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P35572 (IBP6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor-binding protein 6

Short name=IBP-6
Short name=IGF-binding protein 6
Short name=IGFBP-6
Gene names
Name:Igfbp6
Synonyms:Igfbp-6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subcellular location

Secreted.

Post-translational modification

O-glycosylated.

Sequence similarities

Contains 1 IGFBP N-terminal domain.

Contains 1 thyroglobulin type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Ref.4
Chain26 – 226201Insulin-like growth factor-binding protein 6
PRO_0000014391

Regions

Domain26 – 9974IGFBP N-terminal
Domain145 – 22076Thyroglobulin type-1

Amino acid modifications

Disulfide bond30 ↔ 33 By similarity
Disulfide bond49 ↔ 55 By similarity
Disulfide bond63 ↔ 76 By similarity
Disulfide bond70 ↔ 96 By similarity
Disulfide bond148 ↔ 176 By similarity
Disulfide bond187 ↔ 198 By similarity
Disulfide bond200 ↔ 220 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35572 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 212D419303AE3137

FASTA22624,193
        10         20         30         40         50         60 
MTWDGLPTQP LLMLLMLLFA AGSESALAGC PGCGPGVQEE DAGSPADGCA ETGGCFRREG 

        70         80         90        100        110        120 
QPCGVYIPKC APGLQCQPRE NEETPLRALL IGQGRCQRAR GPSEETTKES KPHGGASRPR 

       130        140        150        160        170        180 
DRDRQKNPRT SAAPIRPSPV QDGEMGPCRR HLDSVLQQLQ TEVFRGGANG LYVPNCDLRG 

       190        200        210        220 
FYRKQQCRSS QGNRRGPCWC VDPMGQPLPV SPDGQGSSQC SARSSG 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and molecular cloning of insulin-like growth factor-binding protein-6."
Shimasaki S., Gao L., Shimonaka M., Ling N.
Mol. Endocrinol. 5:938-948(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structural characterization of the rat insulin-like growth factor binding protein-6 gene."
Zhu X., Ling N., Shimasaki S.
Biochem. Biophys. Res. Commun. 191:1237-1243(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[4]"Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human."
Shimasaki S., Shimonaka M., Zhang H.-P., Ling N.
J. Biol. Chem. 266:10646-10653(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-38.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M69055 mRNA. Translation: AAA42019.1.
L11006 Genomic DNA. No translation available.
BC099742 mRNA. Translation: AAH99742.1.
PIRJN0464.
RefSeqNP_037236.1. NM_013104.3.
UniGeneRn.6431.

3D structure databases

ProteinModelPortalP35572.
SMRP35572. Positions 26-96, 146-226.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000014807.

Proteomic databases

PaxDbP35572.
PRIDEP35572.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014807; ENSRNOP00000014807; ENSRNOG00000010977.
GeneID25641.
KEGGrno:25641.

Organism-specific databases

CTD3489.
RGD2877. Igfbp6.

Phylogenomic databases

eggNOGNOG47794.
GeneTreeENSGT00550000074457.
HOGENOMHOG000253012.
HOVERGENHBG002631.
InParanoidP35572.
OMARDQQRNP.
OrthoDBEOG74N5HG.
PhylomeDBP35572.
TreeFamTF331211.

Gene expression databases

GenevestigatorP35572.

Family and domain databases

Gene3D4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR022326. IGFBP-6.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERPTHR11551. PTHR11551. 1 hit.
PfamPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSPR01976. IGFBPFAMILY.
PR01982. IGFBPFAMILY6.
SMARTSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEPS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607483.
PROP35572.

Entry information

Entry nameIBP6_RAT
AccessionPrimary (citable) accession number: P35572
Secondary accession number(s): Q499W1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families