGWFSS
         588-726: Missing.

    Show »
    Length:281
    Mass (Da):31,967
    Checksum:i1CF4ACF5875DDF12
    GO
    Isoform 7 (identifier: P35612-7) [UniParc]FASTAAdd to Basket

    Also known as: Beta-4d

    The sequence of this isoform differs from the canonical sequence as follows:
         78-566: Missing.
         581-587: GEKETAP → APGWFSS
         588-726: Missing.

    Show »
    Length:98
    Mass (Da):11,625
    Checksum:i2FABB44289701D9B
    GO
    Isoform 8 (identifier: P35612-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MPRRRVPGANCKPTGK
         532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
         560-726: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:574
    Mass (Da):64,086
    Checksum:i4169DB571ED52F85
    GO
    Isoform 9 (identifier: P35612-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MPRRRVPGANCKPTGKM
         532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
         560-726: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:575
    Mass (Da):64,217
    Checksum:i99629BA28D32AE6E
    GO

    Sequence cautioni

    The sequence BAD92464.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281D → N.
    Corresponds to variant rs4986 [ dbSNP | Ensembl ].
    VAR_014866
    Natural varianti98 – 981S → C.
    Corresponds to variant rs4987 [ dbSNP | Ensembl ].
    VAR_048195
    Natural varianti335 – 3351E → D.
    Corresponds to variant rs4982 [ dbSNP | Ensembl ].
    VAR_014867
    Natural varianti439 – 4391T → A.1 Publication
    Corresponds to variant rs17855969 [ dbSNP | Ensembl ].
    VAR_025318
    Natural varianti663 – 6631S → R.
    Corresponds to variant rs4985 [ dbSNP | Ensembl ].
    VAR_014868

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MPRRRVPGANCKPTGK in isoform 8. 1 PublicationVSP_043625
    Alternative sequencei1 – 11M → MPRRRVPGANCKPTGKM in isoform 9. 1 PublicationVSP_055309
    Alternative sequencei78 – 566489Missing in isoform 7. 1 PublicationVSP_017241Add
    BLAST
    Alternative sequencei188 – 493306Missing in isoform 5 and isoform 6. 1 PublicationVSP_017242Add
    BLAST
    Alternative sequencei532 – 55928STESQ…NPFSQ → VEQRLPLTGGETCLPSGSSV PGAGLQDP in isoform 2, isoform 8 and isoform 9. 2 PublicationsVSP_000181Add
    BLAST
    Alternative sequencei560 – 726167Missing in isoform 2, isoform 8 and isoform 9. 2 PublicationsVSP_000182Add
    BLAST
    Alternative sequencei581 – 726146GEKET…EKVES → ETGQEREPGSGPAVCEFFSV ALHIWSNILERKKLPQKSLA HLQSLHLLLQCRAQRRRQRQ RAL in isoform 3. 2 PublicationsVSP_000183Add
    BLAST
    Alternative sequencei581 – 5877GEKETAP → APGWFSS in isoform 4, isoform 6 and isoform 7. 1 PublicationVSP_017244
    Alternative sequencei581 – 5866GEKETA → ETGQER in isoform 5. 1 PublicationVSP_017243
    Alternative sequencei587 – 726140Missing in isoform 5. 1 PublicationVSP_017245Add
    BLAST
    Alternative sequencei588 – 726139Missing in isoform 4, isoform 6 and isoform 7. 1 PublicationVSP_017246Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58199 mRNA. Translation: CAA41176.1.
    AF486420 mRNA. Translation: AAP71863.1.
    AF486421 mRNA. Translation: AAP71864.1.
    AF486422 mRNA. Translation: AAP71865.1.
    AF486423 mRNA. Translation: AAP71866.1.
    AK291007 mRNA. Translation: BAF83696.1.
    AK297250 mRNA. Translation: BAG59729.1.
    AK309773 mRNA. No translation available.
    AB209227 mRNA. Translation: BAD92464.1. Different initiation.
    AB593080 mRNA. Translation: BAJ84020.1.
    AC005234 Genomic DNA. Translation: AAD12715.1.
    AC007395 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAW99801.1.
    CH471053 Genomic DNA. Translation: EAW99806.1.
    CH471053 Genomic DNA. Translation: EAW99807.1.
    CH471053 Genomic DNA. Translation: EAW99808.1.
    BC041666 mRNA. Translation: AAH41666.1.
    BC051882 mRNA. Translation: AAH51882.1.
    BC056881 mRNA. Translation: AAH56881.1.
    BC065525 mRNA. Translation: AAH65525.1.
    U43959 mRNA. Translation: AAA86421.1.
    S81079, S81077 Genomic DNA. Translation: AAD14349.1.
    CCDSiCCDS1906.1. [P35612-1]
    CCDS1909.1. [P35612-3]
    CCDS46318.1. [P35612-2]
    CCDS54365.1. [P35612-9]
    PIRiS18208.
    RefSeqiNP_001171983.1. NM_001185054.1. [P35612-1]
    NP_001171984.1. NM_001185055.1.
    NP_001608.1. NM_001617.3. [P35612-1]
    NP_059516.2. NM_017482.3. [P35612-2]
    NP_059522.1. NM_017488.3. [P35612-3]
    UniGeneiHs.188528.

