Reviewed, UniProtKB/Swiss-Prot P35497 (DHSO1_YEAST)

Names and origin

Protein names

Recommended name:
    Sorbitol dehydrogenase 1
    EC=1.1.1.14
Alternative name(s):
    L-iditol 2-dehydrogenase 1

Gene names

Name:	SOR1
Synonyms:	SDH1
Ordered Locus Names:	YJR159W
ORF Names:	J2395

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-iditol + NAD+ = L-sorbose + NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hexose metabolic process Ref.1 Inferred from expression pattern. Source: SGD oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-iditol 2-dehydrogenase activity Ref.1 Inferred from direct assay. Source: SGD protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NUF2	P33895	1	EBI-5861,EBI-12377

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Sorbitol dehydrogenase 1		PRO_0000160821
Sites
	Metal binding	43	1	Zinc; catalytic By similarity
	Metal binding	68	1	Zinc; catalytic By similarity
	Metal binding	69	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35497-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 16843C2040A3334A	FASTA	357	38,166
	10 20 30 40 50 60 MSQNSNPAVV LEKVGDIAIE QRPIPTIKDP HYVKLAIKAT GICGSDIHYY RSGGIGKYIL 70 80 90 100 110 120 KAPMVLGHES SGQVVEVGDA VTRVKVGDRV AIEPGVPSRY SDETKEGRYN LCPHMAFAAT 130 140 150 160 170 180 PPIDGTLVKY YLSPEDFLVK LPEGVSYEEG ACVEPLSVGV HSNKLAGVRF GTKVVVFGAG 190 200 210 220 230 240 PVGLLTGAVA RAFGATDVIF VDVFDNKLQR AKDFGATNTF NSSQFSTDKA QDLADGVQKL 250 260 270 280 290 300 LGGNHADVVF ECSGADVCID AAVKTTKVGG TMVQVGMGKN YTNFPIAEVS GKEMKLIGCF 310 320 330 340 350 RYSFGDYRDA VNLVATGKVN VKPLITHKFK FEDAAKAYDY NIAHGGEVVK TIIFGPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequence determination of the gene encoding sorbitol dehydrogenase from Saccharomyces cerevisiae." Sarthy A.V., Schopp C., Idler K.B. Gene 140:121-126(1994) [PubMed: 8125328] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L11039 Genomic DNA. Translation: AAA35027.1. Z49659 Genomic DNA. Translation: CAA89692.1. AY693012 Genomic DNA. Translation: AAT93031.1.
PIR	S55941.
RefSeq	NP_012693.1.
3D structure databases
HSSP	HSSP built from PDB template 1E3J based on UniProtKB O96496.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1511N.
IntAct	P35497. 9 interactions.
STRING	P35497.
Genome annotation databases
Ensembl	YJR159W; YJR159W; YJR159W; Saccharomyces cerevisiae. [Genome view]
GeneID	853624.
GenomeReviews	Gene locus YJR159W in contig Y13136_GR.
KEGG	sce:YJR159W.
NMPDR	fig|4932.3.peg.3671.
Organism-specific databases
CYGD	YJR159w.
SGD	S000003920. SOR1.
Phylogenomic databases
HOGENOM	P35497.
OMA	NLCPHMA.
Enzyme and pathway databases
BRENDA	1.1.1.14. 250.
Gene expression databases
Genevestigator	P35497.
GermOnline	YJR159W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
ProDom	PD040557. GroES_related. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	974490.

Entry information

Entry name

DHSO1_YEAST

Accession

Primary (citable) accession number: P35497

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	November 3, 2009
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)