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P35462 (DRD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D(3) dopamine receptor
Alternative name(s):
Dopamine D3 receptor
Gene names
Name:DRD3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Ref.9

Subunit structure

Interacts with CLIC6 By similarity. Interacts with GRK4. Interacts with PALM. Ref.8 Ref.9

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. Ref.9

Tissue specificity

Brain.

Post-translational modification

Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma). Ref.9

Involvement in disease

Tremor, hereditary essential 1 (ETM1) [MIM:190300]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.15 Ref.16

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAA03543.1 differs from that shown. Reason: Frameshift at position 288.

The sequence AAA64369.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor internalization

Inferred from direct assay PubMed 18424554. Source: BHF-UCL

G-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 7911712. Source: BHF-UCL

acid secretion

Inferred from sequence or structural similarity. Source: BHF-UCL

adenylate cyclase-activating dopamine receptor signaling pathway

Inferred from direct assay PubMed 18424554. Source: BHF-UCL

adenylate cyclase-inhibiting dopamine receptor signaling pathway

Inferred from direct assay PubMed 18424554PubMed 7907363. Source: BHF-UCL

arachidonic acid secretion

Inferred from direct assay PubMed 8301582. Source: BHF-UCL

behavioral response to cocaine

Inferred from expression pattern PubMed 8815892. Source: BHF-UCL

cellular calcium ion homeostasis

Inferred from direct assay PubMed 7911712. Source: BHF-UCL

circadian regulation of gene expression

Inferred from sequence or structural similarity. Source: BHF-UCL

dopamine metabolic process

Inferred by curator PubMed 8301582. Source: BHF-UCL

gastric emptying

Inferred from electronic annotation. Source: Ensembl

learning

Non-traceable author statement PubMed 15998189. Source: BHF-UCL

learning or memory

Non-traceable author statement PubMed 14681904. Source: BHF-UCL

locomotory behavior

Inferred from sequence or structural similarity. Source: BHF-UCL

musculoskeletal movement, spinal reflex action

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of adenylate cyclase activity

Inferred from direct assay PubMed 7907363. Source: BHF-UCL

negative regulation of blood pressure

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of dopamine receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of oligodendrocyte differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of protein kinase B signaling

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of protein secretion

Inferred from direct assay PubMed 16839358. Source: BHF-UCL

negative regulation of sodium:hydrogen antiporter activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytokinesis

Inferred from mutant phenotype PubMed 22888021. Source: UniProt

positive regulation of dopamine receptor signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of mitosis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

prepulse inhibition

Inferred from mutant phenotype PubMed 18325483. Source: BHF-UCL

regulation of blood volume by renin-angiotensin

Inferred from electronic annotation. Source: Ensembl

regulation of cAMP metabolic process

Inferred from direct assay PubMed 8666994. Source: BHF-UCL

regulation of circadian sleep/wake cycle, sleep

Inferred from electronic annotation. Source: Ensembl

regulation of dopamine secretion

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of dopamine uptake involved in synaptic transmission

Inferred by curator PubMed 8301582. Source: BHF-UCL

regulation of lipid metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of locomotion involved in locomotory behavior

Inferred from electronic annotation. Source: Ensembl

regulation of multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

response to amphetamine

Inferred from electronic annotation. Source: Ensembl

response to cocaine

Inferred from expression pattern PubMed 10415668. Source: BHF-UCL

response to drug

Inferred from sequence or structural similarity. Source: BHF-UCL

response to histamine

Inferred from direct assay PubMed 16839358. Source: BHF-UCL

response to morphine

Inferred from sequence or structural similarity. Source: BHF-UCL

social behavior

Non-traceable author statement PubMed 12860355. Source: BHF-UCL

synaptic transmission, dopaminergic

Inferred from electronic annotation. Source: Ensembl

visual learning

Inferred from sequence or structural similarity. Source: BHF-UCL

   Cellular_componentapical part of cell

Inferred from electronic annotation. Source: Ensembl

cell projection

Inferred from electronic annotation. Source: Ensembl

endocytic vesicle

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred from direct assay PubMed 8413587. Source: BHF-UCL

plasma membrane

Inferred from direct assay Ref.8. Source: UniProtKB

   Molecular_functiondopamine binding

Inferred from electronic annotation. Source: Ensembl

dopamine neurotransmitter receptor activity, coupled via Gi/Go

Inferred from direct assay PubMed 8301582. Source: BHF-UCL

drug binding

Inferred from direct assay PubMed 8413587. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P35462-1)

Also known as: D3;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 3 (identifier: P35462-3)

The sequence of this isoform differs from the canonical sequence as follows:
     287-320: SPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGV → M

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400D(3) dopamine receptor
PRO_0000069397

Regions

Topological domain1 – 3232Extracellular Probable
Transmembrane33 – 5523Helical; Name=1
Topological domain56 – 6510Cytoplasmic Ref.10
Transmembrane66 – 8823Helical; Name=2
Topological domain89 – 10416Extracellular Ref.10
Transmembrane105 – 12622Helical; Name=3
Topological domain127 – 14923Cytoplasmic Ref.10
Transmembrane150 – 17021Helical; Name=4
Topological domain171 – 18717Extracellular Ref.10
Transmembrane188 – 21225Helical; Name=5
Topological domain213 – 329117Cytoplasmic Ref.10
Transmembrane330 – 35122Helical; Name=6
Topological domain352 – 36615Extracellular Ref.10
Transmembrane367 – 38822Helical; Name=7
Topological domain389 – 40012Cytoplasmic Ref.10
Region189 – 1968Agonist binding
Region342 – 3509Agonist binding

Sites

Binding site1101Agonist

Amino acid modifications

Glycosylation121N-linked (GlcNAc...) Potential
Glycosylation191N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Disulfide bond103 ↔ 181 Ref.10
Disulfide bond355 ↔ 358 Ref.10

Natural variations

Alternative sequence287 – 32034SPTIA…QPRGV → M in isoform 3.
VSP_040570
Natural variant91S → G Associated with susceptibility to ETM1; gain of function. Ref.5 Ref.7 Ref.11 Ref.12 Ref.13 Ref.15 Ref.16
Corresponds to variant rs6280 [ dbSNP | Ensembl ].
VAR_003463

Experimental info

Sequence conflict3961K → L in AAH95510. Ref.7

Secondary structure

.......................... 400
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (D3) [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 2CDA789D78378DDA

FASTA40044,225
        10         20         30         40         50         60 
MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV CMAVLKERAL 

        70         80         90        100        110        120 
QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR ICCDVFVTLD VMMCTASILN 

       130        140        150        160        170        180 
LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPTV 

       190        200        210        220        230        240 
CSISNPDFVI YSSVVSFYLP FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ 

       250        260        270        280        290        300 
QTLSPDPAHL ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK 

       310        320        330        340        350        360 
LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV LNTHCQTCHV 

       370        380        390        400 
SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC 

« Hide

Isoform 3 [UniParc].

Checksum: 40F7FFA4519042FD
Show »

