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P35464 (DIHR_MANSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Diuretic hormone receptor
Short name=DH-R
OrganismManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifier7130 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Bombycoidea › Sphingidae › Sphinginae › Sphingini › Manduca

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the insect diurectic hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in Malpighian tubules.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Diuretic hormone receptor
PRO_0000070330

Regions

Topological domain1 – 8787Extracellular Potential
Transmembrane88 – 11124Helical; Name=1; Potential
Topological domain112 – 1198Cytoplasmic Potential
Transmembrane120 – 14021Helical; Name=2; Potential
Topological domain141 – 15515Extracellular Potential
Transmembrane156 – 17621Helical; Name=3; Potential
Topological domain177 – 19519Cytoplasmic Potential
Transmembrane196 – 21722Helical; Name=4; Potential
Topological domain218 – 24831Extracellular Potential
Transmembrane249 – 27224Helical; Name=5; Potential
Topological domain273 – 29523Cytoplasmic Potential
Transmembrane296 – 31419Helical; Name=6; Potential
Topological domain315 – 32915Extracellular Potential
Transmembrane330 – 34920Helical; Name=7; Potential
Topological domain350 – 39546Cytoplasmic Potential

Amino acid modifications

Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P35464 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 3F8C1A3EFEA01B2D

FASTA39545,421
        10         20         30         40         50         60 
MAEECLARKF NLSDNYCPAY FDGLLCWDPT PWNTLAVQKC FKELYGIQYD DTQNASRLCL 

        70         80         90        100        110        120 
DGVWHNYTNY TNCTERIANG SPTDVASLIY LAGYSLSLAV LSLAVFVFLY FKDLRCLRNT 

       130        140        150        160        170        180 
IHTNLMSTYI LSACSWILNL VLQNWSDESQ QDQTSCMILV ICMNYFYLTN FFWMLVEGLY 

       190        200        210        220        230        240 
LYMLVVETFT AENIKLKVYT TIGWGAPAVF ITIWVISRCF VNVLPSTGPD GLAMFPEAKM 

       250        260        270        280        290        300 
CIWMHEHQVD WIHKAPALVG LALNLFFLIR IMWVLITKLR SANTLETEQY RKATKALLVL 

       310        320        330        340        350        360 
IPLLGITNLL VLCGPSDDSW FAYAFDYTRA LMLSTQGFTV ALFYCFMNTE VRHAIRYHVE 

       370        380        390 
RWKTGRTIGG GRRRGASYSK DWSPRSRTES IRLTV

« Hide

References

[1]"Expression cloning of an insect diuretic hormone receptor. A member of the calcitonin/secretin receptor family."
Reagan J.D.
J. Biol. Chem. 269:9-12(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U03489 mRNA. Translation: AAC46469.1.

3D structure databases

ProteinModelPortalP35464.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR002001. GPCR_2_diuretic_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERPTHR12011:SF68. PTHR12011:SF68. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR01127. DIUHORMONER.
PR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDIHR_MANSE
AccessionPrimary (citable) accession number: P35464
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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