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Protein

Myosin-10

Gene

MYH10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 185ATPSequence analysis8

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin-dependent ATPase activity Source: MGI
  • actin filament binding Source: MGI
  • ADP binding Source: MGI
  • ATP binding Source: UniProtKB
  • microfilament motor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Cell adhesion, Cell shape

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133026-MONOMER.
ReactomeiR-HSA-3928663. EPHA-mediated growth cone collapse.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5625900. RHO GTPases activate CIT.
R-HSA-5627117. RHO GTPases Activate ROCKs.
R-HSA-5627123. RHO GTPases activate PAKs.
SIGNORiP35580.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-10
Alternative name(s):
Cellular myosin heavy chain, type B
Myosin heavy chain 10
Myosin heavy chain, non-muscle IIb
Non-muscle myosin heavy chain B
Short name:
NMMHC-B
Non-muscle myosin heavy chain IIb
Short name:
NMMHC II-b
Short name:
NMMHC-IIB
Gene namesi
Name:MYH10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7568. MYH10.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • actomyosin Source: UniProtKB
  • axon Source: Ensembl
  • brush border Source: Ensembl
  • cell cortex Source: UniProtKB
  • cleavage furrow Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • dendritic spine Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • growth cone Source: Ensembl
  • lamellipodium Source: UniProtKB-SubCell
  • midbody Source: UniProtKB
  • mitochondrion Source: HPA
  • myosin complex Source: UniProtKB
  • myosin II complex Source: UniProtKB
  • myosin II filament Source: UniProtKB
  • neuromuscular junction Source: Ensembl
  • neuronal cell body Source: Ensembl
  • nucleus Source: UniProtKB
  • plasma membrane Source: Ensembl
  • spindle Source: Ensembl
  • stress fiber Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Organism-specific databases

DisGeNETi4628.
OpenTargetsiENSG00000133026.
PharmGKBiPA31366.

Polymorphism and mutation databases

BioMutaiMYH10.
DMDMi215274129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234211 – 1976Myosin-10Add BLAST1976

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Omega-N-methylarginineBy similarity1
Modified residuei442N6-acetyllysineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1241N6-acetyllysineBy similarity1
Modified residuei1301N6-acetyllysineBy similarity1
Modified residuei1645N6-acetyllysineCombined sources1
Modified residuei1930Omega-N-methylarginineBy similarity1
Modified residuei1935PhosphoserineCombined sources1
Modified residuei1937PhosphoserineCombined sources1
Modified residuei1938PhosphoserineCombined sources1
Modified residuei1939PhosphoserineCombined sources1
Modified residuei1940Omega-N-methylarginineBy similarity1
Modified residuei1952PhosphoserineCombined sources1
Modified residuei1956PhosphoserineCombined sources1
Modified residuei1960PhosphothreonineCombined sources1
Modified residuei1975PhosphoserineBy similarity1
Isoform 2 (identifier: P35580-2)
Modified residuei214PhosphoserineCombined sources1
Isoform 4 (identifier: P35580-4)
Modified residuei214PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by ABL2.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP35580.
MaxQBiP35580.
PaxDbiP35580.
PeptideAtlasiP35580.
PRIDEiP35580.

PTM databases

iPTMnetiP35580.
PhosphoSitePlusiP35580.
SwissPalmiP35580.

Expressioni

Tissue specificityi

Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.1 Publication

Gene expression databases

BgeeiENSG00000133026.
CleanExiHS_MYH10.
ExpressionAtlasiP35580. baseline and differential.
GenevisibleiP35580. HS.

Organism-specific databases

HPAiCAB017180.
HPA047541.
HPA057198.

Interactioni

Subunit structurei

Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B (By similarity). Interacts with LARP6. Interacts with MCC.By similarity4 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: MGI

Protein-protein interaction databases

BioGridi110713. 68 interactors.
DIPiDIP-31110N.
IntActiP35580. 28 interactors.
MINTiMINT-7901694.
STRINGi9606.ENSP00000269243.

