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P35571

- GPDM_RAT

UniProt

P35571 - GPDM_RAT

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Protein
Glycerol-3-phosphate dehydrogenase, mitochondrial
Gene
Gpd2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FAD.

Enzyme regulationi

Calcium-binding enhance the activity of the enzyme.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 9929FAD Reviewed prediction
Add
BLAST
Calcium bindingi672 – 68312 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: RGD
  3. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. NADH metabolic process Source: RGD
  2. glycerol catabolic process Source: UniProtKB-UniPathway
  3. glycerol-3-phosphate metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calcium, FAD, Flavoprotein, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
Name:Gpd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2726. Gpd2.

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242Mitochondrion1 Publication
Add
BLAST
Chaini43 – 727685Glycerol-3-phosphate dehydrogenase, mitochondrial
PRO_0000010431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei601 – 6011Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP35571.
PRIDEiP35571.

2D gel databases

World-2DPAGEi0004:P35571.

PTM databases

PhosphoSiteiP35571.

Expressioni

Gene expression databases

GenevestigatoriP35571.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063785.

Structurei

3D structure databases

ProteinModelPortaliP35571.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini623 – 65836EF-hand 1
Add
BLAST
Domaini659 – 69436EF-hand 2
Add
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiCOG0578.
HOGENOMiHOG000004813.
HOVERGENiHBG005897.
KOiK00111.
PhylomeDBiP35571.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35571-1 [UniParc]FASTAAdd to Basket

« Hide

MAFQKVVKGT ILMGGGALAT VLGLSQFAHY RRKQVSLAYV EAATCFSEPV    50
NREPPSREAQ LMTLQNTSEF DILVIGGGAT GCGCALDAVT RGLKTALVER 100
NDFASGTSSR STKLIHGGVR YLQKAITNLD VEQYRMVKEA LHERANLLEI 150
APHLSAPLPI MLPLYKWWQL PYYWVGIKMY DLVAGSHCLK SSYVLSKSRA 200
LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG AATANYMEVV 250
SLLKKTDPET GKERVSGARC KDVLTGHEFN VRAKCVINAT GPFTDSVRKM 300
DDNDVVPICQ PSAGVHIVMP GYYSPENMGL LDPATSDGRV IFFLPWEKMT 350
IAGTTDSPTD VTHHPIPSED DINFILNEVR NYLSCDVEVR RGDVLAAWSG 400
IRPLVTDPKS ANTQSISRNH VVEVSDSGLI TIAGGKWTTY RSMAEDTVNK 450
AVKLHNLNAG PSRTVGLFLQ GGKDWSPTLY IRLVQDYGLE SEVAQHLAKT 500
YGDKAFDVAK MASVTGKRWP VVGVRLVSEF PYIEAEVKYG IKEYACTAVD 550
MISRRTRLAF LNVQAAEEAL PKIVELMGRE LNWSELRKQE ELETATRFLY 600
YEMGYKSRTE QLTDSTEISL LPPDIDRYKK RFHMFDEDEK GFITIVDVQR 650
VLESINVQMD EDTLHEILCE VDLNKNGQVE LHEFLQLMSA VHTGRVSGSR 700
LAILMKTAEE NLDRRVPIPV DRSCGGL 727
Length:727
Mass (Da):80,973
Last modified:June 1, 1994 - v1
Checksum:iB2AAA45E93F5F7CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U08027 mRNA. Translation: AAB60443.1.
X78593 mRNA. Translation: CAA55329.1.
BC083565 mRNA. Translation: AAH83565.1.
PIRiA54051.
RefSeqiNP_036868.1. NM_012736.1.
UniGeneiRn.89705.

Genome annotation databases

GeneIDi25062.
KEGGirno:25062.
UCSCiRGD:2726. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U08027 mRNA. Translation: AAB60443.1 .
X78593 mRNA. Translation: CAA55329.1 .
BC083565 mRNA. Translation: AAH83565.1 .
PIRi A54051.
RefSeqi NP_036868.1. NM_012736.1.
UniGenei Rn.89705.

3D structure databases

ProteinModelPortali P35571.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000063785.

PTM databases

PhosphoSitei P35571.

2D gel databases

World-2DPAGEi 0004:P35571.

Proteomic databases

PaxDbi P35571.
PRIDEi P35571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25062.
KEGGi rno:25062.
UCSCi RGD:2726. rat.

Organism-specific databases

CTDi 2820.
RGDi 2726. Gpd2.

Phylogenomic databases

eggNOGi COG0578.
HOGENOMi HOG000004813.
HOVERGENi HBG005897.
KOi K00111.
PhylomeDBi P35571.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00673 .

Miscellaneous databases

NextBioi 605290.
PROi P35571.

Gene expression databases

Genevestigatori P35571.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of rat mitochondrial glycerol-3-phosphate dehydrogenase cDNA. Evidence for EF-hand calcium-binding domains."
    Brown L.J., McDonald M.J., Lehn D.A., Moran S.M.
    J. Biol. Chem. 269:14363-14366(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 43-58.
    Strain: Sprague-Dawley.
    Tissue: Testis.
  2. "Cloning of a cDNA for the FAD-linked glycerol-3-phosphate dehydrogenase from rat liver and its regulation by thyroid hormones."
    Mueller S., Seitz H.J.
    Proc. Natl. Acad. Sci. U.S.A. 91:10581-10585(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGPDM_RAT
AccessioniPrimary (citable) accession number: P35571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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