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P35580

- MYH10_HUMAN

UniProt

P35580 - MYH10_HUMAN

Protein

Myosin-10

Gene

MYH10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi178 – 1858ATPSequence Analysis

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. actin-dependent ATPase activity Source: MGI
    3. actin filament binding Source: MGI
    4. ADP binding Source: MGI
    5. ATP binding Source: UniProtKB
    6. microfilament motor activity Source: MGI
    7. protein binding Source: UniProtKB

    GO - Biological processi

    1. actin filament-based movement Source: MGI
    2. actomyosin structure organization Source: UniProt
    3. adult heart development Source: Ensembl
    4. ATP catabolic process Source: UniProt
    5. axon guidance Source: Reactome
    6. cardiac myofibril assembly Source: Ensembl
    7. cell adhesion Source: UniProtKB-KW
    8. cell proliferation Source: Ensembl
    9. cerebellar Purkinje cell layer development Source: Ensembl
    10. exocytosis Source: Ensembl
    11. fourth ventricle development Source: Ensembl
    12. in utero embryonic development Source: Ensembl
    13. lateral ventricle development Source: Ensembl
    14. mitotic cytokinesis Source: MGI
    15. neuromuscular process controlling balance Source: Ensembl
    16. neuron migration Source: Ensembl
    17. nuclear migration Source: Ensembl
    18. plasma membrane repair Source: Ensembl
    19. regulation of cell shape Source: UniProtKB-KW
    20. retina development in camera-type eye Source: Ensembl
    21. substrate-dependent cell migration, cell extension Source: Ensembl
    22. third ventricle development Source: Ensembl
    23. ventricular cardiac muscle cell development Source: Ensembl

    Keywords - Molecular functioni

    Motor protein, Myosin

    Keywords - Biological processi

    Cell adhesion, Cell shape

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_19277. Sema4D induced cell migration and growth-cone collapse.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin-10
    Alternative name(s):
    Cellular myosin heavy chain, type B
    Myosin heavy chain 10
    Myosin heavy chain, non-muscle IIb
    Non-muscle myosin heavy chain B
    Short name:
    NMMHC-B
    Non-muscle myosin heavy chain IIb
    Short name:
    NMMHC II-b
    Short name:
    NMMHC-IIB
    Gene namesi
    Name:MYH10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7568. MYH10.

    Subcellular locationi

    Cell projectionlamellipodium 2 Publications
    Note: Colocalizes with MCC at the leading edge of migrating cells.

    GO - Cellular componenti

    1. actomyosin Source: UniProt
    2. axon Source: Ensembl
    3. cell cortex Source: UniProtKB
    4. cleavage furrow Source: UniProtKB
    5. cytoplasm Source: UniProtKB
    6. dendritic spine Source: Ensembl
    7. growth cone Source: Ensembl
    8. lamellipodium Source: UniProtKB-SubCell
    9. midbody Source: UniProtKB
    10. myosin complex Source: UniProtKB
    11. myosin II complex Source: UniProt
    12. myosin II filament Source: UniProt
    13. neuromuscular junction Source: Ensembl
    14. neuronal cell body Source: Ensembl
    15. nucleus Source: UniProt
    16. plasma membrane Source: Ensembl
    17. spindle Source: Ensembl
    18. stress fiber Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31366.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19761976Myosin-10PRO_0000123421Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei442 – 4421N6-acetyllysine1 Publication
    Modified residuei1145 – 11451Phosphoserine1 Publication
    Modified residuei1241 – 12411N6-acetyllysineBy similarity
    Modified residuei1301 – 13011N6-acetyllysineBy similarity
    Modified residuei1645 – 16451N6-acetyllysine1 Publication
    Modified residuei1938 – 19381Phosphoserine1 Publication
    Modified residuei1939 – 19391Phosphoserine2 Publications
    Modified residuei1952 – 19521Phosphoserine1 Publication
    Modified residuei1956 – 19561Phosphoserine5 Publications

    Post-translational modificationi

    Phosphorylated by ABL2.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP35580.
    PaxDbiP35580.
    PRIDEiP35580.

    PTM databases

    PhosphoSiteiP35580.

    Expressioni

    Tissue specificityi

    Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.1 Publication

    Gene expression databases

    ArrayExpressiP35580.
    BgeeiP35580.
    CleanExiHS_MYH10.
    GenevestigatoriP35580.

    Organism-specific databases

    HPAiCAB017180.

    Interactioni

    Subunit structurei

    Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B By similarity. Interacts with LARP6. Interacts with MCC.By similarity4 Publications

    Protein-protein interaction databases

    BioGridi110713. 58 interactions.
    DIPiDIP-31110N.
    IntActiP35580. 19 interactions.
    MINTiMINT-7901694.
    STRINGi9606.ENSP00000269243.

    Structurei

    3D structure databases

    ProteinModelPortaliP35580.
    SMRiP35580. Positions 7-963, 1899-1926.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 783699Myosin motorAdd
    BLAST
    Domaini786 – 81530IQPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili845 – 19761132Sequence AnalysisAdd
    BLAST

    Domaini

    The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

    Sequence similaritiesi

    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000173958.
    HOVERGENiHBG004704.
    KOiK10352.
    OMAiASNMESQ.
    PhylomeDBiP35580.
    TreeFamiTF333601.

    Family and domain databases

    Gene3Di4.10.270.10. 1 hit.
    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR008989. Myosin_S1_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00612. IQ. 1 hit.
    PF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50084. SSF50084. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P35580-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI     50
    KEERGDEVMV ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS 100
    VLHNLKDRYY SGLIYTYSGL FCVVINPYKN LPIYSENIIE MYRGKKRHEM 150
    PPHIYAISES AYRCMLQDRE DQSILCTGES GAGKTENTKK VIQYLAHVAS 200
    SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS RFGKFIRINF 250
    DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL 300
    LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV 350
    SSVLQFGNIS FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR 400
    IKVGRDYVQK AQTKEQADFA VEALAKATYE RLFRWLVHRI NKALDRTKRQ 450
    GASFIGILDI AGFEIFELNS FEQLCINYTN EKLQQLFNHT MFILEQEEYQ 500
    REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW FPKATDKTFV 550
    EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN 600
    DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF 650
    RTVGQLYKES LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR 700
    CNGVLEGIRI CRQGFPNRIV FQEFRQRYEI LTPNAIPKGF MDGKQACERM 750
    IRALELDPNL YRIGQSKIFF RAGVLAHLEE ERDLKITDII IFFQAVCRGY 800
    LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK VKPLLQVTRQ 850
    EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET 900
    ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA 950
    HIQDLEEQLD EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE 1000
    KKLMEDRIAE CSSQLAEEEE KAKNLAKIRN KQEVMISDLE ERLKKEEKTR 1050
    QELEKAKRKL DGETTDLQDQ IAELQAQIDE LKLQLAKKEE ELQGALARGD 1100
    DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ KRDLSEELEA 1150
    LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR 1200
    HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES 1250
    EHKRKKLDAQ VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE 1300
    KKGIKFAKDA ASLESQLQDT QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE 1350
    QQEEEEEARK NLEKQVLALQ SQLADTKKKV DDDLGTIESL EEAKKKLLKD 1400
    AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR QVASNLEKKQ 1450
    KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE 1500
    EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE 1550
    LEDELQATED AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE 1600
    LEAELEDERK QRALAVASKK KMEIDLKDLE AQIEAANKAR DEVIKQLRKL 1650
    QAQMKDYQRE LEEARASRDE IFAQSKESEK KLKSLEAEIL QLQEELASSE 1700
    RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ LEEELEEEQS 1750
    NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK 1800
    LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK 1850
    LKEIFMQVED ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR 1900
    RKLQRELDDA TEANEGLSRE VSTLKNRLRR GGPISFSSSR SGRRQLHLEG 1950
    ASLELSDDDT ESKTSDVNET QPPQSE 1976
    Length:1,976
    Mass (Da):228,999
    Last modified:November 25, 2008 - v3
    Checksum:iA7C91944EBC2368F
    GO
    Isoform 2 (identifier: P35580-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         211-211: P → PQESPKPVKHQSGSLLY

    Note: Contains a phosphoserine at position 214.

    Show »
    Length:1,992
    Mass (Da):230,779
    Checksum:i2FCF86A36AB04BC5
    GO
    Isoform 3 (identifier: P35580-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         621-621: D → DEIQNIQRASFYDSVSGLHEPP

    Show »
    Length:1,997
    Mass (Da):231,369
    Checksum:i59FCA83F827E415E
    GO
    Isoform 4 (identifier: P35580-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         211-211: P → PQESPKPVKHQ
         621-621: D → DEIQNIQRASFYDSVSGLHEPP

    Note: No experimental confirmation available. Contains a phosphoserine at position 214.

