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Protein

Coatomer subunit zeta-1

Gene

COPZ1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity
The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

GO - Biological processi

  • intracellular protein transport Source: InterPro
  • intra-Golgi vesicle-mediated transport Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
  • toxin transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit zeta-1
Alternative name(s):
Zeta-1-coat protein
Short name:
Zeta-1 COP
Gene namesi
Name:COPZ1
Synonyms:COPZ
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  • COPI vesicle coat Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938241 – 177Coatomer subunit zeta-1Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP35604.
PeptideAtlasiP35604.
PRIDEiP35604.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005384.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Protein-protein interaction databases

IntActiP35604. 1 interactor.
STRINGi9913.ENSBTAP00000007088.

Structurei

Secondary structure

1177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 19Combined sources7
Beta strandi25 – 30Combined sources6
Beta strandi32 – 35Combined sources4
Helixi38 – 52Combined sources15
Beta strandi59 – 62Combined sources4
Beta strandi65 – 71Combined sources7
Beta strandi76 – 82Combined sources7
Helixi87 – 105Combined sources19
Helixi111 – 116Combined sources6
Helixi118 – 128Combined sources11
Helixi139 – 144Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TJZX-ray2.90C/F1-153[»]
ProteinModelPortaliP35604.
SMRiP35604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3343. Eukaryota.
COG5541. LUCA.
GeneTreeiENSGT00390000004405.
HOGENOMiHOG000214428.
HOVERGENiHBG051077.
InParanoidiP35604.
KOiK20472.
OMAiDSLDIVM.
OrthoDBiEOG091G0TM0.
TreeFamiTF300262.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALILEPSL YTVKAILILD NDGDRLFAKY YDDTYPSVKE QKAFEKNIFN
60 70 80 90 100
KTHRTDSEIA LLEGLTVVYK SSIDLYFYVI GSSYENELML MTVLNCLFDS
110 120 130 140 150
LSQMLRKNVE KRALLENMEG LFLAVDEIVD GGVILESDPQ QVVHRVALRG
160 170
EDVPLTEQTV SQVLQSAKEQ IKWSLLR
Length:177
Mass (Da):20,228
Last modified:June 27, 2006 - v2
Checksum:iD410249532C8BAF8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7E → Q in CAA53539 (PubMed:8276893).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75935 mRNA. Translation: CAA53539.1.
BT020662 mRNA. Translation: AAX08679.1.
BT020725 mRNA. Translation: AAX08742.1.
BC102358 mRNA. Translation: AAI02359.1.
PIRiA49465.
RefSeqiNP_776707.2. NM_174282.3.
UniGeneiBt.43744.

Genome annotation databases

EnsembliENSBTAT00000007088; ENSBTAP00000007088; ENSBTAG00000005384.
GeneIDi281707.
KEGGibta:281707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75935 mRNA. Translation: CAA53539.1.
BT020662 mRNA. Translation: AAX08679.1.
BT020725 mRNA. Translation: AAX08742.1.
BC102358 mRNA. Translation: AAI02359.1.
PIRiA49465.
RefSeqiNP_776707.2. NM_174282.3.
UniGeneiBt.43744.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TJZX-ray2.90C/F1-153[»]
ProteinModelPortaliP35604.
SMRiP35604.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35604. 1 interactor.
STRINGi9913.ENSBTAP00000007088.

Proteomic databases

PaxDbiP35604.
PeptideAtlasiP35604.
PRIDEiP35604.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007088; ENSBTAP00000007088; ENSBTAG00000005384.
GeneIDi281707.
KEGGibta:281707.

Organism-specific databases

CTDi22818.

Phylogenomic databases

eggNOGiKOG3343. Eukaryota.
COG5541. LUCA.
GeneTreeiENSGT00390000004405.
HOGENOMiHOG000214428.
HOVERGENiHBG051077.
InParanoidiP35604.
KOiK20472.
OMAiDSLDIVM.
OrthoDBiEOG091G0TM0.
TreeFamiTF300262.

Enzyme and pathway databases

ReactomeiR-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Gene expression databases

BgeeiENSBTAG00000005384.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOPZ1_BOVIN
AccessioniPrimary (citable) accession number: P35604
Secondary accession number(s): Q5EA44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.