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Protein

Dynactin subunit 1

Gene

DCTN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Dynactin is a major component of activator I, a 20S polypeptide complex that stimulates dynein-mediated vesicle transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 1
Alternative name(s):
150 kDa dynein-associated polypeptide
DAP-150
Short name:
DP-150
p150-glued
Gene namesi
Name:DCTN1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12241224Dynactin subunit 1PRO_0000083521Add
BLAST

Proteomic databases

PRIDEiP35458.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Structurei

Secondary structure

1
1224
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi435 – 53096Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RFXX-ray2.90A/B/C/D/E412-533[»]
ProteinModelPortaliP35458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 9143CAP-GlyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili205 – 540336Sequence analysisAdd
BLAST
Coiled coili936 – 1042107Sequence analysisAdd
BLAST
Coiled coili1081 – 111737Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the dynactin 150 kDa subunit family.Curated
Contains 1 CAP-Gly domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG004956.
InParanoidiP35458.
KOiK04648.
PhylomeDBiP35458.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR027663. DCTN1.
IPR022157. Dynactin.
[Graphical view]
PANTHERiPTHR18916:SF40. PTHR18916:SF40. 1 hit.
PfamiPF01302. CAP_GLY. 1 hit.
PF12455. Dynactin. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: At least 3 isoforms are produced.
Isoform 1 (identifier: P35458-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQSRRHPHG RASSAGPRMS TEASSKPLKV GSRVEVIGKG HRGTVAYVGA
60 70 80 90 100
TLXATGKWVG VILDEAKGKN DGTVQGRKYF TCEENHGIFV RQSQIQVFED
110 120 130 140 150
GADTTSPETP ESAALKVPKR HSRXAAKGSK LRGAKPKKTT ARRPKPTRTP
160 170 180 190 200
TSAPSSGTAG PSGSASASGG EMSSSEPSTP AQTPLVAPVI PSPSLTSPVA
210 220 230 240 250
PMVPSPTKEE ENLRSQVRDL EEKLETLKIK RNEDKAKLKE LEKYKIQLEQ
260 270 280 290 300
VQEWKSKMQE QQADLQRRLK EAKKEAKDAL EAKERYMEEM ADTADAIEMA
310 320 330 340 350
TLDKEMAEER AESLQQEVDS LKEKVEYLTM DLEILKHEIE EKGSDGAASS
360 370 380 390 400
YQVKQLEEQN ARLKEALVRM RDLSASEKQE HVKLQKQMEK KNTELESLRQ
410 420 430 440 450
QREKLQEEVK QAEKTVDELK EQVDAALGAE EMVETLTERN LDLEEKVREL
460 470 480 490 500
RETVGDLEAM NEMNDELQEN ARETELELRE QLDLAAARVR EAEKRVEAAQ
510 520 530 540 550
ETVADYQQTI KKYRELTAHL QDVNRELMSQ QEASAEKQQQ PPPEIFDFKI
560 570 580 590 600
KFAETKAHAK AIEMELRQME VQQANRHVSL LTSFMPDSFL RHGGDHDCIL
610 620 630 640 650
VLLLIPRLIC KADVISKQAQ EKFELNENCT ARAGLRGAAG EQLSFAAGLV
660 670 680 690 700
YSLSLLQATL HKYEQALNKC SVEVYKKVGM LYPEMSVHER SLDFLIELLH
710 720 730 740 750
KDQLDETVNV EPLTKAIKYY QHLYSIHLAE QAEDCTMQLA DHIKFTQSAL
760 770 780 790 800
DCMGVEVCRL RAFLQAGQEA SDLAILLKDL ETSCSDIRQF CKKIRRRMPG
810 820 830 840 850
TDAPGIPAAL GFGQQVSDTL LDCRKHLTWV VAVLQEVAAA GAQLIAPLAE
860 870 880 890 900
NGAAGGEAGG LGLQSQRADL QRSGHQPLRV PAPVLQHPHC HHEQDATAMQ
910 920 930 940 950
EGEYDADRPQ SKPTPPAELR AAALRAEITD AEGLGLKLED RETVIKELKK
960 970 980 990 1000
SLKIKGEELS EANVRLSLLE KKLDSASKDA DDRVEKIQTK LDETQTLLKK
1010 1020 1030 1040 1050
KEKEFEETMD ALQADIDQLE SEKVELKQRL NNQSKRTIEG LRGAPASGVA
1060 1070 1080 1090 1100
SIVSGIAGEE QQRGVGAGQA AGGSAGPVQV KDSPLLLQQI EALQLSIRHL
1110 1120 1130 1140 1150
KNENNRLKGA QMKLELAGLK PLQVAKVSLP QSKQGEGPAT LTLYRKSTQL
1160 1170 1180 1190 1200
LETLYQMSTN AKVVDTKQTK SGRSGARLLE QTARLWAMKG SIEALRTRPC
1210 1220
GRWCSSSRAR ASPPASACSP PRPS
Length:1,224
Mass (Da):135,565
Last modified:July 11, 2001 - v2
Checksum:i03B7FFE68E7C01D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62773 mRNA. Translation: CAA44617.2.
PIRiA41642.
RefSeqiNP_001026538.1. NM_001031367.1. [P35458-1]
UniGeneiGga.48036.

Genome annotation databases

GeneIDi426238.
KEGGigga:426238.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62773 mRNA. Translation: CAA44617.2.
PIRiA41642.
RefSeqiNP_001026538.1. NM_001031367.1. [P35458-1]
UniGeneiGga.48036.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RFXX-ray2.90A/B/C/D/E412-533[»]
ProteinModelPortaliP35458.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP35458.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi426238.
KEGGigga:426238.

Organism-specific databases

CTDi1639.

Phylogenomic databases

HOVERGENiHBG004956.
InParanoidiP35458.
KOiK04648.
PhylomeDBiP35458.

Miscellaneous databases

PROiP35458.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR027663. DCTN1.
IPR022157. Dynactin.
[Graphical view]
PANTHERiPTHR18916:SF40. PTHR18916:SF40. 1 hit.
PfamiPF01302. CAP_GLY. 1 hit.
PF12455. Dynactin. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCTN1_CHICK
AccessioniPrimary (citable) accession number: P35458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 11, 2001
Last modified: June 8, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.