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Protein

Urokinase plasminogen activator surface receptor

Gene

Plaur

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-162791. Attachment of GPI anchor to uPAR.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-75205. Dissolution of Fibrin Clot.

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase plasminogen activator surface receptor
Short name:
U-PAR
Short name:
uPAR
Alternative name(s):
CD_antigen: CD87
Gene namesi
Name:Plaur
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:97612. Plaur.

Subcellular locationi

Isoform 1 :
  • Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity
Isoform 2 :
  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003609624 – ?298Urokinase plasminogen activator surface receptorAdd BLAST275
PropeptideiPRO_0000036097?299 – 327Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 471 Publication
Disulfide bondi29 ↔ 351 Publication
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi40 ↔ 681 Publication
Glycosylationi75N-linked (GlcNAc...)1 Publication1
Disulfide bondi94 ↔ 991 Publication
Disulfide bondi119 ↔ 1461 Publication
Disulfide bondi122 ↔ 1291 Publication
Disulfide bondi139 ↔ 1681 Publication
Disulfide bondi174 ↔ 1911 Publication
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi192 ↔ 1971 Publication
Glycosylationi193N-linked (GlcNAc...)1 Publication1
Disulfide bondi215 ↔ 2431 Publication
Disulfide bondi218 ↔ 2261 Publication
Glycosylationi221N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi236 ↔ 2621 Publication
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi268 ↔ 2871 Publication
Glycosylationi282N-linked (GlcNAc...)1 Publication1
Disulfide bondi288 ↔ 2931 Publication
Lipidationi298GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP35456.
PeptideAtlasiP35456.
PRIDEiP35456.

PTM databases

PhosphoSitePlusiP35456.

Miscellaneous databases

PMAP-CutDBP35456.

Expressioni

Tissue specificityi

Expressed in angiogenic endothelial cells (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000046223.
CleanExiMM_PLAUR.
ExpressionAtlasiP35456. baseline and differential.
GenevisibleiP35456. MM.

Interactioni

Subunit structurei

Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 (By similarity). Interacts with SORL1 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

IntActiP35456. 1 interactor.
STRINGi10090.ENSMUSP00000002284.

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 29Combined sources5
Beta strandi36 – 39Combined sources4
Beta strandi47 – 56Combined sources10
Beta strandi61 – 68Combined sources8
Beta strandi76 – 82Combined sources7
Beta strandi85 – 91Combined sources7
Beta strandi118 – 120Combined sources3
Turni124 – 127Combined sources4
Beta strandi129 – 132Combined sources4
Beta strandi136 – 138Combined sources3
Beta strandi146 – 153Combined sources8
Beta strandi163 – 170Combined sources8
Beta strandi175 – 181Combined sources7
Beta strandi183 – 194Combined sources12
Turni195 – 198Combined sources4
Beta strandi214 – 218Combined sources5
Beta strandi220 – 230Combined sources11
Beta strandi232 – 235Combined sources4
Beta strandi242 – 246Combined sources5
Beta strandi259 – 263Combined sources5
Beta strandi265 – 271Combined sources7
Helixi272 – 275Combined sources4
Beta strandi285 – 291Combined sources7
Helixi292 – 294Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LAQX-ray3.20U/V24-300[»]
ProteinModelPortaliP35456.
SMRiP35456.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35456.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 117UPAR/Ly6 1Add BLAST94
Domaini117 – 212UPAR/Ly6 2Add BLAST96
Domaini213 – 298UPAR/Ly6 3Add BLAST86

Sequence similaritiesi

Contains 3 UPAR/Ly6 domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJ50. Eukaryota.
ENOG410Z47S. LUCA.
GeneTreeiENSGT00510000049144.
HOGENOMiHOG000136855.
HOVERGENiHBG000245.
InParanoidiP35456.
KOiK03985.
OMAiVERGCAH.
OrthoDBiEOG091G0FQ6.
PhylomeDBiP35456.
TreeFamiTF338662.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR033084. U-PAR.
[Graphical view]
PANTHERiPTHR10624:SF6. PTHR10624:SF6. 1 hit.
PfamiPF00021. UPAR_LY6. 3 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35456-1) [UniParc]FASTAAdd to basket
Also known as: GPI-anchored

