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P35467 (S10A1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A1
Alternative name(s):
S-100 protein alpha chain
S-100 protein subunit alpha
S100 calcium-binding protein A1
Gene names
Name:S100a1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length94 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity By similarity.

Subunit structure

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity By similarity. Ref.3 Ref.5 Ref.6

Subcellular location

Cytoplasm.

Tissue specificity

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FKBP4Q027907EBI-6477109,EBI-1047444From a different organism.
HSP90AA1P079004EBI-6477109,EBI-296047From a different organism.
HSPA1BP081074EBI-6477109,EBI-629985From a different organism.
PPIDP268827EBI-6477109,EBI-6477155From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 9493Protein S100-A1
PRO_0000143963

Regions

Domain13 – 4836EF-hand 1
Domain50 – 8536EF-hand 2
Calcium binding20 – 33141; low affinity
Calcium binding63 – 74122; high affinity

Amino acid modifications

Modified residue861S-nitrosocysteine By similarity

Experimental info

Sequence conflict141N → H in AAB20539. Ref.2
Sequence conflict571K → R in AAB20539. Ref.2

Secondary structure

................... 94
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P35467 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 7B9C0A6C1C4FCCE0

FASTA9410,560
        10         20         30         40         50         60 
MGSELETAME TLINVFHAHS GKEGDKYKLS KKELKDLLQT ELSSFLDVQK DADAVDKIMK 

        70         80         90 
ELDENGDGEV DFQEFVVLVA ALTVACNNFF WENS 

« Hide

References

[1]Song W.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
[2]"Isolation of a rat S100 alpha cDNA and distribution of its mRNA in rat tissues."
Zimmer D.B., Song W., Zimmer W.E.
Brain Res. Bull. 27:157-162(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-94.
Tissue: Kidney.
[3]"S100B interaction with the receptor for advanced glycation end products (RAGE): a novel receptor-mediated mechanism for myocyte apoptosis postinfarction."
Tsoporis J.N., Izhar S., Leong-Poi H., Desjardins J.F., Huttunen H.J., Parker T.G.
Circ. Res. 106:93-101(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AGER.
[4]"Three-dimensional solution structure of the calcium-signaling protein apo-S100A1 as determined by NMR."
Rustandi R.R., Baldisseri D.M., Inman K.G., Nizner P., Hamilton S.M., Landar A., Landar A., Zimmer D.B., Weber D.J.
Biochemistry 41:788-796(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
[5]"Solution structure of S100A1 bound to the CapZ peptide (TRTK12)."
Wright N.T., Cannon B.R., Wilder P.T., Morgan M.T., Varney K.M., Zimmer D.B., Weber D.J.
J. Mol. Biol. 386:1265-1277(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR IN COMPLEX WITH CALCIUM IONS AND CAPZA1, SUBUNIT.
[6]"S100A1 and calmodulin compete for the same binding site on ryanodine receptor."
Wright N.T., Prosser B.L., Varney K.M., Zimmer D.B., Schneider M.F., Weber D.J.
J. Biol. Chem. 283:26676-26683(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR IN COMPLEX WITH RYR1, INTERACTION WITH RYR1 AND RYR2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U26358, U26357 Genomic DNA. Translation: AAB53657.1.
S68809 mRNA. Translation: AAB20539.2.
RefSeqNP_001007637.1. NM_001007636.2.
XP_006232665.1. XM_006232603.1.
UniGeneRn.11091.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K2HNMR-A/B2-94[»]
1ZFSNMR-A/B2-93[»]
2K2FNMR-A/B2-94[»]
2KBMNMR-A/B2-94[»]
ProteinModelPortalP35467.
SMRP35467. Positions 2-94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP35467. 4 interactions.
MINTMINT-4591010.
STRING10116.ENSRNOP00000017000.

Proteomic databases

PaxDbP35467.
PRIDEP35467.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000017000; ENSRNOP00000017000; ENSRNOG00000012410.
GeneID295214.
KEGGrno:295214.
UCSCRGD:3614. rat.

Organism-specific databases

CTD6271.
RGD3614. S100a1.

Phylogenomic databases

eggNOGNOG277258.
GeneTreeENSGT00740000114954.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP35467.
OMAINVFHTH.
OrthoDBEOG7R833W.
PhylomeDBP35467.
TreeFamTF332727.

Gene expression databases

GenevestigatorP35467.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028486. S100-A1.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERPTHR11639:SF30. PTHR11639:SF30. 1 hit.
PfamPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP35467.
NextBio639119.
PROP35467.

Entry information

Entry nameS10A1_RAT
AccessionPrimary (citable) accession number: P35467
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references