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Protein

Serum amyloid A-4 protein

Gene

SAA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Molecular functioni

  1. chemoattractant activity Source: GO_Central

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. cell chemotaxis Source: GO_Central
  3. positive chemotaxis Source: GOC
Complete GO annotation...

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-4 protein
Alternative name(s):
Constitutively expressed serum amyloid A protein
Short name:
C-SAA
Gene namesi
Name:SAA4
Synonyms:CSAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:10516. SAA4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: GO_Central
  3. extracellular vesicular exosome Source: UniProtKB
  4. high-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34924.

Polymorphism and mutation databases

BioMutaiSAA4.
DMDMi296452894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 130112Serum amyloid A-4 proteinPRO_0000031583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...); partial3 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35542.
PeptideAtlasiP35542.
PRIDEiP35542.

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Constitutively expressed.

Gene expression databases

BgeeiP35542.
CleanExiHS_SAA4.
GenevestigatoriP35542.

Organism-specific databases

HPAiCAB026061.
HPA060139.

Interactioni

Protein-protein interaction databases

BioGridi112199. 1 interaction.
IntActiP35542. 1 interaction.
MINTiMINT-1445365.
STRINGi9606.ENSP00000278222.

Structurei

3D structure databases

ProteinModelPortaliP35542.
SMRiP35542. Positions 21-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46739.
GeneTreeiENSGT00390000004737.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP35542.
KOiK17310.
OMAiFCSLVMG.
OrthoDBiEOG7QVM4V.
PhylomeDBiP35542.
TreeFamiTF332544.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFTGIVFC SLVMGVTSES WRSFFKEALQ GVGDMGRAYW DIMISNHQNS
60 70 80 90 100
NRYLYARGNY DAAQRGPGGV WAAKLISRSR VYLQGLIDCY LFGNSSTVLE
110 120 130
DSKSNEKAEE WGRSGKDPDR FRPDGLPKKY
Length:130
Mass (Da):14,747
Last modified:May 18, 2010 - v2
Checksum:i0F9BD50ACCF00B1C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891C → Y Polymorphism confirmed at protein level. 7 Publications
Corresponds to variant rs2460827 [ dbSNP | Ensembl ].
VAR_051893

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05920 Genomic DNA. No translation available.
M81349 mRNA. Translation: AAA60298.1.
S48983, S48980, S48981 Genomic DNA. Translation: AAB24060.1.
CR541758 mRNA. Translation: CAG46558.1.
AC090099 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68415.1.
BC007026 mRNA. Translation: AAH07026.1.
CCDSiCCDS7832.1.
PIRiA38974.
RefSeqiNP_006503.2. NM_006512.3.
UniGeneiHs.1955.

Genome annotation databases

EnsembliENST00000278222; ENSP00000278222; ENSG00000148965.
GeneIDi6291.
KEGGihsa:6291.
UCSCiuc001mny.3. human.

Polymorphism and mutation databases

BioMutaiSAA4.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05920 Genomic DNA. No translation available.
M81349 mRNA. Translation: AAA60298.1.
S48983, S48980, S48981 Genomic DNA. Translation: AAB24060.1.
CR541758 mRNA. Translation: CAG46558.1.
AC090099 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68415.1.
BC007026 mRNA. Translation: AAH07026.1.
CCDSiCCDS7832.1.
PIRiA38974.
RefSeqiNP_006503.2. NM_006512.3.
UniGeneiHs.1955.

3D structure databases

ProteinModelPortaliP35542.
SMRiP35542. Positions 21-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112199. 1 interaction.
IntActiP35542. 1 interaction.
MINTiMINT-1445365.
STRINGi9606.ENSP00000278222.

Polymorphism and mutation databases

BioMutaiSAA4.
DMDMi296452894.

Proteomic databases

PaxDbiP35542.
PeptideAtlasiP35542.
PRIDEiP35542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278222; ENSP00000278222; ENSG00000148965.
GeneIDi6291.
KEGGihsa:6291.
UCSCiuc001mny.3. human.

Organism-specific databases

CTDi6291.
GeneCardsiGC11M018252.
HGNCiHGNC:10516. SAA4.
HPAiCAB026061.
HPA060139.
MIMi104752. gene.
neXtProtiNX_P35542.
PharmGKBiPA34924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46739.
GeneTreeiENSGT00390000004737.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP35542.
KOiK17310.
OMAiFCSLVMG.
OrthoDBiEOG7QVM4V.
PhylomeDBiP35542.
TreeFamiTF332544.

Miscellaneous databases

GenomeRNAii6291.
NextBioi24427.
PROiP35542.
SOURCEiSearch...

Gene expression databases

BgeeiP35542.
CleanExiHS_SAA4.
GenevestigatoriP35542.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein."
    Whitehead A.S., Debeer M.C., Steel D.M., Rits M., Lelias J.M., Lane W.S., Debeer F.C.
    J. Biol. Chem. 267:3862-3867(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
    Tissue: Liver.
  2. "A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)."
    Steel D.M., Sellar G.C., Uhlar C.M., Simon S., Debeer F.C., Whitehead A.S.
    Genomics 16:447-454(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
  3. "Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4."
    Watson G., Coade S., Woo P.
    Scand. J. Immunol. 36:703-712(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-89.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TYR-89.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-89.
    Tissue: Liver.
  8. "Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry."
    Ducret A., Bruun C.F., Bures E.J., Marhaug G., Husby G., Aebersold R.
    Electrophoresis 17:866-876(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94.
    Tissue: Plasma.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94.
    Tissue: Liver.
  11. "Quantitative detection of single amino acid polymorphisms by targeted proteomics."
    Su Z.D., Sun L., Yu D.X., Li R.X., Li H.X., Yu Z.J., Sheng Q.H., Lin X., Zeng R., Wu J.R.
    J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TYR-89, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSAA4_HUMAN
AccessioniPrimary (citable) accession number: P35542
Secondary accession number(s): Q6FHJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 18, 2010
Last modified: April 29, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.