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P35462

- DRD3_HUMAN

UniProt

P35462 - DRD3_HUMAN

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Protein
D(3) dopamine receptor
Gene
DRD3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101Agonist

GO - Molecular functioni

  1. dopamine binding Source: Ensembl
  2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
  3. drug binding Source: BHF-UCL
  4. protein binding Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor internalization Source: BHF-UCL
  2. G-protein coupled receptor signaling pathway Source: BHF-UCL
  3. acid secretion Source: BHF-UCL
  4. adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
  5. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCL
  6. arachidonic acid secretion Source: BHF-UCL
  7. behavioral response to cocaine Source: BHF-UCL
  8. cellular calcium ion homeostasis Source: BHF-UCL
  9. circadian regulation of gene expression Source: BHF-UCL
  10. dopamine metabolic process Source: BHF-UCL
  11. gastric emptying Source: Ensembl
  12. learning Source: BHF-UCL
  13. learning or memory Source: BHF-UCL
  14. locomotory behavior Source: BHF-UCL
  15. musculoskeletal movement, spinal reflex action Source: BHF-UCL
  16. negative regulation of adenylate cyclase activity Source: BHF-UCL
  17. negative regulation of blood pressure Source: BHF-UCL
  18. negative regulation of dopamine receptor signaling pathway Source: Ensembl
  19. negative regulation of oligodendrocyte differentiation Source: BHF-UCL
  20. negative regulation of protein kinase B signaling Source: BHF-UCL
  21. negative regulation of protein secretion Source: BHF-UCL
  22. negative regulation of sodium:proton antiporter activity Source: Ensembl
  23. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. positive regulation of cell proliferation Source: Ensembl
  25. positive regulation of cytokinesis Source: UniProt
  26. positive regulation of dopamine receptor signaling pathway Source: BHF-UCL
  27. positive regulation of mitosis Source: BHF-UCL
  28. positive regulation of renal sodium excretion Source: Ensembl
  29. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  30. prepulse inhibition Source: BHF-UCL
  31. regulation of blood volume by renin-angiotensin Source: Ensembl
  32. regulation of cAMP metabolic process Source: BHF-UCL
  33. regulation of circadian sleep/wake cycle, sleep Source: Ensembl
  34. regulation of dopamine secretion Source: BHF-UCL
  35. regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
  36. regulation of lipid metabolic process Source: Ensembl
  37. regulation of locomotion involved in locomotory behavior Source: Ensembl
  38. regulation of multicellular organism growth Source: Ensembl
  39. response to amphetamine Source: Ensembl
  40. response to cocaine Source: BHF-UCL
  41. response to drug Source: BHF-UCL
  42. response to histamine Source: BHF-UCL
  43. response to morphine Source: BHF-UCL
  44. social behavior Source: BHF-UCL
  45. synaptic transmission, dopaminergic Source: Ensembl
  46. visual learning Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16968. Dopamine receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP35462.

Names & Taxonomyi

Protein namesi
Recommended name:
D(3) dopamine receptor
Alternative name(s):
Dopamine D3 receptor
Gene namesi
Name:DRD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:3024. DRD3.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Extracellular Inferred
Add
BLAST
Transmembranei33 – 5523Helical; Name=1
Add
BLAST
Topological domaini56 – 6510Cytoplasmic1 Publication
Transmembranei66 – 8823Helical; Name=2
Add
BLAST
Topological domaini89 – 10416Extracellular1 Publication
Add
BLAST
Transmembranei105 – 12622Helical; Name=3
Add
BLAST
Topological domaini127 – 14923Cytoplasmic1 Publication
Add
BLAST
Transmembranei150 – 17021Helical; Name=4
Add
BLAST
Topological domaini171 – 18717Extracellular1 Publication
Add
BLAST
Transmembranei188 – 21225Helical; Name=5
Add
BLAST
Topological domaini213 – 329117Cytoplasmic1 Publication
Add
BLAST
Transmembranei330 – 35122Helical; Name=6
Add
BLAST
Topological domaini352 – 36615Extracellular1 Publication
Add
BLAST
Transmembranei367 – 38822Helical; Name=7
Add
BLAST
Topological domaini389 – 40012Cytoplasmic1 Publication
Add
BLAST

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. cell projection Source: Ensembl
  3. endocytic vesicle Source: Ensembl
  4. integral component of plasma membrane Source: BHF-UCL
  5. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Tremor, hereditary essential 1 (ETM1) [MIM:190300]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91S → G Associated with susceptibility to ETM1; gain of function. 7 Publications
Corresponds to variant rs6280 [ dbSNP | Ensembl ].
VAR_003463

Organism-specific databases

MIMi190300. phenotype.
Orphaneti862. Hereditary essential tremor.
PharmGKBiPA27479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400D(3) dopamine receptor
PRO_0000069397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19 – 191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi103 ↔ 1811 Publication
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi355 ↔ 3581 Publication

Post-translational modificationi

Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35462.
PRIDEiP35462.