Structurei

Secondary structure

11976
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni9 – 14Combined sources6
Beta strandi36 – 39Combined sources4
Beta strandi41 – 49Combined sources9
Beta strandi57 – 65Combined sources9
Beta strandi68 – 75Combined sources8
Helixi82 – 84Combined sources3
Helixi90 – 92Combined sources3
Helixi98 – 109Combined sources12
Turni110 – 112Combined sources3
Beta strandi115 – 118Combined sources4
Beta strandi121 – 125Combined sources5
Helixi136 – 141Combined sources6
Helixi154 – 167Combined sources14
Beta strandi172 – 178Combined sources7
Helixi180 – 182Combined sources3
Helixi184 – 198Combined sources15
Helixi216 – 218Combined sources3
Helixi221 – 229Combined sources9
Beta strandi237 – 240Combined sources4
Beta strandi242 – 250Combined sources9
Beta strandi256 – 264Combined sources9
Helixi269 – 272Combined sources4
Helixi282 – 290Combined sources9
Helixi293 – 298Combined sources6
Helixi304 – 306Combined sources3
Helixi322 – 335Combined sources14
Helixi340 – 357Combined sources18
Helixi379 – 384Combined sources6
Helixi389 – 397Combined sources9
Helixi414 – 442Combined sources29
Beta strandi453 – 461Combined sources9
Helixi471 – 501Combined sources31
Helixi511 – 514Combined sources4
Helixi516 – 522Combined sources7
Helixi531 – 538Combined sources8
Helixi546 – 556Combined sources11
Beta strandi567 – 569Combined sources3
Beta strandi572 – 578Combined sources7
Beta strandi583 – 586Combined sources4
Helixi591 – 594Combined sources4
Helixi601 – 608Combined sources8
Helixi613 – 618Combined sources6
Helixi653 – 668Combined sources16
Beta strandi671 – 679Combined sources9
Helixi692 – 702Combined sources11
Helixi704 – 711Combined sources8
Beta strandi717 – 720Combined sources4
Helixi721 – 728Combined sources8
Helixi729 – 731Combined sources3
Turni733 – 735Combined sources3
Helixi745 – 754Combined sources10
Beta strandi760 – 763Combined sources4
Beta strandi765 – 770Combined sources6
Helixi774 – 782Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PD3X-ray2.84A/B1-782[»]
ProteinModelPortaliP35580.
SMRiP35580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 783Myosin motorAdd BLAST699
Domaini786 – 815IQPROSITE-ProRule annotationAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili845 – 1976Sequence analysisAdd BLAST1132

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173958.
HOVERGENiHBG004704.
InParanoidiP35580.
KOiK10352.
OMAiRHKHAQE.
OrthoDBiEOG091G009J.
PhylomeDBiP35580.
TreeFamiTF333601.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR008989. Myosin_S1_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF50084. SSF50084. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35580-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI
60 70 80 90 100
KEERGDEVMV ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS
110 120 130 140 150
VLHNLKDRYY SGLIYTYSGL FCVVINPYKN LPIYSENIIE MYRGKKRHEM
160 170 180 190 200
PPHIYAISES AYRCMLQDRE DQSILCTGES GAGKTENTKK VIQYLAHVAS
210 220 230 240 250
SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS RFGKFIRINF
260 270 280 290 300
DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL
310 320 330 340 350
LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV
360 370 380 390 400
SSVLQFGNIS FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR
410 420 430 440 450
IKVGRDYVQK AQTKEQADFA VEALAKATYE RLFRWLVHRI NKALDRTKRQ
460 470 480 490 500
GASFIGILDI AGFEIFELNS FEQLCINYTN EKLQQLFNHT MFILEQEEYQ
510 520 530 540 550
REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW FPKATDKTFV
560 570 580 590 600
EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN
610 620 630 640 650
DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF
660 670 680 690 700
RTVGQLYKES LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR
710 720 730 740 750
CNGVLEGIRI CRQGFPNRIV FQEFRQRYEI LTPNAIPKGF MDGKQACERM
760 770 780 790 800
IRALELDPNL YRIGQSKIFF RAGVLAHLEE ERDLKITDII IFFQAVCRGY
810 820 830 840 850
LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK VKPLLQVTRQ
860 870 880 890 900
EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET
910 920 930 940 950
ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA
960 970 980 990 1000
HIQDLEEQLD EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE
1010 1020 1030 1040 1050
KKLMEDRIAE CSSQLAEEEE KAKNLAKIRN KQEVMISDLE ERLKKEEKTR
1060 1070 1080 1090 1100
QELEKAKRKL DGETTDLQDQ IAELQAQIDE LKLQLAKKEE ELQGALARGD
1110 1120 1130 1140 1150
DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ KRDLSEELEA
1160 1170 1180 1190 1200
LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR
1210 1220 1230 1240 1250
HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES
1260 1270 1280 1290 1300
EHKRKKLDAQ VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE
1310 1320 1330 1340 1350
KKGIKFAKDA ASLESQLQDT QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE
1360 1370 1380 1390 1400
QQEEEEEARK NLEKQVLALQ SQLADTKKKV DDDLGTIESL EEAKKKLLKD
1410 1420 1430 1440 1450
AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR QVASNLEKKQ
1460 1470 1480 1490 1500
KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE
1510 1520 1530 1540 1550
EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE
1560 1570 1580 1590 1600
LEDELQATED AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE
1610 1620 1630 1640 1650
LEAELEDERK QRALAVASKK KMEIDLKDLE AQIEAANKAR DEVIKQLRKL
1660 1670 1680 1690 1700
QAQMKDYQRE LEEARASRDE IFAQSKESEK KLKSLEAEIL QLQEELASSE
1710 1720 1730 1740 1750
RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ LEEELEEEQS
1760 1770 1780 1790 1800
NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK
1810 1820 1830 1840 1850
LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK
1860 1870 1880 1890 1900
LKEIFMQVED ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR
1910 1920 1930 1940 1950
RKLQRELDDA TEANEGLSRE VSTLKNRLRR GGPISFSSSR SGRRQLHLEG
1960 1970
ASLELSDDDT ESKTSDVNET QPPQSE
Length:1,976
Mass (Da):228,999
Last modified:November 25, 2008 - v3
Checksum:iA7C91944EBC2368F
GO
Isoform 2 (identifier: P35580-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: P → PQESPKPVKHQSGSLLY

