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P35573 (GDE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycogen debranching enzyme
Alternative name(s):
Glycogen debrancher

Including the following 2 domains:

  1. 4-alpha-glucanotransferase
    EC=2.4.1.25
    Alternative name(s):
    Oligo-1,4-1,4-glucantransferase
  2. Amylo-alpha-1,6-glucosidase
    Short name=Amylo-1,6-glucosidase
    EC=3.2.1.33
    Alternative name(s):
    Dextrin 6-alpha-D-glucosidase
Gene names
Name:AGL
Synonyms:GDE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1532 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

Catalytic activity

Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.

Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.

Subunit structure

Monomer. Interacts with NHLRC1/malin. Ref.9

Subcellular location

Cytoplasm. Note: Under glycogenolytic conditions localizes to the nucleus. Ref.9

Tissue specificity

Liver, kidney and lymphoblastoid cells express predominantly isoform 1;whereas muscle and heart express not only isoform 1, but also muscle-specific isoform mRNAs(isoforms 2, 3 and 4). Isoforms 5 and 6 are present in both liver and muscle.

Post-translational modification

The N-terminus is blocked.

Ubiquitinated. Ref.9

Involvement in disease

Glycogen storage disease 3 (GSD3) [MIM:232400]: A metabolic disorder associated with an accumulation of abnormal glycogen with short outer chains. It is clinically characterized by hepatomegaly, hypoglycemia, short stature, and variable myopathy. Glycogen storage disease type 3 includes different forms: GSD type 3A patients lack glycogen debrancher enzyme activity in both liver and muscle, while GSD type 3B patients are enzyme-deficient in liver only. In rare cases, selective loss of only 1 of the 2 debranching activities, glucosidase or transferase, results in GSD type 3C or type 3D, respectively.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.11

Sequence similarities

Belongs to the glycogen debranching enzyme family.

Sequence caution

The sequence BAD92104.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGlycogen biosynthesis
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
Glycogen storage disease
   Molecular functionGlycosidase
Glycosyltransferase
Hydrolase
Transferase
   PTMUbl conjugation
   Technical termComplete proteome
Direct protein sequencing
Multifunctional enzyme
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Traceable author statement. Source: Reactome

glucose metabolic process

Traceable author statement. Source: Reactome

glycogen biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

glycogen catabolic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Inferred from electronic annotation. Source: Ensembl

small molecule metabolic process

Traceable author statement. Source: Reactome

   Cellular_componentcytoplasm

Inferred from direct assay Ref.9. Source: UniProtKB

cytosol

Traceable author statement. Source: Reactome

inclusion body

Inferred from electronic annotation. Source: Ensembl

isoamylase complex

Traceable author statement Ref.1. Source: ProtInc

nucleus

Inferred from direct assay. Source: HPA

sarcoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

   Molecular_function4-alpha-glucanotransferase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

amylo-alpha-1,6-glucosidase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

glycogen debranching enzyme activity

Traceable author statement Ref.1. Source: ProtInc

polysaccharide binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P35573-1)

Also known as: 2; 3; 4;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: The products of the mRNAs termed isoforms 1 to 4 are identical.
Isoform 5 (identifier: P35573-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGHSKQIRILLLNEMEKLEKTLFRLEQ → MSLLTCAFYL
Isoform 6 (identifier: P35573-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGHSKQIRILLLNEMEKLEKTLFRLEQ → MAPILSINLFI

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15321532Glycogen debranching enzyme
PRO_0000087450

Regions

Region1 – ?4-alpha-glucanotransferase
Region? – 1532Amylo-1,6-glucosidase

Sites

Active site5261 By similarity
Active site5291 By similarity
Active site6271 By similarity

Natural variations

Alternative sequence1 – 2727MGHSK…FRLEQ → MSLLTCAFYL in isoform 5.
VSP_004270
Alternative sequence1 – 2727MGHSK…FRLEQ → MAPILSINLFI in isoform 6.
VSP_004271
Natural variant381T → A.
Corresponds to variant rs35278779 [ dbSNP | Ensembl ].
VAR_032084
Natural variant2291Q → R.
Corresponds to variant rs17121403 [ dbSNP | Ensembl ].
VAR_028051
Natural variant3871R → Q.
Corresponds to variant rs17121464 [ dbSNP | Ensembl ].
VAR_009621
Natural variant7011A → S.
Corresponds to variant rs3736297 [ dbSNP | Ensembl ].
VAR_028052
Natural variant9621S → C.
Corresponds to variant rs34714252 [ dbSNP | Ensembl ].
VAR_032085
Natural variant10671P → S.
Corresponds to variant rs3753494 [ dbSNP | Ensembl ].
VAR_020389
Natural variant11151G → R. Ref.11
Corresponds to variant rs2230307 [ dbSNP | Ensembl ].
VAR_009230
Natural variant11441I → N.
Corresponds to variant rs2230308 [ dbSNP | Ensembl ].
VAR_028053
Natural variant12071A → T.
Corresponds to variant rs11807956 [ dbSNP | Ensembl ].
VAR_051010
Natural variant12531R → H.
Corresponds to variant rs12043139 [ dbSNP | Ensembl ].
VAR_028054
Natural variant13431E → K.
Corresponds to variant rs112795811 [ dbSNP | Ensembl ].
VAR_009622
Natural variant14481G → R in GSD3; deficient in ability to bind glycogen; unstable due to enhanced ubiquitination; forms aggresomes upon proteasome impairment. Ref.9 Ref.11
VAR_009231
Natural variant14871R → G.
Corresponds to variant rs12118058 [ dbSNP | Ensembl ].
VAR_028055

Experimental info

Sequence conflict13981W → G in AAB41040. Ref.1
Sequence conflict13981W → G in AAB48466. Ref.2
Sequence conflict13981W → G in AAB48467. Ref.2
Sequence conflict13981W → G in AAB48468. Ref.2
Sequence conflict13981W → G in AAB48469. Ref.2
Sequence conflict13981W → G in AAB48470. Ref.2
Sequence conflict13981W → G Ref.3
Isoform 6:
Sequence conflict41I → L in AAB48470. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (2) (3) (4) [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 9BF1BCC43B7904D3

FASTA1,532174,764
        10         20         30         40         50         60 
MGHSKQIRIL LLNEMEKLEK TLFRLEQGYE LQFRLGPTLQ GKAVTVYTNY PFPGETFNRE 

        70         80         90        100        110        120 
KFRSLDWENP TEREDDSDKY CKLNLQQSGS FQYYFLQGNE KSGGGYIVVD PILRVGADNH 

       130        140        150        160        170        180 
VLPLDCVTLQ TFLAKCLGPF DEWESRLRVA KESGYNMIHF TPLQTLGLSR SCYSLANQLE 

       190        200        210        220        230        240 
LNPDFSRPNR KYTWNDVGQL VEKLKKEWNV ICITDVVYNH TAANSKWIQE HPECAYNLVN 

       250        260        270        280        290        300 
SPHLKPAWVL DRALWRFSCD VAEGKYKEKG IPALIENDHH MNSIRKIIWE DIFPKLKLWE 

       310        320        330        340        350        360 
FFQVDVNKAV EQFRRLLTQE NRRVTKSDPN QHLTIIQDPE YRRFGCTVDM NIALTTFIPH 

       370        380        390        400        410        420 
DKGPAAIEEC CNWFHKRMEE LNSEKHRLIN YHQEQAVNCL LGNVFYERLA GHGPKLGPVT 

       430        440        450        460        470        480 
RKHPLVTRYF TFPFEEIDFS MEESMIHLPN KACFLMAHNG WVMGDDPLRN FAEPGSEVYL 

       490        500        510        520        530        540 
RRELICWGDS VKLRYGNKPE DCPYLWAHMK KYTEITATYF QGVRLDNCHS TPLHVAEYML 

       550        560        570        580        590        600 
DAARNLQPNL YVVAELFTGS EDLDNVFVTR LGISSLIREA MSAYNSHEEG RLVYRYGGEP 

       610        620        630        640        650        660 
VGSFVQPCLR PLMPAIAHAL FMDITHDNEC PIVHRSAYDA LPSTTIVSMA CCASGSTRGY 

       670        680        690        700        710        720 
DELVPHQISV VSEERFYTKW NPEALPSNTG EVNFQSGIIA ARCAISKLHQ ELGAKGFIQV 

       730        740        750        760        770        780 
YVDQVDEDIV AVTRHSPSIH QSVVAVSRTA FRNPKTSFYS KEVPQMCIPG KIEEVVLEAR 

       790        800        810        820        830        840 
TIERNTKPYR KDENSINGTP DITVEIREHI QLNESKIVKQ AGVATKGPNE YIQEIEFENL 

       850        860        870        880        890        900 
SPGSVIIFRV SLDPHAQVAV GILRNHLTQF SPHFKSGSLA VDNADPILKI PFASLASRLT 

       910        920        930        940        950        960 
LAELNQILYR CESEEKEDGG GCYDIPNWSA LKYAGLQGLM SVLAEIRPKN DLGHPFCNNL 

       970        980        990       1000       1010       1020 
RSGDWMIDYV SNRLISRSGT IAEVGKWLQA MFFYLKQIPR YLIPCYFDAI LIGAYTTLLD 

      1030       1040       1050       1060       1070       1080 
TAWKQMSSFV QNGSTFVKHL SLGSVQLCGV GKFPSLPILS PALMDVPYRL NEITKEKEQC 

      1090       1100       1110       1120       1130       1140 
CVSLAAGLPH FSSGIFRCWG RDTFIALRGI LLITGRYVEA RNIILAFAGT LRHGLIPNLL 

      1150       1160       1170       1180       1190       1200 
GEGIYARYNC RDAVWWWLQC IQDYCKMVPN GLDILKCPVS RMYPTDDSAP LPAGTLDQPL 

      1210       1220       1230       1240       1250       1260 
FEVIQEAMQK HMQGIQFRER NAGPQIDRNM KDEGFNITAG VDEETGFVYG GNRFNCGTWM 

      1270       1280       1290       1300       1310       1320 
DKMGESDRAR NRGIPATPRD GSAVEIVGLS KSAVRWLLEL SKKNIFPYHE VTVKRHGKAI 

      1330       1340       1350       1360       1370       1380 
KVSYDEWNRK IQDNFEKLFH VSEDPSDLNE KHPNLVHKRG IYKDSYGASS PWCDYQLRPN 

      1390       1400       1410       1420       1430       1440 
FTIAMVVAPE LFTTEKAWKA LEIAEKKLLG PLGMKTLDPD DMVYCGIYDN ALDNDNYNLA 

      1450       1460       1470       1480       1490       1500 
KGFNYHQGPE WLWPIGYFLR AKLYFSRLMG PETTAKTIVL VKNVLSRHYV HLERSPWKGL 

      1510       1520       1530 
PELTNENAQY CPFSCETQAW SIATILETLY DL 

« Hide

Isoform 5 [UniParc].

Checksum: ABAC29497A4B08C6
Show »

FASTA1,515172,626
Isoform 6 [UniParc].

Checksum: C26E3817344DB637
Show »

FASTA1,516172,696

References

« Hide 'large scale' references
[1]"Molecular cloning and nucleotide sequence of cDNA encoding human muscle glycogen debranching enzyme."
Yang B.-Z., Ding J.-H., Enghild J.J., Bao Y., Chen Y.-T.
J. Biol. Chem. 267:9294-9299(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE (ISOFORM 5).
Tissue: Muscle.
[2]"Human glycogen debranching enzyme gene (AGL): complete structural organization and characterization of the 5' flanking region."
Bao Y., Dawson T.L. Jr., Chen Y.-T.
Genomics 38:155-165(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[3]"Isolation and nucleotide sequence of human liver glycogen debranching enzyme mRNA: identification of multiple tissue-specific isoforms."
Bao Y., Yang B.-Z., Dawson T.L. Jr., Chen Y.-T.
Gene 197:389-398(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
Tissue: Liver.
[4]"Heterogeneous mutations in the glycogen-debranching enzyme gene are responsible for glycogen storage disease type IIIa in Japan."
Okubo M., Horinishi A., Takeuchi M., Suzuki Y., Sakura N., Hasegawa Y., Igarashi T., Goto K., Tahara H., Uchimoto S., Omichi K., Kanno H., Hayasaka K., Murase T.
Hum. Genet. 106:108-115(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS.
[5]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[9]"A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease."
Cheng A., Zhang M., Gentry M.S., Worby C.A., Dixon J.E., Saltiel A.R.
Genes Dev. 21:2399-2409(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION, CHARACTERIZATION OF VARIANT GSD3 ARG-1448, INTERACTION WITH NHLRC1, SUBCELLULAR LOCATION.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Glycogen storage disease type IIIa: first report of a causative missense mutation (G1448R) of the glycogen debranching enzyme gene found in a homozygous patient."
Okubo M., Kanda F., Horinishi A., Takahashi K., Okuda S., Chihara K., Murase T.
Hum. Mutat. 14:542-543(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GSD3 ARG-1448, VARIANT ARG-1115.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M85168 mRNA. Translation: AAB41040.1.
U84007 mRNA. Translation: AAB48466.1.
U84008 mRNA. Translation: AAB48467.1.
U84009 mRNA. Translation: AAB48468.1.
U84010 mRNA. Translation: AAB48469.1.
U84011 mRNA. Translation: AAB48470.1.
AB035443 Genomic DNA. Translation: BAA88405.1.
AB208867 mRNA. Translation: BAD92104.1. Different initiation.
AC096949 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW72985.1.
CH471097 Genomic DNA. Translation: EAW72982.1.
CH471097 Genomic DNA. Translation: EAW72983.1.
CH471097 Genomic DNA. Translation: EAW72987.1.
BC078663 mRNA. Translation: AAH78663.1.
RefSeqNP_000019.2. NM_000028.2.
NP_000633.2. NM_000642.2.
NP_000634.2. NM_000643.2.
NP_000635.2. NM_000644.2.
NP_000636.2. NM_000645.2.
NP_000637.2. NM_000646.2.
XP_005270614.1. XM_005270557.1.
UniGeneHs.904.

