Reviewed, UniProtKB/Swiss-Prot P35580 (MYH10_HUMAN)

Names and origin

Protein names

Recommended name:
    Myosin-10
Alternative name(s):
    Myosin heavy chain 10
    Myosin heavy chain, non-muscle IIb
    Non-muscle myosin heavy chain IIb
      Short name=NMMHC II-b
      Short name=NMMHC-IIB
    Cellular myosin heavy chain, type B
    Non-muscle myosin heavy chain B
      Short name=NMMHC-B

Gene names

Name:

MYH10

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1976 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
Subunit structure	Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Ref.7
Tissue specificity	In brain, isoform 1 is predominantly expresssed in cerebellum and spinal chord, isoform 2 in cerebrum and retina; isoform 3 is expressed in the cerebebrum and to a much lower extent in cerebellum. Ref.5
Domain	The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16 Ref.17
Sequence similarities	Contains 1 IQ domain. Contains 1 myosin head-like domain.

Ontologies

Keywords
Biological process	Cell shape
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	ATP-binding Actin-binding Calmodulin-binding Nucleotide-binding
Molecular function	Motor protein Myosin
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	actin filament-based movement Inferred from direct assay. Source: MGI cytokinesis after mitosis Inferred from direct assay. Source: MGI regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell cortex Inferred from direct assay. Source: UniProtKB cleavage furrow Inferred from direct assay. Source: UniProtKB midbody Inferred from direct assay. Source: UniProtKB myosin complex Ref.1 Non-traceable author statement. Source: UniProtKB stress fiber Inferred from direct assay. Source: UniProtKB
Molecular function	ADP binding Inferred from direct assay. Source: MGI ATP binding Ref.5 Non-traceable author statement. Source: UniProtKB actin filament binding Inferred from direct assay. Source: MGI actin-dependent ATPase activity Inferred from direct assay. Source: MGI calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW microfilament motor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IKBKE	Q14164	1	EBI-351758,EBI-307369
LLGL1	Q15334	1	EBI-351758,EBI-299979
MCC	P23508	1	EBI-351758,EBI-307531
PAK2	Q13177	1	EBI-351758,EBI-1045887
PRKAB1	Q9Y478	1	EBI-351758,EBI-719769
TNFRSF10D	Q9UBN6	1	EBI-351758,EBI-1044859

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P35580-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P35580-2)

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: P → PQESPKPVKHQSGSLLY

Isoform 3 (identifier: P35580-3)

The sequence of this isoform differs from the canonical sequence as follows:
     621-621: D → DEIQNIQRASFYDSVSGLHEPP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 1976	1975	Myosin-10		PRO_0000123421
Regions
	Domain	2 – 785	784	Myosin head-like
	Domain	786 – 815	30	IQ
	Nucleotide binding	178 – 185	8	ATP Potential
	Coiled coil	845 – 1976	1132	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.16
	Modified residue	442	1	N6-acetyllysine Ref.18
	Modified residue	552	1	N6-acetyllysine Ref.18
	Modified residue	1013	1	Phosphoserine Ref.10
	Modified residue	1247	1	N6-acetyllysine Ref.18
	Modified residue	1376	1	Phosphothreonine Ref.12
	Modified residue	1415	1	Phosphotyrosine Ref.9
	Modified residue	1645	1	N6-acetyllysine Ref.18
	Modified residue	1938	1	Phosphoserine By similarity
	Modified residue	1939	1	Phosphoserine Ref.13 Ref.17
	Modified residue	1952	1	Phosphoserine Ref.13 Ref.17
	Modified residue	1956	1	Phosphoserine Ref.11 Ref.13 Ref.14 Ref.17
	Modified residue	1960	1	Phosphothreonine Ref.8
	Modified residue	1964	1	Phosphothreonine Ref.16
	Modified residue	1965	1	Phosphoserine Ref.16
	Modified residue	1975	1	Phosphoserine Ref.11 Ref.16
Natural variations
	Alternative sequence	211	1	P → PQESPKPVKHQSGSLLY in isoform 2.		VSP_022013
	Alternative sequence	621	1	D → DEIQNIQRASFYDSVSGLHE PP in isoform 3.		VSP_022014
Experimental info
	Sequence conflict	800	1	Y → C in AAA99177. Ref.1
	Sequence conflict	1751	1	N → D in AAB28952. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: A7C91944EBC2368F	FASTA	1,976	228,999
	10 20 30 40 50 60 MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 70 80 90 100 110 120 ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 130 140 150 160 170 180 FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS 250 260 270 280 290 300 RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL 310 320 330 340 350 360 LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS 370 380 390 400 410 420 FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA 430 440 450 460 470 480 VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN 490 500 510 520 530 540 EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW 550 560 570 580 590 600 FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN 610 620 630 640 650 660 DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES 670 680 690 700 710 720 LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV 730 740 750 760 770 780 FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE 790 800 810 820 830 840 ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK 850 860 870 880 890 900 VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET 910 920 930 940 950 960 ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD 970 980 990 1000 1010 1020 EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE 1030 1040 1050 1060 1070 1080 KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE 1090 1100 1110 1120 1130 1140 LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ 1150 1160 1170 1180 1190 1200 KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR 1210 1220 1230 1240 1250 1260 HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ 1270 1280 1290 1300 1310 1320 VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT 1330 1340 1350 1360 1370 1380 QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV 1390 1400 1410 1420 1430 1440 DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR 1450 1460 1470 1480 1490 1500 QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE 1510 1520 1530 1540 1550 1560 EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED 