Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P35504 (UD15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 1-5

Short name=UDPGT 1-5
Short name=UGT1*5
Short name=UGT1-05
Short name=UGT1.5
EC=2.4.1.17
Alternative name(s):
UDP-glucuronosyltransferase 1-E
Short name=UGT-1E
Short name=UGT1E
UDP-glucuronosyltransferase 1A5
Gene names
Name:UGT1A5
Synonyms:GNT1, UGT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 By similarity.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Isoform 1 and isoform 2 are expressed in colon and small intestine. Neither isoform isexpressed in liver, kidney or esophagus. Ref.5

Miscellaneous

The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P35504-1)

Also known as: i1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P35504-2)

Also known as: i2; UGT1A5s;

The sequence of this isoform differs from the canonical sequence as follows:
     436-534: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 534506UDP-glucuronosyltransferase 1-5
PRO_0000036004

Regions

Transmembrane492 – 50817Helical; Potential

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation3481N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence436 – 53499SYKEN…KSKTH → RKKQQSGRQM in isoform 2.
VSP_053961
Natural variant481L → S.
Corresponds to variant rs3755323 [ dbSNP | Ensembl ].
VAR_052455
Natural variant501D → E.
Corresponds to variant rs3755322 [ dbSNP | Ensembl ].
VAR_059845
Natural variant631L → P.
Corresponds to variant rs3755321 [ dbSNP | Ensembl ].
VAR_052456
Natural variant1421H → N.
Corresponds to variant rs3755320 [ dbSNP | Ensembl ].
VAR_059846
Natural variant1441T → S.
Corresponds to variant rs28946885 [ dbSNP | Ensembl ].
VAR_052457
Natural variant1581A → G.
Corresponds to variant rs12475068 [ dbSNP | Ensembl ].
VAR_052458
Natural variant2251H → Y.
Corresponds to variant rs17862867 [ dbSNP | Ensembl ].
VAR_052459
Natural variant2491V → L.
Corresponds to variant rs17862868 [ dbSNP | Ensembl ].
VAR_052460
Natural variant2591G → R.
Corresponds to variant rs3892170 [ dbSNP | Ensembl ].
VAR_052461

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (i1) [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 05989F2A18EEFAA4

FASTA53460,071
        10         20         30         40         50         60 
MATGLQVPLP QLATGLLLLL SVQPWAESGK VLVVPTDGSH WLSMREALRD LHARGHQVVV 

        70         80         90        100        110        120 
LTLEVNMYIK EENFFTLTTY AISWTQDEFD RLLLGHTQSF FETEHLLMKF SRRMAIMNNM 

       130        140        150        160        170        180 
SLIIHRSCVE LLHNEALIRH LHATSFDVVL TDPFHLCAAV LAKYLSIPAV FFLRNIPCDL 

       190        200        210        220        230        240 
DFKGTQCPNP SSYIPRLLTT NSDHMTFLQR VKNMLYPLAL SYLCHAVSAP YASLASELFQ 

       250        260        270        280        290        300 
REVSVVDLVS HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE 

       310        320        330        340        350        360 
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT ILVKWLPQND 

       370        380        390        400        410        420 
LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD NAKRMETKGA GVTLNVLEMT 

       430        440        450        460        470        480 
SEDLENALKA VINDKSYKEN IMRLSSLHKD RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH 

       490        500        510        520        530 
DLTWYQYHSL DVIGFLLAVV LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH 

« Hide

Isoform 2 (i2) (UGT1A5s) [UniParc].

Checksum: D4273372E4A8C605
Show »

FASTA44549,848

References

« Hide 'large scale' references
[1]"A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini."
Ritter J.K., Chen F., Sheen Y.Y., Tran H.M., Kimura S., Yeatman M.T., Owens I.S.
J. Biol. Chem. 267:3257-3261(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus."
Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C.
Pharmacogenetics 11:357-368(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Guillemette C., Levesque E., Girard H., Bernard O.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-534 (ISOFORM 2).
[5]"Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity."
Girard H., Levesque E., Bellemare J., Journault K., Caillier B., Guillemette C.
Pharmacogenet. Genomics 17:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M84129 Genomic DNA. Translation: AAA61250.1.
M84124, M84122, M84123 Genomic DNA. Translation: AAA61247.1. Sequence problems.
AF297093 Genomic DNA. Translation: AAG30421.1.
AC006985 Genomic DNA. No translation available.
AC114812 Genomic DNA. No translation available.
DQ383514 mRNA. Translation: ABD42927.1.
PIRB42586.
RefSeqNP_061951.1. NM_019078.1.
UniGeneHs.554822.

3D structure databases

ProteinModelPortalP35504.
SMRP35504. Positions 284-445.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000362513.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteP35504.

Polymorphism databases

DMDM549153.

Proteomic databases

PRIDEP35504.

Protocols and materials databases

DNASU54579.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373414; ENSP00000362513; ENSG00000240224. [P35504-1]
GeneID54579.
KEGGhsa:54579.
UCSCuc002vuw.3. human. [P35504-1]

Organism-specific databases

CTD54579.
GeneCardsGC02P234621.
HGNCHGNC:12537. UGT1A5.
MIM191740. gene.
606430. gene.
neXtProtNX_P35504.
PharmGKBPA37180.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000220832.
HOVERGENHBG004033.
InParanoidP35504.
KOK00699.
OMASFFETEH.
OrthoDBEOG78H3T2.
PhylomeDBP35504.
TreeFamTF315472.

Enzyme and pathway databases

BRENDA2.4.1.17. 2681.
ReactomeREACT_111217. Metabolism.

Gene expression databases

GenevestigatorP35504.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiUGT1A5.
GenomeRNAi54579.
NextBio57092.
PROP35504.
SOURCESearch...

Entry information

Entry nameUD15_HUMAN
AccessionPrimary (citable) accession number: P35504
Secondary accession number(s): B8K294
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM