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P35584

- FOXA3_MOUSE

UniProt

P35584 - FOXA3_MOUSE

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Protein

Hepatocyte nuclear factor 3-gamma

Gene
Foxa3, Hnf3g, Tcf-3g, Tcf3g
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites By similarity. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates GLUT2 transcription. Involved in regulation of neuronal-specific transcription. Involved in regulation of spermatogenesis; required for the maintenance of the testicular germ cell population and male fertility.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi118 – 20992Fork-headAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. DNA binding, bending Source: RefGenome
  3. double-stranded DNA binding Source: RefGenome
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  5. sequence-specific DNA binding Source: MGI
  6. transcription factor binding Source: RefGenome
  7. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. cellular glucose homeostasis Source: MGI
  2. cellular response to starvation Source: MGI
  3. chromatin modification Source: UniProtKB-KW
  4. endocrine pancreas development Source: Reactome
  5. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  6. neuron fate specification Source: RefGenome
  7. pattern specification process Source: RefGenome
  8. positive regulation of neuron differentiation Source: RefGenome
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. regulation of hormone levels Source: RefGenome
  11. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  12. regulation of transcription, DNA-templated Source: MGI
  13. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  14. spermatogenesis Source: UniProtKB
  15. tissue development Source: RefGenome
  16. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_214529. Regulation of gene expression in beta cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 3-gamma
Short name:
HNF-3-gamma
Short name:
HNF-3G
Alternative name(s):
Forkhead box protein A3
Gene namesi
Name:Foxa3
Synonyms:Hnf3g, Tcf-3g, Tcf3g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1347477. Foxa3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nucleus Source: MGI
  3. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Reduced expression levels of several HNF3 target genes (phosphoenolpyruvate carboxykinase, transferrin, tyrosine aminotransferase) by 50 to 70%,. The germinal epithelium of testes is characterized by a loss of germ cells secondary to an increase in germ cell apoptosis that ultimately leads to a Sertoli cell-only syndrome. Significantly lower blood glucose in fasted mice.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Hepatocyte nuclear factor 3-gammaPRO_0000091801Add
BLAST

Proteomic databases

PRIDEiP35584.

PTM databases

PhosphoSiteiP35584.

Expressioni

Tissue specificityi

Restricted mainly to endoderm-derived tissues (lung, liver, stomach, and small intestine), also present additionally in ovary, testis, heart, and adipose tissue, but missing from lung.1 Publication

Developmental stagei

Expression peaks around day 15.5 of gestation. Expressed from day 6 to day 70 during postnatal testicular development.1 Publication

Gene expression databases

BgeeiP35584.
CleanExiMM_FOXA3.
GenevestigatoriP35584.

Interactioni

Subunit structurei

Interacts with FOXA2 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043173.

Structurei

3D structure databases

ProteinModelPortaliP35584.
SMRiP35584. Positions 117-217.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00740000115483.
HOGENOMiHOG000231817.
HOVERGENiHBG006621.
InParanoidiP35584.
KOiK08038.
OMAiVYYQGVY.
OrthoDBiEOG7C8GHD.
PhylomeDBiP35584.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR013638. Fork-head_N.
IPR018533. Forkhead_box_C.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
PF08430. Fork_head_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35584-1 [UniParc]FASTAAdd to Basket

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MLGSVKMEAH DLAEWSYYPE AGEVYSPVNP VPTMAPLNSY MTLNPLSSPY    50
PPGGLQASPL PTGPLAPPAP TAPLGPTFPS LGTGGSTGGS ASGYVAPGPG 100
LVHGKEMAKG YRRPLAHAKP PYSYISLITM AIQQAPGKML TLSEIYQWIM 150
DLFPYYRENQ QRWQNSIRHS LSFNDCFVKV ARSPDKPGKG SYWALHPSSG 200
NMFENGCYLR RQKRFKLEEK AKKGNSATSA SRNGTAGSAT SATTTAATAV 250
TSPAQPQPTP SEPEAQSGDD VGGLDCASPP SSTPYFSGLE LPGELKLDAP 300
YNFNHPFSIN NLMSEQTSTP SKLDVGFGGY GAESGEPGVY YQSLYSRSLL 350
NAS 353
Length:353
Mass (Da):37,601
Last modified:June 1, 1994 - v1
Checksum:i28F060A8E944D5B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74938 mRNA. Translation: CAA52892.1.
CCDSiCCDS20886.1.
PIRiC54258.
RefSeqiNP_032286.1. NM_008260.2.
UniGeneiMm.42260.

Genome annotation databases

EnsembliENSMUST00000036018; ENSMUSP00000043173; ENSMUSG00000040891.
GeneIDi15377.
KEGGimmu:15377.
UCSCiuc009fkd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74938 mRNA. Translation: CAA52892.1 .
CCDSi CCDS20886.1.
PIRi C54258.
RefSeqi NP_032286.1. NM_008260.2.
UniGenei Mm.42260.

3D structure databases

ProteinModelPortali P35584.
SMRi P35584. Positions 117-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000043173.

PTM databases

PhosphoSitei P35584.

Proteomic databases

PRIDEi P35584.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036018 ; ENSMUSP00000043173 ; ENSMUSG00000040891 .
GeneIDi 15377.
KEGGi mmu:15377.
UCSCi uc009fkd.1. mouse.

Organism-specific databases

CTDi 3171.
MGIi MGI:1347477. Foxa3.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00740000115483.
HOGENOMi HOG000231817.
HOVERGENi HBG006621.
InParanoidi P35584.
KOi K08038.
OMAi VYYQGVY.
OrthoDBi EOG7C8GHD.
PhylomeDBi P35584.
TreeFami TF316127.

Enzyme and pathway databases

Reactomei REACT_214529. Regulation of gene expression in beta cells.

Miscellaneous databases

NextBioi 288034.
PROi P35584.
SOURCEi Search...

Gene expression databases

Bgeei P35584.
CleanExi MM_FOXA3.
Genevestigatori P35584.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR013638. Fork-head_N.
IPR018533. Forkhead_box_C.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
PF08430. Fork_head_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution."
    Kaestner K., Hiemisch H., Luckow B., Schuetz G.
    Genomics 20:377-385(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes."
    Kaestner K.H., Hiemisch H., Schutz G.
    Mol. Cell. Biol. 18:4245-4251(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LIVER-SPECIFIC TRANSCRIPTION, DISRUPTION PHENOTYPE.
  3. "Foxa3 (hepatocyte nuclear factor 3gamma) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast."
    Shen W., Scearce L.M., Brestelli J.E., Sund N.J., Kaestner K.H.
    J. Biol. Chem. 276:42812-42817(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3."
    Behr R., Sackett S.D., Bochkis I.M., Le P.P., Kaestner K.H.
    Dev. Biol. 306:636-645(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION IN SPERMATOGENESIS.

Entry informationi

Entry nameiFOXA3_MOUSE
AccessioniPrimary (citable) accession number: P35584
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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