1570 1580 1590 1600 1610 1620 AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK 1630 1640 1650 1660 1670 1680 KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK 1690 1700 1710 1720 1730 1740 KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ 1750 1760 1770 1780 1790 1800 LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK 1810 1820 1830 1840 1850 1860 LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED 1870 1880 1890 1900 1910 1920 ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE 1930 1940 1950 1960 1970 VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE
	Isoform 2. Checksum: 2FCF86A36AB04BC5	FASTA	1,992	230,779
	10 20 30 40 50 60 MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 70 80 90 100 110 120 ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 130 140 150 160 170 180 FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PQESPKPVKH QSGSLLYGEL ERQLLQANPI 250 260 270 280 290 300 LESFGNAKTV KNDNSSRFGK FIRINFDVTG YIVGANIETY LLEKSRAVRQ AKDERTFHIF 310 320 330 340 350 360 YQLLSGAGEH LKSDLLLEGF NNYRFLSNGY IPIPGQQDKD NFQETMEAMH IMGFSHEEIL 370 380 390 400 410 420 SMLKVVSSVL QFGNISFKKE RNTDQASMPE NTVAQKLCHL LGMNVMEFTR AILTPRIKVG 430 440 450 460 470 480 RDYVQKAQTK EQADFAVEAL AKATYERLFR WLVHRINKAL DRTKRQGASF IGILDIAGFE 490 500 510 520 530 540 IFELNSFEQL CINYTNEKLQ QLFNHTMFIL EQEEYQREGI EWNFIDFGLD LQPCIDLIER 550 560 570 580 590 600 PANPPGVLAL LDEECWFPKA TDKTFVEKLV QEQGSHSKFQ KPRQLKDKAD FCIIHYAGKV 610 620 630 640 650 660 DYKADEWLMK NMDPLNDNVA TLLHQSSDRF VAELWKDVDR IVGLDQVTGM TETAFGSAYK 670 680 690 700 710 720 TKKGMFRTVG QLYKESLTKL MATLRNTNPN FVRCIIPNHE KRAGKLDPHL VLDQLRCNGV 730 740 750 760 770 780 LEGIRICRQG FPNRIVFQEF RQRYEILTPN AIPKGFMDGK QACERMIRAL ELDPNLYRIG 790 800 810 820 830 840 QSKIFFRAGV LAHLEEERDL KITDIIIFFQ AVCRGYLARK AFAKKQQQLS ALKVLQRNCA 850 860 870 880 890 900 AYLKLRHWQW WRVFTKVKPL LQVTRQEEEL QAKDEELLKV KEKQTKVEGE LEEMERKHQQ 910 920 930 940 950 960 LLEEKNILAE QLQAETELFA EAEEMRARLA AKKQELEEIL HDLESRVEEE EERNQILQNE 970 980 990 1000 1010 1020 KKKMQAHIQD LEEQLDEEEG ARQKLQLEKV TAEAKIKKME EEILLLEDQN SKFIKEKKLM 1030 1040 1050 1060 1070 1080 EDRIAECSSQ LAEEEEKAKN LAKIRNKQEV MISDLEERLK KEEKTRQELE KAKRKLDGET 1090 1100 1110 1120 1130 1140 TDLQDQIAEL QAQIDELKLQ LAKKEEELQG ALARGDDETL HKNNALKVVR ELQAQIAELQ 1150 1160 1170 1180 1190 1200 EDFESEKASR NKAEKQKRDL SEELEALKTE LEDTLDTTAA QQELRTKREQ EVAELKKALE 1210 1220 1230 1240 1250 1260 EETKNHEAQI QDMRQRHATA LEELSEQLEQ AKRFKANLEK NKQGLETDNK ELACEVKVLQ 1270 1280 1290 1300 1310 1320 QVKAESEHKR KKLDAQVQEL HAKVSEGDRL RVELAEKASK LQNELDNVST LLEEAEKKGI 1330 1340 1350 1360 1370 1380 KFAKDAASLE SQLQDTQELL QEETRQKLNL SSRIRQLEEE KNSLQEQQEE EEEARKNLEK 1390 1400 1410 1420 1430 1440 QVLALQSQLA DTKKKVDDDL GTIESLEEAK KKLLKDAEAL SQRLEEKALA YDKLEKTKNR 1450 1460 1470 1480 1490 1500 LQQELDDLTV DLDHQRQVAS NLEKKQKKFD QLLAEEKSIS ARYAEERDRA EAEAREKETK 1510 1520 1530 1540 1550 1560 ALSLARALEE ALEAKEEFER QNKQLRADME DLMSSKDDVG KNVHELEKSK RALEQQVEEM 1570 1580 1590 1600 1610 1620 RTQLEELEDE LQATEDAKLR LEVNMQAMKA QFERDLQTRD EQNEEKKRLL IKQVRELEAE 1630 1640 1650 1660 1670 1680 LEDERKQRAL AVASKKKMEI DLKDLEAQIE AANKARDEVI KQLRKLQAQM KDYQRELEEA 1690 1700 1710 1720 1730 1740 RASRDEIFAQ SKESEKKLKS LEAEILQLQE ELASSERARR HAEQERDELA DEITNSASGK 1750 1760 1770 1780 1790 1800 SALLDEKRRL EARIAQLEEE LEEEQSNMEL LNDRFRKTTL QVDTLNAELA AERSAAQKSD 1810 1820 1830 1840 1850 1860 NARQQLERQN KELKAKLQEL EGAVKSKFKA TISALEAKIG QLEEQLEQEA KERAAANKLV 1870 1880 1890 1900 1910 1920 RRTEKKLKEI FMQVEDERRH ADQYKEQMEK ANARMKQLKR QLEEAEEEAT RANASRRKLQ 1930 1940 1950 1960 1970 1980 RELDDATEAN EGLSREVSTL KNRLRRGGPI SFSSSRSGRR QLHLEGASLE LSDDDTESKT 1990 SDVNETQPPQ SE
