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P35485 (ODPA_ACHLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component subunit alpha

EC=1.2.4.1
Gene names
Name:pdhA
OrganismAcholeplasma laidlawii
Taxonomic identifier2148 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma

Protein attributes

Sequence length345 AA.
Sequence statusFragment.
Protein existencePredicted

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate.

Subunit structure

Heterodimer of an alpha and a beta chain.

Ontologies

Keywords
   Biological processGlycolysis
   LigandPyruvate
Thiamine pyrophosphate
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpyruvate dehydrogenase (acetyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

thiamine pyrophosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 345›345Pyruvate dehydrogenase E1 component subunit alpha
PRO_0000162197

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P35485 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 797F9F67DE0C2995

FASTA34538,962
        10         20         30         40         50         60 
DQNGKVVNEK MEPKLPKETL LKMYKTAVLG RNADIKALQY QRQGRMLTYA PNMGQEAAQI 

        70         80         90        100        110        120 
GMAAAMEPQD WNSPMYRELN TLLYRGDKLE NVFLYWYGNE RGSIKPEGVK ILPTNIIIGS 

       130        140        150        160        170        180 
QSNIAAGLAM ASKIRKTNEV TAFTIGDGGT AHGEFYEGLN FAASFKAPVV AVIQNNQWAI 

       190        200        210        220        230        240 
STPVRKASNS ETLAQKGVAF GIPYIQVDGN DMLAMYVASK EAMDRARKGD GPTLIEAFTY 

       250        260        270        280        290        300 
RMGPHTTSDD PCSIYRTKEE ENEWAKKDQI ARFKTYLINK GYWSEEEDKK LEEEVLAEIN 

       310        320        330        340 
DTFKKVESYG ANVELIEIFE HTYAEMTPQL KEQYEEHKKY LEGVK 

« Hide

References

[1]"Identification and analysis of the genes coding for the putative pyruvate dehydrogenase enzyme complex in Acholeplasma laidlawii."
Wallbrandt P., Tegman V., Jonsson B.-H., Wieslander A.
J. Bacteriol. 174:1388-1396(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81753 Genomic DNA. Translation: AAA21907.1.
PIRA42653.

3D structure databases

ProteinModelPortalP35485.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001017. DH_E1.
IPR017596. Pyrv_DH_E1_asu_subgrp-x.
[Graphical view]
PfamPF00676. E1_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODPA_ACHLA
AccessionPrimary (citable) accession number: P35485
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 16, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program