P35580 (MYH10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myosin-10

Alternative name(s):
Cellular myosin heavy chain, type B
Myosin heavy chain 10
Myosin heavy chain, non-muscle IIb
Non-muscle myosin heavy chain B
Short name=NMMHC-B
Non-muscle myosin heavy chain IIb
Short name=NMMHC II-b
Short name=NMMHC-IIB

Gene names

Name:

MYH10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1976 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Ref.18
Subunit structure	Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B By similarity. Interacts with LARP6. Ref.11 Ref.17 Ref.18
Tissue specificity	Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum. Ref.8
Domain	The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Post-translational modification	Phosphorylated by ABL2 By similarity.
Sequence similarities	Contains 1 IQ domain. Contains 1 myosin head-like domain.
Caution	Represents a conventional non-muscle myosin. This protein should not be confused with the unconventional myosin-10 (MYO10).
Sequence caution	The sequence BAE06108.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell shape
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	ATP-binding Actin-binding Calmodulin-binding Nucleotide-binding
Molecular function	Motor protein Myosin
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament-based movement Inferred from direct assay PubMed 15845534. Source: MGI adult heart development Inferred from electronic annotation. Source: Compara axon guidance Traceable author statement. Source: Reactome cardiac myofibril assembly Inferred from electronic annotation. Source: Compara cell proliferation Inferred from electronic annotation. Source: Compara cerebellar Purkinje cell layer development Inferred from electronic annotation. Source: Compara cytokinesis after mitosis Inferred from direct assay PubMed 15774463. Source: MGI exocytosis Inferred from electronic annotation. Source: Compara fourth ventricle development Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara lateral ventricle development Inferred from electronic annotation. Source: Compara neuromuscular process controlling balance Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara nuclear migration Inferred from electronic annotation. Source: Compara plasma membrane repair Inferred from electronic annotation. Source: Compara regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW retina development in camera-type eye Inferred from electronic annotation. Source: Compara substrate-dependent cell migration, cell extension Inferred from electronic annotation. Source: Compara third ventricle development Inferred from electronic annotation. Source: Compara ventricular cardiac muscle cell development Inferred from electronic annotation. Source: Compara
Cellular_component	axon Inferred from electronic annotation. Source: Compara cell cortex Inferred from direct assay PubMed 7699007. Source: UniProtKB cleavage furrow Inferred from direct assay PubMed 11029059PubMed 7699007. Source: UniProtKB dendritic spine Inferred from electronic annotation. Source: Compara growth cone Inferred from electronic annotation. Source: Compara midbody Inferred from direct assay PubMed 11029059. Source: UniProtKB myosin II complex Inferred from electronic annotation. Source: Compara myosin complex Non-traceable author statement Ref.1. Source: UniProtKB neuromuscular junction Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara spindle Inferred from electronic annotation. Source: Compara stress fiber Inferred from direct assay PubMed 7699007. Source: UniProtKB
Molecular_function	ADP binding Inferred from direct assay PubMed 15845534. Source: MGI ATP binding Non-traceable author statement Ref.8. Source: UniProtKB actin filament binding Inferred from direct assay PubMed 15845534. Source: MGI actin-dependent ATPase activity Inferred from direct assay PubMed 15845534. Source: MGI microfilament motor activity Inferred from direct assay PubMed 15845534. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P35580-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P35580-2)

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: P → PQESPKPVKHQSGSLLY

Note: Contains a phosphoserine at position 214.

