Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35544

- UBIM_HUMAN

UniProt

P35544 - UBIM_HUMAN

Protein

Ubiquitin-like protein FUBI

Gene

FAU

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like protein FUBI
    Gene namesi
    Name:FAU
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:3597. FAU.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28010.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7474Ubiquitin-like protein FUBIPRO_0000114882Add
    BLAST

    Proteomic databases

    MaxQBiP35544.
    PaxDbiP35544.
    PRIDEiP35544.

    Expressioni

    Gene expression databases

    BgeeiP35544.
    CleanExiHS_FAU.
    GenevestigatoriP35544.

    Organism-specific databases

    HPAiHPA059015.

    Interactioni

    Protein-protein interaction databases

    BioGridi108491. 54 interactions.
    IntActiP35544. 2 interactions.
    MINTiMINT-1217659.
    STRINGi9606.ENSP00000279259.

    Structurei

    Secondary structure

    1
    74
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 1413
    Helixi21 – 3212
    Helixi36 – 383
    Beta strandi40 – 434
    Helixi54 – 574
    Beta strandi64 – 685

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L7RNMR-A1-74[»]
    ProteinModelPortaliP35544.
    SMRiP35544. Positions 1-74.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP35544.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin family.Curated

    Phylogenomic databases

    eggNOGiNOG285974.
    HOVERGENiHBG000057.
    InParanoidiP35544.
    KOiK02983.
    PhylomeDBiP35544.
    TreeFamiTF313779.

    Family and domain databases

    InterProiIPR019956. Ubiquitin.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR019954. Ubiquitin_CS.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    [Graphical view]
    PRINTSiPR00348. UBIQUITIN.
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS00299. UBIQUITIN_1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35544-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLFVRAQEL HTFEVTGQET VAQIKAHVAS LEGIAPEDQV VLLAGAPLED   50
    EATLGQCGVE ALTTLEVAGR MLGG 74
    Length:74
    Mass (Da):7,760
    Last modified:June 1, 1994 - v1
    Checksum:i396E67918520D387
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531T → I.1 Publication
    Corresponds to variant rs13807 [ dbSNP | Ensembl ].
    VAR_019644

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65921 Genomic DNA. Translation: CAA46714.1. Different termination.
    X65923 mRNA. Translation: CAA46716.1. Different termination.
    AK026639 mRNA. Translation: BAB15515.1. Different termination.
    CR541974 mRNA. Translation: CAG46772.1. Different termination.
    AY398663 Genomic DNA. Translation: AAQ87877.1. Different termination.
    AP003068 Genomic DNA. No translation available.
    BC033877 mRNA. Translation: AAH33877.1. Different termination.
    PIRiJC1278.
    RefSeqiNP_001988.1. NM_001997.4.
    UniGeneiHs.387208.

    Genome annotation databases

    EnsembliENST00000529639; ENSP00000435370; ENSG00000149806.
    ENST00000531743; ENSP00000431822; ENSG00000149806.
    GeneIDi2197.
    KEGGihsa:2197.

    Polymorphism databases

    DMDMi549147.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65921 Genomic DNA. Translation: CAA46714.1 . Different termination.
    X65923 mRNA. Translation: CAA46716.1 . Different termination.
    AK026639 mRNA. Translation: BAB15515.1 . Different termination.
    CR541974 mRNA. Translation: CAG46772.1 . Different termination.
    AY398663 Genomic DNA. Translation: AAQ87877.1 . Different termination.
    AP003068 Genomic DNA. No translation available.
    BC033877 mRNA. Translation: AAH33877.1 . Different termination.
    PIRi JC1278.
    RefSeqi NP_001988.1. NM_001997.4.
    UniGenei Hs.387208.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L7R NMR - A 1-74 [» ]
    ProteinModelPortali P35544.
    SMRi P35544. Positions 1-74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108491. 54 interactions.
    IntActi P35544. 2 interactions.
    MINTi MINT-1217659.
    STRINGi 9606.ENSP00000279259.

    Polymorphism databases

    DMDMi 549147.

    Proteomic databases

    MaxQBi P35544.
    PaxDbi P35544.
    PRIDEi P35544.

    Protocols and materials databases

    DNASUi 2197.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000529639 ; ENSP00000435370 ; ENSG00000149806 .
    ENST00000531743 ; ENSP00000431822 ; ENSG00000149806 .
    GeneIDi 2197.
    KEGGi hsa:2197.

    Organism-specific databases

    CTDi 2197.
    GeneCardsi GC11M064888.
    HGNCi HGNC:3597. FAU.
    HPAi HPA059015.
    MIMi 134690. gene.
    neXtProti NX_P35544.
    PharmGKBi PA28010.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285974.
    HOVERGENi HBG000057.
    InParanoidi P35544.
    KOi K02983.
    PhylomeDBi P35544.
    TreeFami TF313779.

    Miscellaneous databases

    ChiTaRSi FAU. human.
    EvolutionaryTracei P35544.
    GeneWikii FAU_(gene).
    GenomeRNAii 2197.
    NextBioi 8881.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35544.
    CleanExi HS_FAU.
    Genevestigatori P35544.

    Family and domain databases

    InterProi IPR019956. Ubiquitin.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR019954. Ubiquitin_CS.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    PRINTSi PR00348. UBIQUITIN.
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS00299. UBIQUITIN_1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein."
      Kas K., Michiels L., Merregaert J.
      Biochem. Biophys. Res. Commun. 187:927-933(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus."
      Michiels L., van der Rauwelaert E., van Hasselt F., Kas K., Merregaert J.
      Oncogene 8:2537-2546(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. NIEHS SNPs program
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-53.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    8. "Solution NMR structure of N-terminal ubiquitin-like domain of FUBI, a ribosomal protein S30 precursor from Homo sapiens. Northeast structural genomics consortium (NESG) target HR6166."
      Northeast structural genomics consortium (NESG)
      Submitted (JAN-2011) to the PDB data bank
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiUBIM_HUMAN
    AccessioniPrimary (citable) accession number: P35544
    Secondary accession number(s): Q9H5V4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This protein is synthesized with ribosomal S30 as its C-terminal extension.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3