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Protein

D(3) dopamine receptor

Gene

DRD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101Agonist

GO - Molecular functioni

  • dopamine binding Source: Ensembl
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
  • drug binding Source: BHF-UCL
  • G-protein coupled amine receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16968. Dopamine receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP35462.

Names & Taxonomyi

Protein namesi
Recommended name:
D(3) dopamine receptor
Alternative name(s):
Dopamine D3 receptor
Gene namesi
Name:DRD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:3024. DRD3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularCuratedAdd
BLAST
Transmembranei33 – 5523Helical; Name=1Add
BLAST
Topological domaini56 – 6510Cytoplasmic
Transmembranei66 – 8823Helical; Name=2Add
BLAST
Topological domaini89 – 10416ExtracellularAdd
BLAST
Transmembranei105 – 12622Helical; Name=3Add
BLAST
Topological domaini127 – 14923CytoplasmicAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Add
BLAST
Topological domaini171 – 18717ExtracellularAdd
BLAST
Transmembranei188 – 21225Helical; Name=5Add
BLAST
Topological domaini213 – 329117CytoplasmicAdd
BLAST
Transmembranei330 – 35122Helical; Name=6Add
BLAST
Topological domaini352 – 36615ExtracellularAdd
BLAST
Transmembranei367 – 38822Helical; Name=7Add
BLAST
Topological domaini389 – 40012CytoplasmicAdd
BLAST

GO - Cellular componenti

  • apical part of cell Source: Ensembl
  • cell projection Source: Ensembl
  • endocytic vesicle Source: Ensembl
  • integral component of plasma membrane Source: BHF-UCL
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Tremor, hereditary essential 1 (ETM1)2 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.

See also OMIM:190300
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91S → G Associated with susceptibility to ETM1; gain of function. 7 Publications
Corresponds to variant rs6280 [ dbSNP | Ensembl ].
VAR_003463

Organism-specific databases

MIMi190300. phenotype.
Orphaneti862. Hereditary essential tremor.
PharmGKBiPA27479.

Chemistry

DrugBankiDB06288. Amisulpride.
DB00543. Amoxapine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB09014. Captodiame.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00363. Clozapine.
DB01184. Domperidone.
DB00988. Dopamine.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB01235. L-DOPA.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB01100. Pimozide.
DB00413. Pramipexole.
DB01224. Quetiapine.
DB00409. Remoxipride.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB00391. Sulpiride.
DB01392. Yohimbine.
DB00246. Ziprasidone.

Polymorphism and mutation databases

DMDMi1169206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400D(3) dopamine receptorPRO_0000069397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi103 ↔ 181PROSITE-ProRule annotation1 Publication
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi355 ↔ 358PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35462.
PRIDEiP35462.

PTM databases

PhosphoSiteiP35462.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiP35462.
CleanExiHS_DRD3.
ExpressionAtlasiP35462. baseline.
GenevisibleiP35462. HS.

Interactioni

Subunit structurei

Interacts with CLIC6 (By similarity). Interacts with GRK4. Interacts with PALM.By similarity3 Publications

Protein-protein interaction databases

BioGridi108148. 10 interactions.
DIPiDIP-5976N.
STRINGi9606.ENSP00000373169.

Structurei

Secondary structure

1
400
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 5622Combined sources
Helixi63 – 8119Combined sources
Helixi83 – 919Combined sources
Helixi100 – 13334Combined sources
Helixi135 – 1406Combined sources
Beta strandi143 – 1453Combined sources
Helixi147 – 16923Combined sources
Turni170 – 1723Combined sources
Helixi186 – 19611Combined sources
Helixi198 – 21619Combined sources
Helixi322 – 35332Combined sources
Helixi362 – 38625Combined sources
Helixi388 – 39811Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PBLX-ray2.89A/B2-221[»]
A/B319-400[»]
ProteinModelPortaliP35462.
SMRiP35462. Positions 32-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni189 – 1968Agonist binding
Regioni342 – 3509Agonist binding

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG309657.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35462.
KOiK04146.
OrthoDBiEOG769ZMG.
PhylomeDBiP35462.
TreeFamiTF334382.