Show »
Length:1,992
Mass (Da):230,779
Checksum:i2FCF86A36AB04BC5
GO
Isoform 3 (identifier: P35580-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-621: D → DEIQNIQRASFYDSVSGLHEPP

Show »
Length:1,997
Mass (Da):231,369
Checksum:i59FCA83F827E415E
GO
Isoform 4 (identifier: P35580-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: P → PQESPKPVKHQ
     621-621: D → DEIQNIQRASFYDSVSGLHEPP

Note: No experimental confirmation available.Combined sources
Show »
Length:2,007
Mass (Da):232,528
Checksum:iD56BDA1A873045A2
GO
Isoform 5 (identifier: P35580-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: P → PESPKPVKHQ

Note: No experimental confirmation available.
Show »
Length:1,985
Mass (Da):230,030
Checksum:i493EC32CF0F26E58
GO

Sequence cautioni

The sequence BAE06108 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti800Y → C in AAA99177 (PubMed:7499478).Curated1
Sequence conflicti943 – 944NE → KK in AAH08968 (Ref. 5) Curated2
Sequence conflicti1429L → P in AAI17691 (Ref. 5) Curated1
Sequence conflicti1751N → D in AAB28952 (PubMed:7916668).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022013211P → PQESPKPVKHQSGSLLY in isoform 2. 1 Publication1
Alternative sequenceiVSP_046033211P → PQESPKPVKHQ in isoform 4. 1 Publication1
Alternative sequenceiVSP_054974211P → PESPKPVKHQ in isoform 5. 1 Publication1
Alternative sequenceiVSP_022014621D → DEIQNIQRASFYDSVSGLHE PP in isoform 3 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69181 mRNA. Translation: AAA99177.1.
AB210026 mRNA. Translation: BAE06108.1. Different initiation.
AC011061 Genomic DNA. No translation available.
AC025518 Genomic DNA. No translation available.
AC026130 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90046.1.
CH471108 Genomic DNA. Translation: EAW90047.1.
CH471108 Genomic DNA. Translation: EAW90048.1.
CH471108 Genomic DNA. Translation: EAW90049.1.
BC000280 mRNA. Translation: AAH00280.1.
BC008968 mRNA. Translation: AAH08968.1.
BC117690 mRNA. Translation: AAI17691.1.
BC117691 mRNA. Translation: AAI17692.1.
BC144668 mRNA. Translation: AAI44669.1.
BC150634 mRNA. Translation: AAI50635.1.
U15618 mRNA. Translation: AAA87712.1.
S67247 mRNA. Translation: AAB28952.1.
CCDSiCCDS11144.1. [P35580-1]
CCDS58515.1. [P35580-4]
CCDS73984.1. [P35580-5]
PIRiA59252.
I65769.
RefSeqiNP_001242941.1. NM_001256012.1. [P35580-4]
NP_001243024.1. NM_001256095.1. [P35580-5]
NP_005955.3. NM_005964.3. [P35580-1]
XP_016880169.1. XM_017024680.1. [P35580-5]
XP_016880170.1. XM_017024681.1. [P35580-1]
XP_016880171.1. XM_017024682.1. [P35580-1]
UniGeneiHs.16355.

