Reviewed,
UniProtKB/Swiss-Prot P35542 (SAA4_HUMAN)
Last modified
January 19, 2010.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Serum amyloid A-4 protein Alternative name(s): Constitutively expressed serum amyloid A protein Short name=C-SAA | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 130 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Major acute phase reactant. Apolipoprotein of the HDL complex. |
| Subcellular location | |
| Tissue specificity | Expressed by the liver; secreted in plasma. |
| Induction | Constitutively expressed. |
| Sequence similarities | Belongs to the SAA family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Acute phase |
| Cellular component | HDL Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| PTM | Glycoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | acute-phase response Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | high-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | |||||||
| Chain | 19 – 130 | 112 | Serum amyloid A-4 protein | PRO_0000031583 | |||||
Amino acid modifications | |||||||||
| Glycosylation | 94 | 1 | N-linked (GlcNAc...); partial Ref.8 Ref.9 Ref.1 | ||||||
Natural variations | |||||||||
| Natural variant | 89 | 1 | Y → C: dbSNP rs2460827. | VAR_051893 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein." Whitehead A.S., Debeer M.C., Steel D.M., Rits M., Lelias J.M., Lane W.S., Debeer F.C. J. Biol. Chem. 267:3862-3867(1992) [PubMed: 1740433] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver. |
| [2] | "A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)." Steel D.M., Sellar G.C., Uhlar C.M., Simon S., Debeer F.C., Whitehead A.S. Genomics 16:447-454(1993) [PubMed: 7686132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4." Watson G., Coade S., Woo P. Scand. J. Immunol. 36:703-712(1992) [PubMed: 1439582] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver. |
| [7] | "Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry." Ducret A., Bruun C.F., Bures E.J., Marhaug G., Husby G., Aebersold R. Electrophoresis 17:866-876(1996) [PubMed: 8783012] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. |
| [8] | "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94, MASS SPECTROMETRY. Tissue: Plasma. |
| [9] | "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94, MASS SPECTROMETRY. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | S48983, S48980, S48981 Genomic DNA. Translation: AAB24060.1. L05920 Genomic DNA. No translation available. M81349 mRNA. Translation: AAA60298.1. CR541758 mRNA. Translation: CAG46558.1. CH471064 Genomic DNA. Translation: EAW68415.1. BC007026 mRNA. Translation: AAH07026.1. |
| IPI | IPI00019399. |
| PIR | A38974. |
| RefSeq | NP_006503.1. |
| UniGene | Hs.654493 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P35542. 2 interactions. |
| STRING | P35542. |
Proteomic databases | |
| PeptideAtlas | P35542. |
| PRIDE | P35542. |
Genome annotation databases | |
| Ensembl | ENST00000278222; ENSP00000278222; ENSG00000148965; Homo sapiens. [Genome view] |
| GeneID | 6291. |
| KEGG | hsa:6291. |
| UCSC | uc001mny.1. human. |
Organism-specific databases | |
| CTD | 6291. |
| GeneCards | GC11M018209. |
| H-InvDB | HIX0009482. |
| HGNC | HGNC:10516. SAA4. |
| HPA | CAB026061. |
| MIM | 104752. gene. |
| PharmGKB | PA34924. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG19977. |
| HOGENOM | HBG261240. |
| HOVERGEN | P35542. |
| InParanoid | P35542. |
Gene expression databases | |
| ArrayExpress | P35542. |
| Bgee | P35542. |
| CleanEx | HS_SAA4. |
| Genevestigator | P35542. |
| GermOnline | ENSG00000148965. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000096. Serum_amyloid_A. [Graphical view] |
| PANTHER | PTHR23424. Serum_amyloid_A. 1 hit. |
| Pfam | PF00277. SAA. 1 hit. [Graphical view] |
| PIRSF | PIRSF002472. Serum_amyloid_A. 1 hit. |
| PRINTS | PR00306. SERUMAMYLOID. |
| SMART | SM00197. SAA. 1 hit. [Graphical view] |
| PROSITE | PS00992. SAA. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 24427. |
| SOURCE | Search... |
Entry information
| Entry name | SAA4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P35542 Secondary accession number(s): Q6FHJ4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