    Show »
    Length:2,007
    Mass (Da):232,528
    Checksum:iD56BDA1A873045A2
    GO
    Isoform 5 (identifier: P35580-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         211-211: P → PESPKPVKHQ

    Note: No experimental confirmation available.

    Show »
    Length:1,985
    Mass (Da):230,030
    Checksum:i493EC32CF0F26E58
    GO

    Sequence cautioni

    The sequence BAE06108.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti800 – 8001Y → C in AAA99177. (PubMed:7499478)Curated
    Sequence conflicti943 – 9442NE → KK in AAH08968. 1 PublicationCurated
    Sequence conflicti1429 – 14291L → P in AAI17691. 1 PublicationCurated
    Sequence conflicti1751 – 17511N → D in AAB28952. (PubMed:7916668)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei211 – 2111P → PQESPKPVKHQSGSLLY in isoform 2. 1 PublicationVSP_022013
    Alternative sequencei211 – 2111P → PQESPKPVKHQ in isoform 4. 1 PublicationVSP_046033
    Alternative sequencei211 – 2111P → PESPKPVKHQ in isoform 5. 1 PublicationVSP_054974
    Alternative sequencei621 – 6211D → DEIQNIQRASFYDSVSGLHE PP in isoform 3 and isoform 4. 1 PublicationVSP_022014

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69181 mRNA. Translation: AAA99177.1.
    AB210026 mRNA. Translation: BAE06108.1. Different initiation.
    AC011061 Genomic DNA. No translation available.
    AC025518 Genomic DNA. No translation available.
    AC026130 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90046.1.
    CH471108 Genomic DNA. Translation: EAW90047.1.
    CH471108 Genomic DNA. Translation: EAW90048.1.
    CH471108 Genomic DNA. Translation: EAW90049.1.
    BC000280 mRNA. Translation: AAH00280.1.
    BC008968 mRNA. Translation: AAH08968.1.
    BC117690 mRNA. Translation: AAI17691.1.
    BC117691 mRNA. Translation: AAI17692.1.
    BC144668 mRNA. Translation: AAI44669.1.
    BC150634 mRNA. Translation: AAI50635.1.
    U15618 mRNA. Translation: AAA87712.1.
    S67247 mRNA. Translation: AAB28952.1.
    CCDSiCCDS11144.1. [P35580-1]
    CCDS58515.1. [P35580-4]
    PIRiA59252.
    I65769.
    RefSeqiNP_001242941.1. NM_001256012.1. [P35580-4]
    NP_001243024.1. NM_001256095.1.
    NP_005955.3. NM_005964.3. [P35580-1]
    XP_005256708.1. XM_005256651.2. [P35580-4]
    XP_005256709.1. XM_005256652.2. [P35580-3]
    UniGeneiHs.16355.

    Genome annotation databases

    EnsembliENST00000269243; ENSP00000269243; ENSG00000133026. [P35580-1]
    ENST00000360416; ENSP00000353590; ENSG00000133026. [P35580-4]
    GeneIDi4628.
    KEGGihsa:4628.
    UCSCiuc002gll.4. human. [P35580-1]

    Polymorphism databases

    DMDMi215274129.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69181 mRNA. Translation: AAA99177.1 .
    AB210026 mRNA. Translation: BAE06108.1 . Different initiation.
    AC011061 Genomic DNA. No translation available.
    AC025518 Genomic DNA. No translation available.
    AC026130 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90046.1 .
    CH471108 Genomic DNA. Translation: EAW90047.1 .
    CH471108 Genomic DNA. Translation: EAW90048.1 .
    CH471108 Genomic DNA. Translation: EAW90049.1 .
    BC000280 mRNA. Translation: AAH00280.1 .
    BC008968 mRNA. Translation: AAH08968.1 .
    BC117690 mRNA. Translation: AAI17691.1 .
    BC117691 mRNA. Translation: AAI17692.1 .
    BC144668 mRNA. Translation: AAI44669.1 .
    BC150634 mRNA. Translation: AAI50635.1 .
    U15618 mRNA. Translation: AAA87712.1 .
    S67247 mRNA. Translation: AAB28952.1 .
    CCDSi CCDS11144.1. [P35580-1 ]
    CCDS58515.1. [P35580-4 ]
    PIRi A59252.
    I65769.
    RefSeqi NP_001242941.1. NM_001256012.1. [P35580-4 ]
    NP_001243024.1. NM_001256095.1.
    NP_005955.3. NM_005964.3. [P35580-1 ]
    XP_005256708.1. XM_005256651.2. [P35580-4 ]
    XP_005256709.1. XM_005256652.2. [P35580-3 ]
    UniGenei Hs.16355.