	Isoform 3. Checksum: 59FCA83F827E415E	FASTA	1,997	231,369
	10 20 30 40 50 60 MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 70 80 90 100 110 120 ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 130 140 150 160 170 180 FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS 250 260 270 280 290 300 RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL 310 320 330 340 350 360 LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS 370 380 390 400 410 420 FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA 430 440 450 460 470 480 VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN 490 500 510 520 530 540 EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW 550 560 570 580 590 600 FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN 610 620 630 640 650 660 DNVATLLHQS SDRFVAELWK DEIQNIQRAS FYDSVSGLHE PPVDRIVGLD QVTGMTETAF 670 680 690 700 710 720 GSAYKTKKGM FRTVGQLYKE SLTKLMATLR NTNPNFVRCI IPNHEKRAGK LDPHLVLDQL 730 740 750 760 770 780 RCNGVLEGIR ICRQGFPNRI VFQEFRQRYE ILTPNAIPKG FMDGKQACER MIRALELDPN 790 800 810 820 830 840 LYRIGQSKIF FRAGVLAHLE EERDLKITDI IIFFQAVCRG YLARKAFAKK QQQLSALKVL 850 860 870 880 890 900 QRNCAAYLKL RHWQWWRVFT KVKPLLQVTR QEEELQAKDE ELLKVKEKQT KVEGELEEME 910 920 930 940 950 960 RKHQQLLEEK NILAEQLQAE TELFAEAEEM RARLAAKKQE LEEILHDLES RVEEEEERNQ 970 980 990 1000 1010 1020 ILQNEKKKMQ AHIQDLEEQL DEEEGARQKL QLEKVTAEAK IKKMEEEILL LEDQNSKFIK 1030 1040 1050 1060 1070 1080 EKKLMEDRIA ECSSQLAEEE EKAKNLAKIR NKQEVMISDL EERLKKEEKT RQELEKAKRK 1090 1100 1110 1120 1130 1140 LDGETTDLQD QIAELQAQID ELKLQLAKKE EELQGALARG DDETLHKNNA LKVVRELQAQ 1150 1160 1170 1180 1190 1200 IAELQEDFES EKASRNKAEK QKRDLSEELE ALKTELEDTL DTTAAQQELR TKREQEVAEL 1210 1220 1230 1240 1250 1260 KKALEEETKN HEAQIQDMRQ RHATALEELS EQLEQAKRFK ANLEKNKQGL ETDNKELACE 1270 1280 1290 1300 1310 1320 VKVLQQVKAE SEHKRKKLDA QVQELHAKVS EGDRLRVELA EKASKLQNEL DNVSTLLEEA 1330 1340 1350 1360 1370 1380 EKKGIKFAKD AASLESQLQD TQELLQEETR QKLNLSSRIR QLEEEKNSLQ EQQEEEEEAR 1390 1400 1410 1420 1430 1440 KNLEKQVLAL QSQLADTKKK VDDDLGTIES LEEAKKKLLK DAEALSQRLE EKALAYDKLE 1450 1460 1470 1480 1490 1500 KTKNRLQQEL DDLTVDLDHQ RQVASNLEKK QKKFDQLLAE EKSISARYAE ERDRAEAEAR 1510 1520 1530 1540 1550 1560 EKETKALSLA RALEEALEAK EEFERQNKQL RADMEDLMSS KDDVGKNVHE LEKSKRALEQ 1570 1580 1590 1600 1610 1620 QVEEMRTQLE ELEDELQATE DAKLRLEVNM QAMKAQFERD LQTRDEQNEE KKRLLIKQVR 1630 1640 1650 1660 1670 1680 ELEAELEDER KQRALAVASK KKMEIDLKDL EAQIEAANKA RDEVIKQLRK LQAQMKDYQR 1690 1700 1710 1720 1730 1740 ELEEARASRD EIFAQSKESE KKLKSLEAEI LQLQEELASS ERARRHAEQE RDELADEITN 1750 1760 1770 1780 1790 1800 SASGKSALLD EKRRLEARIA QLEEELEEEQ SNMELLNDRF RKTTLQVDTL NAELAAERSA 1810 1820 1830 1840 1850 1860 AQKSDNARQQ LERQNKELKA KLQELEGAVK SKFKATISAL EAKIGQLEEQ LEQEAKERAA 1870 1880 1890 1900 1910 1920 ANKLVRRTEK KLKEIFMQVE DERRHADQYK EQMEKANARM KQLKRQLEEA EEEATRANAS 1930 1940 1950 1960 1970 1980 RRKLQRELDD ATEANEGLSR EVSTLKNRLR RGGPISFSSS RSGRRQLHLE GASLELSDDD 1990 TESKTSDVNE TQPPQSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies." Phillips C.L., Yamakawa K., Adelstein R.S. J. Muscle Res. Cell Motil. 16:379-389(1995) [PubMed: 7499478] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes." Simons M., Wang M., McBride O.W., Kawamoto S., Yamakawa K., Gdula D., Adelstein R.S., Weir L. Circ. Res. 69:530-539(1991) [PubMed: 1860190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-722 (ISOFORM 1).