    Genome annotation databases

    EnsembliENST00000264436; ENSP00000264436; ENSG00000075340. [P35612-1]
    ENST00000355733; ENSP00000347972; ENSG00000075340. [P35612-3]
    ENST00000403045; ENSP00000384303; ENSG00000075340. [P35612-1]
    ENST00000407644; ENSP00000384677; ENSG00000075340. [P35612-1]
    ENST00000413157; ENSP00000388072; ENSG00000075340. [P35612-2]
    ENST00000430656; ENSP00000398112; ENSG00000075340. [P35612-9]
    GeneIDi119.
    KEGGihsa:119.
    UCSCiuc002sgy.3. human. [P35612-3]
    uc002sgz.3. human. [P35612-1]
    uc002shc.2. human. [P35612-2]
    uc010fdt.2. human. [P35612-4]

    Polymorphism databases

    DMDMi543774.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58199 mRNA. Translation: CAA41176.1 .
    AF486420 mRNA. Translation: AAP71863.1 .
    AF486421 mRNA. Translation: AAP71864.1 .
    AF486422 mRNA. Translation: AAP71865.1 .
    AF486423 mRNA. Translation: AAP71866.1 .
    AK291007 mRNA. Translation: BAF83696.1 .
    AK297250 mRNA. Translation: BAG59729.1 .
    AK309773 mRNA. No translation available.
    AB209227 mRNA. Translation: BAD92464.1 . Different initiation.
    AB593080 mRNA. Translation: BAJ84020.1 .
    AC005234 Genomic DNA. Translation: AAD12715.1 .
    AC007395 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAW99801.1 .
    CH471053 Genomic DNA. Translation: EAW99806.1 .
    CH471053 Genomic DNA. Translation: EAW99807.1 .
    CH471053 Genomic DNA. Translation: EAW99808.1 .
    BC041666 mRNA. Translation: AAH41666.1 .
    BC051882 mRNA. Translation: AAH51882.1 .
    BC056881 mRNA. Translation: AAH56881.1 .
    BC065525 mRNA. Translation: AAH65525.1 .
    U43959 mRNA. Translation: AAA86421.1 .
    S81079 , S81077 Genomic DNA. Translation: AAD14349.1 .
    CCDSi CCDS1906.1. [P35612-1 ]
    CCDS1909.1. [P35612-3 ]
    CCDS46318.1. [P35612-2 ]
    CCDS54365.1. [P35612-9 ]
    PIRi S18208.
    RefSeqi NP_001171983.1. NM_001185054.1. [P35612-1 ]
    NP_001171984.1. NM_001185055.1.
    NP_001608.1. NM_001617.3. [P35612-1 ]
    NP_059516.2. NM_017482.3. [P35612-2 ]
    NP_059522.1. NM_017488.3. [P35612-3 ]
    UniGenei Hs.188528.

    3D structure databases

    DisProti DP00241.
    ProteinModelPortali P35612.
    SMRi P35612. Positions 149-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106632. 4 interactions.

    PTM databases

    PhosphoSitei P35612.

    Polymorphism databases

    DMDMi 543774.

