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Protein

UDP-glucuronosyltransferase 1-3

Gene

UGT1A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.1 Publication

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • glucuronosyltransferase activity Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • retinoic acid binding Source: BHF-UCL

GO - Biological processi

  • cellular glucuronidation Source: UniProtKB
  • flavonoid biosynthetic process Source: GO_Central
  • flavonoid glucuronidation Source: BHF-UCL
  • metabolic process Source: ProtInc
  • negative regulation of cellular glucuronidation Source: BHF-UCL
  • negative regulation of fatty acid metabolic process Source: BHF-UCL
  • negative regulation of glucuronosyltransferase activity Source: BHF-UCL
  • retinoic acid metabolic process Source: BHF-UCL
  • xenobiotic glucuronidation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS09519-MONOMER.
BRENDAi2.4.1.17. 2681.
ReactomeiR-HSA-156588. Glucuronidation.
SABIO-RKP35503.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-3 (EC:2.4.1.17)
Short name:
UDPGT 1-3
Short name:
UGT1*3
Short name:
UGT1-03
Short name:
UGT1.3
Alternative name(s):
UDP-glucuronosyltransferase 1-C
Short name:
UGT-1C
Short name:
UGT1C
UDP-glucuronosyltransferase 1A3
Gene namesi
Name:UGT1A3
Synonyms:GNT1, UGT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12535. UGT1A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei492 – 508HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: BHF-UCL
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi54659.
OpenTargetsiENSG00000243135.
PharmGKBiPA37178.

Chemistry databases

ChEMBLiCHEMBL3542435.
DrugBankiDB06403. Ambrisentan.
DB01076. Atorvastatin.
DB00796. Candesartan.
DB00434. Cyproheptadine.
DB06210. Eltrombopag.
DB00749. Etodolac.
DB00973. Ezetimibe.
DB04953. Ezogabine.
DB01544. Flunitrazepam.
DB00712. Flurbiprofen.
DB01095. Fluvastatin.
DB01050. Ibuprofen.
DB01029. Irbesartan.
DB00555. Lamotrigine.
DB00678. Losartan.
DB00227. Lovastatin.
DB01252. Mitiglinide.
DB00295. Morphine.
DB08860. Pitavastatin.
DB00641. Simvastatin.
DB00313. Valproic Acid.

Polymorphism and mutation databases

BioMutaiUGT1A3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003600229 – 534UDP-glucuronosyltransferase 1-3Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)1 Publication1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi348N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35503.
PeptideAtlasiP35503.
PRIDEiP35503.

PTM databases

iPTMnetiP35503.
PhosphoSitePlusiP35503.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 1 but not isoform 2 is expressed in esophagus.1 Publication

Gene expression databases

ExpressionAtlasiP35503. baseline and differential.
GenevisibleiP35503. HS.

Interactioni

Subunit structurei

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10.1 Publication

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

IntActiP35503. 7 interactors.
STRINGi9606.ENSP00000418532.

Chemistry databases

BindingDBiP35503.

Structurei

3D structure databases

ProteinModelPortaliP35503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiP35503.
KOiK00699.
OMAiFFRSMAM.
OrthoDBiEOG091G06JC.
PhylomeDBiP35503.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35503-1) [UniParc]FASTAAdd to basket
Also known as: i1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATGLQVPLP WLATGLLLLL SVQPWAESGK VLVVPIDGSH WLSMREVLRE
60 70 80 90 100
LHARGHQAVV LTPEVNMHIK EENFFTLTTY AISWTQDEFD RHVLGHTQLY
110 120 130 140 150
FETEHFLKKF FRSMAMLNNM SLVYHRSCVE LLHNEALIRH LNATSFDVVL
160 170 180 190 200
TDPVNLCAAV LAKYLSIPTV FFLRNIPCDL DFKGTQCPNP SSYIPRLLTT
210 220 230 240 250
NSDHMTFMQR VKNMLYPLAL SYICHAFSAP YASLASELFQ REVSVVDILS
260 270 280 290 300
HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANRKPLSQE FEAYINASGE
310 320 330 340 350
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT
360 370 380 390 400
ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD
410 420 430 440 450
NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD
460 470 480 490 500
RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV
510 520 530
LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH
Length:534
Mass (Da):60,338
Last modified:June 1, 1994 - v1
Checksum:i9C5833652A4D9B3D
GO
Isoform 2 (identifier: P35503-3) [UniParc]FASTAAdd to basket
Also known as: i2, UGT1A3s

