Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

D(3) dopamine receptor

Gene

DRD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110Agonist1

GO - Molecular functioni

  • dopamine binding Source: GO_Central
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: GO_Central
  • drug binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151577-MONOMER.
ReactomeiR-HSA-390651. Dopamine receptors.
R-HSA-418594. G alpha (i) signalling events.
SignaLinkiP35462.

Protein family/group databases

TCDBi9.A.14.3.9. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
D(3) dopamine receptor
Alternative name(s):
Dopamine D3 receptor
Gene namesi
Name:DRD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:3024. DRD3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularCuratedAdd BLAST32
Transmembranei33 – 55Helical; Name=1Add BLAST23
Topological domaini56 – 65Cytoplasmic10
Transmembranei66 – 88Helical; Name=2Add BLAST23
Topological domaini89 – 104ExtracellularAdd BLAST16
Transmembranei105 – 126Helical; Name=3Add BLAST22
Topological domaini127 – 149CytoplasmicAdd BLAST23
Transmembranei150 – 170Helical; Name=4Add BLAST21
Topological domaini171 – 187ExtracellularAdd BLAST17
Transmembranei188 – 212Helical; Name=5Add BLAST25
Topological domaini213 – 329CytoplasmicAdd BLAST117
Transmembranei330 – 351Helical; Name=6Add BLAST22
Topological domaini352 – 366ExtracellularAdd BLAST15
Transmembranei367 – 388Helical; Name=7Add BLAST22
Topological domaini389 – 400CytoplasmicAdd BLAST12

GO - Cellular componenti

  • apical part of cell Source: Ensembl
  • cell projection Source: Ensembl
  • endocytic vesicle Source: Ensembl
  • integral component of plasma membrane Source: BHF-UCL
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Tremor, hereditary essential 1 (ETM1)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
See also OMIM:190300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0034639S → G Associated with susceptibility to ETM1; gain of function. 7 PublicationsCorresponds to variant rs6280dbSNPEnsembl.1

Organism-specific databases

DisGeNETi1814.
MalaCardsiDRD3.
MIMi190300. phenotype.
Orphaneti862. Hereditary essential tremor.
PharmGKBiPA27479.

Chemistry databases

ChEMBLiCHEMBL234.
DrugBankiDB06288. Amisulpride.
DB00543. Amoxapine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB09014. Captodiame.
DB06016. Cariprazine.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00363. Clozapine.
DB01184. Domperidone.
DB00988. Dopamine.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB01235. Levodopa.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB01100. Pimozide.
DB00413. Pramipexole.
DB01224. Quetiapine.
DB00409. Remoxipride.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB00391. Sulpiride.
DB01392. Yohimbine.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi216.

Polymorphism and mutation databases

DMDMi1169206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693971 – 400D(3) dopamine receptorAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi103 ↔ 181PROSITE-ProRule annotation1 Publication
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi355 ↔ 358PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35462.
PeptideAtlasiP35462.
PRIDEiP35462.

PTM databases

iPTMnetiP35462.
PhosphoSitePlusiP35462.
SwissPalmiP35462.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000151577.
CleanExiHS_DRD3.
ExpressionAtlasiP35462. baseline and differential.
GenevisibleiP35462. HS.

Interactioni

Subunit structurei

Interacts with CLIC6 (By similarity). Interacts with GRK4 (PubMed:19520868). Interacts with PALM (PubMed:16386234). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).By similarity3 Publications

Protein-protein interaction databases

BioGridi108148. 10 interactors.
DIPiDIP-5976N.
STRINGi9606.ENSP00000373169.

Chemistry databases

BindingDBiP35462.

Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 56Combined sources22
Helixi63 – 81Combined sources19
Helixi83 – 91Combined sources9
Helixi100 – 133Combined sources34
Helixi135 – 140Combined sources6
Beta strandi143 – 145Combined sources3
Helixi147 – 169Combined sources23
Turni170 – 172Combined sources3
Helixi186 – 196Combined sources11
Helixi198 – 216Combined sources19
Helixi322 – 353Combined sources32
Helixi362 – 386Combined sources25
Helixi388 – 398Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PBLX-ray2.89A/B2-221[»]
A/B319-400[»]
ProteinModelPortaliP35462.
SMRiP35462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 196Agonist binding8
Regioni342 – 350Agonist binding9

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35462.
KOiK04146.
OrthoDBiEOG091G06VI.
PhylomeDBiP35462.
TreeFamiTF334382.

