##gff-version 3
P35590	UniProtKB	Signal peptide	1	21	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161	
P35590	UniProtKB	Chain	22	1138	.	.	.	ID=PRO_0000024471;Note=Tyrosine-protein kinase receptor Tie-1	
P35590	UniProtKB	Topological domain	22	759	.	.	.	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P35590	UniProtKB	Transmembrane	760	784	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P35590	UniProtKB	Topological domain	785	1138	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P35590	UniProtKB	Domain	43	105	.	.	.	Note=Ig-like C2-type 1	
P35590	UniProtKB	Domain	214	256	.	.	.	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076	
P35590	UniProtKB	Domain	258	303	.	.	.	Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076	
P35590	UniProtKB	Domain	305	345	.	.	.	Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076	
P35590	UniProtKB	Domain	372	426	.	.	.	Note=Ig-like C2-type 2	
P35590	UniProtKB	Domain	446	545	.	.	.	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316	
P35590	UniProtKB	Domain	548	642	.	.	.	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316	
P35590	UniProtKB	Domain	646	739	.	.	.	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316	
P35590	UniProtKB	Domain	839	1118	.	.	.	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P35590	UniProtKB	Active site	979	979	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028	
P35590	UniProtKB	Binding site	845	853	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P35590	UniProtKB	Binding site	870	870	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P35590	UniProtKB	Modified residue	1007	1007	.	.	.	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P35590	UniProtKB	Glycosylation	83	83	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P35590	UniProtKB	Glycosylation	161	161	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P35590	UniProtKB	Glycosylation	503	503	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P35590	UniProtKB	Glycosylation	596	596	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P35590	UniProtKB	Glycosylation	709	709	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P35590	UniProtKB	Disulfide bond	228	237	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076	
P35590	UniProtKB	Disulfide bond	231	244	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076	
P35590	UniProtKB	Disulfide bond	246	255	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076	
P35590	UniProtKB	Disulfide bond	315	327	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076	
P35590	UniProtKB	Disulfide bond	321	333	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076	
P35590	UniProtKB	Disulfide bond	335	344	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076	
P35590	UniProtKB	Alternative sequence	305	317	.	.	.	ID=VSP_047607;Note=In isoform 3. ACAPGHFGADCRL->VHQGHCGAREDHS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464	
P35590	UniProtKB	Alternative sequence	318	1138	.	.	.	ID=VSP_047608;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464	
P35590	UniProtKB	Alternative sequence	348	379	.	.	.	ID=VSP_047609;Note=In isoform 2. DRIPQILNMASELEFNLETMPRINCAAAGNPF->GWRDWVDTSTEKQNTDEGRFGGHVSAPVGAPG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464	
P35590	UniProtKB	Alternative sequence	380	1138	.	.	.	ID=VSP_047610;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18593464;Dbxref=PMID:18593464	
P35590	UniProtKB	Natural variant	448	448	.	.	.	ID=VAR_041852;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56302794,PMID:17344846	
P35590	UniProtKB	Natural variant	481	481	.	.	.	ID=VAR_085888;Note=In LMPHM11%3B uncertain significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32947856;Dbxref=dbSNP:rs139244400,PMID:32947856	
P35590	UniProtKB	Natural variant	1061	1061	.	.	.	ID=VAR_085889;Note=In LMPHM11%3B uncertain significance. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32947856;Dbxref=dbSNP:rs760492428,PMID:32947856	
P35590	UniProtKB	Natural variant	1104	1104	.	.	.	ID=VAR_041853;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35573981,PMID:17344846	
P35590	UniProtKB	Natural variant	1109	1109	.	.	.	ID=VAR_041854;Note=In LMPHM11%3B uncertain significance. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:32947856;Dbxref=dbSNP:rs34993202,PMID:17344846,PMID:32947856	
P35590	UniProtKB	Beta strand	648	656	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5N06	
P35590	UniProtKB	Beta strand	659	665	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5N06	
P35590	UniProtKB	Beta strand	676	682	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5N06	
P35590	UniProtKB	Beta strand	691	695	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5N06	
P35590	UniProtKB	Beta strand	701	707	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5N06	
P35590	UniProtKB	Beta strand	714	728	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5N06