Isoform 3 (identifier: P35580-3)

The sequence of this isoform differs from the canonical sequence as follows:
     621-621: D → DEIQNIQRASFYDSVSGLHEPP

Isoform 4 (identifier: P35580-4)

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: P → PQESPKPVKHQ
     621-621: D → DEIQNIQRASFYDSVSGLHEPP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1976	1976	Myosin-10		PRO_0000123421
Regions
	Domain	2 – 785	784	Myosin head-like
	Domain	786 – 815	30	IQ
	Nucleotide binding	178 – 185	8	ATP Potential
	Coiled coil	845 – 1976	1132	Potential
Amino acid modifications
	Modified residue	442	1	N6-acetyllysine Ref.16
	Modified residue	1145	1	Phosphoserine Ref.21
	Modified residue	1645	1	N6-acetyllysine Ref.16
	Modified residue	1938	1	Phosphoserine Ref.21
	Modified residue	1939	1	Phosphoserine Ref.13 Ref.15
	Modified residue	1952	1	Phosphoserine Ref.13
	Modified residue	1956	1	Phosphoserine Ref.13 Ref.14 Ref.15 Ref.19 Ref.21
	Modified residue	1960	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	211	1	P → PQESPKPVKHQSGSLLY in isoform 2.		VSP_022013
	Alternative sequence	211	1	P → PQESPKPVKHQ in isoform 4.		VSP_046033
	Alternative sequence	621	1	D → DEIQNIQRASFYDSVSGLHE PP in isoform 3 and isoform 4.		VSP_022014
Experimental info
	Sequence conflict	800	1	Y → C in AAA99177. Ref.1
	Sequence conflict	943 – 944	2	NE → KK in AAH08968. Ref.5
	Sequence conflict	1429	1	L → P in AAI17691. Ref.5
	Sequence conflict	1751	1	N → D in AAB28952. Ref.9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: A7C91944EBC2368F	FASTA	1,976	228,999
	10 20 30 40 50 60 MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 70 80 90 100 110 120 ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 130 140 150 160 170 180 FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS 250 260 270 280 290 300 RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL 310 320 330 340 350 360 LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS 370 380 390 400 410 420 FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA 430 440 450 460 470 480 VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN 490 500 510 520 530 540 EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW 550 560 570 580 590 600 FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN 610 620 630 640 650 660 DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES 670 680 690 700 710 720 LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV 730 740 750 760 770 780 FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE 790 800 810 820 830 840 ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK 850 860 870 880 890 900 VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET 910 920 930 940 950 960 ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD 970 980 990 1000 1010 1020 EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE 1030 1040 1050 1060 1070 1080 KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE 1090 1100 1110 1120 1130 1140 LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ 1150 1160 1170 1180 1190 1200 KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR 1210 1220 1230 