Family and domain databases

InterProiIPR001620. Dopamine_D3_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF38. PTHR24249:SF38. 3 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00568. DOPAMINED3R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35462-1) [UniParc]FASTAAdd to basket
Also known as: D3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV
60 70 80 90 100
CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR
110 120 130 140 150
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV
160 170 180 190 200
ALMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP
210 220 230 240 250
FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDPAHL
260 270 280 290 300
ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK
310 320 330 340 350
LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV
360 370 380 390 400
LNTHCQTCHV SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC
Length:400
Mass (Da):44,225
Last modified:November 1, 1995 - v2
Checksum:i2CDA789D78378DDA
GO
Isoform 3 (identifier: P35462-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-320: SPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGV → M

Show »
Length:367
Mass (Da):40,760
Checksum:i40F7FFA4519042FD
GO

Sequence cautioni

The sequence AAA03543 differs from that shown. Reason: Frameshift at position 288.Curated
The sequence AAA64369 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti396K → L in AAH95510 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0034639S → G Associated with susceptibility to ETM1; gain of function. 7 PublicationsCorresponds to variant rs6280dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040570287 – 320SPTIA…QPRGV → M in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20469 mRNA. Translation: AAA03543.1. Frameshift.
AH003061 Genomic DNA. Translation: AAA64369.1. Sequence problems.
U32499 mRNA. Translation: AAA73929.1.
AC092896 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79610.1.
BC095510 mRNA. Translation: AAH95510.1.
BC128123 mRNA. Translation: AAI28124.1.
CCDSiCCDS2978.1. [P35462-1]
CCDS33829.1. [P35462-3]
PIRiA48258.
A55419.
G01977.
RefSeqiNP_000787.2. NM_000796.5.
NP_001269492.1. NM_001282563.2.
NP_001277738.1. NM_001290809.1.
NP_387512.3. NM_033663.5.
UniGeneiHs.121478.

Genome annotation databases

EnsembliENST00000383673; ENSP00000373169; ENSG00000151577.
ENST00000460779; ENSP00000419402; ENSG00000151577.
ENST00000467632; ENSP00000420662; ENSG00000151577.
GeneIDi1814.
KEGGihsa:1814.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20469 mRNA. Translation: AAA03543.1. Frameshift.
AH003061 Genomic DNA. Translation: AAA64369.1. Sequence problems.
U32499 mRNA. Translation: AAA73929.1.
AC092896 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79610.1.
BC095510 mRNA. Translation: AAH95510.1.
BC128123 mRNA. Translation: AAI28124.1.
CCDSiCCDS2978.1. [P35462-1]
CCDS33829.1. [P35462-3]
PIRiA48258.
A55419.
G01977.
RefSeqiNP_000787.2. NM_000796.5.
NP_001269492.1. NM_001282563.2.
NP_001277738.1. NM_001290809.1.
NP_387512.3. NM_033663.5.
UniGeneiHs.121478.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PBLX-ray2.89A/B2-221[»]
A/B319-400[»]
ProteinModelPortaliP35462.
SMRiP35462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108148. 10 interactors.
DIPiDIP-5976N.
STRINGi9606.ENSP00000373169.

Chemistry databases

BindingDBiP35462.
ChEMBLiCHEMBL234.
DrugBankiDB06288. Amisulpride.
DB00543. Amoxapine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB09014. Captodiame.
DB06016. Cariprazine.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00363. Clozapine.
DB01184. Domperidone.
DB00988. Dopamine.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB01235. Levodopa.
DB00589. Lisuride.
DB00408. Loxapine.
DB01403. Methotrimeprazine.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB01100. Pimozide.
DB00413. Pramipexole.
DB01224. Quetiapine.
DB00409. Remoxipride.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB00391. Sulpiride.
DB01392. Yohimbine.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi216.

Protein family/group databases

TCDBi9.A.14.3.9. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP35462.
PhosphoSitePlusiP35462.
SwissPalmiP35462.

Polymorphism and mutation databases

DMDMi1169206.

Proteomic databases

PaxDbiP35462.
PeptideAtlasiP35462.
PRIDEiP35462.

Protocols and materials databases

DNASUi1814.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383673; ENSP00000373169; ENSG00000151577.
ENST00000460779; ENSP00000419402; ENSG00000151577.
ENST00000467632; ENSP00000420662; ENSG00000151577.
GeneIDi1814.
KEGGihsa:1814.

Organism-specific databases

CTDi1814.
DisGeNETi1814.
GeneCardsiDRD3.
H-InvDBHIX0030774.
HIX0163472.
HGNCiHGNC:3024. DRD3.
MalaCardsiDRD3.
MIMi126451. gene.
190300. phenotype.
neXtProtiNX_P35462.
Orphaneti862. Hereditary essential tremor.
PharmGKBiPA27479.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35462.
KOiK04146.
OrthoDBiEOG091G06VI.
PhylomeDBiP35462.
TreeFamiTF334382.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151577-MONOMER.
ReactomeiR-HSA-390651. Dopamine receptors.
R-HSA-418594. G alpha (i) signalling events.
SignaLinkiP35462.

Miscellaneous databases

GenomeRNAii1814.
PROiP35462.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151577.
CleanExiHS_DRD3.
ExpressionAtlasiP35462. baseline and differential.
GenevisibleiP35462. HS.

Family and domain databases

InterProiIPR001620. Dopamine_D3_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF38. PTHR24249:SF38. 3 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00568. DOPAMINED3R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRD3_HUMAN
AccessioniPrimary (citable) accession number: P35462
Secondary accession number(s): A1A4V5, Q4VBM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.