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Protein

Ubiquitin-like protein FUBI

Gene

FAU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein FUBI
Gene namesi
Name:FAU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3597. FAU.

Pathology & Biotechi

Organism-specific databases

DisGeNETi2197.
PharmGKBiPA28010.

Polymorphism and mutation databases

BioMutaiZNHIT2.
DMDMi549147.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001148821 – 74Ubiquitin-like protein FUBIAdd BLAST74

Proteomic databases

EPDiP35544.
MaxQBiP35544.
PaxDbiP35544.
PeptideAtlasiP35544.
PRIDEiP35544.

Expressioni

Gene expression databases

BgeeiENSG00000149806.
CleanExiHS_FAU.
ExpressionAtlasiP35544. baseline and differential.
GenevisibleiP35544. HS.

Interactioni

Protein-protein interaction databases

BioGridi108491. 64 interactors.
IntActiP35544. 2 interactors.
MINTiMINT-1217659.
STRINGi9606.ENSP00000431822.

Structurei

Secondary structure

174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 14Combined sources13
Helixi21 – 32Combined sources12
Helixi36 – 38Combined sources3
Beta strandi40 – 43Combined sources4
Helixi54 – 57Combined sources4
Beta strandi64 – 68Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L7RNMR-A1-74[»]
ProteinModelPortaliP35544.
SMRiP35544.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35544.

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin family.Curated

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
KOG0009. Eukaryota.
ENOG41123KC. LUCA.
HOVERGENiHBG000057.
InParanoidiP35544.
KOiK02983.
OrthoDBiEOG091G0X8P.
PhylomeDBiP35544.
TreeFamiTF313779.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLFVRAQEL HTFEVTGQET VAQIKAHVAS LEGIAPEDQV VLLAGAPLED
60 70
EATLGQCGVE ALTTLEVAGR MLGG
Length:74
Mass (Da):7,760
Last modified:June 1, 1994 - v1
Checksum:i396E67918520D387
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01964453T → I.1 PublicationCorresponds to variant rs13807dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65921 Genomic DNA. Translation: CAA46714.1. Different termination.
X65923 mRNA. Translation: CAA46716.1. Different termination.
AK026639 mRNA. Translation: BAB15515.1. Different termination.
CR541974 mRNA. Translation: CAG46772.1. Different termination.
AY398663 Genomic DNA. Translation: AAQ87877.1. Different termination.
AP003068 Genomic DNA. No translation available.
BC033877 mRNA. Translation: AAH33877.1. Different termination.
PIRiJC1278.
RefSeqiNP_001988.1. NM_001997.4.
UniGeneiHs.387208.

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806.
ENST00000529639; ENSP00000435370; ENSG00000149806.
ENST00000531743; ENSP00000431822; ENSG00000149806.
GeneIDi2197.
KEGGihsa:2197.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65921 Genomic DNA. Translation: CAA46714.1. Different termination.
X65923 mRNA. Translation: CAA46716.1. Different termination.
AK026639 mRNA. Translation: BAB15515.1. Different termination.
CR541974 mRNA. Translation: CAG46772.1. Different termination.
AY398663 Genomic DNA. Translation: AAQ87877.1. Different termination.
AP003068 Genomic DNA. No translation available.
BC033877 mRNA. Translation: AAH33877.1. Different termination.
PIRiJC1278.
RefSeqiNP_001988.1. NM_001997.4.
UniGeneiHs.387208.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L7RNMR-A1-74[»]
ProteinModelPortaliP35544.
SMRiP35544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108491. 64 interactors.
IntActiP35544. 2 interactors.
MINTiMINT-1217659.
STRINGi9606.ENSP00000431822.

Polymorphism and mutation databases

BioMutaiZNHIT2.
DMDMi549147.

Proteomic databases

EPDiP35544.
MaxQBiP35544.
PaxDbiP35544.
PeptideAtlasiP35544.
PRIDEiP35544.

Protocols and materials databases

DNASUi2197.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806.
ENST00000529639; ENSP00000435370; ENSG00000149806.
ENST00000531743; ENSP00000431822; ENSG00000149806.
GeneIDi2197.
KEGGihsa:2197.

Organism-specific databases

CTDi2197.
DisGeNETi2197.
GeneCardsiFAU.
HGNCiHGNC:3597. FAU.
MIMi134690. gene.
neXtProtiNX_P35544.
PharmGKBiPA28010.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
KOG0009. Eukaryota.
ENOG41123KC. LUCA.
HOVERGENiHBG000057.
InParanoidiP35544.
KOiK02983.
OrthoDBiEOG091G0X8P.
PhylomeDBiP35544.
TreeFamiTF313779.

Miscellaneous databases

ChiTaRSiFAU. human.
EvolutionaryTraceiP35544.
GeneWikiiFAU_(gene).
GenomeRNAii2197.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149806.
CleanExiHS_FAU.
ExpressionAtlasiP35544. baseline and differential.
GenevisibleiP35544. HS.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBIM_HUMAN
AccessioniPrimary (citable) accession number: P35544
Secondary accession number(s): Q9H5V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is synthesized with ribosomal S30 as its C-terminal extension.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.