1240 1250 1260 HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ 1270 1280 1290 1300 1310 1320 VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT 1330 1340 1350 1360 1370 1380 QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV 1390 1400 1410 1420 1430 1440 DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR 1450 1460 1470 1480 1490 1500 QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE 1510 1520 1530 1540 1550 1560 EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED 1570 1580 1590 1600 1610 1620 AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK 1630 1640 1650 1660 1670 1680 KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK 1690 1700 1710 1720 1730 1740 KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ 1750 1760 1770 1780 1790 1800 LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK 1810 1820 1830 1840 1850 1860 LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED 1870 1880 1890 1900 1910 1920 ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE 1930 1940 1950 1960 1970 VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE
	Isoform 2 [UniParc]. Checksum: 2FCF86A36AB04BC5	FASTA	1,992	230,779
	10 20 30 40 50 60 MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 70 80 90 100 110 120 ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 130 140 150 160 170 180 FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PQESPKPVKH QSGSLLYGEL ERQLLQANPI 250 260 270 280 290 300 LESFGNAKTV KNDNSSRFGK FIRINFDVTG YIVGANIETY LLEKSRAVRQ AKDERTFHIF 310 320 330 340 350 360 YQLLSGAGEH LKSDLLLEGF NNYRFLSNGY IPIPGQQDKD NFQETMEAMH IMGFSHEEIL 370 380 390 400 410 420 SMLKVVSSVL QFGNISFKKE RNTDQASMPE NTVAQKLCHL LGMNVMEFTR AILTPRIKVG 430 440 450 460 470 480 RDYVQKAQTK EQADFAVEAL AKATYERLFR WLVHRINKAL DRTKRQGASF IGILDIAGFE 490 500 510 520 530 540 IFELNSFEQL CINYTNEKLQ QLFNHTMFIL EQEEYQREGI EWNFIDFGLD LQPCIDLIER 550 560 570 580 590 600 PANPPGVLAL LDEECWFPKA TDKTFVEKLV QEQGSHSKFQ KPRQLKDKAD FCIIHYAGKV 610 620 630 640 650 660 DYKADEWLMK NMDPLNDNVA TLLHQSSDRF VAELWKDVDR IVGLDQVTGM TETAFGSAYK 670 680 690 700 710 720 TKKGMFRTVG QLYKESLTKL MATLRNTNPN FVRCIIPNHE KRAGKLDPHL VLDQLRCNGV 730 740 750 760 770 780 LEGIRICRQG FPNRIVFQEF RQRYEILTPN AIPKGFMDGK QACERMIRAL ELDPNLYRIG 790 800 810 820 830 840 QSKIFFRAGV LAHLEEERDL KITDIIIFFQ AVCRGYLARK AFAKKQQQLS ALKVLQRNCA 850 860 870 880 890 900 AYLKLRHWQW WRVFTKVKPL LQVTRQEEEL QAKDEELLKV KEKQTKVEGE LEEMERKHQQ 910 920 930 940 950 960 LLEEKNILAE QLQAETELFA EAEEMRARLA AKKQELEEIL HDLESRVEEE EERNQILQNE 970 980 990 1000 1010 1020 KKKMQAHIQD LEEQLDEEEG ARQKLQLEKV TAEAKIKKME EEILLLEDQN SKFIKEKKLM 1030 1040 1050 1060 1070 1080 EDRIAECSSQ LAEEEEKAKN LAKIRNKQEV MISDLEERLK KEEKTRQELE KAKRKLDGET 1090 1100 1110 1120 1130 1140 TDLQDQIAEL QAQIDELKLQ LAKKEEELQG ALARGDDETL HKNNALKVVR ELQAQIAELQ 1150 1160 1170 1180 1190 1200 EDFESEKASR NKAEKQKRDL SEELEALKTE LEDTLDTTAA QQELRTKREQ EVAELKKALE 1210 1220 1230 1240 1250 1260 EETKNHEAQI QDMRQRHATA LEELSEQLEQ AKRFKANLEK NKQGLETDNK ELACEVKVLQ 1270 1280 1290 1300 1310 1320 QVKAESEHKR KKLDAQVQEL HAKVSEGDRL RVELAEKASK LQNELDNVST LLEEAEKKGI 1330 