3D structure databases

ProteinModelPortalP35573.
SMRP35573. Positions 138-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106686. 19 interactions.
IntActP35573. 9 interactions.
MINTMINT-2802883.
STRING9606.ENSP00000294724.

Chemistry

BindingDBP35573.
ChEMBLCHEMBL5272.

Protein family/group databases

CAZyGH13. Glycoside Hydrolase Family 13.

PTM databases

PhosphoSiteP35573.

Polymorphism databases

DMDM116242491.

Proteomic databases

PaxDbP35573.
PRIDEP35573.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294724; ENSP00000294724; ENSG00000162688. [P35573-1]
ENST00000361302; ENSP00000354971; ENSG00000162688. [P35573-3]
ENST00000361522; ENSP00000354635; ENSG00000162688. [P35573-2]
ENST00000361915; ENSP00000355106; ENSG00000162688. [P35573-1]
ENST00000370161; ENSP00000359180; ENSG00000162688. [P35573-3]
ENST00000370163; ENSP00000359182; ENSG00000162688. [P35573-1]
ENST00000370165; ENSP00000359184; ENSG00000162688. [P35573-1]
GeneID178.
KEGGhsa:178.
UCSCuc001dsi.1. human. [P35573-1]
uc001dsm.1. human. [P35573-3]
uc001dsn.1. human. [P35573-2]

Organism-specific databases

CTD178.
GeneCardsGC01P100315.
HGNCHGNC:321. AGL.
HPAHPA028498.
MIM232400. phenotype.
610860. gene.
neXtProtNX_P35573.
Orphanet366. Glycogen storage disease due to glycogen debranching enzyme deficiency.
PharmGKBPA24618.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG3408.
HOVERGENHBG005824.
InParanoidP35573.
KOK01196.
OMAVGILRNH.
OrthoDBEOG7C5M7F.
PhylomeDBP35573.
TreeFamTF300697.

Enzyme and pathway databases

BioCycMetaCyc:HS08717-MONOMER.
ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressP35573.
BgeeP35573.
CleanExHS_AGL.
GenevestigatorP35573.

Family and domain databases

Gene3D3.20.20.80. 3 hits.
InterProIPR008928. 6-hairpin_glycosidase-like.
IPR010401. AGL/Gdb1.
IPR013781. Glyco_hydro_catalytic_dom.
IPR006421. Glycogen_debranch_met.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10569. PTHR10569. 1 hit.
PfamPF06202. GDE_C. 1 hit.
[Graphical view]
SUPFAMSSF48208. SSF48208. 2 hits.
SSF51445. SSF51445. 2 hits.
TIGRFAMsTIGR01531. glyc_debranch. 1 hit.
ProtoNetSearch...

Other

GeneWikiGlycogen_debranching_enzyme.
GenomeRNAi178.
NextBio722.
PROP35573.
SOURCESearch...

Entry information

Entry nameGDE_HUMAN
AccessionPrimary (citable) accession number: P35573
Secondary accession number(s): A6NCX7 expand/collapse secondary AC list , A6NEK2, D3DT51, P78354, P78544, Q59H92, Q6AZ90, Q9UF08
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM