Reviewed,
UniProtKB/Swiss-Prot P35504 (UD15_HUMAN)
Last modified
July 7, 2009.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UDP-glucuronosyltransferase 1-5 EC=2.4.1.17 Alternative name(s): UDP-glucuronosyltransferase 1A5 Short name=UDPGT Short name=UGT1*5 UGT1-05 Short name=UGT1.5 UGT-1E Short name=UGT1E | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 534 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. |
| Catalytic activity | UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| Subcellular location | Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential. |
| Sequence similarities | Belongs to the UDP-glycosyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | xenobiotic metabolic process Non-traceable author statement. Source: UniProtKB |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW microsomeNon-traceable author statement. Source: UniProtKB |
| Molecular function | glucuronosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues. | ||||||
| Isoform 1 (identifier: P35504-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 28 | 28 | Potential | ||||||
| Chain | 29 – 534 | 506 | UDP-glucuronosyltransferase 1-5 | PRO_0000036004 | |||||
Regions | |||||||||
| Transmembrane | 492 – 508 | 17 | Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 119 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 296 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 348 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 48 | 1 | L → S: dbSNP rs3755323. | VAR_052455 | |||||
| Natural variant | 63 | 1 | L → P: dbSNP rs3755321. | VAR_052456 | |||||
| Natural variant | 144 | 1 | T → S: dbSNP rs28946885. | VAR_052457 | |||||
| Natural variant | 158 | 1 | A → G: dbSNP rs12475068. | VAR_052458 | |||||
| Natural variant | 225 | 1 | H → Y: dbSNP rs17862867. | VAR_052459 | |||||
| Natural variant | 249 | 1 | V → L: dbSNP rs17862868. | VAR_052460 | |||||
| Natural variant | 259 | 1 | G → R: dbSNP rs3892170. | VAR_052461 | |||||
Sequences
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References
| [1] | "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini." Ritter J.K., Chen F., Sheen Y.Y., Tran H.M., Kimura S., Yeatman M.T., Owens I.S. J. Biol. Chem. 267:3257-3261(1992) [PubMed: 1339448] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus." Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C. Pharmacogenetics 11:357-368(2001) [PubMed: 11434514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M84129 Genomic DNA. Translation: AAA61250.1. M84124, M84122, M84123 Genomic DNA. Translation: AAA61247.1. Sequence problems. AF297093 Genomic DNA. Translation: AAG30421.1. | |
| IPI | IPI00472824. |
| PIR | B42586. |
| RefSeq | NP_061951.1. |
| UniGene | Hs.554822 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT1. Glycosyltransferase Family 1. |
Proteomic databases | |
| PRIDE | P35504. |
Genome annotation databases | |
| Ensembl | ENSG00000167165. Homo sapiens. [Contig view] |
| GeneID | 54579. |
| KEGG | hsa:54579. |
| UCSC | uc002vuw.1. human. |
Organism-specific databases | |
| GeneCards | GC02P234216. |
| HGNC | HGNC:12537. UGT1A5. |
| MIM | 191740. gene. 606430. gene. |
| Orphanet | 205. Crigler-Najjar syndrome. 357. Gilbert syndrome. 2312. Hyperbilirubinemia transient familial neonatal. |
| PharmGKB | PA37180. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P35504. |
| OMA | P35504. LKWLEDE. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.17. 247. |
| Reactome | REACT_13433. Biological oxidations. |
Gene expression databases | |
| ArrayExpress | P35504. |
| Bgee | P35504. |
| GermOnline | ENSG00000167165. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002213. UDP_glucos_trans. [Graphical view] |
| PANTHER | PTHR11926. UDP_glucos_trans. 1 hit. |
| Pfam | PF00201. UDPGT. 1 hit. [Graphical view] |
| PROSITE | PS00375. UDPGT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 57092. |
| SOURCE | Search... |
Entry information
| Entry name | UD15_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P35504 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


