P35544 (UBIM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like protein FUBI

Gene names

Name:

FAU

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	74 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	This protein is synthesized with ribosomal S30 as its C-terminal extension.
Sequence similarities	Belongs to the ubiquitin family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 74

74

Ubiquitin-like protein FUBI

PRO_0000114882

Natural variations

Natural variant

53

1

T → I. Ref.5
Corresponds to variant rs13807 [ dbSNP | Ensembl ].

VAR_019644

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

74

Helix Strand Turn

Details...

Beta strand

2 – 14

13

Helix

21 – 32

12

Helix

36 – 38

3

Beta strand

40 – 43

4

Helix

54 – 57

4

Beta strand

64 – 68

5

Sequences

	Sequence		Length	Mass (Da)
	P35544 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 396E67918520D387	FASTA	74	7,760
	10 20 30 40 50 60 MQLFVRAQEL HTFEVTGQET VAQIKAHVAS LEGIAPEDQV VLLAGAPLED EATLGQCGVE 70 ALTTLEVAGR MLGG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein." Kas K., Michiels L., Merregaert J. Biochem. Biophys. Res. Commun. 187:927-933(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus." Michiels L., van der Rauwelaert E., van Hasselt F., Kas K., Merregaert J. Oncogene 8:2537-2546(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	NIEHS SNPs program Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-53.
[6]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[8]	"Solution NMR structure of N-terminal ubiquitin-like domain of FUBI, a ribosomal protein S30 precursor from Homo sapiens. Northeast structural genomics consortium (NESG) target HR6166." Northeast structural genomics consortium (NESG) Submitted (JAN-2011) to the PDB data bank Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X65921 Genomic DNA. Translation: CAA46714.1. Different termination.
X65923 mRNA. Translation: CAA46716.1. Different termination.
AK026639 mRNA. Translation: BAB15515.1. Different termination.
CR541974 mRNA. Translation: CAG46772.1. Different termination.
AY398663 Genomic DNA. Translation: AAQ87877.1. Different termination.
AP003068 Genomic DNA. No translation available.
BC033877 mRNA. Translation: AAH33877.1. Different termination.

IPI

IPI00974363.

PIR

JC1278.

RefSeq

NP_001988.1. NM_001997.4.

UniGene

Hs.387208.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2L7R	NMR	-	A	1-74	[»]

ProteinModelPortal

P35544.

ModBase

Search...

Protein-protein interaction databases

IntAct

P35544. 2 interactions.

MINT

MINT-1217659.

STRING

9606.ENSP00000279259.

Polymorphism databases

DMDM

549147.

Proteomic databases

PaxDb

P35544.

PRIDE

P35544.

Protocols and materials databases

DNASU

2197.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000527548; ENSP00000434440; ENSG00000149806.
ENST00000529639; ENSP00000435370; ENSG00000149806.
ENST00000531743; ENSP00000431822; ENSG00000149806.

GeneID

2197.

KEGG

hsa:2197.

Organism-specific databases

CTD

2197.

GeneCards

GC11M064888.

HGNC

HGNC:3597. FAU.

MIM

134690. gene.

neXtProt

NX_P35544.

PharmGKB

PA28010.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG285974.

HOVERGEN

HBG000057.

InParanoid

P35544.

KO

K02983.

Gene expression databases

ArrayExpress

P35544.

Bgee

P35544.

CleanEx

HS_FAU.

Genevestigator

P35544.

Family and domain databases

InterPro

IPR000626. Ubiquitin.
IPR019954. Ubiquitin_CS.
IPR019956. Ubiquitin_subgr.
IPR019955. Ubiquitin_supergroup.
[Graphical view]

Pfam

PF00240. ubiquitin. 1 hit.
[Graphical view]

PRINTS

PR00348. UBIQUITIN.

SMART

SM00213. UBQ. 1 hit.
[Graphical view]

PROSITE

PS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

FAU. human.

EvolutionaryTrace

P35544.

GenomeRNAi

2197.

NextBio

8881.

SOURCE

Search...

Entry information

Entry name

UBIM_HUMAN

Accession

Primary (citable) accession number: P35544
Secondary accession number(s): Q9H5V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.