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P35542 (SAA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serum amyloid A-4 protein
Alternative name(s):
Constitutively expressed serum amyloid A protein
Short name=C-SAA
Gene names
Name:SAA4
Synonyms:CSAA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Major acute phase reactant. Apolipoprotein of the HDL complex.

Subcellular location

Secreted.

Tissue specificity

Expressed by the liver; secreted in plasma.

Induction

Constitutively expressed.

Sequence similarities

Belongs to the SAA family.

Ontologies

Keywords
   Biological processAcute phase
   Cellular componentHDL
Secreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processacute-phase response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Non-traceable author statement PubMed 14718574. Source: UniProtKB

high-density lipoprotein particle

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 130112Serum amyloid A-4 protein
PRO_0000031583

Amino acid modifications

Glycosylation941N-linked (GlcNAc...); partial Ref.1 Ref.9 Ref.10

Natural variations

Natural variant891C → Y Polymorphism confirmed at protein level. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Ref.7 Ref.12
Corresponds to variant rs2460827 [ dbSNP | Ensembl ].
VAR_051893

Sequences

Sequence LengthMass (Da)Tools
P35542 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 0F9BD50ACCF00B1C

FASTA13014,747
        10         20         30         40         50         60 
MRLFTGIVFC SLVMGVTSES WRSFFKEALQ GVGDMGRAYW DIMISNHQNS NRYLYARGNY 

        70         80         90        100        110        120 
DAAQRGPGGV WAAKLISRSR VYLQGLIDCY LFGNSSTVLE DSKSNEKAEE WGRSGKDPDR 

       130 
FRPDGLPKKY 

« Hide

References

« Hide 'large scale' references
[1]"Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein."
Whitehead A.S., Debeer M.C., Steel D.M., Rits M., Lelias J.M., Lane W.S., Debeer F.C.
J. Biol. Chem. 267:3862-3867(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
Tissue: Liver.
[2]"A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)."
Steel D.M., Sellar G.C., Uhlar C.M., Simon S., Debeer F.C., Whitehead A.S.
Genomics 16:447-454(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
[3]"Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4."
Watson G., Coade S., Woo P.
Scand. J. Immunol. 36:703-712(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-89.
[5]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TYR-89.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-89.
Tissue: Liver.
[8]"Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry."
Ducret A., Bruun C.F., Bures E.J., Marhaug G., Husby G., Aebersold R.
Electrophoresis 17:866-876(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
[9]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94.
Tissue: Plasma.
[10]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94.
Tissue: Liver.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Quantitative detection of single amino acid polymorphisms by targeted proteomics."
Su Z.D., Sun L., Yu D.X., Li R.X., Li H.X., Yu Z.J., Sheng Q.H., Lin X., Zeng R., Wu J.R.
J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT TYR-89, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05920 Genomic DNA. No translation available.
M81349 mRNA. Translation: AAA60298.1.
S48983, S48980, S48981 Genomic DNA. Translation: AAB24060.1.
CR541758 mRNA. Translation: CAG46558.1.
AC090099 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68415.1.
BC007026 mRNA. Translation: AAH07026.1.
CCDSCCDS7832.1.
PIRA38974.
RefSeqNP_006503.2. NM_006512.3.
UniGeneHs.1955.

3D structure databases

ProteinModelPortalP35542.
SMRP35542. Positions 20-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112199. 1 interaction.
IntActP35542. 1 interaction.
MINTMINT-1445365.
STRING9606.ENSP00000278222.

Polymorphism databases

DMDM296452894.

Proteomic databases

PaxDbP35542.
PeptideAtlasP35542.
PRIDEP35542.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278222; ENSP00000278222; ENSG00000148965.
GeneID6291.
KEGGhsa:6291.
UCSCuc001mny.3. human.

Organism-specific databases

CTD6291.
GeneCardsGC11M018252.
HGNCHGNC:10516. SAA4.
HPACAB026061.
HPA059444.
HPA060139.
MIM104752. gene.
neXtProtNX_P35542.
PharmGKBPA34924.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46739.
HOGENOMHOG000126881.
HOVERGENHBG016327.
InParanoidP35542.
KOK17310.
OMAFCSLVMG.
OrthoDBEOG7QVM4V.
PhylomeDBP35542.
TreeFamTF332544.

Gene expression databases

BgeeP35542.
CleanExHS_SAA4.
GenevestigatorP35542.

Family and domain databases

InterProIPR000096. Serum_amyloid_A.
[Graphical view]
PfamPF00277. SAA. 1 hit.
[Graphical view]
PIRSFPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSPR00306. SERUMAMYLOID.
SMARTSM00197. SAA. 1 hit.
[Graphical view]
PROSITEPS00992. SAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi6291.
NextBio24427.
PROP35542.
SOURCESearch...

Entry information

Entry nameSAA4_HUMAN
AccessionPrimary (citable) accession number: P35542
Secondary accession number(s): Q6FHJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM