P35461 (LY6G_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lymphocyte antigen 6G
Short name=Ly-6G

Alternative name(s):
Ly-6G.1

Gene names

Name:

Ly6g

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	111 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.
Tissue specificity	Expressed in bone marrow.
Sequence similarities	Contains 1 UPAR/Ly6 domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW external side of plasma membrane Inferred from direct assay PubMed 10072077PubMed 10848813PubMed 10943842PubMed 14609575PubMed 15845452PubMed 16287714PubMed 19015308PubMed 20660734PubMed 8788039. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	‹1 – 3	›3	Potential
	Chain	4 – ?96	93	Lymphocyte antigen 6G		PRO_0000036146
	Propeptide	?97 – 111	15	Removed in mature form Potential		PRO_0000036147
Regions
	Domain	4 – 96	93	UPAR/Ly6
Amino acid modifications
	Lipidation	96	1	GPI-anchor amidated glycine Potential
	Disulfide bond	6 ↔ 30		By similarity
	Disulfide bond	9 ↔ 18		By similarity
	Disulfide bond	23 ↔ 51		By similarity
	Disulfide bond	55 ↔ 75		By similarity
	Disulfide bond	76 ↔ 81		By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P35461 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 2117B664004CE655	FASTA	111	11,798
	10 20 30 40 50 60 AQGLECYNCI GVPPETSCNT TTCPFSDGFC VALEIEVIVD SHRSKVKSNL CLPICPTTLD 70 80 90 100 110 NTEITGNAVN VKTYCCKEDL CNAAVPTGGS SWTMAGVLLF SLVSVLLQTF L

References

[1]	"Characterization of two novel Ly-6 genes. Protein sequence and potential structural similarity to alpha-bungarotoxin and other neurotoxins." Fleming T.J., O'Huigin C., Malek T.R. J. Immunol. 150:5379-5390(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70920, X70921 Genomic DNA. Translation: CAA50269.1.
IPI	IPI00850120.
PIR	I48640.
3D structure databases
ProteinModelPortal	P35461.
SMR	P35461. Positions 19-84.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000023246.
Proteomic databases
PRIDE	P35461.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023246; ENSMUSP00000023246; ENSMUSG00000022582.
Organism-specific databases
MGI	MGI:109440. Ly6g.
Phylogenomic databases
eggNOG	opiNOG14058.
GeneTree	ENSGT00610000086181.
HOGENOM	HOG000035114.
HOVERGEN	HBG001716.
InParanoid	P35461.
OMA	CVALEIE.
Gene expression databases
Bgee	P35461.
Genevestigator	P35461.
GermOnline	ENSMUSG00000022582. Mus musculus.
Family and domain databases
InterPro	IPR018363. CD59_antigen_CS. IPR016054. LY6_UPA_recep-like. IPR001526. LY6_UPAR. [Graphical view]
Pfam	PF00021. UPAR_LY6. 1 hit. [Graphical view]
SMART	SM00134. LU. 1 hit. [Graphical view]
PROSITE	PS00983. LY6_UPAR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

LY6G_MOUSE

Accession

Primary (citable) accession number: P35461

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program