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P35492

- HUTH_MOUSE

UniProt

P35492 - HUTH_MOUSE

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Protein

Histidine ammonia-lyase

Gene
Hal, Hsd, Huth
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-histidine = urocanate + NH3.

Pathwayi

GO - Molecular functioni

  1. histidine ammonia-lyase activity Source: MGI

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. histidine catabolic process Source: MGI
  3. histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
  4. histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Histidine metabolism

Enzyme and pathway databases

UniPathwayiUPA00379; UER00549.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine ammonia-lyase (EC:4.3.1.3)
Short name:
Histidase
Gene namesi
Name:Hal
Synonyms:Hsd, Huth
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:96010. Hal.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Defects in Hal are the cause of histidinemia (His).

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Histidine ammonia-lyasePRO_0000161059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki253 ↔ 2555-imidazolinone (Ala-Gly) By similarity
Modified residuei254 – 25412,3-didehydroalanine (Ser) By similarity
Modified residuei396 – 3961Phosphothreonine1 Publication
Modified residuei648 – 6481Phosphoserine1 Publication

Post-translational modificationi

Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP35492.
PaxDbiP35492.
PRIDEiP35492.

PTM databases

PhosphoSiteiP35492.

Expressioni

Gene expression databases

ArrayExpressiP35492.
BgeeiP35492.
CleanExiMM_HAL.
GenevestigatoriP35492.

Interactioni

Protein-protein interaction databases

BioGridi200203. 1 interaction.
MINTiMINT-1856476.

Structurei

3D structure databases

ProteinModelPortaliP35492.
SMRiP35492. Positions 113-621.

Family & Domainsi

Sequence similaritiesi

Belongs to the PAL/histidase family.

Phylogenomic databases

eggNOGiCOG2986.
GeneTreeiENSGT00390000009047.
HOVERGENiHBG004509.
InParanoidiP35492.
KOiK01745.
OMAiVHIRDEW.
OrthoDBiEOG73RB9V.
PhylomeDBiP35492.
TreeFamiTF313824.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR001106. Aromatic_Lyase.
IPR024083. Fumarase/histidase_N.
IPR005921. HutH.
IPR008948. L-Aspartase-like.
IPR022313. Phe/His_NH3-lyase_AS.
[Graphical view]
PfamiPF00221. Lyase_aromatic. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR01225. hutH. 1 hit.
PROSITEiPS00488. PAL_HISTIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35492-1 [UniParc]FASTAAdd to Basket

« Hide

MPRYTVHVRG EWLAVPCQDG KLTVGWLGRE AVRRYMKNKP DNGGFTSVDE    50
VQFLVHRCKG LGLLDNEDEL EVALEDNEFV EVVIEGDVMS PDFIPSQPEG 100
VFLYSKYREP EKYIALDGDS LSTEDLVNLG KGRYKIKLTS IAEKKVQQSR 150
EVIDSIIKER TVVYGITTGF GKFARTVIPA NKLQELQVNL VRSHSSGVGK 200
PLSPERCRML LALRINVLAK GYSGISLETL KQVIEAFNAS CLSYVPEKGT 250
VGASGDLAPL SHLALGLIGE GKMWSPKSGW ADAKYVLEAH GLKPIVLKPK 300
EGLALINGTQ MITSLGCEAL ERASAIARQA DIVAALTLEV LKGTTKAFDT 350
DIHAVRPHRG QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC 400
PQVHGVVNDT IAFVKDIITT ELNSATDNPM VFASRGETIS GGNFHGEYPA 450
KALDYLAIGV HELAAISERR IERLCNPSLS ELPAFLVAEG GLNSGFMIAH 500
CTAAALVSES KALCHPSSVD SLSTSAATED HVSMGGWAAR KALRVVEHVE 550
QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI 600
EAAHRLLLDQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LESLRKNSAT 650
IPESDDL 657
Length:657
Mass (Da):72,258
Last modified:June 1, 1994 - v1
Checksum:i03402C348686C22D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti322 – 3221R → Q in His; reduced stability. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07645 mRNA. Translation: AAA37777.1.
AK014518 mRNA. Translation: BAB29407.1.
BC057637 mRNA. Translation: AAH57637.1.
CCDSiCCDS36036.1.
PIRiA46128.
RefSeqiNP_034531.1. NM_010401.3.
UniGeneiMm.13000.

Genome annotation databases

EnsembliENSMUST00000129421; ENSMUSP00000123336; ENSMUSG00000020017.
GeneIDi15109.
KEGGimmu:15109.
UCSCiuc007gus.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07645 mRNA. Translation: AAA37777.1 .
AK014518 mRNA. Translation: BAB29407.1 .
BC057637 mRNA. Translation: AAH57637.1 .
CCDSi CCDS36036.1.
PIRi A46128.
RefSeqi NP_034531.1. NM_010401.3.
UniGenei Mm.13000.

3D structure databases

ProteinModelPortali P35492.
SMRi P35492. Positions 113-621.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200203. 1 interaction.
MINTi MINT-1856476.

PTM databases

PhosphoSitei P35492.

Proteomic databases

MaxQBi P35492.
PaxDbi P35492.
PRIDEi P35492.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000129421 ; ENSMUSP00000123336 ; ENSMUSG00000020017 .
GeneIDi 15109.
KEGGi mmu:15109.
UCSCi uc007gus.1. mouse.

Organism-specific databases

CTDi 3034.
MGIi MGI:96010. Hal.

Phylogenomic databases

eggNOGi COG2986.
GeneTreei ENSGT00390000009047.
HOVERGENi HBG004509.
InParanoidi P35492.
KOi K01745.
OMAi VHIRDEW.
OrthoDBi EOG73RB9V.
PhylomeDBi P35492.
TreeFami TF313824.

Enzyme and pathway databases

UniPathwayi UPA00379 ; UER00549 .

Miscellaneous databases

NextBioi 287506.
PROi P35492.
SOURCEi Search...

Gene expression databases

ArrayExpressi P35492.
Bgeei P35492.
CleanExi MM_HAL.
Genevestigatori P35492.

Family and domain databases

Gene3Di 1.10.275.10. 1 hit.
InterProi IPR001106. Aromatic_Lyase.
IPR024083. Fumarase/histidase_N.
IPR005921. HutH.
IPR008948. L-Aspartase-like.
IPR022313. Phe/His_NH3-lyase_AS.
[Graphical view ]
Pfami PF00221. Lyase_aromatic. 1 hit.
[Graphical view ]
SUPFAMi SSF48557. SSF48557. 1 hit.
TIGRFAMsi TIGR01225. hutH. 1 hit.
PROSITEi PS00488. PAL_HISTIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the mutation in murine histidinemia (his) and genetic mapping of the murine histidase locus (Hal) on chromosome 10."
    Taylor R.G., Grieco D., Clarke G.A., McInnes R.R., Taylor B.A.
    Genomics 16:231-240(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS GLN-322.
    Strain: C57BL/6J.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-396 AND SER-648, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHUTH_MOUSE
AccessioniPrimary (citable) accession number: P35492
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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