PTM databases

PhosphoSiteiP35462.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

ArrayExpressiP35462.
BgeeiP35462.
CleanExiHS_DRD3.
GenevestigatoriP35462.

Interactioni

Subunit structurei

Interacts with CLIC6 By similarity. Interacts with GRK4. Interacts with PALM.2 Publications

Protein-protein interaction databases

BioGridi108148. 8 interactions.
DIPiDIP-5976N.
STRINGi9606.ENSP00000373169.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 5622
Helixi63 – 8119
Helixi83 – 919
Helixi100 – 13334
Helixi135 – 1406
Beta strandi143 – 1453
Helixi147 – 16923
Turni170 – 1723
Helixi186 – 19611
Helixi198 – 21619
Helixi322 – 35332
Helixi362 – 38625
Helixi388 – 39811

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PBLX-ray2.89A/B2-221[»]
A/B319-400[»]
ProteinModelPortaliP35462.
SMRiP35462. Positions 32-400.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni189 – 1968Agonist binding
Regioni342 – 3509Agonist binding

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG309657.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35462.
OrthoDBiEOG769ZMG.
PhylomeDBiP35462.
TreeFamiTF334382.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR001620. Dopamine_D3_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF38. PTHR24249:SF38. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00568. DOPAMINED3R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P35462-1) [UniParc]FASTAAdd to Basket

Also known as: D3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV    50
CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR 100
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV 150
ALMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP 200
FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDPAHL 250
ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK 300
LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV 350
LNTHCQTCHV SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC 400
Length:400
Mass (Da):44,225
Last modified:November 1, 1995 - v2
Checksum:i2CDA789D78378DDA
GO
Isoform 3 (identifier: P35462-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-320: SPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGV → M

Show »
Length:367
Mass (Da):40,760
Checksum:i40F7FFA4519042FD
GO

Sequence cautioni

The sequence AAA03543.1 differs from that shown. Reason: Frameshift at position 288.
The sequence AAA64369.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91S → G Associated with susceptibility to ETM1; gain of function. 7 Publications
Corresponds to variant rs6280 [ dbSNP | Ensembl ].
VAR_003463

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei287 – 32034SPTIA…QPRGV → M in isoform 3.
VSP_040570Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti396 – 3961K → L in AAH95510. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20469 mRNA. Translation: AAA03543.1. Frameshift.
AH003061 Genomic DNA. Translation: AAA64369.1. Sequence problems.
U32499 mRNA. Translation: AAA73929.1.
AC092896 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79610.1.
BC095510 mRNA. Translation: AAH95510.1.
BC128123 mRNA. Translation: AAI28124.1.
CCDSiCCDS2978.1. [P35462-1]
CCDS33829.1. [P35462-3]
PIRiA48258.
A55419.
G01977.
RefSeqiNP_000787.2. NM_000796.5.
NP_001269492.1. NM_001282563.2.
NP_001277738.1. NM_001290809.1.
NP_387512.3. NM_033663.5.
UniGeneiHs.121478.

Genome annotation databases

EnsembliENST00000383673; ENSP00000373169; ENSG00000151577.
ENST00000460779; ENSP00000419402; ENSG00000151577.
ENST00000467632; ENSP00000420662; ENSG00000151577.
GeneIDi1814.
UCSCiuc003ebc.1. human. [P35462-1]

Polymorphism databases

DMDMi1169206.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20469 mRNA. Translation: AAA03543.1 . Frameshift.
AH003061 Genomic DNA. Translation: AAA64369.1 . Sequence problems.
U32499 mRNA. Translation: AAA73929.1 .
AC092896 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79610.1 .
BC095510 mRNA. Translation: AAH95510.1 .
BC128123 mRNA. Translation: AAI28124.1 .
CCDSi CCDS2978.1. [P35462-1 ]
CCDS33829.1. [P35462-3 ]
PIRi A48258.
A55419.
G01977.
RefSeqi NP_000787.2. NM_000796.5.
NP_001269492.1. NM_001282563.2.
NP_001277738.1. NM_001290809.1.
NP_387512.3. NM_033663.5.
UniGenei Hs.121478.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PBL X-ray 2.89 A/B 2-221 [» ]
A/B 319-400 [» ]
ProteinModelPortali P35462.
SMRi P35462. Positions 32-400.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108148. 8 interactions.
DIPi DIP-5976N.
STRINGi 9606.ENSP00000373169.

Chemistry

BindingDBi P35462.
ChEMBLi CHEMBL2097165.
DrugBanki DB00714. Apomorphine.
DB01239. Chlorprothixene.
DB00907. Cocaine.
DB01403. Methotrimeprazine.
DB00334. Olanzapine.
DB00413. Pramipexole.
DB00268. Ropinirole.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi 216.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35462.

