UDP-glucuronosyltransferase 1-3 precursor

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P35503 (UD13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 118. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
UDP-glucuronosyltransferase 1-3
Short name=UDPGT 1-3
Short name=UGT1*3
Short name=UGT1-03
Short name=UGT1.3
EC=2.4.1.17

Alternative name(s):
UDP-glucuronosyltransferase 1-C
Short name=UGT-1C
Short name=UGT1C
UDP-glucuronosyltransferase 1A3

Gene names

Name:	UGT1A3
Synonyms:	GNT1, UGT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	534 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	flavonoid glucuronidation Inferred from direct assay PubMed 20056724. Source: BHF-UCL retinoic acid metabolic process Inferred by curator PubMed 20308471. Source: BHF-UCL xenobiotic glucuronidation Inferred from direct assay PubMed 20056724. Source: BHF-UCL
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	enzyme binding Inferred from direct assay PubMed 20610558. Source: BHF-UCL glucuronosyltransferase activity Inferred from direct assay PubMed 18052087 PubMed 20056724 PubMed 20308471. Source: BHF-UCL retinoic acid binding Inferred from direct assay PubMed 20308471. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: P35503-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

Potential

Chain

29 – 534

506

UDP-glucuronosyltransferase 1-3

PRO_0000036002

Regions

Transmembrane

492 – 508

Helical; Potential

Amino acid modifications

Glycosylation

119

N-linked (GlcNAc...) Potential

Glycosylation

142

N-linked (GlcNAc...) Ref.3

Glycosylation

296

N-linked (GlcNAc...) Potential

Glycosylation

348

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

Q → R.
Corresponds to variant rs28898617 [ dbSNP | Ensembl ].

VAR_052445

Natural variant

W → R. Ref.4
Corresponds to variant rs3821242 [ dbSNP | Ensembl ].

VAR_052446

Natural variant

R → W.
Corresponds to variant rs45625338 [ dbSNP | Ensembl ].

VAR_052447

Natural variant

V → A. Ref.4
Corresponds to variant rs6431625 [ dbSNP | Ensembl ].

VAR_052448

Natural variant

R → W.
Corresponds to variant rs45595237 [ dbSNP | Ensembl ].

VAR_052449

Natural variant

T → I.
Corresponds to variant rs28898618 [ dbSNP | Ensembl ].

VAR_052450

Natural variant

114

M → I.
Corresponds to variant rs28898619 [ dbSNP | Ensembl ].

VAR_052451

Natural variant

144

T → I.
Corresponds to variant rs13406898 [ dbSNP | Ensembl ].

VAR_052452

Natural variant

158

A → V. Ref.4

VAR_058583

Natural variant

270

M → V. Ref.4
Corresponds to variant rs45449995 [ dbSNP | Ensembl ].

VAR_052453

Sequences

Sequence

Length

Mass (Da)

Tools

Isoform 1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 9C5833652A4D9B3D
Show »

FASTA

534

60,338

        10         20         30         40         50         60 
MATGLQVPLP WLATGLLLLL SVQPWAESGK VLVVPIDGSH WLSMREVLRE LHARGHQAVV 

        70         80         90        100        110        120 
LTPEVNMHIK EENFFTLTTY AISWTQDEFD RHVLGHTQLY FETEHFLKKF FRSMAMLNNM 

       130        140        150        160        170        180 
SLVYHRSCVE LLHNEALIRH LNATSFDVVL TDPVNLCAAV LAKYLSIPTV FFLRNIPCDL 

       190        200        210        220        230        240 
DFKGTQCPNP SSYIPRLLTT NSDHMTFMQR VKNMLYPLAL SYICHAFSAP YASLASELFQ 

       250        260        270        280        290        300 
REVSVVDILS HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANRKPLSQE FEAYINASGE 

       310        320        330        340        350        360 
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT ILVKWLPQND 

       370        380        390        400        410        420 
LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD NAKRMETKGA GVTLNVLEMT 

       430        440        450        460        470        480 
SEDLENALKA VINDKSYKEN IMRLSSLHKD RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH 

       490        500        510        520        530 
DLTWYQYHSL DVIGFLLAVV LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini." Ritter J.K., Chen F., Sheen Y.Y., Tran H.M., Kimura S., Yeatman M.T., Owens I.S. J. Biol. Chem. 267:3257-3261(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus." Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C. Pharmacogenetics 11:357-368(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142, MASS SPECTROMETRY. Tissue: Liver.
[4]	"Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population." Menard V., Girard H., Harvey M., Perusse L., Guillemette C. Hum. Mutat. 30:677-687(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ARG-11; ALA-47; VAL-158 AND VAL-270.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M84127 Genomic DNA. Translation: AAA92020.1. M84124, M84122, M84123 Genomic DNA. Translation: AAA61247.1. Sequence problems. AF297093 Genomic DNA. Translation: AAG30423.1.
IPI	IPI00473079.
PIR	D42586.
RefSeq	NP_061966.1. NM_019093.2.
UniGene	Hs.554822.
3D structure databases
ProteinModelPortal	P35503.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000418532.
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
PTM databases
PhosphoSite	P35503.
Polymorphism databases
DMDM	549152.
Proteomic databases
PaxDb	P35503.
PRIDE	P35503.
Protocols and materials databases
DNASU	54659.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000482026; ENSP00000418532; ENSG00000243135.
GeneID	54659.
KEGG	hsa:54659.
UCSC	uc002vuy.3. human.
Organism-specific databases
CTD	54659.
GeneCards	GC02P234637.
HGNC	HGNC:12535. UGT1A3.
MIM	191740. gene. 606428. gene.
neXtProt	NX_P35503.
PharmGKB	PA37178.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1819.
HOGENOM	HOG000220832.
HOVERGEN	HBG004033.
KO	K00699.
OMA	TITELYS.
OrthoDB	EOG45B1FF.
PhylomeDB	P35503.
Enzyme and pathway databases
BioCyc	MetaCyc:UGT1A3-MONOMER.
BRENDA	2.4.1.17. 2681.
Reactome	REACT_111217. Metabolism.
SABIO-RK	P35503.
Gene expression databases
ArrayExpress	P35503.
Bgee	P35503.
Genevestigator	P35503.
GermOnline	ENSG00000167165. Homo sapiens.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. PTHR11926. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54659.
NextBio	57192.
SOURCE	Search...

Entry information

Entry name

UD13_HUMAN

Accession

Primary (citable) accession number: P35503

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents