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P35577

- THBG_RAT

UniProt

P35577 - THBG_RAT

Protein

Thyroxine-binding globulin

Gene

Serpina7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Major thyroid hormone transport protein in serum.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei296 – 2961ThyroxineBy similarity
    Binding sitei401 – 4011ThyroxineBy similarity

    GO - Molecular functioni

    1. hormone binding Source: RGD
    2. serine-type endopeptidase inhibitor activity Source: RefGenome
    3. thyroid hormone transmembrane transporter activity Source: RGD

    GO - Biological processi

    1. aging Source: RGD
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. post-embryonic development Source: RGD
    4. regulation of proteolysis Source: RefGenome
    5. response to corticosterone Source: RGD
    6. response to drug Source: RGD
    7. response to nutrient levels Source: RGD
    8. response to peptide hormone Source: RGD
    9. response to prostaglandin E Source: RGD
    10. response to steroid hormone Source: RGD
    11. response to vitamin A Source: RGD
    12. thyroid hormone transport Source: GOC

    Protein family/group databases

    MEROPSiI04.955.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thyroxine-binding globulin
    Alternative name(s):
    Serpin A7
    T4-binding globulin
    Gene namesi
    Name:Serpina7
    Synonyms:Tbg
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi619833. Serpina7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 418398Thyroxine-binding globulinPRO_0000032440Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP35577.
    PRIDEiP35577.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.

    Gene expression databases

    GenevestigatoriP35577.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000014739.

    Structurei

    3D structure databases

    ProteinModelPortaliP35577.
    SMRiP35577. Positions 43-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00740000115120.
    HOGENOMiHOG000238521.
    HOVERGENiHBG005957.
    InParanoidiP35577.
    OMAiFNLTDTP.
    OrthoDBiEOG7QC7W9.
    PhylomeDBiP35577.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35577-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMFFYLFLL VLGLQATIHC APHNSSEGKV TTCHLPQQNA TLYKMPSINA    50
    DFAFRLYRKL SVENPDLNIF FSPVSISAAL AMLSFGSGSS TQTQILEVLG 100
    FNLTDTPVKE LQQGFQHLIC SLNFPNNELE LQMGNAVFIG QQLKPLAKFL 150
    DDVKTLYETE VFSTDFSNVS AAQHEINSYV EKQTKGKIVG LIQDLKLNII 200
    MILVNYIHFK AQWANPFRVS KTEESSNFSV DKSTTVQVPM MHQLEQYYHY 250
    VDVELNCTVL QMDYSANALA LFVLPKEGHM EWVEAAMSSK TLKKWNHLLQ 300
    KGWVELFVPK FSISATYDLG STLQKMGMRD AFAESADFPG ITKDNGLKLS 350
    YAFHKAVLHI GEEGTKEGAS PEAGSLDQPE VAPLHAVIRL DRTFLLMILE 400
    KRTRSVLFLG KVVDPTKE 418
    Length:418
    Mass (Da):46,938
    Last modified:June 7, 2004 - v2
    Checksum:i3B1984814A388D19
    GO

    Sequence cautioni

    The sequence AAA42205.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63991 mRNA. Translation: AAA42205.1. Different initiation.
    PIRiA39567.
    UniGeneiRn.9948.

    Genome annotation databases

    EnsembliENSRNOT00000014739; ENSRNOP00000014739; ENSRNOG00000011081.
    UCSCiRGD:619833. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63991 mRNA. Translation: AAA42205.1 . Different initiation.
    PIRi A39567.
    UniGenei Rn.9948.

    3D structure databases

    ProteinModelPortali P35577.
    SMRi P35577. Positions 43-417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000014739.

    Protein family/group databases

    MEROPSi I04.955.

    Proteomic databases

    PaxDbi P35577.
    PRIDEi P35577.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014739 ; ENSRNOP00000014739 ; ENSRNOG00000011081 .
    UCSCi RGD:619833. rat.

    Organism-specific databases

    RGDi 619833. Serpina7.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00740000115120.
    HOGENOMi HOG000238521.
    HOVERGENi HBG005957.
    InParanoidi P35577.
    OMAi FNLTDTP.
    OrthoDBi EOG7QC7W9.
    PhylomeDBi P35577.

    Miscellaneous databases

    NextBioi 615671.
    PROi P35577.

    Gene expression databases

    Genevestigatori P35577.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the rat thyroxine-binding globulin gene and analysis of its promoter activity."
      Tani Y., Mori Y., Miura Y., Okamoto H., Inagaki A., Saito H., Oiso Y.
      Endocrinology 135:2731-2736(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and primary structure of rat thyroxine-binding globulin."
      Imamura S., Mori Y., Murata Y., Yamamori I., Miura Y., Oiso Y., Seo H., Matsui N., Refetoff S.
      Biochemistry 30:5406-5411(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-418, PARTIAL PROTEIN SEQUENCE.
      Tissue: Liver.

    Entry informationi

    Entry nameiTHBG_RAT
    AccessioniPrimary (citable) accession number: P35577
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3