Polymorphism databases

DMDMi 1169206.

Proteomic databases

PaxDbi P35462.
PRIDEi P35462.

Protocols and materials databases

DNASUi 1814.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000383673 ; ENSP00000373169 ; ENSG00000151577 .
ENST00000460779 ; ENSP00000419402 ; ENSG00000151577 .
ENST00000467632 ; ENSP00000420662 ; ENSG00000151577 .
GeneIDi 1814.
UCSCi uc003ebc.1. human. [P35462-1 ]

Organism-specific databases

GeneCardsi GC03M113847.
H-InvDB HIX0030774.
HIX0163472.
HGNCi HGNC:3024. DRD3.
MIMi 126451. gene.
190300. phenotype.
neXtProti NX_P35462.
Orphaneti 862. Hereditary essential tremor.
PharmGKBi PA27479.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309657.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P35462.
OrthoDBi EOG769ZMG.
PhylomeDBi P35462.
TreeFami TF334382.

Enzyme and pathway databases

Reactomei REACT_16968. Dopamine receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinki P35462.

Miscellaneous databases

NextBioi 7395.
PROi P35462.
SOURCEi Search...

Gene expression databases

ArrayExpressi P35462.
Bgeei P35462.
CleanExi HS_DRD3.
Genevestigatori P35462.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR001620. Dopamine_D3_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24249:SF38. PTHR24249:SF38. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00568. DOPAMINED3R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene cloning of human dopaminergic D3 receptor and identification of its chromosome."
    Giros B., Martres M.-P., Sokoloff P., Schwartz J.-C.
    C. R. Acad. Sci. III, Sci. Vie 311:501-508(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia."
    Schmauss C., Haroutunian V., Davis K.L., Davidson M.
    Proc. Natl. Acad. Sci. U.S.A. 90:8942-8946(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  3. "On the origin of mRNA encoding the truncated dopamine D3-type receptor D3nf and detection of D3nf-like immunoreactivity in human brain."
    Liu K., Bergson C., Levenson R., Schmauss C.
    J. Biol. Chem. 269:29220-29226(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    Tissue: Brain.
  4. Fishburn C.S., Park B.-H., Fuchs S.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-9.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-9.
  8. "Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling."
    Basile M., Lin R., Kabbani N., Karpa K., Kilimann M., Simpson I., Kester M.
    Arch. Biochem. Biophys. 446:60-68(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PALM.
  9. "G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor."
    Villar V.A.M., Jones J.E., Armando I., Palmes-Saloma C., Yu P., Pascua A.M., Keever L., Arnaldo F.B., Wang Z., Luo Y., Felder R.A., Jose P.A.
    J. Biol. Chem. 284:21425-21434(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY GRK4, SUBCELLULAR LOCATION, INTERACTION WITH GRK4, FUNCTION.
  10. "Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist."
    Chien E.Y., Liu W., Zhao Q., Katritch V., Han G.W., Hanson M.A., Shi L., Newman A.H., Javitch J.A., Cherezov V., Stevens R.C.
    Science 330:1091-1095(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) IN COMPLEX WITH THE ANTAGONIST ETICLOPRIDE, DISULFIDE BONDS, MEMBRANE TOPOLOGY.
  11. "Amino-acid substitution in the dopamine D3 receptor as useful polymorphism for investigating psychiatric disorders."
    Lannfelt T., Sokoloff P., Martres M.-P., Pilon C., Giros B., Joensson E., Sedvall G., Schwartz J.-C.
    Psychiatr. Genet. 2:249-256(1992)
    Cited for: VARIANT GLY-9.
  12. "Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia."
    Chen C.-H., Liu M.-Y., Wei F.-C., Koong F.-J., Hwu H.-G., Hsiao K.-J.
    Am. J. Med. Genet. 74:40-43(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-9.
  13. Cited for: VARIANT GLY-9.
  14. "Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families."
    Lucotte G., Lagarde J.-P., Funalot B., Sokoloff P.
    Clin. Genet. 69:437-440(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-9, INVOLVEMENT IN SUSCEPTIBILITY TO ETM1.
  15. "A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor."
    Jeanneteau F., Funalot B., Jankovic J., Deng H., Lagarde J.-P., Lucotte G., Sokoloff P.
    Proc. Natl. Acad. Sci. U.S.A. 103:10753-10758(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-9, CHARACTERIZATION OF VARIANT GLY-9, INVOLVEMENT IN SUSCEPTIBILITY TO ETM1.

Entry informationi

Entry nameiDRD3_HUMAN
AccessioniPrimary (citable) accession number: P35462
Secondary accession number(s): A1A4V5, Q4VBM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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