Reviewed, UniProtKB/Swiss-Prot P35503 (UD13_HUMAN)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-3
    EC=2.4.1.17
Alternative name(s):
    UDP-glucuronosyltransferase 1A3
      Short name=UDPGT
      Short name=UGT1*3
    UGT1-03
      Short name=UGT1.3
    UGT-1C
      Short name=UGT1C

Gene names

Name:	UGT1A3
Synonyms:	GNT1, UGT1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	534 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Traceable author statement. Source: ProtInc
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: P35503-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 534	506	UDP-glucuronosyltransferase 1-3		PRO_0000036002
Regions
	Transmembrane	492 – 508	17	Potential
Amino acid modifications
	Glycosylation	119	1	N-linked (GlcNAc...) Potential
	Glycosylation	142	1	N-linked (GlcNAc...)
	Glycosylation	296	1	N-linked (GlcNAc...) Potential
	Glycosylation	348	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	6	1	Q → R: dbSNP rs28898617.		VAR_052445
	Natural variant	11	1	W → R: dbSNP rs3821242.		VAR_052446
	Natural variant	45	1	R → W: dbSNP rs45625338.		VAR_052447
	Natural variant	47	1	V → A: dbSNP rs6431625.		VAR_052448
	Natural variant	49	1	R → W: dbSNP rs45595237.		VAR_052449
	Natural variant	78	1	T → I: dbSNP rs28898618.		VAR_052450
	Natural variant	114	1	M → I: dbSNP rs28898619.		VAR_052451
	Natural variant	144	1	T → I: dbSNP rs13406898.		VAR_052452
	Natural variant	270	1	M → V: dbSNP rs45449995.		VAR_052453

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 9C5833652A4D9B3D	FASTA	534	60,338
	10 20 30 40 50 60 MATGLQVPLP WLATGLLLLL SVQPWAESGK VLVVPIDGSH WLSMREVLRE LHARGHQAVV 70 80 90 100 110 120 LTPEVNMHIK EENFFTLTTY AISWTQDEFD RHVLGHTQLY FETEHFLKKF FRSMAMLNNM 130 140 150 160 170 180 SLVYHRSCVE LLHNEALIRH LNATSFDVVL TDPVNLCAAV LAKYLSIPTV FFLRNIPCDL 190 200 210 220 230 240 DFKGTQCPNP SSYIPRLLTT NSDHMTFMQR VKNMLYPLAL SYICHAFSAP YASLASELFQ 250 260 270 280 290 300 REVSVVDILS HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANRKPLSQE FEAYINASGE 310 320 330 340 350 360 HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT ILVKWLPQND 370 380 390 400 410 420 LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD NAKRMETKGA GVTLNVLEMT 430 440 450 460 470 480 SEDLENALKA VINDKSYKEN IMRLSSLHKD RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH 490 500 510 520 530 DLTWYQYHSL DVIGFLLAVV LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini." Ritter J.K., Chen F., Sheen Y.Y., Tran H.M., Kimura S., Yeatman M.T., Owens I.S. J. Biol. Chem. 267:3257-3261(1992) [PubMed: 1339448] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus." Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C. Pharmacogenetics 11:357-368(2001) [PubMed: 11434514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M84127 Genomic DNA. Translation: AAA92020.1. M84124, M84122, M84123 Genomic DNA. Translation: AAA61247.1. Sequence problems. AF297093 Genomic DNA. Translation: AAG30423.1.
IPI	IPI00473079.
PIR	D42586.
RefSeq	NP_061966.1.
UniGene	Hs.554822
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
PTM databases
PhosphoSite	P35503.
Proteomic databases
PRIDE	P35503.
Genome annotation databases
Ensembl	ENSG00000167165. Homo sapiens. [Contig view]
GeneID	54659.
KEGG	hsa:54659.
UCSC	uc002vuy.1. human.
Organism-specific databases
GeneCards	GC02P234214.
HGNC	HGNC:12535. UGT1A3.
MIM	191740. gene. 606428. gene.
Orphanet	205. Crigler-Najjar syndrome. 357. Gilbert syndrome. 2312. Hyperbilirubinemia transient familial neonatal.
PharmGKB	PA37178.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P35503.
OMA	P35503. SLVYHRS.
Enzyme and pathway databases
BRENDA	2.4.1.17. 247.
Reactome	REACT_13433. Biological oxidations.
Gene expression databases
ArrayExpress	P35503.
Bgee	P35503.
GermOnline	ENSG00000167165. Homo sapiens.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	57192.
SOURCE	Search...

Entry information

Entry name

UD13_HUMAN

Accession

Primary (citable) accession number: P35503

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	July 7, 2009
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)