##gff-version 3
P35569	UniProtKB	Chain	1	1233	.	.	.	ID=PRO_0000084237;Note=Insulin receptor substrate 1	
P35569	UniProtKB	Domain	12	115	.	.	.	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145	
P35569	UniProtKB	Domain	155	259	.	.	.	Note=IRS-type PTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00389	
P35569	UniProtKB	Region	3	133	.	.	.	Note=Mediates interaction with PHIP;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P35569	UniProtKB	Region	257	425	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Region	651	720	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Region	766	985	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Region	891	893	.	.	.	Note=GRB2-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P35569	UniProtKB	Region	1015	1137	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Region	1178	1233	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Motif	460	463	.	.	.	Note=YXXM motif 1	
P35569	UniProtKB	Motif	546	549	.	.	.	Note=YXXM motif 2	
P35569	UniProtKB	Motif	608	611	.	.	.	Note=YXXM motif 3	
P35569	UniProtKB	Motif	628	631	.	.	.	Note=YXXM motif 4	
P35569	UniProtKB	Motif	658	661	.	.	.	Note=YXXM motif 5	
P35569	UniProtKB	Motif	727	730	.	.	.	Note=YXXM motif 6	
P35569	UniProtKB	Motif	935	938	.	.	.	Note=YXXM motif 7	
P35569	UniProtKB	Motif	983	986	.	.	.	Note=YXXM motif 8	
P35569	UniProtKB	Motif	1006	1009	.	.	.	Note=YXXM motif 9	
P35569	UniProtKB	Compositional bias	261	276	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Compositional bias	288	311	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Compositional bias	362	425	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Compositional bias	668	693	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Compositional bias	769	783	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Compositional bias	784	812	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Compositional bias	867	883	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Compositional bias	1029	1056	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Compositional bias	1067	1085	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Compositional bias	1204	1227	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P35569	UniProtKB	Modified residue	3	3	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35570	
P35569	UniProtKB	Modified residue	99	99	.	.	.	Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35570	
P35569	UniProtKB	Modified residue	265	265	.	.	.	Note=Phosphoserine%3B by RPS6KB1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35568	
P35569	UniProtKB	Modified residue	302	302	.	.	.	Note=Phosphoserine%3B by RPS6KB1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35568	
P35569	UniProtKB	Modified residue	307	307	.	.	.	Note=Phosphoserine%3B by IKKB%2C MAPK8 and RPS6KB1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35568	
P35569	UniProtKB	Modified residue	318	318	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35568	
P35569	UniProtKB	Modified residue	325	325	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
P35569	UniProtKB	Modified residue	340	340	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17242355;Dbxref=PMID:17242355	
P35569	UniProtKB	Modified residue	343	343	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35568	
P35569	UniProtKB	Modified residue	414	414	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
P35569	UniProtKB	Modified residue	441	441	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35570	
P35569	UniProtKB	Modified residue	448	448	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35568	
P35569	UniProtKB	Modified residue	460	460	.	.	.	Note=Phosphotyrosine%3B by INSR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35570	
P35569	UniProtKB	Modified residue	522	522	.	.	.	Note=Phosphoserine%3B by RPS6KB1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35568	
P35569	UniProtKB	Modified residue	608	608	.	.	.	Note=Phosphotyrosine%3B by INSR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35570	
P35569	UniProtKB	Modified residue	612	612	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24187137;Dbxref=PMID:24187137	
P35569	UniProtKB	Modified residue	628	628	.	.	.	Note=Phosphotyrosine%3B by INSR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35570	
P35569	UniProtKB	Modified residue	632	632	.	.	.	Note=Phosphoserine%3B by RPS6KB1 and ROCK2;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:16098829;Dbxref=PMID:16098829	
P35569	UniProtKB	Modified residue	658	658	.	.	.	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35568	
P35569	UniProtKB	Modified residue	789	789	.	.	.	Note=Phosphoserine%3B by AMPK and SIK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11598104;Dbxref=PMID:11598104	
P35569	UniProtKB	Modified residue	887	887	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
P35569	UniProtKB	Modified residue	891	891	.	.	.	Note=Phosphotyrosine%3B by INSR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35570	
P35569	UniProtKB	Modified residue	935	935	.	.	.	Note=Phosphotyrosine%3B by INSR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35568	
P35569	UniProtKB	Modified residue	983	983	.	.	.	Note=Phosphotyrosine%3B by INSR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35570	
P35569	UniProtKB	Modified residue	1096	1096	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
P35569	UniProtKB	Modified residue	1097	1097	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17242355,ECO:0007744|PubMed:21183079;Dbxref=PMID:17242355,PMID:21183079	
P35569	UniProtKB	Modified residue	1173	1173	.	.	.	Note=Phosphotyrosine%3B by INSR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35570	
P35569	UniProtKB	Modified residue	1220	1220	.	.	.	Note=Phosphotyrosine%3B by INSR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35570	
P35569	UniProtKB	Sequence conflict	1038	1039	.	.	.	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P35569	UniProtKB	Sequence conflict	1182	1182	.	.	.	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305