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Protein

Sorbitol dehydrogenase 1

Gene

SOR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43Zinc; catalyticBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi68Zinc; catalyticBy similarity1
Metal bindingi69Zinc; catalyticBy similarity1
Binding sitei154SubstrateBy similarity1
Binding sitei301SubstrateBy similarity1
Binding sitei302SubstrateBy similarity1

GO - Molecular functioni

  • L-iditol 2-dehydrogenase activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • hexose metabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciYEAST:YJR159W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase 1 (EC:1.1.1.14)
Alternative name(s):
L-iditol 2-dehydrogenase 1
Gene namesi
Name:SOR1
Synonyms:SDH1
Ordered Locus Names:YJR159W
ORF Names:J2395
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR159W
SGDiS000003920 SOR1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001608211 – 357Sorbitol dehydrogenase 1Add BLAST357

Proteomic databases

PaxDbiP35497
PRIDEiP35497

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi33913, 95 interactors
DIPiDIP-1511N
IntActiP35497, 9 interactors
MINTiP35497
STRINGi4932.YJR159W

Structurei

3D structure databases

ProteinModelPortaliP35497
SMRiP35497
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074781
HOGENOMiHOG000294670
InParanoidiP35497
KOiK00008
OMAiIAGPNEK
OrthoDBiEOG092C2LBV

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P35497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQNSNPAVV LEKVGDIAIE QRPIPTIKDP HYVKLAIKAT GICGSDIHYY
60 70 80 90 100
RSGGIGKYIL KAPMVLGHES SGQVVEVGDA VTRVKVGDRV AIEPGVPSRY
110 120 130 140 150
SDETKEGRYN LCPHMAFAAT PPIDGTLVKY YLSPEDFLVK LPEGVSYEEG
160 170 180 190 200
ACVEPLSVGV HSNKLAGVRF GTKVVVFGAG PVGLLTGAVA RAFGATDVIF
210 220 230 240 250
VDVFDNKLQR AKDFGATNTF NSSQFSTDKA QDLADGVQKL LGGNHADVVF
260 270 280 290 300
ECSGADVCID AAVKTTKVGG TMVQVGMGKN YTNFPIAEVS GKEMKLIGCF
310 320 330 340 350
RYSFGDYRDA VNLVATGKVN VKPLITHKFK FEDAAKAYDY NIAHGGEVVK

TIIFGPE
Length:357
Mass (Da):38,166
Last modified:June 1, 1994 - v1
Checksum:i16843C2040A3334A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11039 Genomic DNA Translation: AAA35027.1
Z49659 Genomic DNA Translation: CAA89692.1
AY693012 Genomic DNA Translation: AAT93031.1
BK006943 Genomic DNA Translation: DAA08943.1
PIRiS55941
RefSeqiNP_012693.1, NM_001181817.1

Genome annotation databases

EnsemblFungiiYJR159W; YJR159W; YJR159W
GeneIDi853624
KEGGisce:YJR159W

Similar proteinsi

Entry informationi

Entry nameiDHSO1_YEAST
AccessioniPrimary (citable) accession number: P35497
Secondary accession number(s): D6VWX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health