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P35492

- HUTH_MOUSE

UniProt

P35492 - HUTH_MOUSE

Protein

Histidine ammonia-lyase

Gene

Hal

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-histidine = urocanate + NH3.PROSITE-ProRule annotation

    Pathwayi

    GO - Molecular functioni

    1. histidine ammonia-lyase activity Source: MGI

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. histidine catabolic process Source: MGI
    3. histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
    4. histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Histidine metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00379; UER00549.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine ammonia-lyase (EC:4.3.1.3)
    Short name:
    Histidase
    Gene namesi
    Name:Hal
    Synonyms:Hsd, Huth
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:96010. Hal.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Hal are the cause of histidinemia (His).

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 657657Histidine ammonia-lyasePRO_0000161059Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki253 ↔ 2555-imidazolinone (Ala-Gly)By similarity
    Modified residuei254 – 25412,3-didehydroalanine (Ser)PROSITE-ProRule annotation
    Modified residuei396 – 3961Phosphothreonine1 Publication
    Modified residuei648 – 6481Phosphoserine1 Publication

    Post-translational modificationi

    Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP35492.
    PaxDbiP35492.
    PRIDEiP35492.

    PTM databases

    PhosphoSiteiP35492.

    Expressioni

    Gene expression databases

    ArrayExpressiP35492.
    BgeeiP35492.
    CleanExiMM_HAL.
    GenevestigatoriP35492.

    Interactioni

    Protein-protein interaction databases

    BioGridi200203. 1 interaction.
    MINTiMINT-1856476.

    Structurei

    3D structure databases

    ProteinModelPortaliP35492.
    SMRiP35492. Positions 113-621.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PAL/histidase family.Curated

    Phylogenomic databases

    eggNOGiCOG2986.
    GeneTreeiENSGT00390000009047.
    HOVERGENiHBG004509.
    InParanoidiP35492.
    KOiK01745.
    OMAiVHIRDEW.
    OrthoDBiEOG73RB9V.
    PhylomeDBiP35492.
    TreeFamiTF313824.

    Family and domain databases

    Gene3Di1.10.275.10. 1 hit.
    InterProiIPR001106. Aromatic_Lyase.
    IPR024083. Fumarase/histidase_N.
    IPR005921. HutH.
    IPR008948. L-Aspartase-like.
    IPR022313. Phe/His_NH3-lyase_AS.
    [Graphical view]
    PfamiPF00221. Lyase_aromatic. 1 hit.
    [Graphical view]
    SUPFAMiSSF48557. SSF48557. 1 hit.
    TIGRFAMsiTIGR01225. hutH. 1 hit.
    PROSITEiPS00488. PAL_HISTIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35492-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRYTVHVRG EWLAVPCQDG KLTVGWLGRE AVRRYMKNKP DNGGFTSVDE    50
    VQFLVHRCKG LGLLDNEDEL EVALEDNEFV EVVIEGDVMS PDFIPSQPEG 100
    VFLYSKYREP EKYIALDGDS LSTEDLVNLG KGRYKIKLTS IAEKKVQQSR 150
    EVIDSIIKER TVVYGITTGF GKFARTVIPA NKLQELQVNL VRSHSSGVGK 200
    PLSPERCRML LALRINVLAK GYSGISLETL KQVIEAFNAS CLSYVPEKGT 250
    VGASGDLAPL SHLALGLIGE GKMWSPKSGW ADAKYVLEAH GLKPIVLKPK 300
    EGLALINGTQ MITSLGCEAL ERASAIARQA DIVAALTLEV LKGTTKAFDT 350
    DIHAVRPHRG QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC 400
    PQVHGVVNDT IAFVKDIITT ELNSATDNPM VFASRGETIS GGNFHGEYPA 450
    KALDYLAIGV HELAAISERR IERLCNPSLS ELPAFLVAEG GLNSGFMIAH 500
    CTAAALVSES KALCHPSSVD SLSTSAATED HVSMGGWAAR KALRVVEHVE 550
    QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI 600
    EAAHRLLLDQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LESLRKNSAT 650
    IPESDDL 657
    Length:657
    Mass (Da):72,258
    Last modified:June 1, 1994 - v1
    Checksum:i03402C348686C22D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti322 – 3221R → Q in His; reduced stability. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07645 mRNA. Translation: AAA37777.1.
    AK014518 mRNA. Translation: BAB29407.1.
    BC057637 mRNA. Translation: AAH57637.1.
    CCDSiCCDS36036.1.
    PIRiA46128.
    RefSeqiNP_034531.1. NM_010401.3.
    UniGeneiMm.13000.

    Genome annotation databases

    EnsembliENSMUST00000129421; ENSMUSP00000123336; ENSMUSG00000020017.
    GeneIDi15109.
    KEGGimmu:15109.
    UCSCiuc007gus.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07645 mRNA. Translation: AAA37777.1 .
    AK014518 mRNA. Translation: BAB29407.1 .
    BC057637 mRNA. Translation: AAH57637.1 .
    CCDSi CCDS36036.1.
    PIRi A46128.
    RefSeqi NP_034531.1. NM_010401.3.
    UniGenei Mm.13000.

    3D structure databases

    ProteinModelPortali P35492.
    SMRi P35492. Positions 113-621.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200203. 1 interaction.
    MINTi MINT-1856476.

    PTM databases

    PhosphoSitei P35492.

    Proteomic databases

    MaxQBi P35492.
    PaxDbi P35492.
    PRIDEi P35492.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000129421 ; ENSMUSP00000123336 ; ENSMUSG00000020017 .
    GeneIDi 15109.
    KEGGi mmu:15109.
    UCSCi uc007gus.1. mouse.

    Organism-specific databases

    CTDi 3034.
    MGIi MGI:96010. Hal.

    Phylogenomic databases

    eggNOGi COG2986.
    GeneTreei ENSGT00390000009047.
    HOVERGENi HBG004509.
    InParanoidi P35492.
    KOi K01745.
    OMAi VHIRDEW.
    OrthoDBi EOG73RB9V.
    PhylomeDBi P35492.
    TreeFami TF313824.

    Enzyme and pathway databases

    UniPathwayi UPA00379 ; UER00549 .

    Miscellaneous databases

    NextBioi 287506.
    PROi P35492.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35492.
    Bgeei P35492.
    CleanExi MM_HAL.
    Genevestigatori P35492.

    Family and domain databases

    Gene3Di 1.10.275.10. 1 hit.
    InterProi IPR001106. Aromatic_Lyase.
    IPR024083. Fumarase/histidase_N.
    IPR005921. HutH.
    IPR008948. L-Aspartase-like.
    IPR022313. Phe/His_NH3-lyase_AS.
    [Graphical view ]
    Pfami PF00221. Lyase_aromatic. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48557. SSF48557. 1 hit.
    TIGRFAMsi TIGR01225. hutH. 1 hit.
    PROSITEi PS00488. PAL_HISTIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the mutation in murine histidinemia (his) and genetic mapping of the murine histidase locus (Hal) on chromosome 10."
      Taylor R.G., Grieco D., Clarke G.A., McInnes R.R., Taylor B.A.
      Genomics 16:231-240(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS GLN-322.
      Strain: C57BL/6J.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-396 AND SER-648, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiHUTH_MOUSE
    AccessioniPrimary (citable) accession number: P35492
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3