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P35504

- UD15_HUMAN

UniProt

P35504 - UD15_HUMAN

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Protein

UDP-glucuronosyltransferase 1-5

Gene

UGT1A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-5 (EC:2.4.1.17)
Short name:
UDPGT 1-5
Short name:
UGT1*5
Short name:
UGT1-05
Short name:
UGT1.5
Alternative name(s):
UDP-glucuronosyltransferase 1-E
Short name:
UGT-1E
Short name:
UGT1E
UDP-glucuronosyltransferase 1A5
Gene namesi
Name:UGT1A5
Synonyms:GNT1, UGT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:12537. UGT1A5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 534506UDP-glucuronosyltransferase 1-5PRO_0000036004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP35504.

PTM databases

PhosphoSiteiP35504.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in colon and small intestine. Neither isoform is expressed in liver, kidney or esophagus.1 Publication

Gene expression databases

ExpressionAtlasiP35504. baseline.
GenevestigatoriP35504.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362513.

Structurei

3D structure databases

ProteinModelPortaliP35504.
SMRiP35504. Positions 284-445.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei492 – 50817HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiP35504.
KOiK00699.
OMAiSFFETEH.
OrthoDBiEOG78H3T2.
PhylomeDBiP35504.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P35504-1) [UniParc]FASTAAdd to Basket

Also known as: i1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATGLQVPLP QLATGLLLLL SVQPWAESGK VLVVPTDGSH WLSMREALRD
60 70 80 90 100
LHARGHQVVV LTLEVNMYIK EENFFTLTTY AISWTQDEFD RLLLGHTQSF
110 120 130 140 150
FETEHLLMKF SRRMAIMNNM SLIIHRSCVE LLHNEALIRH LHATSFDVVL
160 170 180 190 200
TDPFHLCAAV LAKYLSIPAV FFLRNIPCDL DFKGTQCPNP SSYIPRLLTT
210 220 230 240 250
NSDHMTFLQR VKNMLYPLAL SYLCHAVSAP YASLASELFQ REVSVVDLVS
260 270 280 290 300
HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE
310 320 330 340 350
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT
360 370 380 390 400
ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD
410 420 430 440 450
NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD
460 470 480 490 500
RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV
510 520 530
LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH
Length:534
Mass (Da):60,071
Last modified:June 1, 1994 - v1
Checksum:i05989F2A18EEFAA4
GO
Isoform 2 (identifier: P35504-2) [UniParc]FASTAAdd to Basket

Also known as: i2, UGT1A5s

The sequence of this isoform differs from the canonical sequence as follows:
     436-534: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:445
Mass (Da):49,848
Checksum:iD4273372E4A8C605
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481L → S.
Corresponds to variant rs3755323 [ dbSNP | Ensembl ].
VAR_052455
Natural varianti50 – 501D → E.
Corresponds to variant rs3755322 [ dbSNP | Ensembl ].
VAR_059845
Natural varianti63 – 631L → P.
Corresponds to variant rs3755321 [ dbSNP | Ensembl ].
VAR_052456
Natural varianti142 – 1421H → N.
Corresponds to variant rs3755320 [ dbSNP | Ensembl ].
VAR_059846
Natural varianti144 – 1441T → S.
Corresponds to variant rs28946885 [ dbSNP | Ensembl ].
VAR_052457
Natural varianti158 – 1581A → G.
Corresponds to variant rs12475068 [ dbSNP | Ensembl ].
VAR_052458
Natural varianti225 – 2251H → Y.
Corresponds to variant rs17862867 [ dbSNP | Ensembl ].
VAR_052459
Natural varianti249 – 2491V → L.
Corresponds to variant rs17862868 [ dbSNP | Ensembl ].
VAR_052460
Natural varianti259 – 2591G → R.
Corresponds to variant rs3892170 [ dbSNP | Ensembl ].
VAR_052461

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei436 – 53499SYKEN…KSKTH → RKKQQSGRQM in isoform 2. 1 PublicationVSP_053961Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84129 Genomic DNA. Translation: AAA61250.1.
M84124, M84122, M84123 Genomic DNA. Translation: AAA61247.1. Sequence problems.
AF297093 Genomic DNA. Translation: AAG30421.1.
AC006985 Genomic DNA. No translation available.
AC114812 Genomic DNA. No translation available.
DQ383514 mRNA. Translation: ABD42927.1.
CCDSiCCDS33404.1. [P35504-1]
PIRiB42586.
RefSeqiNP_061951.1. NM_019078.1. [P35504-1]
UniGeneiHs.554822.

Genome annotation databases

EnsembliENST00000373414; ENSP00000362513; ENSG00000240224. [P35504-1]
GeneIDi54579.
KEGGihsa:54579.
UCSCiuc002vuw.3. human. [P35504-1]

Polymorphism databases

DMDMi549153.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84129 Genomic DNA. Translation: AAA61250.1 .
M84124 , M84122 , M84123 Genomic DNA. Translation: AAA61247.1 . Sequence problems.
AF297093 Genomic DNA. Translation: AAG30421.1 .
AC006985 Genomic DNA. No translation available.
AC114812 Genomic DNA. No translation available.
DQ383514 mRNA. Translation: ABD42927.1 .
CCDSi CCDS33404.1. [P35504-1 ]
PIRi B42586.
RefSeqi NP_061951.1. NM_019078.1. [P35504-1 ]
UniGenei Hs.554822.

3D structure databases

ProteinModelPortali P35504.
SMRi P35504. Positions 284-445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000362513.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei P35504.

Polymorphism databases

DMDMi 549153.

Proteomic databases

PRIDEi P35504.

Protocols and materials databases

DNASUi 54579.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373414 ; ENSP00000362513 ; ENSG00000240224 . [P35504-1 ]
GeneIDi 54579.
KEGGi hsa:54579.
UCSCi uc002vuw.3. human. [P35504-1 ]

Organism-specific databases

CTDi 54579.
GeneCardsi GC02P234621.
HGNCi HGNC:12537. UGT1A5.
MIMi 191740. gene.
606430. gene.
neXtProti NX_P35504.
PharmGKBi PA37180.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000220832.
HOVERGENi HBG004033.
InParanoidi P35504.
KOi K00699.
OMAi SFFETEH.
OrthoDBi EOG78H3T2.
PhylomeDBi P35504.
TreeFami TF315472.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 2681.
Reactomei REACT_6784. Glucuronidation.

Miscellaneous databases

GeneWikii UGT1A5.
GenomeRNAii 54579.
NextBioi 35481516.
PROi P35504.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi P35504. baseline.
Genevestigatori P35504.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini."
    Ritter J.K., Chen F., Sheen Y.Y., Tran H.M., Kimura S., Yeatman M.T., Owens I.S.
    J. Biol. Chem. 267:3257-3261(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus."
    Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C.
    Pharmacogenetics 11:357-368(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Guillemette C., Levesque E., Girard H., Bernard O.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-534 (ISOFORM 2).
  5. "Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity."
    Girard H., Levesque E., Bellemare J., Journault K., Caillier B., Guillemette C.
    Pharmacogenet. Genomics 17:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

Entry informationi

Entry nameiUD15_HUMAN
AccessioniPrimary (citable) accession number: P35504
Secondary accession number(s): B8K294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3