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Protein

Serum amyloid A protein

Gene

SAA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A protein
Short name:
SAA
Cleaved into the following chain:
Alternative name(s):
Amyloid fibril protein AA
Gene namesi
Name:SAA1
Synonyms:SAA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000003156819 – 130Serum amyloid A proteinAdd BLAST112
ChainiPRO_000003156919 – 108Amyloid protein AAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1

Post-translational modificationi

This protein is the precursor of amyloid protein A, which is formed by the removal of residues from the C-terminal end.

Keywords - PTMi

Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP35541.
PRIDEiP35541.

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Upon cytokine stimulation.

Gene expression databases

BgeeiENSBTAG00000022394.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030310.

Structurei

3D structure databases

ProteinModelPortaliP35541.
SMRiP35541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXU4. Eukaryota.
ENOG410YSBK. LUCA.
GeneTreeiENSGT00390000004737.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP35541.
KOiK17310.
OMAiDMREADY.
OrthoDBiEOG091G17YH.
TreeFamiTF332544.

Family and domain databases

InterProiView protein in InterPro
IPR000096. Serum_amyloid_A.
PfamiView protein in Pfam
PF00277. SAA. 1 hit.
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiView protein in SMART
SM00197. SAA. 1 hit.
PROSITEiView protein in PROSITE
PS00992. SAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFTGLILC SLVLGVHSQW MSFFGEAYEG AKDMWRAYSD MREANYKGAD
60 70 80 90 100
KYFHARGNYD AAQRGPGGAW AAKVISDARE NIQRFTDPLF KGTTSGQGQE
110 120 130
DSRADQAANE WGRSGKDPNH FRPAGLPDKY
Length:130
Mass (Da):14,516
Last modified:April 3, 2007 - v2
Checksum:iEA917CD1BAB5DCEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109787 mRNA. Translation: AAI09788.1.
PIRiA60952.
RefSeqiNP_001068728.1. NM_001075260.2.
UniGeneiBt.88760.

Genome annotation databases

EnsembliENSBTAT00000030326; ENSBTAP00000030310; ENSBTAG00000022394.
GeneIDi506412.
KEGGibta:506412.

Similar proteinsi

Entry informationi

Entry nameiSAA_BOVIN
AccessioniPrimary (citable) accession number: P35541
Secondary accession number(s): Q32L36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 3, 2007
Last modified: August 30, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families