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Protein

Ubiquitin-like protein FUBI

Gene

FAU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein FUBI
Gene namesi
Name:FAU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:3597. FAU.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7474Ubiquitin-like protein FUBIPRO_0000114882Add
BLAST

Proteomic databases

MaxQBiP35544.
PaxDbiP35544.
PRIDEiP35544.

Expressioni

Gene expression databases

BgeeiP35544.
CleanExiHS_FAU.
ExpressionAtlasiP35544. baseline and differential.
GenevestigatoriP35544.

Interactioni

Protein-protein interaction databases

BioGridi108491. 54 interactions.
IntActiP35544. 2 interactions.
MINTiMINT-1217659.
STRINGi9606.ENSP00000279259.

Structurei

Secondary structure

1
74
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1413Combined sources
Helixi21 – 3212Combined sources
Helixi36 – 383Combined sources
Beta strandi40 – 434Combined sources
Helixi54 – 574Combined sources
Beta strandi64 – 685Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L7RNMR-A1-74[»]
ProteinModelPortaliP35544.
SMRiP35544. Positions 1-74.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35544.

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin family.Curated

Phylogenomic databases

eggNOGiNOG285974.
HOVERGENiHBG000057.
InParanoidiP35544.
KOiK02983.
PhylomeDBiP35544.
TreeFamiTF313779.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLFVRAQEL HTFEVTGQET VAQIKAHVAS LEGIAPEDQV VLLAGAPLED
60 70
EATLGQCGVE ALTTLEVAGR MLGG
Length:74
Mass (Da):7,760
Last modified:June 1, 1994 - v1
Checksum:i396E67918520D387
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531T → I.1 Publication
Corresponds to variant rs13807 [ dbSNP | Ensembl ].
VAR_019644

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65921 Genomic DNA. Translation: CAA46714.1. Different termination.
X65923 mRNA. Translation: CAA46716.1. Different termination.
AK026639 mRNA. Translation: BAB15515.1. Different termination.
CR541974 mRNA. Translation: CAG46772.1. Different termination.
AY398663 Genomic DNA. Translation: AAQ87877.1. Different termination.
AP003068 Genomic DNA. No translation available.
BC033877 mRNA. Translation: AAH33877.1. Different termination.
PIRiJC1278.
RefSeqiNP_001988.1. NM_001997.4.
UniGeneiHs.387208.

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806.
ENST00000529639; ENSP00000435370; ENSG00000149806.
ENST00000531743; ENSP00000431822; ENSG00000149806.
GeneIDi2197.
KEGGihsa:2197.

Polymorphism databases

DMDMi549147.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65921 Genomic DNA. Translation: CAA46714.1. Different termination.
X65923 mRNA. Translation: CAA46716.1. Different termination.
AK026639 mRNA. Translation: BAB15515.1. Different termination.
CR541974 mRNA. Translation: CAG46772.1. Different termination.
AY398663 Genomic DNA. Translation: AAQ87877.1. Different termination.
AP003068 Genomic DNA. No translation available.
BC033877 mRNA. Translation: AAH33877.1. Different termination.
PIRiJC1278.
RefSeqiNP_001988.1. NM_001997.4.
UniGeneiHs.387208.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L7RNMR-A1-74[»]
ProteinModelPortaliP35544.
SMRiP35544. Positions 1-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108491. 54 interactions.
IntActiP35544. 2 interactions.
MINTiMINT-1217659.
STRINGi9606.ENSP00000279259.

Polymorphism databases

DMDMi549147.

Proteomic databases

MaxQBiP35544.
PaxDbiP35544.
PRIDEiP35544.

Protocols and materials databases

DNASUi2197.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806.
ENST00000529639; ENSP00000435370; ENSG00000149806.
ENST00000531743; ENSP00000431822; ENSG00000149806.
GeneIDi2197.
KEGGihsa:2197.

Organism-specific databases

CTDi2197.
GeneCardsiGC11M064888.
HGNCiHGNC:3597. FAU.
MIMi134690. gene.
neXtProtiNX_P35544.
PharmGKBiPA28010.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG285974.
HOVERGENiHBG000057.
InParanoidiP35544.
KOiK02983.
PhylomeDBiP35544.
TreeFamiTF313779.

Miscellaneous databases

ChiTaRSiFAU. human.
EvolutionaryTraceiP35544.
GeneWikiiFAU_(gene).
GenomeRNAii2197.
NextBioi8881.
SOURCEiSearch...

Gene expression databases

BgeeiP35544.
CleanExiHS_FAU.
ExpressionAtlasiP35544. baseline and differential.
GenevestigatoriP35544.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein."
    Kas K., Michiels L., Merregaert J.
    Biochem. Biophys. Res. Commun. 187:927-933(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus."
    Michiels L., van der Rauwelaert E., van Hasselt F., Kas K., Merregaert J.
    Oncogene 8:2537-2546(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. NIEHS SNPs program
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-53.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  8. "Solution NMR structure of N-terminal ubiquitin-like domain of FUBI, a ribosomal protein S30 precursor from Homo sapiens. Northeast structural genomics consortium (NESG) target HR6166."
    Northeast structural genomics consortium (NESG)
    Submitted (JAN-2011) to the PDB data bank
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiUBIM_HUMAN
AccessioniPrimary (citable) accession number: P35544
Secondary accession number(s): Q9H5V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 4, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is synthesized with ribosomal S30 as its C-terminal extension.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.