Reviewed, UniProtKB/Swiss-Prot P35542 (SAA4_HUMAN)

Names and origin

Protein names

Recommended name:
    Serum amyloid A-4 protein
Alternative name(s):
    Constitutively expressed serum amyloid A protein
      Short name=C-SAA

Gene names

Name:	SAA4
Synonyms:	CSAA

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Major acute phase reactant. Apolipoprotein of the HDL complex.
Subcellular location	Secreted.
Tissue specificity	Expressed by the liver; secreted in plasma.
Induction	Constitutively expressed.
Sequence similarities	Belongs to the SAA family.

Ontologies

Keywords
Biological process	Acute phase
Cellular component	HDL Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	acute-phase response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	high-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18
	Chain	19 – 130	112	Serum amyloid A-4 protein		PRO_0000031583
Amino acid modifications
	Glycosylation	94	1	N-linked (GlcNAc...); partial Ref.8 Ref.9 Ref.1
Natural variations
	Natural variant	89	1	Y → C: dbSNP rs2460827.		VAR_051893

Sequences

	Sequence		Length	Mass (Da)
	P35542-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 0F86E9F91EF00B1C	FASTA	130	14,807
	10 20 30 40 50 60 MRLFTGIVFC SLVMGVTSES WRSFFKEALQ GVGDMGRAYW DIMISNHQNS NRYLYARGNY 70 80 90 100 110 120 DAAQRGPGGV WAAKLISRSR VYLQGLIDYY LFGNSSTVLE DSKSNEKAEE WGRSGKDPDR 130 FRPDGLPKKY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein." Whitehead A.S., Debeer M.C., Steel D.M., Rits M., Lelias J.M., Lane W.S., Debeer F.C. J. Biol. Chem. 267:3862-3867(1992) [PubMed: 1740433] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	"A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)." Steel D.M., Sellar G.C., Uhlar C.M., Simon S., Debeer F.C., Whitehead A.S. Genomics 16:447-454(1993) [PubMed: 7686132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4." Watson G., Coade S., Woo P. Scand. J. Immunol. 36:703-712(1992) [PubMed: 1439582] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[7]	"Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry." Ducret A., Bruun C.F., Bures E.J., Marhaug G., Husby G., Aebersold R. Electrophoresis 17:866-876(1996) [PubMed: 8783012] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
[8]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94, MASS SPECTROMETRY. Tissue: Plasma.
[9]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S48983, S48980, S48981 Genomic DNA. Translation: AAB24060.1. L05920 Genomic DNA. No translation available. M81349 mRNA. Translation: AAA60298.1. CR541758 mRNA. Translation: CAG46558.1. CH471064 Genomic DNA. Translation: EAW68415.1. BC007026 mRNA. Translation: AAH07026.1.
IPI	IPI00019399.
PIR	A38974.
RefSeq	NP_006503.1.
UniGene	Hs.654493
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P35542. 2 interactions.
STRING	P35542.
Proteomic databases
PeptideAtlas	P35542.
PRIDE	P35542.
Genome annotation databases
Ensembl	ENST00000278222; ENSP00000278222; ENSG00000148965; Homo sapiens. [Genome view]
GeneID	6291.
KEGG	hsa:6291.
UCSC	uc001mny.1. human.
Organism-specific databases
CTD	6291.
GeneCards	GC11M018209.
H-InvDB	HIX0009482.
HGNC	HGNC:10516. SAA4.
HPA	CAB026061.
MIM	104752. gene.
PharmGKB	PA34924.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19977.
HOGENOM	HBG261240.
HOVERGEN	P35542.
InParanoid	P35542.
Gene expression databases
ArrayExpress	P35542.
Bgee	P35542.
CleanEx	HS_SAA4.
Genevestigator	P35542.
GermOnline	ENSG00000148965. Homo sapiens.
Family and domain databases
InterPro	IPR000096. Serum_amyloid_A. [Graphical view]
PANTHER	PTHR23424. Serum_amyloid_A. 1 hit.
Pfam	PF00277. SAA. 1 hit. [Graphical view]
PIRSF	PIRSF002472. Serum_amyloid_A. 1 hit.
PRINTS	PR00306. SERUMAMYLOID.
SMART	SM00197. SAA. 1 hit. [Graphical view]
PROSITE	PS00992. SAA. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	24427.
SOURCE	Search...

Entry information

Entry name

SAA4_HUMAN

Accession

Primary (citable) accession number: P35542
Secondary accession number(s): Q6FHJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	January 19, 2010
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.