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P35462

- DRD3_HUMAN

UniProt

P35462 - DRD3_HUMAN

Protein

D(3) dopamine receptor

Gene

DRD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei110 – 1101Agonist

    GO - Molecular functioni

    1. dopamine binding Source: Ensembl
    2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
    3. drug binding Source: BHF-UCL
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. acid secretion Source: BHF-UCL
    2. adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
    3. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCL
    4. arachidonic acid secretion Source: BHF-UCL
    5. behavioral response to cocaine Source: BHF-UCL
    6. cellular calcium ion homeostasis Source: BHF-UCL
    7. circadian regulation of gene expression Source: BHF-UCL
    8. dopamine metabolic process Source: BHF-UCL
    9. gastric emptying Source: Ensembl
    10. G-protein coupled receptor internalization Source: BHF-UCL
    11. G-protein coupled receptor signaling pathway Source: BHF-UCL
    12. learning Source: BHF-UCL
    13. learning or memory Source: BHF-UCL
    14. locomotory behavior Source: BHF-UCL
    15. musculoskeletal movement, spinal reflex action Source: BHF-UCL
    16. negative regulation of adenylate cyclase activity Source: BHF-UCL
    17. negative regulation of blood pressure Source: BHF-UCL
    18. negative regulation of dopamine receptor signaling pathway Source: Ensembl
    19. negative regulation of oligodendrocyte differentiation Source: BHF-UCL
    20. negative regulation of protein kinase B signaling Source: BHF-UCL
    21. negative regulation of protein secretion Source: BHF-UCL
    22. negative regulation of sodium:proton antiporter activity Source: Ensembl
    23. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. positive regulation of cell proliferation Source: Ensembl
    25. positive regulation of cytokinesis Source: UniProt
    26. positive regulation of dopamine receptor signaling pathway Source: BHF-UCL
    27. positive regulation of mitosis Source: BHF-UCL
    28. positive regulation of renal sodium excretion Source: Ensembl
    29. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    30. prepulse inhibition Source: BHF-UCL
    31. regulation of blood volume by renin-angiotensin Source: Ensembl
    32. regulation of cAMP metabolic process Source: BHF-UCL
    33. regulation of circadian sleep/wake cycle, sleep Source: Ensembl
    34. regulation of dopamine secretion Source: BHF-UCL
    35. regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
    36. regulation of lipid metabolic process Source: Ensembl
    37. regulation of locomotion involved in locomotory behavior Source: Ensembl
    38. regulation of multicellular organism growth Source: Ensembl
    39. response to amphetamine Source: Ensembl
    40. response to cocaine Source: BHF-UCL
    41. response to drug Source: BHF-UCL
    42. response to histamine Source: BHF-UCL
    43. response to morphine Source: BHF-UCL
    44. social behavior Source: BHF-UCL
    45. synaptic transmission, dopaminergic Source: Ensembl
    46. visual learning Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16968. Dopamine receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiP35462.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D(3) dopamine receptor
    Alternative name(s):
    Dopamine D3 receptor
    Gene namesi
    Name:DRD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:3024. DRD3.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. cell projection Source: Ensembl
    3. endocytic vesicle Source: Ensembl
    4. integral component of plasma membrane Source: BHF-UCL
    5. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Tremor, hereditary essential 1 (ETM1) [MIM:190300]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.2 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91S → G Associated with susceptibility to ETM1; gain of function. 7 Publications
    Corresponds to variant rs6280 [ dbSNP | Ensembl ].
    VAR_003463

    Organism-specific databases

    MIMi190300. phenotype.
    Orphaneti862. Hereditary essential tremor.
    PharmGKBiPA27479.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400D(3) dopamine receptorPRO_0000069397Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi103 ↔ 1811 PublicationPROSITE-ProRule annotation
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi355 ↔ 3581 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP35462.
    PRIDEiP35462.

    PTM databases

    PhosphoSiteiP35462.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    ArrayExpressiP35462.
    BgeeiP35462.
    CleanExiHS_DRD3.
    GenevestigatoriP35462.

    Interactioni

    Subunit structurei

    Interacts with CLIC6 By similarity. Interacts with GRK4. Interacts with PALM.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi108148. 8 interactions.
    DIPiDIP-5976N.
    STRINGi9606.ENSP00000373169.