    3D structure databases

    ProteinModelPortali P35580.
    SMRi P35580. Positions 7-963, 1899-1926.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110713. 58 interactions.
    DIPi DIP-31110N.
    IntActi P35580. 19 interactions.
    MINTi MINT-7901694.
    STRINGi 9606.ENSP00000269243.

    PTM databases

    PhosphoSitei P35580.

    Polymorphism databases

    DMDMi 215274129.

    Proteomic databases

    MaxQBi P35580.
    PaxDbi P35580.
    PRIDEi P35580.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269243 ; ENSP00000269243 ; ENSG00000133026 . [P35580-1 ]
    ENST00000360416 ; ENSP00000353590 ; ENSG00000133026 . [P35580-4 ]
    GeneIDi 4628.
    KEGGi hsa:4628.
    UCSCi uc002gll.4. human. [P35580-1 ]

    Organism-specific databases

    CTDi 4628.
    GeneCardsi GC17M008318.
    H-InvDB HIX0013525.
    HGNCi HGNC:7568. MYH10.
    HPAi CAB017180.
    MIMi 160776. gene.
    neXtProti NX_P35580.
    PharmGKBi PA31366.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000173958.
    HOVERGENi HBG004704.
    KOi K10352.
    OMAi ASNMESQ.
    PhylomeDBi P35580.
    TreeFami TF333601.

    Enzyme and pathway databases

    Reactomei REACT_19277. Sema4D induced cell migration and growth-cone collapse.

    Miscellaneous databases

    ChiTaRSi MYH10. human.
    GeneWikii MYH10.
    GenomeRNAii 4628.
    NextBioi 17814.
    PROi P35580.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35580.
    Bgeei P35580.
    CleanExi HS_MYH10.
    Genevestigatori P35580.

    Family and domain databases

    Gene3Di 4.10.270.10. 1 hit.
    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR008989. Myosin_S1_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00612. IQ. 1 hit.
    PF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50084. SSF50084. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies."
      Phillips C.L., Yamakawa K., Adelstein R.S.
      J. Muscle Res. Cell Motil. 16:379-389(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles."
      Abdelhaleem M.M., Hameed S., Klassen D., Greenberg A.H.
      J. Immunol. 156:2026-2035(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
      Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
      Tissue: Eye and Muscle.
    7. "Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes."
      Simons M., Wang M., McBride O.W., Kawamoto S., Yamakawa K., Gdula D., Adelstein R.S., Weir L.
      Circ. Res. 69:530-539(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-722 (ISOFORM 1).
    8. "Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B."
      Itoh K., Adelstein R.S.
      J. Biol. Chem. 270:14533-14540(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-301 (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 3), TISSUE SPECIFICITY.
    9. "Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis."
      Aikawa M., Sivam P.N., Kuro-O M., Kimura K., Nakahara K., Takewaki S., Ueda M., Yamaguchi H., Yazaki Y., Periasamy M.
      Circ. Res. 73:1000-1012(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1751-1976.
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis."
      Wu D., Asiedu M., Adelstein R.S., Wei Q.
      Cell Cycle 5:1234-1239(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLEKHG6.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939; SER-1952 AND SER-1956, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1956, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939 AND SER-1956, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-442 AND LYS-1645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."
      Gorbea C., Pratt G., Ustrell V., Bell R., Sahasrabudhe S., Hughes R.E., Rechsteiner M.
      J. Biol. Chem. 285:31616-31633(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ECM29.
    19. "Nonmuscle myosin-dependent synthesis of type I collagen."
      Cai L., Fritz D., Stefanovic L., Stefanovic B.
      J. Mol. Biol. 401:564-578(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH LARP6.
    20. "Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading."
      Betapudi V.
      PLoS ONE 5:E8560-E8560(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1956, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214 (ISOFORMS 2 AND 4), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1145; SER-1938 AND SER-1956, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214 (ISOFORMS 2 AND 4), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    24. "The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells."
      Pangon L., Van Kralingen C., Abas M., Daly R.J., Musgrove E.A., Kohonen-Corish M.R.
      Biochim. Biophys. Acta 1823:1058-1067(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MCC, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMYH10_HUMAN
    AccessioniPrimary (citable) accession number: P35580
    Secondary accession number(s): B2RWP9
    , D3DTS1, F8VTL3, Q12989, Q149N3, Q149N4, Q16087, Q4LE45, Q6PK16, Q9BWG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 149 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3