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLPRRLLLL LLLATTCVPA SQGLQCMQCE SNQSCLVEEC ALGQDLCRTT
60 70 80 90 100
VLREWQDDRE LEVVTRGCAH SEKTNRTMSY RMGSMIISLT ETVCATNLCN
110 120 130 140 150
RPRPGARGRA FPQGRYLECA SCTSLDQSCE RGREQSLQCR YPTEHCIEVV
160 170 180 190 200
TLQSTERSLK DEDYTRGCGS LPGCPGTAGF HSNQTFHFLK CCNYTHCNGG
210 220 230 240 250
PVLDLQSFPP NGFQCYSCEG NNTLGCSSEE ASLINCRGPM NQCLVATGLD
260 270 280 290 300
VLGNRSYTVR GCATASWCQG SHVADSFPTH LNVSVSCCHG SGCNSPTGGA
310 320
PRPGPAQLSL IASLLLTLGL WGVLLWT
Note: GPI-anchored form.
Length:327
Mass (Da):35,428
Last modified:June 1, 1994 - v1
Checksum:iA117441D738B6343
GO
Isoform 2 (identifier: P35456-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     157-222: RSLKDEDYTR...FQCYSCEGNN → SKLPSAGQLL...LVMSRILLSF
     223-327: Missing.

Show »
Length:222
Mass (Da):24,619
Checksum:i8BA6B9F21389C587
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031837157 – 222RSLKD…CEGNN → SKLPSAGQLLVEIFKSWEQS ASKRQLNPHTVTGPTFSVTG SSGSLDQLGSDQEPSYLVMS RILLSF in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_031838223 – 327Missing in isoform 2. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62700 mRNA. Translation: CAA44574.1.
X62701 mRNA. Translation: CAA44575.1.
U12235 Genomic DNA. Translation: AAB60484.1.
CCDSiCCDS20950.1. [P35456-1]
PIRiA55356.
B41643.
RefSeqiNP_035243.1. NM_011113.4. [P35456-1]
XP_006539702.1. XM_006539639.3. [P35456-1]
XP_006539703.1. XM_006539640.3. [P35456-1]
UniGeneiMm.1359.

Genome annotation databases

EnsembliENSMUST00000002284; ENSMUSP00000002284; ENSMUSG00000046223. [P35456-1]
GeneIDi18793.
KEGGimmu:18793.
UCSCiuc009fpr.1. mouse. [P35456-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62700 mRNA. Translation: CAA44574.1.
X62701 mRNA. Translation: CAA44575.1.
U12235 Genomic DNA. Translation: AAB60484.1.
CCDSiCCDS20950.1. [P35456-1]
PIRiA55356.
B41643.
RefSeqiNP_035243.1. NM_011113.4. [P35456-1]
XP_006539702.1. XM_006539639.3. [P35456-1]
XP_006539703.1. XM_006539640.3. [P35456-1]
UniGeneiMm.1359.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LAQX-ray3.20U/V24-300[»]
ProteinModelPortaliP35456.
SMRiP35456.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35456. 1 interactor.
STRINGi10090.ENSMUSP00000002284.

PTM databases

PhosphoSitePlusiP35456.

Proteomic databases

PaxDbiP35456.
PeptideAtlasiP35456.
PRIDEiP35456.

Protocols and materials databases

DNASUi18793.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002284; ENSMUSP00000002284; ENSMUSG00000046223. [P35456-1]
GeneIDi18793.
KEGGimmu:18793.
UCSCiuc009fpr.1. mouse. [P35456-1]

Organism-specific databases

CTDi5329.
MGIiMGI:97612. Plaur.

Phylogenomic databases

eggNOGiENOG410IJ50. Eukaryota.
ENOG410Z47S. LUCA.
GeneTreeiENSGT00510000049144.
HOGENOMiHOG000136855.
HOVERGENiHBG000245.
InParanoidiP35456.
KOiK03985.
OMAiVERGCAH.
OrthoDBiEOG091G0FQ6.
PhylomeDBiP35456.
TreeFamiTF338662.

Enzyme and pathway databases

ReactomeiR-MMU-162791. Attachment of GPI anchor to uPAR.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-75205. Dissolution of Fibrin Clot.

Miscellaneous databases

EvolutionaryTraceiP35456.
PMAP-CutDBP35456.
PROiP35456.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046223.
CleanExiMM_PLAUR.
ExpressionAtlasiP35456. baseline and differential.
GenevisibleiP35456. MM.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR033084. U-PAR.
[Graphical view]
PANTHERiPTHR10624:SF6. PTHR10624:SF6. 1 hit.
PfamiPF00021. UPAR_LY6. 3 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPAR_MOUSE
AccessioniPrimary (citable) accession number: P35456
Secondary accession number(s): P35457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.