    Structurei

    Secondary structure

    1
    400
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi35 – 5622
    Helixi63 – 8119
    Helixi83 – 919
    Helixi100 – 13334
    Helixi135 – 1406
    Beta strandi143 – 1453
    Helixi147 – 16923
    Turni170 – 1723
    Helixi186 – 19611
    Helixi198 – 21619
    Helixi322 – 35332
    Helixi362 – 38625
    Helixi388 – 39811

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3PBLX-ray2.89A/B2-221[»]
    A/B319-400[»]
    ProteinModelPortaliP35462.
    SMRiP35462. Positions 32-400.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularCuratedAdd
    BLAST
    Topological domaini56 – 6510Cytoplasmic
    Topological domaini89 – 10416ExtracellularAdd
    BLAST
    Topological domaini127 – 14923CytoplasmicAdd
    BLAST
    Topological domaini171 – 18717ExtracellularAdd
    BLAST
    Topological domaini213 – 329117CytoplasmicAdd
    BLAST
    Topological domaini352 – 36615ExtracellularAdd
    BLAST
    Topological domaini389 – 40012CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5523Helical; Name=1Add
    BLAST
    Transmembranei66 – 8823Helical; Name=2Add
    BLAST
    Transmembranei105 – 12622Helical; Name=3Add
    BLAST
    Transmembranei150 – 17021Helical; Name=4Add
    BLAST
    Transmembranei188 – 21225Helical; Name=5Add
    BLAST
    Transmembranei330 – 35122Helical; Name=6Add
    BLAST
    Transmembranei367 – 38822Helical; Name=7Add
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni189 – 1968Agonist binding
    Regioni342 – 3509Agonist binding

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG309657.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP35462.
    OrthoDBiEOG769ZMG.
    PhylomeDBiP35462.
    TreeFamiTF334382.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR001620. Dopamine_D3_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24249:SF38. PTHR24249:SF38. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00568. DOPAMINED3R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P35462-1) [UniParc]FASTAAdd to Basket

    Also known as: D3

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV    50
    CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR 100
    ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV 150
    ALMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP 200
    FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDPAHL 250
    ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK 300
    LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV 350
    LNTHCQTCHV SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC 400
    Length:400
    Mass (Da):44,225
    Last modified:November 1, 1995 - v2
    Checksum:i2CDA789D78378DDA
    GO
    Isoform 3 (identifier: P35462-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         287-320: SPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGV → M

    Show »
    Length:367
    Mass (Da):40,760
    Checksum:i40F7FFA4519042FD
    GO

    Sequence cautioni

    The sequence AAA03543.1 differs from that shown. Reason: Frameshift at position 288.
    The sequence AAA64369.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti396 – 3961K → L in AAH95510. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91S → G Associated with susceptibility to ETM1; gain of function. 7 Publications
    Corresponds to variant rs6280 [ dbSNP | Ensembl ].
    VAR_003463

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei287 – 32034SPTIA…QPRGV → M in isoform 3. 1 PublicationVSP_040570Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20469 mRNA. Translation: AAA03543.1. Frameshift.
    AH003061 Genomic DNA. Translation: AAA64369.1. Sequence problems.
    U32499 mRNA. Translation: AAA73929.1.
    AC092896 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79610.1.
    BC095510 mRNA. Translation: AAH95510.1.
    BC128123 mRNA. Translation: AAI28124.1.
    CCDSiCCDS2978.1. [P35462-1]
    CCDS33829.1. [P35462-3]
    PIRiA48258.
    A55419.
    G01977.
    RefSeqiNP_000787.2. NM_000796.5.
    NP_001269492.1. NM_001282563.2.
    NP_001277738.1. NM_001290809.1.
    NP_387512.3. NM_033663.5.
    UniGeneiHs.121478.

    Genome annotation databases

    EnsembliENST00000383673; ENSP00000373169; ENSG00000151577.
    ENST00000460779; ENSP00000419402; ENSG00000151577.
    ENST00000467632; ENSP00000420662; ENSG00000151577.
    GeneIDi1814.
    UCSCiuc003ebc.1. human. [P35462-1]

    Polymorphism databases

    DMDMi1169206.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20469 mRNA. Translation: AAA03543.1 . Frameshift.
    AH003061 Genomic DNA. Translation: AAA64369.1 . Sequence problems.
    U32499 mRNA. Translation: AAA73929.1 .
    AC092896 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79610.1 .
    BC095510 mRNA. Translation: AAH95510.1 .
    BC128123 mRNA. Translation: AAI28124.1 .
    CCDSi CCDS2978.1. [P35462-1 ]
    CCDS33829.1. [P35462-3 ]
    PIRi A48258.
    A55419.
    G01977.
    RefSeqi NP_000787.2. NM_000796.5.
    NP_001269492.1. NM_001282563.2.
    NP_001277738.1. NM_001290809.1.
    NP_387512.3. NM_033663.5.
    UniGenei Hs.121478.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3PBL X-ray 2.89 A/B 2-221 [» ]
    A/B 319-400 [» ]
    ProteinModelPortali P35462.
    SMRi P35462. Positions 32-400.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108148. 8 interactions.
    DIPi DIP-5976N.
    STRINGi 9606.ENSP00000373169.

    Chemistry

    BindingDBi P35462.
    ChEMBLi CHEMBL2097165.
    DrugBanki DB00714. Apomorphine.
    DB01239. Chlorprothixene.
    DB00907. Cocaine.
    DB01403. Methotrimeprazine.
    DB00334. Olanzapine.
    DB00413. Pramipexole.
    DB00268. Ropinirole.
    DB00246. Ziprasidone.
    GuidetoPHARMACOLOGYi 216.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35462.

    Polymorphism databases

    DMDMi 1169206.

    Proteomic databases

    PaxDbi P35462.
    PRIDEi P35462.

    Protocols and materials databases

    DNASUi 1814.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383673 ; ENSP00000373169 ; ENSG00000151577 .
    ENST00000460779 ; ENSP00000419402 ; ENSG00000151577 .
    ENST00000467632 ; ENSP00000420662 ; ENSG00000151577 .
    GeneIDi 1814.
    UCSCi uc003ebc.1. human. [P35462-1 ]

    Organism-specific databases

    GeneCardsi GC03M113847.
    H-InvDB HIX0030774.
    HIX0163472.
    HGNCi HGNC:3024. DRD3.
    MIMi 126451. gene.
    190300. phenotype.
    neXtProti NX_P35462.
    Orphaneti 862. Hereditary essential tremor.
    PharmGKBi PA27479.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309657.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P35462.
    OrthoDBi EOG769ZMG.
    PhylomeDBi P35462.
    TreeFami TF334382.

    Enzyme and pathway databases

    Reactomei REACT_16968. Dopamine receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinki P35462.

    Miscellaneous databases

    NextBioi 7395.
    PROi P35462.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35462.
    Bgeei P35462.
    CleanExi HS_DRD3.
    Genevestigatori P35462.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR001620. Dopamine_D3_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24249:SF38. PTHR24249:SF38. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00568. DOPAMINED3R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene cloning of human dopaminergic D3 receptor and identification of its chromosome."
      Giros B., Martres M.-P., Sokoloff P., Schwartz J.-C.
      C. R. Acad. Sci. III, Sci. Vie 311:501-508(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia."
      Schmauss C., Haroutunian V., Davis K.L., Davidson M.
      Proc. Natl. Acad. Sci. U.S.A. 90:8942-8946(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Brain.
    3. "On the origin of mRNA encoding the truncated dopamine D3-type receptor D3nf and detection of D3nf-like immunoreactivity in human brain."
      Liu K., Bergson C., Levenson R., Schmauss C.
      J. Biol. Chem. 269:29220-29226(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
      Tissue: Brain.
    4. Fishburn C.S., Park B.-H., Fuchs S.
      Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-9.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-9.
    8. "Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling."
      Basile M., Lin R., Kabbani N., Karpa K., Kilimann M., Simpson I., Kester M.
      Arch. Biochem. Biophys. 446:60-68(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PALM.
    9. "G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor."
      Villar V.A.M., Jones J.E., Armando I., Palmes-Saloma C., Yu P., Pascua A.M., Keever L., Arnaldo F.B., Wang Z., Luo Y., Felder R.A., Jose P.A.
      J. Biol. Chem. 284:21425-21434(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY GRK4, SUBCELLULAR LOCATION, INTERACTION WITH GRK4, FUNCTION.
    10. "Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist."
      Chien E.Y., Liu W., Zhao Q., Katritch V., Han G.W., Hanson M.A., Shi L., Newman A.H., Javitch J.A., Cherezov V., Stevens R.C.
      Science 330:1091-1095(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) IN COMPLEX WITH THE ANTAGONIST ETICLOPRIDE, DISULFIDE BONDS, MEMBRANE TOPOLOGY.
    11. "Amino-acid substitution in the dopamine D3 receptor as useful polymorphism for investigating psychiatric disorders."
      Lannfelt T., Sokoloff P., Martres M.-P., Pilon C., Giros B., Joensson E., Sedvall G., Schwartz J.-C.
      Psychiatr. Genet. 2:249-256(1992)
      Cited for: VARIANT GLY-9.
    12. "Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia."
      Chen C.-H., Liu M.-Y., Wei F.-C., Koong F.-J., Hwu H.-G., Hsiao K.-J.
      Am. J. Med. Genet. 74:40-43(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLY-9.
    13. Cited for: VARIANT GLY-9.
    14. "Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families."
      Lucotte G., Lagarde J.-P., Funalot B., Sokoloff P.
      Clin. Genet. 69:437-440(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLY-9, INVOLVEMENT IN SUSCEPTIBILITY TO ETM1.
    15. "A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor."
      Jeanneteau F., Funalot B., Jankovic J., Deng H., Lagarde J.-P., Lucotte G., Sokoloff P.
      Proc. Natl. Acad. Sci. U.S.A. 103:10753-10758(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLY-9, CHARACTERIZATION OF VARIANT GLY-9, INVOLVEMENT IN SUSCEPTIBILITY TO ETM1.

    Entry informationi

    Entry nameiDRD3_HUMAN
    AccessioniPrimary (citable) accession number: P35462
    Secondary accession number(s): A1A4V5, Q4VBM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 148 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3