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P35577 (THBG_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thyroxine-binding globulin
Alternative name(s):
Serpin A7
T4-binding globulin
Gene names
Name:Serpina7
Synonyms:Tbg
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Major thyroid hormone transport protein in serum.

Subcellular location

Secreted.

Tissue specificity

Expressed by the liver and secreted in plasma.

Sequence similarities

Belongs to the serpin family.

Sequence caution

The sequence AAA42205.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processaging

Inferred from expression pattern PubMed 1907201. Source: RGD

negative regulation of endopeptidase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

post-embryonic development

Inferred from direct assay PubMed 1520259. Source: RGD

regulation of proteolysis

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to corticosterone

Inferred from expression pattern PubMed 8365361. Source: RGD

response to drug

Inferred from direct assay PubMed 2495002. Source: RGD

response to nutrient levels

Inferred from expression pattern PubMed 1471456. Source: RGD

response to peptide hormone

Inferred from expression pattern PubMed 7964287. Source: RGD

response to prostaglandin E

Inferred from expression pattern PubMed 970439. Source: RGD

response to steroid hormone

Inferred from expression pattern PubMed 8597480. Source: RGD

response to vitamin A

Inferred from direct assay PubMed 6785400. Source: RGD

thyroid hormone transport

Traceable author statement PubMed 7964287. Source: GOC

   Cellular_componentextracellular space

Inferred from direct assay PubMed 1520259. Source: RGD

   Molecular_functionhormone binding

Inferred from direct assay PubMed 1520259. Source: RGD

serine-type endopeptidase inhibitor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

thyroid hormone transmembrane transporter activity

Traceable author statement PubMed 7964287. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 418398Thyroxine-binding globulin
PRO_0000032440

Sites

Binding site2961Thyroxine By similarity
Binding site4011Thyroxine By similarity

Amino acid modifications

Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P35577 [UniParc].

Last modified June 7, 2004. Version 2.
Checksum: 3B1984814A388D19

FASTA41846,938
        10         20         30         40         50         60 
MSMFFYLFLL VLGLQATIHC APHNSSEGKV TTCHLPQQNA TLYKMPSINA DFAFRLYRKL 

        70         80         90        100        110        120 
SVENPDLNIF FSPVSISAAL AMLSFGSGSS TQTQILEVLG FNLTDTPVKE LQQGFQHLIC 

       130        140        150        160        170        180 
SLNFPNNELE LQMGNAVFIG QQLKPLAKFL DDVKTLYETE VFSTDFSNVS AAQHEINSYV 

       190        200        210        220        230        240 
EKQTKGKIVG LIQDLKLNII MILVNYIHFK AQWANPFRVS KTEESSNFSV DKSTTVQVPM 

       250        260        270        280        290        300 
MHQLEQYYHY VDVELNCTVL QMDYSANALA LFVLPKEGHM EWVEAAMSSK TLKKWNHLLQ 

       310        320        330        340        350        360 
KGWVELFVPK FSISATYDLG STLQKMGMRD AFAESADFPG ITKDNGLKLS YAFHKAVLHI 

       370        380        390        400        410 
GEEGTKEGAS PEAGSLDQPE VAPLHAVIRL DRTFLLMILE KRTRSVLFLG KVVDPTKE 

« Hide

References

[1]"Molecular cloning of the rat thyroxine-binding globulin gene and analysis of its promoter activity."
Tani Y., Mori Y., Miura Y., Okamoto H., Inagaki A., Saito H., Oiso Y.
Endocrinology 135:2731-2736(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning and primary structure of rat thyroxine-binding globulin."
Imamura S., Mori Y., Murata Y., Yamamori I., Miura Y., Oiso Y., Seo H., Matsui N., Refetoff S.
Biochemistry 30:5406-5411(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-418, PARTIAL PROTEIN SEQUENCE.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63991 mRNA. Translation: AAA42205.1. Different initiation.
PIRA39567.
UniGeneRn.9948.

3D structure databases

ProteinModelPortalP35577.
SMRP35577. Positions 43-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000014739.

Protein family/group databases

MEROPSI04.955.

Proteomic databases

PaxDbP35577.
PRIDEP35577.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014739; ENSRNOP00000014739; ENSRNOG00000011081.
UCSCRGD:619833. rat.

Organism-specific databases

RGD619833. Serpina7.

Phylogenomic databases

eggNOGCOG4826.
GeneTreeENSGT00740000115120.
HOGENOMHOG000238521.
HOVERGENHBG005957.
InParanoidP35577.
OMAFNLTDTP.
OrthoDBEOG7QC7W9.
PhylomeDBP35577.

Gene expression databases

GenevestigatorP35577.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615671.
PROP35577.

Entry information

Entry nameTHBG_RAT
AccessionPrimary (citable) accession number: P35577
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 7, 2004
Last modified: May 14, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families