[5]	"Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B." Itoh K., Adelstein R.S. J. Biol. Chem. 270:14533-14540(1995) [PubMed: 7782316] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-301 (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 3), TISSUE SPECIFICITY.
[6]	"Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis." Aikawa M., Sivam P.N., Kuro-O M., Kimura K., Nakahara K., Takewaki S., Ueda M., Yamaguchi H., Yazaki Y., Periasamy M. Circ. Res. 73:1000-1012(1993) [PubMed: 7916668] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1751-1976.
[7]	"A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis." Wu D., Asiedu M., Adelstein R.S., Wei Q. Cell Cycle 5:1234-1239(2006) [PubMed: 16721066] [Abstract] Cited for: INTERACTION WITH PLEKHG6.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1960, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1415, MASS SPECTROMETRY.
[10]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1013, MASS SPECTROMETRY.
[11]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1956 AND SER-1975, MASS SPECTROMETRY.
[12]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1376, MASS SPECTROMETRY.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939; SER-1952 AND SER-1956, MASS SPECTROMETRY.
[14]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1956, MASS SPECTROMETRY. Tissue: Liver.
[15]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[16]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1964; SER-1965 AND SER-1975, MASS SPECTROMETRY.
[17]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939; SER-1952 AND SER-1956, MASS SPECTROMETRY. Tissue: T-cell.
[18]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-442; LYS-552; LYS-1247 AND LYS-1645, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M69181 mRNA. Translation: AAA99177.1. CH471108 Genomic DNA. Translation: EAW90049.1. BC117691 mRNA. Translation: AAI17692.1. U15618 mRNA. Translation: AAA87712.1. S67247 mRNA. Translation: AAB28952.1.
IPI	IPI00397526. IPI00479307. IPI00790503.
PIR	A59252. I65769.
RefSeq	NP_005955.1.
UniGene	Hs.16355
3D structure databases
SMR	P35580. Positions 7-815, 26-843, 843-964.
ModBase	Search...
Protein-protein interaction databases
IntAct	P35580. 19 interactions.
STRING	P35580.
PTM databases
PhosphoSite	P35580.
Proteomic databases
PRIDE	P35580.
Genome annotation databases
Ensembl	ENST00000269243; ENSP00000269243; ENSG00000133026; Homo sapiens. [Genome view]
GeneID	4628.
KEGG	hsa:4628.
Organism-specific databases
CTD	4628.
GeneCards	GC17M008318.
H-InvDB	HIX0013525.
HGNC	HGNC:7568. MYH10.
HPA	CAB017180.
MIM	160776. gene.
PharmGKB	PA31366.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG15268.
HOVERGEN	P35580.
PhylomeDB	P35580.
Enzyme and pathway databases
Reactome	REACT_18266. Axon guidance.
Gene expression databases
ArrayExpress	P35580.
Bgee	P35580.
CleanEx	HS_MYH10.
Genevestigator	P35580.
GermOnline	ENSG00000133026. Homo sapiens.
Family and domain databases
InterPro	IPR000048. IQ_CaM_bd_region. IPR001609. Myosin_head_motor_dom. IPR004009. Myosin_N. IPR008989. Myosin_S1_N. IPR002928. Myosin_tail. [Graphical view]
Pfam	PF00612. IQ. 1 hit. PF00063. Myosin_head. 1 hit. PF02736. Myosin_N. 1 hit. PF01576. Myosin_tail_1. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00015. IQ. 1 hit. SM00242. MYSc. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	17814.
SOURCE	Search...

Entry information

Entry name

MYH10_HUMAN

Accession

Primary (citable) accession number: P35580
Secondary accession number(s): Q12989, Q149N3, Q16087

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 25, 2008
Last modified:	January 19, 2010
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.