    Proteomic databases

    MaxQBi P35612.
    PaxDbi P35612.
    PRIDEi P35612.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264436 ; ENSP00000264436 ; ENSG00000075340 . [P35612-1 ]
    ENST00000355733 ; ENSP00000347972 ; ENSG00000075340 . [P35612-3 ]
    ENST00000403045 ; ENSP00000384303 ; ENSG00000075340 . [P35612-1 ]
    ENST00000407644 ; ENSP00000384677 ; ENSG00000075340 . [P35612-1 ]
    ENST00000413157 ; ENSP00000388072 ; ENSG00000075340 . [P35612-2 ]
    ENST00000430656 ; ENSP00000398112 ; ENSG00000075340 . [P35612-9 ]
    GeneIDi 119.
    KEGGi hsa:119.
    UCSCi uc002sgy.3. human. [P35612-3 ]
    uc002sgz.3. human. [P35612-1 ]
    uc002shc.2. human. [P35612-2 ]
    uc010fdt.2. human. [P35612-4 ]

    Organism-specific databases

    CTDi 119.
    GeneCardsi GC02M070800.
    HGNCi HGNC:244. ADD2.
    HPAi CAB009796.
    HPA034509.
    HPA034510.
    MIMi 102681. gene.
    neXtProti NX_P35612.
    PharmGKBi PA24566.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0235.
    HOVERGENi HBG004180.
    InParanoidi P35612.
    OMAi SGPMSPE.
    OrthoDBi EOG7HF1HR.
    PhylomeDBi P35612.
    TreeFami TF313003.

    Miscellaneous databases

    GeneWikii ADD2.
    GenomeRNAii 119.
    NextBioi 469.
    PROi P35612.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35612.
    Bgeei P35612.
    Genevestigatori P35612.

    Family and domain databases

    Gene3Di 3.40.225.10. 1 hit.
    InterProi IPR027773. ADD2.
    IPR001303. Aldolase_II/adducin_N.
    [Graphical view ]
    PANTHERi PTHR10672:SF6. PTHR10672:SF6. 1 hit.
    Pfami PF00596. Aldolase_II. 1 hit.
    [Graphical view ]
    SMARTi SM01007. Aldolase_II. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53639. SSF53639. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure and domain organization of human alpha and beta adducin."
      Joshi R.L., Gilligan D.M., Otto E., McLaughlin T., Bennett V.D.
      J. Cell Biol. 115:665-675(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
      Tissue: Reticulocyte.
    2. "Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants."
      Citterio L., Tizzoni L., Catalano M., Zerbini G., Bianchi G., Barlassina C.
      Biochem. Biophys. Res. Commun. 309:359-367(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6 AND 7), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Fetal kidney and Umbilical vein endothelial cell.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 8 AND 9).
    4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
      Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
      Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ALA-439.
      Tissue: Eye.
    9. "A novel isoform of beta adducin utilizes an alternatively spliced exon near the C-terminus."
      Sinard J.H., Stewart G.W., Argent A.C., Gilligan D.M., Morrow J.S.
      Mol. Biol. Cell 6:269-269(1995)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 332-726 (ISOFORM 3).
      Tissue: Bone marrow.
    10. "Genomic organisation and chromosomal localisation of the gene encoding human beta adducin."
      Tisminetzky S., Devescovi G., Tripodi G., Muro A., Bianchi G., Colombi M., Moro L., Barlati S., Tuteja R., Baralle F.E.
      Gene 167:313-316(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 462-559 (ISOFORM 2), ALTERNATIVE SPLICING.
    11. "Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C."
      Matsuoka Y., Hughes C.A., Bennett V.
      J. Biol. Chem. 271:25157-25166(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-55; SER-703 AND SER-713, PARTIAL PROTEIN SEQUENCE.
    12. "Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1."
      Khan A.A., Hanada T., Mohseni M., Jeong J.J., Zeng L., Gaetani M., Li D., Reed B.C., Speicher D.W., Chishti A.H.
      J. Biol. Chem. 283:14600-14609(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH DMTN AND SLC2A1, INTERACTION WITH SLC2A1.
    13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530; SER-592; SER-596; SER-600; SER-604; THR-611; SER-613; SER-617; SER-693 AND SER-697, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiADDB_HUMAN
    AccessioniPrimary (citable) accession number: P35612
    Secondary accession number(s): A8K4P2
    , B4DM17, D6W5G7, D6W5G8, Q13482, Q16412, Q59G82, Q5U5P4, Q6P0P2, Q6PGQ4, Q7Z688, Q7Z689, Q7Z690, Q7Z691
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3