Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35577

- THBG_RAT

UniProt

P35577 - THBG_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thyroxine-binding globulin

Gene

Serpina7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Major thyroid hormone transport protein in serum.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei296 – 2961ThyroxineBy similarity
Binding sitei401 – 4011ThyroxineBy similarity

GO - Molecular functioni

  1. hormone binding Source: RGD
  2. serine-type endopeptidase inhibitor activity Source: RefGenome
  3. thyroid hormone transmembrane transporter activity Source: RGD

GO - Biological processi

  1. aging Source: RGD
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. post-embryonic development Source: RGD
  4. regulation of proteolysis Source: RefGenome
  5. response to corticosterone Source: RGD
  6. response to drug Source: RGD
  7. response to nutrient levels Source: RGD
  8. response to peptide hormone Source: RGD
  9. response to prostaglandin E Source: RGD
  10. response to steroid hormone Source: RGD
  11. response to vitamin A Source: RGD
Complete GO annotation...

Protein family/group databases

MEROPSiI04.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroxine-binding globulin
Alternative name(s):
Serpin A7
T4-binding globulin
Gene namesi
Name:Serpina7
Synonyms:Tbg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi619833. Serpina7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 418398Thyroxine-binding globulinPRO_0000032440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35577.
PRIDEiP35577.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

GenevestigatoriP35577.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014739.

Structurei

3D structure databases

ProteinModelPortaliP35577.
SMRiP35577. Positions 43-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiP35577.
OMAiFNLTDTP.
OrthoDBiEOG7QC7W9.
PhylomeDBiP35577.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35577 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMFFYLFLL VLGLQATIHC APHNSSEGKV TTCHLPQQNA TLYKMPSINA
60 70 80 90 100
DFAFRLYRKL SVENPDLNIF FSPVSISAAL AMLSFGSGSS TQTQILEVLG
110 120 130 140 150
FNLTDTPVKE LQQGFQHLIC SLNFPNNELE LQMGNAVFIG QQLKPLAKFL
160 170 180 190 200
DDVKTLYETE VFSTDFSNVS AAQHEINSYV EKQTKGKIVG LIQDLKLNII
210 220 230 240 250
MILVNYIHFK AQWANPFRVS KTEESSNFSV DKSTTVQVPM MHQLEQYYHY
260 270 280 290 300
VDVELNCTVL QMDYSANALA LFVLPKEGHM EWVEAAMSSK TLKKWNHLLQ
310 320 330 340 350
KGWVELFVPK FSISATYDLG STLQKMGMRD AFAESADFPG ITKDNGLKLS
360 370 380 390 400
YAFHKAVLHI GEEGTKEGAS PEAGSLDQPE VAPLHAVIRL DRTFLLMILE
410
KRTRSVLFLG KVVDPTKE
Length:418
Mass (Da):46,938
Last modified:June 7, 2004 - v2
Checksum:i3B1984814A388D19
GO

Sequence cautioni

The sequence AAA42205.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63991 mRNA. Translation: AAA42205.1. Different initiation.
PIRiA39567.
UniGeneiRn.9948.

Genome annotation databases

EnsembliENSRNOT00000014739; ENSRNOP00000014739; ENSRNOG00000011081.
UCSCiRGD:619833. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63991 mRNA. Translation: AAA42205.1 . Different initiation.
PIRi A39567.
UniGenei Rn.9948.

3D structure databases

ProteinModelPortali P35577.
SMRi P35577. Positions 43-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000014739.

Protein family/group databases

MEROPSi I04.029.

Proteomic databases

PaxDbi P35577.
PRIDEi P35577.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014739 ; ENSRNOP00000014739 ; ENSRNOG00000011081 .
UCSCi RGD:619833. rat.

Organism-specific databases

RGDi 619833. Serpina7.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118839.
HOGENOMi HOG000238521.
HOVERGENi HBG005957.
InParanoidi P35577.
OMAi FNLTDTP.
OrthoDBi EOG7QC7W9.
PhylomeDBi P35577.

Miscellaneous databases

NextBioi 615671.
PROi P35577.

Gene expression databases

Genevestigatori P35577.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the rat thyroxine-binding globulin gene and analysis of its promoter activity."
    Tani Y., Mori Y., Miura Y., Okamoto H., Inagaki A., Saito H., Oiso Y.
    Endocrinology 135:2731-2736(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and primary structure of rat thyroxine-binding globulin."
    Imamura S., Mori Y., Murata Y., Yamamori I., Miura Y., Oiso Y., Seo H., Matsui N., Refetoff S.
    Biochemistry 30:5406-5411(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-418, PARTIAL PROTEIN SEQUENCE.
    Tissue: Liver.

Entry informationi

Entry nameiTHBG_RAT
AccessioniPrimary (citable) accession number: P35577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3