1340 1350 1360 1370 1380 KFAKDAASLE SQLQDTQELL QEETRQKLNL SSRIRQLEEE KNSLQEQQEE EEEARKNLEK 1390 1400 1410 1420 1430 1440 QVLALQSQLA DTKKKVDDDL GTIESLEEAK KKLLKDAEAL SQRLEEKALA YDKLEKTKNR 1450 1460 1470 1480 1490 1500 LQQELDDLTV DLDHQRQVAS NLEKKQKKFD QLLAEEKSIS ARYAEERDRA EAEAREKETK 1510 1520 1530 1540 1550 1560 ALSLARALEE ALEAKEEFER QNKQLRADME DLMSSKDDVG KNVHELEKSK RALEQQVEEM 1570 1580 1590 1600 1610 1620 RTQLEELEDE LQATEDAKLR LEVNMQAMKA QFERDLQTRD EQNEEKKRLL IKQVRELEAE 1630 1640 1650 1660 1670 1680 LEDERKQRAL AVASKKKMEI DLKDLEAQIE AANKARDEVI KQLRKLQAQM KDYQRELEEA 1690 1700 1710 1720 1730 1740 RASRDEIFAQ SKESEKKLKS LEAEILQLQE ELASSERARR HAEQERDELA DEITNSASGK 1750 1760 1770 1780 1790 1800 SALLDEKRRL EARIAQLEEE LEEEQSNMEL LNDRFRKTTL QVDTLNAELA AERSAAQKSD 1810 1820 1830 1840 1850 1860 NARQQLERQN KELKAKLQEL EGAVKSKFKA TISALEAKIG QLEEQLEQEA KERAAANKLV 1870 1880 1890 1900 1910 1920 RRTEKKLKEI FMQVEDERRH ADQYKEQMEK ANARMKQLKR QLEEAEEEAT RANASRRKLQ 1930 1940 1950 1960 1970 1980 RELDDATEAN EGLSREVSTL KNRLRRGGPI SFSSSRSGRR QLHLEGASLE LSDDDTESKT 1990 SDVNETQPPQ SE
	Isoform 3 [UniParc]. Checksum: 59FCA83F827E415E	FASTA	1,997	231,369
	10 20 30 40 50 60 MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 70 80 90 100 110 120 ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 130 140 150 160 170 180 FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS 250 260 270 280 290 300 RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL 310 320 330 340 350 360 LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS 370 380 390 400 410 420 FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA 430 440 450 460 470 480 VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN 490 500 510 520 530 540 EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW 550 560 570 580 590 600 FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN 610 620 630 640 650 660 DNVATLLHQS SDRFVAELWK DEIQNIQRAS FYDSVSGLHE PPVDRIVGLD QVTGMTETAF 670 680 690 700 710 720 GSAYKTKKGM FRTVGQLYKE SLTKLMATLR NTNPNFVRCI IPNHEKRAGK LDPHLVLDQL 730 740 750 760 770 780 RCNGVLEGIR ICRQGFPNRI VFQEFRQRYE ILTPNAIPKG FMDGKQACER MIRALELDPN 790 800 810 820 830 840 LYRIGQSKIF FRAGVLAHLE EERDLKITDI IIFFQAVCRG YLARKAFAKK QQQLSALKVL 850 860 870 880 890 900 QRNCAAYLKL RHWQWWRVFT KVKPLLQVTR QEEELQAKDE ELLKVKEKQT KVEGELEEME 910 920 930 940 950 960 RKHQQLLEEK NILAEQLQAE TELFAEAEEM RARLAAKKQE LEEILHDLES RVEEEEERNQ 970 980 990 1000 1010 1020 ILQNEKKKMQ AHIQDLEEQL DEEEGARQKL QLEKVTAEAK IKKMEEEILL LEDQNSKFIK 1030 1040 1050 1060 1070 1080 EKKLMEDRIA ECSSQLAEEE EKAKNLAKIR NKQEVMISDL EERLKKEEKT RQELEKAKRK 1090 1100 1110 1120 1130 1140 LDGETTDLQD QIAELQAQID ELKLQLAKKE EELQGALARG DDETLHKNNA LKVVRELQAQ 1150 1160 1170 1180 1190 1200 IAELQEDFES EKASRNKAEK QKRDLSEELE ALKTELEDTL DTTAAQQELR TKREQEVAEL 1210 1220 1230 1240 1250 1260 KKALEEETKN HEAQIQDMRQ RHATALEELS EQLEQAKRFK ANLEKNKQGL ETDNKELACE 1270 1280 1290 1300 1310 1320 VKVLQQVKAE SEHKRKKLDA QVQELHAKVS EGDRLRVELA EKASKLQNEL DNVSTLLEEA 1330 1340 1350 1360 1370 1380 EKKGIKFAKD AASLESQLQD TQELLQEETR QKLNLSSRIR QLEEEKNSLQ EQQEEEEEAR 1390 1400 1410 1420 1430 1440 KNLEKQVLAL QSQLADTKKK VDDDLGTIES LEEAKKKLLK DAEALSQRLE EKALAYDKLE 1450 1460 1470 1480 1490 1500 KTKNRLQQEL DDLTVDLDHQ RQVASNLEKK QKKFDQLLAE EKSISARYAE ERDRAEAEAR 1510 1520 1530 1540 1550 1560 EKETKALSLA RALEEALEAK EEFERQNKQL RADMEDLMSS KDDVGKNVHE LEKSKRALEQ 1570 1580 1590 1600 1610 1620 QVEEMRTQLE ELEDELQATE DAKLRLEVNM QAMKAQFERD LQTRDEQNEE KKRLLIKQVR 1630 1640 1650 1660 1670 1680 ELEAELEDER KQRALAVASK KKMEIDLKDL EAQIEAANKA RDEVIKQLRK LQAQMKDYQR 1690 1700 1710 1720 1730 1740 ELEEARASRD EIFAQSKESE KKLKSLEAEI LQLQEELASS ERARRHAEQE RDELADEITN 1750 1760 1770 1780 1790 1800 SASGKSALLD EKRRLEARIA QLEEELEEEQ SNMELLNDRF RKTTLQVDTL NAELAAERSA 1810 1820 1830 1840 1850 1860 AQKSDNARQQ LERQNKELKA KLQELEGAVK SKFKATISAL EAKIGQLEEQ LEQEAKERAA 1870 1880 1890 1900 1910 1920 ANKLVRRTEK KLKEIFMQVE DERRHADQYK EQMEKANARM KQLKRQLEEA EEEATRANAS 1930 1940 1950 1960 1970 1980 RRKLQRELDD ATEANEGLSR EVSTLKNRLR RGGPISFSSS RSGRRQLHLE GASLELSDDD 1990 TESKTSDVNE TQPPQSE
	Isoform 4 [UniParc]. Checksum: D56BDA1A873045A2	FASTA	2,007	232,528
	10 20 30 40 50 60 MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 70 80 90 100 110 120 ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 130 140 150 160 170 180 FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PQESPKPVKH QGELERQLLQ ANPILESFGN 250 260 270 280 290 300 AKTVKNDNSS RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG 310 320 330 340 350 360 AGEHLKSDLL LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV 370 380 390 400 410 420 SSVLQFGNIS FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK 430 440 450 460 470 480 AQTKEQADFA VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS 490 500 510 520 530 540 FEQLCINYTN EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG 550 560 570 580 590 600 VLALLDEECW FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE 610 620 630 640 650 660 WLMKNMDPLN DNVATLLHQS SDRFVAELWK DEIQNIQRAS FYDSVSGLHE PPVDRIVGLD 670 680 690 700 710 720 QVTGMTETAF GSAYKTKKGM FRTVGQLYKE SLTKLMATLR NTNPNFVRCI IPNHEKRAGK 730 740 750 760 770 780 LDPHLVLDQL RCNGVLEGIR ICRQGFPNRI VFQEFRQRYE ILTPNAIPKG FMDGKQACER 790 800 810 820 830 840 MIRALELDPN LYRIGQSKIF FRAGVLAHLE EERDLKITDI IIFFQAVCRG YLARKAFAKK 850 860 870 880 890 900 QQQLSALKVL QRNCAAYLKL RHWQWWRVFT KVKPLLQVTR QEEELQAKDE ELLKVKEKQT 910 920 930 940 950 960 KVEGELEEME RKHQQLLEEK NILAEQLQAE TELFAEAEEM RARLAAKKQE LEEILHDLES 970 980 990 1000 1010 1020 RVEEEEERNQ ILQNEKKKMQ AHIQDLEEQL DEEEGARQKL QLEKVTAEAK IKKMEEEILL 1030 1040 1050 1060 1070 1080 LEDQNSKFIK EKKLMEDRIA ECSSQLAEEE EKAKNLAKIR NKQEVMISDL EERLKKEEKT 1090 1100 1110 1120 1130 1140 RQELEKAKRK LDGETTDLQD QIAELQAQID ELKLQLAKKE EELQGALARG DDETLHKNNA 1150 1160 1170 1180 1190 1200 LKVVRELQAQ IAELQEDFES EKASRNKAEK QKRDLSEELE ALKTELEDTL DTTAAQQELR 1210 1220 1230 1240 1250 1260 TKREQEVAEL KKALEEETKN HEAQIQDMRQ RHATALEELS EQLEQAKRFK ANLEKNKQGL 1270 1280 1290 1300 1310 1320 ETDNKELACE VKVLQQVKAE SEHKRKKLDA QVQELHAKVS EGDRLRVELA EKASKLQNEL 1330 1340 1350 1360 1370 1380 DNVSTLLEEA EKKGIKFAKD AASLESQLQD TQELLQEETR QKLNLSSRIR QLEEEKNSLQ 1390 1400 1410 1420 1430 1440 EQQEEEEEAR