Genome annotation databases

EnsembliENST00000269243; ENSP00000269243; ENSG00000133026. [P35580-1]
ENST00000360416; ENSP00000353590; ENSG00000133026. [P35580-4]
ENST00000379980; ENSP00000369315; ENSG00000133026. [P35580-5]
GeneIDi4628.
KEGGihsa:4628.
UCSCiuc002gll.5. human. [P35580-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69181 mRNA. Translation: AAA99177.1.
AB210026 mRNA. Translation: BAE06108.1. Different initiation.
AC011061 Genomic DNA. No translation available.
AC025518 Genomic DNA. No translation available.
AC026130 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90046.1.
CH471108 Genomic DNA. Translation: EAW90047.1.
CH471108 Genomic DNA. Translation: EAW90048.1.
CH471108 Genomic DNA. Translation: EAW90049.1.
BC000280 mRNA. Translation: AAH00280.1.
BC008968 mRNA. Translation: AAH08968.1.
BC117690 mRNA. Translation: AAI17691.1.
BC117691 mRNA. Translation: AAI17692.1.
BC144668 mRNA. Translation: AAI44669.1.
BC150634 mRNA. Translation: AAI50635.1.
U15618 mRNA. Translation: AAA87712.1.
S67247 mRNA. Translation: AAB28952.1.
CCDSiCCDS11144.1. [P35580-1]
CCDS58515.1. [P35580-4]
CCDS73984.1. [P35580-5]
PIRiA59252.
I65769.
RefSeqiNP_001242941.1. NM_001256012.1. [P35580-4]
NP_001243024.1. NM_001256095.1. [P35580-5]
NP_005955.3. NM_005964.3. [P35580-1]
XP_016880169.1. XM_017024680.1. [P35580-5]
XP_016880170.1. XM_017024681.1. [P35580-1]
XP_016880171.1. XM_017024682.1. [P35580-1]
UniGeneiHs.16355.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PD3X-ray2.84A/B1-782[»]
ProteinModelPortaliP35580.
SMRiP35580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110713. 68 interactors.
DIPiDIP-31110N.
IntActiP35580. 28 interactors.
MINTiMINT-7901694.
STRINGi9606.ENSP00000269243.

PTM databases

iPTMnetiP35580.
PhosphoSitePlusiP35580.
SwissPalmiP35580.

Polymorphism and mutation databases

BioMutaiMYH10.
DMDMi215274129.

Proteomic databases

EPDiP35580.
MaxQBiP35580.
PaxDbiP35580.
PeptideAtlasiP35580.
PRIDEiP35580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269243; ENSP00000269243; ENSG00000133026. [P35580-1]
ENST00000360416; ENSP00000353590; ENSG00000133026. [P35580-4]
ENST00000379980; ENSP00000369315; ENSG00000133026. [P35580-5]
GeneIDi4628.
KEGGihsa:4628.
UCSCiuc002gll.5. human. [P35580-1]

Organism-specific databases

CTDi4628.
DisGeNETi4628.
GeneCardsiMYH10.
H-InvDBHIX0013525.
HGNCiHGNC:7568. MYH10.
HPAiCAB017180.
HPA047541.
HPA057198.
MIMi160776. gene.
neXtProtiNX_P35580.
OpenTargetsiENSG00000133026.
PharmGKBiPA31366.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173958.
HOVERGENiHBG004704.
InParanoidiP35580.
KOiK10352.
OMAiRHKHAQE.
OrthoDBiEOG091G009J.
PhylomeDBiP35580.
TreeFamiTF333601.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133026-MONOMER.
ReactomeiR-HSA-3928663. EPHA-mediated growth cone collapse.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5625900. RHO GTPases activate CIT.
R-HSA-5627117. RHO GTPases Activate ROCKs.
R-HSA-5627123. RHO GTPases activate PAKs.
SIGNORiP35580.

Miscellaneous databases

ChiTaRSiMYH10. human.
GeneWikiiMYH10.
GenomeRNAii4628.
PROiP35580.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133026.
CleanExiHS_MYH10.
ExpressionAtlasiP35580. baseline and differential.
GenevisibleiP35580. HS.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR008989. Myosin_S1_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF50084. SSF50084. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYH10_HUMAN
AccessioniPrimary (citable) accession number: P35580
Secondary accession number(s): B2RWP9
, D3DTS1, F8VTL3, Q12989, Q149N3, Q149N4, Q16087, Q4LE45, Q6PK16, Q9BWG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 173 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents a conventional non-muscle myosin. This protein should not be confused with the unconventional myosin-10 (MYO10).Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.