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Protein

Insulin-like growth factor-binding protein 6

Gene

Igfbp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  • insulin-like growth factor I binding Source: RGD
  • insulin-like growth factor II binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiREACT_277593. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 6
Short name:
IBP-6
Short name:
IGF-binding protein 6
Short name:
IGFBP-6
Gene namesi
Name:Igfbp6
Synonyms:Igfbp-6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2877. Igfbp6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular exosome Source: Ensembl
  • extracellular space Source: RGD
  • Golgi apparatus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 226201Insulin-like growth factor-binding protein 6PRO_0000014391Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 33PROSITE-ProRule annotation
Disulfide bondi49 ↔ 55PROSITE-ProRule annotation
Disulfide bondi63 ↔ 76PROSITE-ProRule annotation
Disulfide bondi70 ↔ 96PROSITE-ProRule annotation
Disulfide bondi148 ↔ 176PROSITE-ProRule annotation
Disulfide bondi187 ↔ 198PROSITE-ProRule annotation
Disulfide bondi200 ↔ 220PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35572.
PRIDEiP35572.

Expressioni

Gene expression databases

GenevestigatoriP35572.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014807.

Structurei

3D structure databases

ProteinModelPortaliP35572.
SMRiP35572. Positions 26-96, 146-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 9974IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini145 – 22076Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47794.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP35572.
OMAiRDQQRNP.
OrthoDBiEOG74N5HG.
PhylomeDBiP35572.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR022326. IGFBP-6.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01982. IGFBPFAMILY6.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWDGLPTQP LLMLLMLLFA AGSESALAGC PGCGPGVQEE DAGSPADGCA
60 70 80 90 100
ETGGCFRREG QPCGVYIPKC APGLQCQPRE NEETPLRALL IGQGRCQRAR
110 120 130 140 150
GPSEETTKES KPHGGASRPR DRDRQKNPRT SAAPIRPSPV QDGEMGPCRR
160 170 180 190 200
HLDSVLQQLQ TEVFRGGANG LYVPNCDLRG FYRKQQCRSS QGNRRGPCWC
210 220
VDPMGQPLPV SPDGQGSSQC SARSSG
Length:226
Mass (Da):24,193
Last modified:June 1, 1994 - v1
Checksum:i212D419303AE3137
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69055 mRNA. Translation: AAA42019.1.
L11006 Genomic DNA. No translation available.
BC099742 mRNA. Translation: AAH99742.1.
PIRiJN0464.
RefSeqiNP_037236.1. NM_013104.3.
UniGeneiRn.6431.

Genome annotation databases

EnsembliENSRNOT00000014807; ENSRNOP00000014807; ENSRNOG00000010977.
GeneIDi25641.
KEGGirno:25641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69055 mRNA. Translation: AAA42019.1.
L11006 Genomic DNA. No translation available.
BC099742 mRNA. Translation: AAH99742.1.
PIRiJN0464.
RefSeqiNP_037236.1. NM_013104.3.
UniGeneiRn.6431.

3D structure databases

ProteinModelPortaliP35572.
SMRiP35572. Positions 26-96, 146-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014807.

Protein family/group databases

MEROPSiI31.952.

Proteomic databases

PaxDbiP35572.
PRIDEiP35572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014807; ENSRNOP00000014807; ENSRNOG00000010977.
GeneIDi25641.
KEGGirno:25641.

Organism-specific databases

CTDi3489.
RGDi2877. Igfbp6.

Phylogenomic databases

eggNOGiNOG47794.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP35572.
OMAiRDQQRNP.
OrthoDBiEOG74N5HG.
PhylomeDBiP35572.
TreeFamiTF331211.

Enzyme and pathway databases

ReactomeiREACT_277593. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

NextBioi607483.
PROiP35572.

Gene expression databases

GenevestigatoriP35572.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR022326. IGFBP-6.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01982. IGFBPFAMILY6.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and molecular cloning of insulin-like growth factor-binding protein-6."
    Shimasaki S., Gao L., Shimonaka M., Ling N.
    Mol. Endocrinol. 5:938-948(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural characterization of the rat insulin-like growth factor binding protein-6 gene."
    Zhu X., Ling N., Shimasaki S.
    Biochem. Biophys. Res. Commun. 191:1237-1243(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human."
    Shimasaki S., Shimonaka M., Zhang H.-P., Ling N.
    J. Biol. Chem. 266:10646-10653(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-38.

Entry informationi

Entry nameiIBP6_RAT
AccessioniPrimary (citable) accession number: P35572
Secondary accession number(s): Q499W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 27, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.