Family and domain databases

InterProiIPR001620. Dopamine_D3_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF38. PTHR24249:SF38. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00568. DOPAMINED3R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35462-1) [UniParc]FASTAAdd to basket

Also known as: D3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV
60 70 80 90 100
CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR
110 120 130 140 150
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV
160 170 180 190 200
ALMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP
210 220 230 240 250
FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDPAHL
260 270 280 290 300
ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK
310 320 330 340 350
LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV
360 370 380 390 400
LNTHCQTCHV SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC
Length:400
Mass (Da):44,225
Last modified:November 1, 1995 - v2
Checksum:i2CDA789D78378DDA
GO
Isoform 3 (identifier: P35462-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-320: SPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGV → M

Show »
Length:367
Mass (Da):40,760
Checksum:i40F7FFA4519042FD
GO

Sequence cautioni

The sequence AAA03543.1 differs from that shown. Reason: Frameshift at position 288. Curated
The sequence AAA64369.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti396 – 3961K → L in AAH95510 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91S → G Associated with susceptibility to ETM1; gain of function. 7 Publications
Corresponds to variant rs6280 [ dbSNP | Ensembl ].
VAR_003463

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei287 – 32034SPTIA…QPRGV → M in isoform 3. 1 PublicationVSP_040570Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20469 mRNA. Translation: AAA03543.1. Frameshift.
AH003061 Genomic DNA. Translation: AAA64369.1. Sequence problems.
U32499 mRNA. Translation: AAA73929.1.
AC092896 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79610.1.
BC095510 mRNA. Translation: AAH95510.1.
BC128123 mRNA. Translation: AAI28124.1.
CCDSiCCDS2978.1. [P35462-1]
CCDS33829.1. [P35462-3]
PIRiA48258.
A55419.
G01977.
RefSeqiNP_000787.2. NM_000796.5.
NP_001269492.1. NM_001282563.2.
NP_001277738.1. NM_001290809.1.
NP_387512.3. NM_033663.5.
UniGeneiHs.121478.

Genome annotation databases

EnsembliENST00000383673; ENSP00000373169; ENSG00000151577.
ENST00000460779; ENSP00000419402; ENSG00000151577.
ENST00000467632; ENSP00000420662; ENSG00000151577.
GeneIDi1814.
KEGGihsa:1814.
UCSCiuc003ebc.1. human. [P35462-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20469 mRNA. Translation: AAA03543.1. Frameshift.
AH003061 Genomic DNA. Translation: AAA64369.1. Sequence problems.
U32499 mRNA. Translation: AAA73929.1.
AC092896 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79610.1.
BC095510 mRNA. Translation: AAH95510.1.
BC128123 mRNA. Translation: AAI28124.1.
CCDSiCCDS2978.1. [P35462-1]
CCDS33829.1. [P35462-3]
PIRiA48258.
A55419.
G01977.
RefSeqiNP_000787.2. NM_000796.5.
NP_001269492.1. NM_001282563.2.
NP_001277738.1. NM_001290809.1.
NP_387512.3. NM_033663.5.
UniGeneiHs.121478.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PBLX-ray2.89A/B2-221[»]
A/B319-400[»]
ProteinModelPortaliP35462.
SMRiP35462. Positions 32-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108148. 10 interactions.
DIPiDIP-5976N.
STRINGi9606.ENSP00000373169.

Chemistry

BindingDBiP35462.
ChEMBLiCHEMBL2096905.
DrugBankiDB06288. Amisulpride.
DB00543. Amoxapine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB09014. Captodiame.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00363. Clozapine.
DB01184. Domperidone.
DB00988. Dopamine.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB01235. L-DOPA.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB01100. Pimozide.
DB00413. Pramipexole.
DB01224. Quetiapine.
DB00409. Remoxipride.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB00391. Sulpiride.
DB01392. Yohimbine.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi216.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP35462.

Polymorphism and mutation databases

DMDMi1169206.

Proteomic databases

PaxDbiP35462.
PRIDEiP35462.

