ATP-dependent Clp protease ATP-binding subunit ClpE - Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

Preferred order of sections

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpE

Alternative name(s):
Exported protein 4

Gene names

Name:	clpE
Synonyms:	exp4
Ordered Locus Names:	SP_0820

Organism

Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]

Taxonomic identifier

170187 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length	752 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could be necessary for degrading proteins generated by certain types of stress By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein.
Induction	By heat shock Probable.
Sequence similarities	Belongs to the clpA/clpB family. ClpE subfamily. Contains 1 UVR domain.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cell membrane Membrane
Domain	Repeat Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 752

752

ATP-dependent Clp protease ATP-binding subunit ClpE

PRO_0000191227

Regions

Domain

365 – 400

36

UVR

Zinc finger

3 – 32

30

C4-type Potential

Nucleotide binding

158 – 165

8

ATP Potential

Nucleotide binding

487 – 494

8

ATP Potential

Region

113 – 360

248

I

Region

413 – 604

192

II

Sequences

Sequence

Length

Mass (Da)

Tools

P35594 [UniParc].

Last modified September 26, 2001. Version 2.
Checksum: 376989EA320F0C88
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FASTA

752

83,814

        10         20         30         40         50         60 
MLCQNCKIND STIHLYTNLN GKQKQIDLCQ NCYKIIKTDP NNSLFKGMTD LNNRDFDPFG 

        70         80         90        100        110        120 
DFFNDLNNFR PSSNTPPIPP TQSGGGYGGN GGYGSQNRGS AQTPPPSQEK GLLEEFGINV 

       130        140        150        160        170        180 
TEIARRGDID PVIGRDDEII RVIEILNRRT KNNPVLIGEP GVGKTAVVEG LAQKIVDGDV 

       190        200        210        220        230        240 
PHKLQGKQVI RLDVVSLVQG TGIRGQFEER MQKLMEEIRK REDIILFIDE IHEIVGAGSA 

       250        260        270        280        290        300 
SDGNMDAGNI LKPALARGEL QLVGATTLNE YRIIEKDAAL ERRMQPVKVD EPTVDETITI 

       310        320        330        340        350        360 
LKGIQKKYED YHHVQYTDAA IEAAATLSNR YIQDRFLPDK AIDLLDEAGS KMNLTLNFVD 

       370        380        390        400        410        420 
PKVIDQRLIE AENLKSQATR EEDFEKAAYF RDQIAKYKEM QKKKITDQDT PSISEKTIEH 

       430        440        450        460        470        480 
IIEQKTNIPV GDLKEKEQSQ LIHLAEDLKS HVIGQDDAVD KIAKAIRRNR VGLGTPNRPI 

       490        500        510        520        530        540 
GSFLFVGPTG VGKTELSKQL AIELFGSADS MIRFDMSEYM EKHSVAKLVG APPGYVGYDE 

       550        560        570        580        590        600 
AGQLTEKVRH NPYSLILLDE VEKAHPDVMH MFLQVLDDGR LTDGQGRTVS FKDAIIIMTS 

       610        620        630        640        650        660 
NAGTGKTEAS VGFGAAREGR TNSVLGELGN FFSPEFMNRF DGIIEFKALS KDNLLQIVEL 

       670        680        690        700        710        720 
MLADVNKRLS SNNIRLDVTD KVKEKLVDLG YDPKMGARPL RRTIQDYIED TITDYYLENP 

       730        740        750 
SEKDLKAVMT SKGNIQIKSA KKAEVKSSEK EK

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. Fraser C.M. Science 293:498-506(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.
[2]	"Genetic identification of exported proteins in Streptococcus pneumoniae." Pearce B.J., Yin Y.B., Masure H.R. Mol. Microbiol. 9:1037-1050(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 600-692. Strain: R6x.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005672 Genomic DNA. Translation: AAK74952.1. L20558 Genomic DNA. Translation: AAA26880.1.
PIR	G95094.
RefSeq	NP_345312.1. NC_003028.3.
3D structure databases
ProteinModelPortal	P35594.
SMR	P35594. Positions 113-302.
ModBase	Search...
Protein-protein interaction databases
STRING	170187.SP_0820.
Proteomic databases
PRIDE	P35594.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK74952; AAK74952; SP_0820.
GeneID	930770.
KEGG	spn:SP_0820.
PATRIC	19706015. VBIStrPne105772_0854.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0542.
HOGENOM	HOG000218211.
KO	K03697.
OMA	RTIQDHI.
ProtClustDB	CLSK876751.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR013093. ATPase_AAA-2. IPR003959. ATPase_AAA_core. IPR018368. Chaperonin_ClpA/B_CS. IPR001270. Chaprnin_ClpA/B. IPR019489. Clp_ATPase_C. IPR001943. UVR_dom. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF07724. AAA_2. 1 hit. PF10431. ClpB_D2-small. 1 hit. PF02151. UVR. 1 hit. [Graphical view]
PRINTS	PR00300. CLPPROTEASEA.
SMART	SM00382. AAA. 2 hits. SM01086. ClpB_D2-small. 1 hit. [Graphical view]
PROSITE	PS00870. CLPAB_1. 1 hit. PS00871. CLPAB_2. 1 hit. PS50151. UVR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPE_STRPN

Accession

Primary (citable) accession number: P35594

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	September 26, 2001
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents