SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35572

- IBP6_RAT

UniProt

P35572 - IBP6_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Insulin-like growth factor-binding protein 6

Gene
Igfbp6, Igfbp-6
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  1. insulin-like growth factor I binding Source: RGD
  2. insulin-like growth factor II binding Source: RGD

GO - Biological processi

  1. regulation of cell growth Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 6
Short name:
IBP-6
Short name:
IGF-binding protein 6
Short name:
IGFBP-6
Gene namesi
Name:Igfbp6
Synonyms:Igfbp-6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi2877. Igfbp6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
  3. Golgi apparatus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 226201Insulin-like growth factor-binding protein 6PRO_0000014391Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 33 By similarity
Disulfide bondi49 ↔ 55 By similarity
Disulfide bondi63 ↔ 76 By similarity
Disulfide bondi70 ↔ 96 By similarity
Disulfide bondi148 ↔ 176 By similarity
Disulfide bondi187 ↔ 198 By similarity
Disulfide bondi200 ↔ 220 By similarity

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35572.
PRIDEiP35572.

Expressioni

Gene expression databases

GenevestigatoriP35572.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014807.

Structurei

3D structure databases

ProteinModelPortaliP35572.
SMRiP35572. Positions 26-96, 146-226.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 9974IGFBP N-terminalAdd
BLAST
Domaini145 – 22076Thyroglobulin type-1Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47794.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP35572.
OMAiRDQQRNP.
OrthoDBiEOG74N5HG.
PhylomeDBiP35572.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR022326. IGFBP-6.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01982. IGFBPFAMILY6.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35572-1 [UniParc]FASTAAdd to Basket

« Hide

MTWDGLPTQP LLMLLMLLFA AGSESALAGC PGCGPGVQEE DAGSPADGCA    50
ETGGCFRREG QPCGVYIPKC APGLQCQPRE NEETPLRALL IGQGRCQRAR 100
GPSEETTKES KPHGGASRPR DRDRQKNPRT SAAPIRPSPV QDGEMGPCRR 150
HLDSVLQQLQ TEVFRGGANG LYVPNCDLRG FYRKQQCRSS QGNRRGPCWC 200
VDPMGQPLPV SPDGQGSSQC SARSSG 226
Length:226
Mass (Da):24,193
Last modified:June 1, 1994 - v1
Checksum:i212D419303AE3137
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M69055 mRNA. Translation: AAA42019.1.
L11006 Genomic DNA. No translation available.
BC099742 mRNA. Translation: AAH99742.1.
PIRiJN0464.
RefSeqiNP_037236.1. NM_013104.3.
UniGeneiRn.6431.

Genome annotation databases

EnsembliENSRNOT00000014807; ENSRNOP00000014807; ENSRNOG00000010977.
GeneIDi25641.
KEGGirno:25641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M69055 mRNA. Translation: AAA42019.1 .
L11006 Genomic DNA. No translation available.
BC099742 mRNA. Translation: AAH99742.1 .
PIRi JN0464.
RefSeqi NP_037236.1. NM_013104.3.
UniGenei Rn.6431.

3D structure databases

ProteinModelPortali P35572.
SMRi P35572. Positions 26-96, 146-226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000014807.

Proteomic databases

PaxDbi P35572.
PRIDEi P35572.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014807 ; ENSRNOP00000014807 ; ENSRNOG00000010977 .
GeneIDi 25641.
KEGGi rno:25641.

Organism-specific databases

CTDi 3489.
RGDi 2877. Igfbp6.

Phylogenomic databases

eggNOGi NOG47794.
GeneTreei ENSGT00550000074457.
HOGENOMi HOG000253012.
HOVERGENi HBG002631.
InParanoidi P35572.
OMAi RDQQRNP.
OrthoDBi EOG74N5HG.
PhylomeDBi P35572.
TreeFami TF331211.

Miscellaneous databases

NextBioi 607483.
PROi P35572.

Gene expression databases

Genevestigatori P35572.

Family and domain databases

Gene3Di 4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR022326. IGFBP-6.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR11551. PTHR11551. 1 hit.
Pfami PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
PRINTSi PR01976. IGFBPFAMILY.
PR01982. IGFBPFAMILY6.
SMARTi SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEi PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and molecular cloning of insulin-like growth factor-binding protein-6."
    Shimasaki S., Gao L., Shimonaka M., Ling N.
    Mol. Endocrinol. 5:938-948(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural characterization of the rat insulin-like growth factor binding protein-6 gene."
    Zhu X., Ling N., Shimasaki S.
    Biochem. Biophys. Res. Commun. 191:1237-1243(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human."
    Shimasaki S., Shimonaka M., Zhang H.-P., Ling N.
    J. Biol. Chem. 266:10646-10653(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-38.

Entry informationi

Entry nameiIBP6_RAT
AccessioniPrimary (citable) accession number: P35572
Secondary accession number(s): Q499W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi