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Protein

Insulin-like growth factor-binding protein 6

Gene

Igfbp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  • insulin-like growth factor I binding Source: RGD
  • insulin-like growth factor II binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 6
Short name:
IBP-6
Short name:
IGF-binding protein 6
Short name:
IGFBP-6
Gene namesi
Name:Igfbp6
Synonyms:Igfbp-6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2877 Igfbp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001439126 – 226Insulin-like growth factor-binding protein 6Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 33PROSITE-ProRule annotation
Disulfide bondi49 ↔ 55PROSITE-ProRule annotation
Disulfide bondi63 ↔ 76PROSITE-ProRule annotation
Disulfide bondi70 ↔ 96PROSITE-ProRule annotation
Disulfide bondi148 ↔ 176PROSITE-ProRule annotation
Disulfide bondi187 ↔ 198PROSITE-ProRule annotation
Disulfide bondi200 ↔ 220PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35572
PRIDEiP35572

Expressioni

Gene expression databases

BgeeiENSRNOG00000010977
GenevisibleiP35572 RN

Interactioni

GO - Molecular functioni

  • insulin-like growth factor I binding Source: RGD
  • insulin-like growth factor II binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014807

Structurei

3D structure databases

ProteinModelPortaliP35572
SMRiP35572
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 99IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST74
Domaini145 – 220Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVZ3 Eukaryota
ENOG410YQXU LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP35572
OMAiRDQQRNP
OrthoDBiEOG091G0L46
PhylomeDBiP35572
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022326 IGFBP-6
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF14 PTHR11551:SF14, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01982 IGFBPFAMILY6
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWDGLPTQP LLMLLMLLFA AGSESALAGC PGCGPGVQEE DAGSPADGCA
60 70 80 90 100
ETGGCFRREG QPCGVYIPKC APGLQCQPRE NEETPLRALL IGQGRCQRAR
110 120 130 140 150
GPSEETTKES KPHGGASRPR DRDRQKNPRT SAAPIRPSPV QDGEMGPCRR
160 170 180 190 200
HLDSVLQQLQ TEVFRGGANG LYVPNCDLRG FYRKQQCRSS QGNRRGPCWC
210 220
VDPMGQPLPV SPDGQGSSQC SARSSG
Length:226
Mass (Da):24,193
Last modified:June 1, 1994 - v1
Checksum:i212D419303AE3137
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69055 mRNA Translation: AAA42019.1
L11006 Genomic DNA No translation available.
BC099742 mRNA Translation: AAH99742.1
PIRiJN0464
RefSeqiNP_037236.1, NM_013104.3
UniGeneiRn.6431

Genome annotation databases

EnsembliENSRNOT00000014807; ENSRNOP00000014807; ENSRNOG00000010977
GeneIDi25641
KEGGirno:25641

Similar proteinsi

Entry informationi

Entry nameiIBP6_RAT
AccessioniPrimary (citable) accession number: P35572
Secondary accession number(s): Q499W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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