Protocols and materials databases

DNASUi1814.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383673; ENSP00000373169; ENSG00000151577.
ENST00000460779; ENSP00000419402; ENSG00000151577.
ENST00000467632; ENSP00000420662; ENSG00000151577.
GeneIDi1814.
KEGGihsa:1814.
UCSCiuc003ebc.1. human. [P35462-1]

Organism-specific databases

CTDi1814.
GeneCardsiGC03M113847.
H-InvDBHIX0030774.
HIX0163472.
HGNCiHGNC:3024. DRD3.
MIMi126451. gene.
190300. phenotype.
neXtProtiNX_P35462.
Orphaneti862. Hereditary essential tremor.
PharmGKBiPA27479.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG309657.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35462.
KOiK04146.
OrthoDBiEOG769ZMG.
PhylomeDBiP35462.
TreeFamiTF334382.

Enzyme and pathway databases

ReactomeiREACT_16968. Dopamine receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP35462.

Miscellaneous databases

NextBioi7395.
PROiP35462.
SOURCEiSearch...

Gene expression databases

BgeeiP35462.
CleanExiHS_DRD3.
ExpressionAtlasiP35462. baseline.
GenevisibleiP35462. HS.

Family and domain databases

InterProiIPR001620. Dopamine_D3_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF38. PTHR24249:SF38. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00568. DOPAMINED3R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene cloning of human dopaminergic D3 receptor and identification of its chromosome."
    Giros B., Martres M.-P., Sokoloff P., Schwartz J.-C.
    C. R. Acad. Sci. III, Sci. Vie 311:501-508(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia."
    Schmauss C., Haroutunian V., Davis K.L., Davidson M.
    Proc. Natl. Acad. Sci. U.S.A. 90:8942-8946(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  3. "On the origin of mRNA encoding the truncated dopamine D3-type receptor D3nf and detection of D3nf-like immunoreactivity in human brain."
    Liu K., Bergson C., Levenson R., Schmauss C.
    J. Biol. Chem. 269:29220-29226(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    Tissue: Brain.
  4. Fishburn C.S., Park B.-H., Fuchs S.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-9.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-9.
  8. "Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling."
    Basile M., Lin R., Kabbani N., Karpa K., Kilimann M., Simpson I., Kester M.
    Arch. Biochem. Biophys. 446:60-68(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PALM.
  9. "G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor."
    Villar V.A.M., Jones J.E., Armando I., Palmes-Saloma C., Yu P., Pascua A.M., Keever L., Arnaldo F.B., Wang Z., Luo Y., Felder R.A., Jose P.A.
    J. Biol. Chem. 284:21425-21434(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY GRK4, SUBCELLULAR LOCATION, INTERACTION WITH GRK4, FUNCTION.
  10. "Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist."
    Chien E.Y., Liu W., Zhao Q., Katritch V., Han G.W., Hanson M.A., Shi L., Newman A.H., Javitch J.A., Cherezov V., Stevens R.C.
    Science 330:1091-1095(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) IN COMPLEX WITH THE ANTAGONIST ETICLOPRIDE, DISULFIDE BONDS, MEMBRANE TOPOLOGY.
  11. "Amino-acid substitution in the dopamine D3 receptor as useful polymorphism for investigating psychiatric disorders."
    Lannfelt T., Sokoloff P., Martres M.-P., Pilon C., Giros B., Joensson E., Sedvall G., Schwartz J.-C.
    Psychiatr. Genet. 2:249-256(1992)
    Cited for: VARIANT GLY-9.
  12. "Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia."
    Chen C.-H., Liu M.-Y., Wei F.-C., Koong F.-J., Hwu H.-G., Hsiao K.-J.
    Am. J. Med. Genet. 74:40-43(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-9.
  13. Cited for: VARIANT GLY-9.
  14. "Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families."
    Lucotte G., Lagarde J.-P., Funalot B., Sokoloff P.
    Clin. Genet. 69:437-440(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-9, INVOLVEMENT IN SUSCEPTIBILITY TO ETM1.
  15. "A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor."
    Jeanneteau F., Funalot B., Jankovic J., Deng H., Lagarde J.-P., Lucotte G., Sokoloff P.
    Proc. Natl. Acad. Sci. U.S.A. 103:10753-10758(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-9, CHARACTERIZATION OF VARIANT GLY-9, INVOLVEMENT IN SUSCEPTIBILITY TO ETM1.

Entry informationi

Entry nameiDRD3_HUMAN
AccessioniPrimary (citable) accession number: P35462
Secondary accession number(s): A1A4V5, Q4VBM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.