P35542 (SAA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serum amyloid A-4 protein

Alternative name(s):
Constitutively expressed serum amyloid A protein
Short name=C-SAA

Gene names

Name:	SAA4
Synonyms:	CSAA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Major acute phase reactant. Apolipoprotein of the HDL complex.
Subcellular location	Secreted.
Tissue specificity	Expressed by the liver; secreted in plasma.
Induction	Constitutively expressed.
Sequence similarities	Belongs to the SAA family.

Ontologies

Keywords
Biological process	Acute phase
Cellular component	HDL Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	acute-phase response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Non-traceable author statement PubMed 14718574. Source: UniProtKB high-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18
	Chain	19 – 130	112	Serum amyloid A-4 protein		PRO_0000031583
Amino acid modifications
	Glycosylation	94	1	N-linked (GlcNAc...); partial Ref.1 Ref.9 Ref.10
Natural variations
	Natural variant	89	1	C → Y Polymorphism confirmed at protein level. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Ref.7 Ref.12 Corresponds to variant rs2460827 [ dbSNP | Ensembl ].		VAR_051893

Sequences

	Sequence		Length	Mass (Da)
	P35542 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 0F9BD50ACCF00B1C	FASTA	130	14,747
	10 20 30 40 50 60 MRLFTGIVFC SLVMGVTSES WRSFFKEALQ GVGDMGRAYW DIMISNHQNS NRYLYARGNY 70 80 90 100 110 120 DAAQRGPGGV WAAKLISRSR VYLQGLIDCY LFGNSSTVLE DSKSNEKAEE WGRSGKDPDR 130 FRPDGLPKKY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein." Whitehead A.S., Debeer M.C., Steel D.M., Rits M., Lelias J.M., Lane W.S., Debeer F.C. J. Biol. Chem. 267:3862-3867(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89. Tissue: Liver.
[2]	"A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)." Steel D.M., Sellar G.C., Uhlar C.M., Simon S., Debeer F.C., Whitehead A.S. Genomics 16:447-454(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
[3]	"Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4." Watson G., Coade S., Woo P. Scand. J. Immunol. 36:703-712(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-89.
[5]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TYR-89.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-89. Tissue: Liver.
[8]	"Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry." Ducret A., Bruun C.F., Bures E.J., Marhaug G., Husby G., Aebersold R. Electrophoresis 17:866-876(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
[9]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94, MASS SPECTROMETRY. Tissue: Plasma.
[10]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94, MASS SPECTROMETRY. Tissue: Liver.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Quantitative detection of single amino acid polymorphisms by targeted proteomics." Su Z.D., Sun L., Yu D.X., Li R.X., Li H.X., Yu Z.J., Sheng Q.H., Lin X., Zeng R., Wu J.R. J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT TYR-89, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L05920 Genomic DNA. No translation available. M81349 mRNA. Translation: AAA60298.1. S48983, S48980, S48981 Genomic DNA. Translation: AAB24060.1. CR541758 mRNA. Translation: CAG46558.1. AC090099 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW68415.1. BC007026 mRNA. Translation: AAH07026.1.
IPI	IPI00019399.
PIR	A38974.
RefSeq	NP_006503.2. NM_006512.3.
UniGene	Hs.1955.
3D structure databases
ProteinModelPortal	P35542.
ModBase	Search...
Protein-protein interaction databases
IntAct	P35542. 1 interaction.
MINT	MINT-1445365.
STRING	9606.ENSP00000278222.
Polymorphism databases
DMDM	296452894.
Proteomic databases
PaxDb	P35542.
PeptideAtlas	P35542.
PRIDE	P35542.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278222; ENSP00000278222; ENSG00000148965.
GeneID	6291.
KEGG	hsa:6291.
UCSC	uc001mny.3. human.
Organism-specific databases
CTD	6291.
GeneCards	GC11M018252.
HGNC	HGNC:10516. SAA4.
HPA	CAB026061.
MIM	104752. gene.
neXtProt	NX_P35542.
PharmGKB	PA34924.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46739.
HOGENOM	HOG000126881.
HOVERGEN	HBG016327.
InParanoid	P35542.
OMA	NEKAEEW.
OrthoDB	EOG4FR0SZ.
PhylomeDB	P35542.
Gene expression databases
Bgee	P35542.
CleanEx	HS_SAA4.
Genevestigator	P35542.
GermOnline	ENSG00000148965. Homo sapiens.
Family and domain databases
InterPro	IPR000096. Serum_amyloid_A. [Graphical view]
PANTHER	PTHR23424. PTHR23424. 1 hit.
Pfam	PF00277. SAA. 1 hit. [Graphical view]
PIRSF	PIRSF002472. Serum_amyloid_A. 1 hit.
PRINTS	PR00306. SERUMAMYLOID.
SMART	SM00197. SAA. 1 hit. [Graphical view]
PROSITE	PS00992. SAA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6291.
NextBio	24427.
SOURCE	Search...

Entry information

Entry name

SAA4_HUMAN

Accession

Primary (citable) accession number: P35542
Secondary accession number(s): Q6FHJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.