The sequence of this isoform differs from the canonical sequence as follows:
     436-534: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:445
Mass (Da):50,115
Checksum:iC30BB9928D337B4F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0524456Q → R.Corresponds to variant rs28898617dbSNPEnsembl.1
Natural variantiVAR_05244611W → R.1 PublicationCorresponds to variant rs3821242dbSNPEnsembl.1
Natural variantiVAR_05244745R → W.Corresponds to variant rs45625338dbSNPEnsembl.1
Natural variantiVAR_05244847V → A.1 PublicationCorresponds to variant rs6431625dbSNPEnsembl.1
Natural variantiVAR_05244949R → W.Corresponds to variant rs45595237dbSNPEnsembl.1
Natural variantiVAR_05245078T → I.Corresponds to variant rs28898618dbSNPEnsembl.1
Natural variantiVAR_052451114M → I.Corresponds to variant rs28898619dbSNPEnsembl.1
Natural variantiVAR_052452144T → I.Corresponds to variant rs13406898dbSNPEnsembl.1
Natural variantiVAR_058583158A → V.1 PublicationCorresponds to variant rs61764030dbSNPEnsembl.1
Natural variantiVAR_052453270M → V.1 PublicationCorresponds to variant rs45449995dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053959436 – 534SYKEN…KSKTH → RKKQQSGRQM in isoform 2. CuratedAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84127 Genomic DNA. Translation: AAA92020.1.
M84124, M84122, M84123 Genomic DNA. Translation: AAA61247.1. Sequence problems.
AF297093 Genomic DNA. Translation: AAG30423.1.
AC006985 Genomic DNA. No translation available.
AC114812 Genomic DNA. No translation available.
DQ364248 mRNA. Translation: ABC96772.1.
CCDSiCCDS2509.1. [P35503-1]
PIRiD42586.
RefSeqiNP_061966.1. NM_019093.2. [P35503-1]
UniGeneiHs.554822.

Genome annotation databases

EnsembliENST00000482026; ENSP00000418532; ENSG00000243135. [P35503-1]
GeneIDi54659.
KEGGihsa:54659.
UCSCiuc061tvt.1. human. [P35503-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84127 Genomic DNA. Translation: AAA92020.1.
M84124, M84122, M84123 Genomic DNA. Translation: AAA61247.1. Sequence problems.
AF297093 Genomic DNA. Translation: AAG30423.1.
AC006985 Genomic DNA. No translation available.
AC114812 Genomic DNA. No translation available.
DQ364248 mRNA. Translation: ABC96772.1.
CCDSiCCDS2509.1. [P35503-1]
PIRiD42586.
RefSeqiNP_061966.1. NM_019093.2. [P35503-1]
UniGeneiHs.554822.

3D structure databases

ProteinModelPortaliP35503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35503. 7 interactors.
STRINGi9606.ENSP00000418532.

Chemistry databases

BindingDBiP35503.
ChEMBLiCHEMBL3542435.
DrugBankiDB06403. Ambrisentan.
DB01076. Atorvastatin.
DB00796. Candesartan.
DB00434. Cyproheptadine.
DB06210. Eltrombopag.
DB00749. Etodolac.
DB00973. Ezetimibe.
DB04953. Ezogabine.
DB01544. Flunitrazepam.
DB00712. Flurbiprofen.
DB01095. Fluvastatin.
DB01050. Ibuprofen.
DB01029. Irbesartan.
DB00555. Lamotrigine.
DB00678. Losartan.
DB00227. Lovastatin.
DB01252. Mitiglinide.
DB00295. Morphine.
DB08860. Pitavastatin.
DB00641. Simvastatin.
DB00313. Valproic Acid.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiP35503.
PhosphoSitePlusiP35503.

Polymorphism and mutation databases

BioMutaiUGT1A3.

Proteomic databases

PaxDbiP35503.
PeptideAtlasiP35503.
PRIDEiP35503.

Protocols and materials databases

DNASUi54659.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000482026; ENSP00000418532; ENSG00000243135. [P35503-1]
GeneIDi54659.
KEGGihsa:54659.
UCSCiuc061tvt.1. human. [P35503-1]

Organism-specific databases

CTDi54659.
DisGeNETi54659.
GeneCardsiUGT1A3.
HGNCiHGNC:12535. UGT1A3.
MIMi191740. gene.
606428. gene.
neXtProtiNX_P35503.
OpenTargetsiENSG00000243135.
PharmGKBiPA37178.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiP35503.
KOiK00699.
OMAiFFRSMAM.
OrthoDBiEOG091G06JC.
PhylomeDBiP35503.
TreeFamiTF315472.

Enzyme and pathway databases

BioCyciMetaCyc:HS09519-MONOMER.
BRENDAi2.4.1.17. 2681.
ReactomeiR-HSA-156588. Glucuronidation.
SABIO-RKP35503.

Miscellaneous databases

GeneWikiiUGT1A3.
GenomeRNAii54659.
PROiP35503.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP35503. baseline and differential.
GenevisibleiP35503. HS.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD13_HUMAN
AccessioniPrimary (citable) accession number: P35503
Secondary accession number(s): B8K287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.