FASTA36740,760

References

« Hide 'large scale' references
[1]"Gene cloning of human dopaminergic D3 receptor and identification of its chromosome."
Giros B., Martres M.-P., Sokoloff P., Schwartz J.-C.
C. R. Acad. Sci. III, Sci. Vie 311:501-508(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia."
Schmauss C., Haroutunian V., Davis K.L., Davidson M.
Proc. Natl. Acad. Sci. U.S.A. 90:8942-8946(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
Tissue: Brain.
[3]"On the origin of mRNA encoding the truncated dopamine D3-type receptor D3nf and detection of D3nf-like immunoreactivity in human brain."
Liu K., Bergson C., Levenson R., Schmauss C.
J. Biol. Chem. 269:29220-29226(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
Tissue: Brain.
[4]Fishburn C.S., Park B.-H., Fuchs S.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-9.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-9.
[8]"Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling."
Basile M., Lin R., Kabbani N., Karpa K., Kilimann M., Simpson I., Kester M.
Arch. Biochem. Biophys. 446:60-68(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PALM.
[9]"G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor."
Villar V.A.M., Jones J.E., Armando I., Palmes-Saloma C., Yu P., Pascua A.M., Keever L., Arnaldo F.B., Wang Z., Luo Y., Felder R.A., Jose P.A.
J. Biol. Chem. 284:21425-21434(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION BY GRK4, SUBCELLULAR LOCATION, INTERACTION WITH GRK4, FUNCTION.
[10]"Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist."
Chien E.Y., Liu W., Zhao Q., Katritch V., Han G.W., Hanson M.A., Shi L., Newman A.H., Javitch J.A., Cherezov V., Stevens R.C.
Science 330:1091-1095(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) IN COMPLEX WITH THE ANTAGONIST ETICLOPRIDE, DISULFIDE BONDS, MEMBRANE TOPOLOGY.
[11]"Amino-acid substitution in the dopamine D3 receptor as useful polymorphism for investigating psychiatric disorders."
Lannfelt T., Sokoloff P., Martres M.-P., Pilon C., Giros B., Joensson E., Sedvall G., Schwartz J.-C.
Psychiatr. Genet. 2:249-256(1992)
Cited for: VARIANT GLY-9.
[12]"Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia."
Chen C.-H., Liu M.-Y., Wei F.-C., Koong F.-J., Hwu H.-G., Hsiao K.-J.
Am. J. Med. Genet. 74:40-43(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLY-9.
[13]"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLY-9.
[14]Erratum
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 23:373-373(1999)
[15]"Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families."
Lucotte G., Lagarde J.-P., Funalot B., Sokoloff P.
Clin. Genet. 69:437-440(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLY-9, INVOLVEMENT IN SUSCEPTIBILITY TO ETM1.
[16]"A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor."
Jeanneteau F., Funalot B., Jankovic J., Deng H., Lagarde J.-P., Lucotte G., Sokoloff P.
Proc. Natl. Acad. Sci. U.S.A. 103:10753-10758(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLY-9, CHARACTERIZATION OF VARIANT GLY-9, INVOLVEMENT IN SUSCEPTIBILITY TO ETM1.
+Additional computationally mapped references.

Web resources

SHMPD

The Singapore human mutation and polymorphism database

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L20469 mRNA. Translation: AAA03543.1. Frameshift.
AH003061 Genomic DNA. Translation: AAA64369.1. Sequence problems.
U32499 mRNA. Translation: AAA73929.1.
AC092896 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79610.1.
BC095510 mRNA. Translation: AAH95510.1.
BC128123 mRNA. Translation: AAI28124.1.
PIRA48258.
A55419.
G01977.
RefSeqNP_000787.2. NM_000796.4.
NP_387512.3. NM_033663.4.
UniGeneHs.121478.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3PBLX-ray2.89A/B2-400[»]
ProteinModelPortalP35462.
SMRP35462. Positions 32-400.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108148. 8 interactions.
DIPDIP-5976N.
STRING9606.ENSP00000373169.

Chemistry

BindingDBP35462.
ChEMBLCHEMBL2096905.
DrugBankDB00714. Apomorphine.
DB01239. Chlorprothixene.
DB00907. Cocaine.
DB01403. Methotrimeprazine.
DB00334. Olanzapine.
DB00413. Pramipexole.
DB00268. Ropinirole.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGY216.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP35462.

Polymorphism databases

DMDM1169206.

Proteomic databases

PaxDbP35462.
PRIDEP35462.

Protocols and materials databases

DNASU1814.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000383673; ENSP00000373169; ENSG00000151577.
ENST00000460779; ENSP00000419402; ENSG00000151577.
ENST00000467632; ENSP00000420662; ENSG00000151577.
GeneID1814.
KEGGhsa:1814.
UCSCuc003ebc.1. human. [P35462-1]

Organism-specific databases

CTD1814.
GeneCardsGC03M113847.
H-InvDBHIX0030774.
HIX0163472.
HGNCHGNC:3024. DRD3.
MIM126451. gene.
190300. phenotype.
neXtProtNX_P35462.
Orphanet862. Hereditary essential tremor.
PharmGKBPA27479.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG309657.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP35462.
KOK04146.
OrthoDBEOG769ZMG.
PhylomeDBP35462.
TreeFamTF334382.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP35462.

Gene expression databases

ArrayExpressP35462.
BgeeP35462.
CleanExHS_DRD3.
GenevestigatorP35462.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR001620. Dopamine_D3_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24249:SF38. PTHR24249:SF38. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00568. DOPAMINED3R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio7395.
PROP35462.
SOURCESearch...

Entry information

Entry nameDRD3_HUMAN
AccessionPrimary (citable) accession number: P35462
Secondary accession number(s): A1A4V5, Q4VBM8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries