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P35504

- UD15_HUMAN

UniProt

P35504 - UD15_HUMAN

Protein

UDP-glucuronosyltransferase 1-5

Gene

UGT1A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 2681.
    ReactomeiREACT_6784. Glucuronidation.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-5 (EC:2.4.1.17)
    Short name:
    UDPGT 1-5
    Short name:
    UGT1*5
    Short name:
    UGT1-05
    Short name:
    UGT1.5
    Alternative name(s):
    UDP-glucuronosyltransferase 1-E
    Short name:
    UGT-1E
    Short name:
    UGT1E
    UDP-glucuronosyltransferase 1A5
    Gene namesi
    Name:UGT1A5
    Synonyms:GNT1, UGT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:12537. UGT1A5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37180.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 534506UDP-glucuronosyltransferase 1-5PRO_0000036004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP35504.

    PTM databases

    PhosphoSiteiP35504.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 2 are expressed in colon and small intestine. Neither isoform is expressed in liver, kidney or esophagus.1 Publication

    Gene expression databases

    GenevestigatoriP35504.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000362513.

    Structurei

    3D structure databases

    ProteinModelPortaliP35504.
    SMRiP35504. Positions 284-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei492 – 50817HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000220832.
    HOVERGENiHBG004033.
    InParanoidiP35504.
    KOiK00699.
    OMAiSFFETEH.
    OrthoDBiEOG78H3T2.
    PhylomeDBiP35504.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P35504-1) [UniParc]FASTAAdd to Basket

    Also known as: i1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATGLQVPLP QLATGLLLLL SVQPWAESGK VLVVPTDGSH WLSMREALRD    50
    LHARGHQVVV LTLEVNMYIK EENFFTLTTY AISWTQDEFD RLLLGHTQSF 100
    FETEHLLMKF SRRMAIMNNM SLIIHRSCVE LLHNEALIRH LHATSFDVVL 150
    TDPFHLCAAV LAKYLSIPAV FFLRNIPCDL DFKGTQCPNP SSYIPRLLTT 200
    NSDHMTFLQR VKNMLYPLAL SYLCHAVSAP YASLASELFQ REVSVVDLVS 250
    HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE 300
    HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT 350
    ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD 400
    NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD 450
    RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV 500
    LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH 534
    Length:534
    Mass (Da):60,071
    Last modified:June 1, 1994 - v1
    Checksum:i05989F2A18EEFAA4
    GO
    Isoform 2 (identifier: P35504-2) [UniParc]FASTAAdd to Basket

    Also known as: i2, UGT1A5s

    The sequence of this isoform differs from the canonical sequence as follows:
         436-534: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

    Show »
    Length:445
    Mass (Da):49,848
    Checksum:iD4273372E4A8C605
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481L → S.
    Corresponds to variant rs3755323 [ dbSNP | Ensembl ].
    VAR_052455
    Natural varianti50 – 501D → E.
    Corresponds to variant rs3755322 [ dbSNP | Ensembl ].
    VAR_059845
    Natural varianti63 – 631L → P.
    Corresponds to variant rs3755321 [ dbSNP | Ensembl ].
    VAR_052456
    Natural varianti142 – 1421H → N.
    Corresponds to variant rs3755320 [ dbSNP | Ensembl ].
    VAR_059846
    Natural varianti144 – 1441T → S.
    Corresponds to variant rs28946885 [ dbSNP | Ensembl ].
    VAR_052457
    Natural varianti158 – 1581A → G.
    Corresponds to variant rs12475068 [ dbSNP | Ensembl ].
    VAR_052458
    Natural varianti225 – 2251H → Y.
    Corresponds to variant rs17862867 [ dbSNP | Ensembl ].
    VAR_052459
    Natural varianti249 – 2491V → L.
    Corresponds to variant rs17862868 [ dbSNP | Ensembl ].
    VAR_052460
    Natural varianti259 – 2591G → R.
    Corresponds to variant rs3892170 [ dbSNP | Ensembl ].
    VAR_052461

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei436 – 53499SYKEN…KSKTH → RKKQQSGRQM in isoform 2. 1 PublicationVSP_053961Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84129 Genomic DNA. Translation: AAA61250.1.
    M84124, M84122, M84123 Genomic DNA. Translation: AAA61247.1. Sequence problems.
    AF297093 Genomic DNA. Translation: AAG30421.1.
    AC006985 Genomic DNA. No translation available.
    AC114812 Genomic DNA. No translation available.
    DQ383514 mRNA. Translation: ABD42927.1.
    CCDSiCCDS33404.1. [P35504-1]
    PIRiB42586.
    RefSeqiNP_061951.1. NM_019078.1. [P35504-1]
    UniGeneiHs.554822.

    Genome annotation databases

    EnsembliENST00000373414; ENSP00000362513; ENSG00000240224. [P35504-1]
    GeneIDi54579.
    KEGGihsa:54579.
    UCSCiuc002vuw.3. human. [P35504-1]

    Polymorphism databases

    DMDMi549153.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84129 Genomic DNA. Translation: AAA61250.1 .
    M84124 , M84122 , M84123 Genomic DNA. Translation: AAA61247.1 . Sequence problems.
    AF297093 Genomic DNA. Translation: AAG30421.1 .
    AC006985 Genomic DNA. No translation available.
    AC114812 Genomic DNA. No translation available.
    DQ383514 mRNA. Translation: ABD42927.1 .
    CCDSi CCDS33404.1. [P35504-1 ]
    PIRi B42586.
    RefSeqi NP_061951.1. NM_019078.1. [P35504-1 ]
    UniGenei Hs.554822.

    3D structure databases

    ProteinModelPortali P35504.
    SMRi P35504. Positions 284-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000362513.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei P35504.

    Polymorphism databases

    DMDMi 549153.

    Proteomic databases

    PRIDEi P35504.

    Protocols and materials databases

    DNASUi 54579.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373414 ; ENSP00000362513 ; ENSG00000240224 . [P35504-1 ]
    GeneIDi 54579.
    KEGGi hsa:54579.
    UCSCi uc002vuw.3. human. [P35504-1 ]

    Organism-specific databases

    CTDi 54579.
    GeneCardsi GC02P234621.
    HGNCi HGNC:12537. UGT1A5.
    MIMi 191740. gene.
    606430. gene.
    neXtProti NX_P35504.
    PharmGKBi PA37180.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000220832.
    HOVERGENi HBG004033.
    InParanoidi P35504.
    KOi K00699.
    OMAi SFFETEH.
    OrthoDBi EOG78H3T2.
    PhylomeDBi P35504.
    TreeFami TF315472.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 2681.
    Reactomei REACT_6784. Glucuronidation.

    Miscellaneous databases

    GeneWikii UGT1A5.
    GenomeRNAii 54579.
    NextBioi 35481516.
    PROi P35504.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P35504.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini."
      Ritter J.K., Chen F., Sheen Y.Y., Tran H.M., Kimura S., Yeatman M.T., Owens I.S.
      J. Biol. Chem. 267:3257-3261(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus."
      Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C.
      Pharmacogenetics 11:357-368(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Guillemette C., Levesque E., Girard H., Bernard O.
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-534 (ISOFORM 2).
    5. "Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity."
      Girard H., Levesque E., Bellemare J., Journault K., Caillier B., Guillemette C.
      Pharmacogenet. Genomics 17:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiUD15_HUMAN
    AccessioniPrimary (citable) accession number: P35504
    Secondary accession number(s): B8K294
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3