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P35542

- SAA4_HUMAN

UniProt

P35542 - SAA4_HUMAN

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Protein

Serum amyloid A-4 protein

Gene

SAA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-4 protein
Alternative name(s):
Constitutively expressed serum amyloid A protein
Short name:
C-SAA
Gene namesi
Name:SAA4
Synonyms:CSAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:10516. SAA4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
  3. high-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 130112Serum amyloid A-4 proteinPRO_0000031583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...); partial3 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35542.
PeptideAtlasiP35542.
PRIDEiP35542.

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Constitutively expressed.

Gene expression databases

BgeeiP35542.
CleanExiHS_SAA4.
GenevestigatoriP35542.

Organism-specific databases

HPAiCAB026061.
HPA059444.
HPA060139.

Interactioni

Protein-protein interaction databases

BioGridi112199. 1 interaction.
IntActiP35542. 1 interaction.
MINTiMINT-1445365.
STRINGi9606.ENSP00000278222.

Structurei

3D structure databases

ProteinModelPortaliP35542.
SMRiP35542. Positions 21-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46739.
GeneTreeiENSGT00390000004737.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP35542.
KOiK17310.
OMAiFCSLVMG.
OrthoDBiEOG7QVM4V.
PhylomeDBiP35542.
TreeFamiTF332544.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35542-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLFTGIVFC SLVMGVTSES WRSFFKEALQ GVGDMGRAYW DIMISNHQNS
60 70 80 90 100
NRYLYARGNY DAAQRGPGGV WAAKLISRSR VYLQGLIDCY LFGNSSTVLE
110 120 130
DSKSNEKAEE WGRSGKDPDR FRPDGLPKKY
Length:130
Mass (Da):14,747
Last modified:May 18, 2010 - v2
Checksum:i0F9BD50ACCF00B1C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891C → Y Polymorphism confirmed at protein level. 7 Publications
Corresponds to variant rs2460827 [ dbSNP | Ensembl ].
VAR_051893

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05920 Genomic DNA. No translation available.
M81349 mRNA. Translation: AAA60298.1.
S48983, S48980, S48981 Genomic DNA. Translation: AAB24060.1.
CR541758 mRNA. Translation: CAG46558.1.
AC090099 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68415.1.
BC007026 mRNA. Translation: AAH07026.1.
CCDSiCCDS7832.1.
PIRiA38974.
RefSeqiNP_006503.2. NM_006512.3.
UniGeneiHs.1955.

Genome annotation databases

EnsembliENST00000278222; ENSP00000278222; ENSG00000148965.
GeneIDi6291.
KEGGihsa:6291.
UCSCiuc001mny.3. human.

Polymorphism databases

DMDMi296452894.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05920 Genomic DNA. No translation available.
M81349 mRNA. Translation: AAA60298.1 .
S48983 , S48980 , S48981 Genomic DNA. Translation: AAB24060.1 .
CR541758 mRNA. Translation: CAG46558.1 .
AC090099 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68415.1 .
BC007026 mRNA. Translation: AAH07026.1 .
CCDSi CCDS7832.1.
PIRi A38974.
RefSeqi NP_006503.2. NM_006512.3.
UniGenei Hs.1955.

3D structure databases

ProteinModelPortali P35542.
SMRi P35542. Positions 21-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112199. 1 interaction.
IntActi P35542. 1 interaction.
MINTi MINT-1445365.
STRINGi 9606.ENSP00000278222.

Polymorphism databases

DMDMi 296452894.

Proteomic databases

PaxDbi P35542.
PeptideAtlasi P35542.
PRIDEi P35542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278222 ; ENSP00000278222 ; ENSG00000148965 .
GeneIDi 6291.
KEGGi hsa:6291.
UCSCi uc001mny.3. human.

Organism-specific databases

CTDi 6291.
GeneCardsi GC11M018252.
HGNCi HGNC:10516. SAA4.
HPAi CAB026061.
HPA059444.
HPA060139.
MIMi 104752. gene.
neXtProti NX_P35542.
PharmGKBi PA34924.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46739.
GeneTreei ENSGT00390000004737.
HOGENOMi HOG000126881.
HOVERGENi HBG016327.
InParanoidi P35542.
KOi K17310.
OMAi FCSLVMG.
OrthoDBi EOG7QVM4V.
PhylomeDBi P35542.
TreeFami TF332544.

Miscellaneous databases

GenomeRNAii 6291.
NextBioi 24427.
PROi P35542.
SOURCEi Search...

Gene expression databases

Bgeei P35542.
CleanExi HS_SAA4.
Genevestigatori P35542.

Family and domain databases

InterProi IPR000096. Serum_amyloid_A.
[Graphical view ]
Pfami PF00277. SAA. 1 hit.
[Graphical view ]
PIRSFi PIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSi PR00306. SERUMAMYLOID.
SMARTi SM00197. SAA. 1 hit.
[Graphical view ]
PROSITEi PS00992. SAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein."
    Whitehead A.S., Debeer M.C., Steel D.M., Rits M., Lelias J.M., Lane W.S., Debeer F.C.
    J. Biol. Chem. 267:3862-3867(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
    Tissue: Liver.
  2. "A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)."
    Steel D.M., Sellar G.C., Uhlar C.M., Simon S., Debeer F.C., Whitehead A.S.
    Genomics 16:447-454(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
  3. "Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4."
    Watson G., Coade S., Woo P.
    Scand. J. Immunol. 36:703-712(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-89.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-89.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TYR-89.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-89.
    Tissue: Liver.
  8. "Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry."
    Ducret A., Bruun C.F., Bures E.J., Marhaug G., Husby G., Aebersold R.
    Electrophoresis 17:866-876(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94.
    Tissue: Plasma.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94.
    Tissue: Liver.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative detection of single amino acid polymorphisms by targeted proteomics."
    Su Z.D., Sun L., Yu D.X., Li R.X., Li H.X., Yu Z.J., Sheng Q.H., Lin X., Zeng R., Wu J.R.
    J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TYR-89, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSAA4_HUMAN
AccessioniPrimary (citable) accession number: P35542
Secondary accession number(s): Q6FHJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3