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P35572

- IBP6_RAT

UniProt

P35572 - IBP6_RAT

Protein

Insulin-like growth factor-binding protein 6

Gene

Igfbp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

    GO - Molecular functioni

    1. insulin-like growth factor I binding Source: RGD
    2. insulin-like growth factor II binding Source: RGD

    GO - Biological processi

    1. regulation of cell growth Source: InterPro

    Keywords - Ligandi

    Growth factor binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 6
    Short name:
    IBP-6
    Short name:
    IGF-binding protein 6
    Short name:
    IGFBP-6
    Gene namesi
    Name:Igfbp6
    Synonyms:Igfbp-6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi2877. Igfbp6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. extracellular space Source: RGD
    3. Golgi apparatus Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 25251 PublicationAdd
    BLAST
    Chaini26 – 226201Insulin-like growth factor-binding protein 6PRO_0000014391Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 33PROSITE-ProRule annotation
    Disulfide bondi49 ↔ 55PROSITE-ProRule annotation
    Disulfide bondi63 ↔ 76PROSITE-ProRule annotation
    Disulfide bondi70 ↔ 96PROSITE-ProRule annotation
    Disulfide bondi148 ↔ 176PROSITE-ProRule annotation
    Disulfide bondi187 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi200 ↔ 220PROSITE-ProRule annotation

    Post-translational modificationi

    O-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP35572.
    PRIDEiP35572.

    Expressioni

    Gene expression databases

    GenevestigatoriP35572.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000014807.

    Structurei

    3D structure databases

    ProteinModelPortaliP35572.
    SMRiP35572. Positions 26-96, 146-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 9974IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini145 – 22076Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47794.
    GeneTreeiENSGT00550000074457.
    HOGENOMiHOG000253012.
    HOVERGENiHBG002631.
    InParanoidiP35572.
    OMAiRDQQRNP.
    OrthoDBiEOG74N5HG.
    PhylomeDBiP35572.
    TreeFamiTF331211.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR022326. IGFBP-6.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01982. IGFBPFAMILY6.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35572-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTWDGLPTQP LLMLLMLLFA AGSESALAGC PGCGPGVQEE DAGSPADGCA    50
    ETGGCFRREG QPCGVYIPKC APGLQCQPRE NEETPLRALL IGQGRCQRAR 100
    GPSEETTKES KPHGGASRPR DRDRQKNPRT SAAPIRPSPV QDGEMGPCRR 150
    HLDSVLQQLQ TEVFRGGANG LYVPNCDLRG FYRKQQCRSS QGNRRGPCWC 200
    VDPMGQPLPV SPDGQGSSQC SARSSG 226
    Length:226
    Mass (Da):24,193
    Last modified:June 1, 1994 - v1
    Checksum:i212D419303AE3137
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69055 mRNA. Translation: AAA42019.1.
    L11006 Genomic DNA. No translation available.
    BC099742 mRNA. Translation: AAH99742.1.
    PIRiJN0464.
    RefSeqiNP_037236.1. NM_013104.3.
    UniGeneiRn.6431.

    Genome annotation databases

    EnsembliENSRNOT00000014807; ENSRNOP00000014807; ENSRNOG00000010977.
    GeneIDi25641.
    KEGGirno:25641.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69055 mRNA. Translation: AAA42019.1 .
    L11006 Genomic DNA. No translation available.
    BC099742 mRNA. Translation: AAH99742.1 .
    PIRi JN0464.
    RefSeqi NP_037236.1. NM_013104.3.
    UniGenei Rn.6431.

    3D structure databases

    ProteinModelPortali P35572.
    SMRi P35572. Positions 26-96, 146-226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000014807.

    Proteomic databases

    PaxDbi P35572.
    PRIDEi P35572.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014807 ; ENSRNOP00000014807 ; ENSRNOG00000010977 .
    GeneIDi 25641.
    KEGGi rno:25641.

    Organism-specific databases

    CTDi 3489.
    RGDi 2877. Igfbp6.

    Phylogenomic databases

    eggNOGi NOG47794.
    GeneTreei ENSGT00550000074457.
    HOGENOMi HOG000253012.
    HOVERGENi HBG002631.
    InParanoidi P35572.
    OMAi RDQQRNP.
    OrthoDBi EOG74N5HG.
    PhylomeDBi P35572.
    TreeFami TF331211.

    Miscellaneous databases

    NextBioi 607483.
    PROi P35572.

    Gene expression databases

    Genevestigatori P35572.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR022326. IGFBP-6.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01982. IGFBPFAMILY6.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and molecular cloning of insulin-like growth factor-binding protein-6."
      Shimasaki S., Gao L., Shimonaka M., Ling N.
      Mol. Endocrinol. 5:938-948(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structural characterization of the rat insulin-like growth factor binding protein-6 gene."
      Zhu X., Ling N., Shimasaki S.
      Biochem. Biophys. Res. Commun. 191:1237-1243(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    4. "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human."
      Shimasaki S., Shimonaka M., Zhang H.-P., Ling N.
      J. Biol. Chem. 266:10646-10653(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-38.

    Entry informationi

    Entry nameiIBP6_RAT
    AccessioniPrimary (citable) accession number: P35572
    Secondary accession number(s): Q499W1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3