KNLEKQVLAL QSQLADTKKK VDDDLGTIES LEEAKKKLLK DAEALSQRLE 1450 1460 1470 1480 1490 1500 EKALAYDKLE KTKNRLQQEL DDLTVDLDHQ RQVASNLEKK QKKFDQLLAE EKSISARYAE 1510 1520 1530 1540 1550 1560 ERDRAEAEAR EKETKALSLA RALEEALEAK EEFERQNKQL RADMEDLMSS KDDVGKNVHE 1570 1580 1590 1600 1610 1620 LEKSKRALEQ QVEEMRTQLE ELEDELQATE DAKLRLEVNM QAMKAQFERD LQTRDEQNEE 1630 1640 1650 1660 1670 1680 KKRLLIKQVR ELEAELEDER KQRALAVASK KKMEIDLKDL EAQIEAANKA RDEVIKQLRK 1690 1700 1710 1720 1730 1740 LQAQMKDYQR ELEEARASRD EIFAQSKESE KKLKSLEAEI LQLQEELASS ERARRHAEQE 1750 1760 1770 1780 1790 1800 RDELADEITN SASGKSALLD EKRRLEARIA QLEEELEEEQ SNMELLNDRF RKTTLQVDTL 1810 1820 1830 1840 1850 1860 NAELAAERSA AQKSDNARQQ LERQNKELKA KLQELEGAVK SKFKATISAL EAKIGQLEEQ 1870 1880 1890 1900 1910 1920 LEQEAKERAA ANKLVRRTEK KLKEIFMQVE DERRHADQYK EQMEKANARM KQLKRQLEEA 1930 1940 1950 1960 1970 1980 EEEATRANAS RRKLQRELDD ATEANEGLSR EVSTLKNRLR RGGPISFSSS RSGRRQLHLE 1990 2000 GASLELSDDD TESKTSDVNE TQPPQSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies." Phillips C.L., Yamakawa K., Adelstein R.S. J. Muscle Res. Cell Motil. 16:379-389(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles." Abdelhaleem M.M., Hameed S., Klassen D., Greenberg A.H. J. Immunol. 156:2026-2035(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method." Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle.
[7]	"Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes." Simons M., Wang M., McBride O.W., Kawamoto S., Yamakawa K., Gdula D., Adelstein R.S., Weir L. Circ. Res. 69:530-539(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-722 (ISOFORM 1).
[8]	"Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B." Itoh K., Adelstein R.S. J. Biol. Chem. 270:14533-14540(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-301 (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 3), TISSUE SPECIFICITY.
[9]	"Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis." Aikawa M., Sivam P.N., Kuro-O M., Kimura K., Nakahara K., Takewaki S., Ueda M., Yamaguchi H., Yazaki Y., Periasamy M. Circ. Res. 73:1000-1012(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1751-1976.
[10]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis." Wu D., Asiedu M., Adelstein R.S., Wei Q. Cell Cycle 5:1234-1239(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PLEKHG6.
[12]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939; SER-1952 AND SER-1956, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1956, MASS SPECTROMETRY. Tissue: Liver.
[15]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939 AND SER-1956, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[16]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-442 AND LYS-1645, MASS SPECTROMETRY.
[17]	"A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components." Gorbea C., Pratt G., Ustrell V., Bell R., Sahasrabudhe S., Hughes R.E., Rechsteiner M. J. Biol. Chem. 285:31616-31633(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ECM29.
[18]	"Nonmuscle myosin-dependent synthesis of type I collagen." Cai L., Fritz D., Stefanovic L., Stefanovic B. J. Mol. Biol. 401:564-578(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH LARP6.
[19]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1956, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214 (ISOFORM 2), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[20]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[21]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1145; SER-1938 AND SER-1956, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214 (ISOFORM 2), MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M69181 mRNA. Translation: AAA99177.1. AB210026 mRNA. Translation: BAE06108.1. Different initiation. AC011061 Genomic DNA. No translation available. AC025518 Genomic DNA. No translation available. AC026130 Genomic DNA. No translation available. CH471108 Genomic DNA. Translation: EAW90049.1. BC008968 mRNA. Translation: AAH08968.1. BC117690 mRNA. Translation: AAI17691.1. BC117691 mRNA. Translation: AAI17692.1. U15618 mRNA. Translation: AAA87712.1. S67247 mRNA. Translation: AAB28952.1.
IPI	IPI00397526. IPI00479307. IPI00790503.
PIR	A59252. I65769.
RefSeq	NP_001242941.1. NM_001256012.1. NP_001243024.1. NM_001256095.1. NP_005955.3. NM_005964.3.
UniGene	Hs.16355.
3D structure databases
ProteinModelPortal	P35580.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-31110N.
IntAct	P35580. 13 interactions.
MINT	MINT-1133516.
STRING	9606.ENSP00000269243.
PTM databases
PhosphoSite	P35580.
Polymorphism databases
DMDM	215274129.
Proteomic databases
PaxDb	P35580.
PRIDE	P35580.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000269243; ENSP00000269243; ENSG00000133026. ENST00000360416; ENSP00000353590; ENSG00000133026. ENST00000396239; ENSP00000379539; ENSG00000133026.
GeneID	4628.
KEGG	hsa:4628.
UCSC	uc002gll.3. human.
Organism-specific databases
CTD	4628.
GeneCards	GC17M008318.
H-InvDB	HIX0013525.
HGNC	HGNC:7568. MYH10.
HPA	CAB017180.
MIM	160776. gene.
neXtProt	NX_P35580.
PharmGKB	PA31366.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5022.
HOGENOM	HOG000173958.
HOVERGEN	HBG004704.
KO	K10352.
OrthoDB	EOG4TXBR1.
PhylomeDB	P35580.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	P35580.
Bgee	P35580.
CleanEx	HS_MYH10.
Genevestigator	P35580.
GermOnline	ENSG00000133026. Homo sapiens.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR001609. Myosin_head_motor_dom. IPR004009. Myosin_N. IPR008989. Myosin_S1_N. IPR002928. Myosin_tail. [Graphical view]
Pfam	PF00612. IQ. 1 hit. PF00063. Myosin_head. 1 hit. PF02736. Myosin_N. 1 hit. PF01576. Myosin_tail_1. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00015. IQ. 1 hit. SM00242. MYSc. 1 hit. [Graphical view]
SUPFAM	SSF50084. Myosin_S1_N. 1 hit.
PROSITE	PS50096. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MYH10. human.
GenomeRNAi	4628.
NextBio	17814.
SOURCE	Search...

Entry information

Entry name

MYH10_HUMAN

Accession

Primary (citable) accession number: P35580
Secondary accession number(s): F8VTL3 , Q12989, Q149N3, Q149N4, Q16087, Q4LE45, Q6PK16

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 134 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.