Reviewed,
UniProtKB/Swiss-Prot P35482 (PPBL_PSEAE)
Last modified
November 3, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alkaline phosphatase L Short name=L-AP EC=3.1.3.1 Alternative name(s): Low molecular weight phosphatase | ||||
| Gene names |
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| Organism | Pseudomonas aeruginosa [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 287 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas |
Protein attributes
| Sequence length | 368 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Has both a phosphomonoesterase and phosphodiesterase activity. |
| Catalytic activity | A phosphate monoester + H2O = an alcohol + phosphate. |
| Cofactor | Binds 1 magnesium ion per subunit. Binds 2 zinc ions per subunit. |
| Subunit structure | Homodimer. |
| Subcellular location | Secreted. Periplasm. Note: Secreted and to some extent periplasmic. |
| Developmental stage | Expressed 7 hours after introduction into phosphate poor media. |
| Induction | In phosphate poor media. |
| Sequence similarities | Belongs to the pstS family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Periplasm Secreted |
| Domain | Signal |
| Ligand | Magnesium Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell periplasmic spaceInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | alkaline phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and preliminary characterization of phoA encoding alkaline phosphatase of Pseudomonas aeruginosa." Schuermann M., Liebeton K., Jaeger K.-E. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228. |
| [2] | "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. Olson M.V.Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228. |
| [3] | "Isolation and characterization of two immunochemically distinct alkaline phosphatases from Pseudomonas aeruginosa." Tan A.S.P., Worobec E.A. FEMS Microbiol. Lett. 106:281-286(1993) [PubMed: 8454193] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-37. Strain: H103. |
Cross-references
Sequence databases | |
|---|---|
| AF047381 Genomic DNA. Translation: AAC04870.1. AE004091 Genomic DNA. Translation: AAG04077.1. | |
| PIR | E83559. |
| RefSeq | NP_249379.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 880790. |
| GenomeReviews | Gene locus PA0688 in contig AE004091_GR. |
| KEGG | pae:PA0688. |
| NMPDR | fig|208964.1.peg.689. |
Organism-specific databases | |
| PseudoCAP | PA0688. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P35482. |
| OMA | PFNKAGS. |
Enzyme and pathway databases | |
| BioCyc | PAER208964:PA0688-MON. |
| BRENDA | 3.1.3.1. 354. |
Family and domain databases | |
| ProtoNet | Search... |
Entry information
| Entry name | PPBL_PSEAE | ||||||||
| Accession | Primary (citable) accession number: P35482 Secondary accession number(s): O52768 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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