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P35456 (UPAR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urokinase plasminogen activator surface receptor

Short name=U-PAR
Short name=uPAR
Alternative name(s):
CD_antigen=CD87
Gene names
Name:Plaur
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.

Subunit structure

Monomer Probable. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 By similarity. Interacts with SORL1 By similarity. Ref.3

Subcellular location

Isoform 1: Cell membrane; Lipid-anchorGPI-anchor.

Isoform 2: Secreted.

Tissue specificity

Expressed in angiogenic endothelial cells (at protein level). Ref.3

Sequence similarities

Contains 3 UPAR/Ly6 domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P35456-1)

Also known as: GPI-anchored;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: GPI-anchored form.
Isoform 2 (identifier: P35456-2)

Also known as: Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     157-222: RSLKDEDYTR...FQCYSCEGNN → SKLPSAGQLL...LVMSRILLSF
     223-327: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – ?298275Urokinase plasminogen activator surface receptor
PRO_0000036096
Propeptide?299 – 32729Removed in mature form Potential
PRO_0000036097

Regions

Domain24 – 11794UPAR/Ly6 1
Domain117 – 21296UPAR/Ly6 2
Domain213 – 29886UPAR/Ly6 3

Amino acid modifications

Lipidation2981GPI-anchor amidated glycine Potential
Glycosylation321N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Ref.4
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Ref.4
Glycosylation2211N-linked (GlcNAc...) Potential
Glycosylation2541N-linked (GlcNAc...) Potential
Glycosylation2821N-linked (GlcNAc...) Ref.4
Disulfide bond26 ↔ 47 Ref.4
Disulfide bond29 ↔ 35 Ref.4
Disulfide bond40 ↔ 68 Ref.4
Disulfide bond94 ↔ 99 Ref.4
Disulfide bond119 ↔ 146 Ref.4
Disulfide bond122 ↔ 129 Ref.4
Disulfide bond139 ↔ 168 Ref.4
Disulfide bond174 ↔ 191 Ref.4
Disulfide bond192 ↔ 197 Ref.4
Disulfide bond215 ↔ 243 Ref.4
Disulfide bond218 ↔ 226 Ref.4
Disulfide bond236 ↔ 262 Ref.4
Disulfide bond268 ↔ 287 Ref.4
Disulfide bond288 ↔ 293 Ref.4

Natural variations

Alternative sequence157 – 22266RSLKD…CEGNN → SKLPSAGQLLVEIFKSWEQS ASKRQLNPHTVTGPTFSVTG SSGSLDQLGSDQEPSYLVMS RILLSF in isoform 2.
VSP_031837
Alternative sequence223 – 327105Missing in isoform 2.
VSP_031838

Secondary structure

.............................................. 327
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (GPI-anchored) [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: A117441D738B6343

FASTA32735,428
        10         20         30         40         50         60 
MGLPRRLLLL LLLATTCVPA SQGLQCMQCE SNQSCLVEEC ALGQDLCRTT VLREWQDDRE 

        70         80         90        100        110        120 
LEVVTRGCAH SEKTNRTMSY RMGSMIISLT ETVCATNLCN RPRPGARGRA FPQGRYLECA 

       130        140        150        160        170        180 
SCTSLDQSCE RGREQSLQCR YPTEHCIEVV TLQSTERSLK DEDYTRGCGS LPGCPGTAGF 

       190        200        210        220        230        240 
HSNQTFHFLK CCNYTHCNGG PVLDLQSFPP NGFQCYSCEG NNTLGCSSEE ASLINCRGPM 

       250        260        270        280        290        300 
NQCLVATGLD VLGNRSYTVR GCATASWCQG SHVADSFPTH LNVSVSCCHG SGCNSPTGGA 

       310        320 
PRPGPAQLSL IASLLLTLGL WGVLLWT 

« Hide

Isoform 2 (Secreted) [UniParc] [UniParc].

Checksum: 8BA6B9F21389C587
Show »

FASTA22224,619

References

[1]"Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract."
Kristensen P., Eriksen J., Blasi F., Danoe K.
J. Cell Biol. 115:1763-1771(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING.
Tissue: Macrophage.
[2]"The murine urokinase-type plasminogen activator receptor gene."
Suh T.T., Nerlov C., Dano K., Degen J.L.
J. Biol. Chem. 269:25992-25998(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sushi repeat protein X-linked 2, a novel mediator of angiogenesis."
Miljkovic-Licina M., Hammel P., Garrido-Urbani S., Bradfield P.F., Szepetowski P., Imhof B.A.
FASEB J. 23:4105-4116(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SRPX2, TISSUE SPECIFICITY.
[4]"Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy."
Lin L., Gardsvoll H., Huai Q., Huang M., Ploug M.
J. Biol. Chem. 285:10982-10992(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 24-300 IN COMPLEX WITH PLAU, DISULFIDE BONDS, GLYCOSYLATION AT ASN-75; ASN-193 AND ASN-282.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62700 mRNA. Translation: CAA44574.1.
X62701 mRNA. Translation: CAA44575.1.
U12235 Genomic DNA. Translation: AAB60484.1.
CCDSCCDS20950.1. [P35456-1]
PIRA55356.
B41643.
RefSeqNP_035243.1. NM_011113.3. [P35456-1]
XP_006539702.1. XM_006539639.1. [P35456-1]
XP_006539703.1. XM_006539640.1. [P35456-1]
XP_006539704.1. XM_006539641.1. [P35456-1]
UniGeneMm.1359.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3LAQX-ray3.20U/V24-300[»]
ProteinModelPortalP35456.
SMRP35456. Positions 24-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP35456. 1 interaction.

Proteomic databases

PaxDbP35456.
PRIDEP35456.

Protocols and materials databases

DNASU18793.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000002284; ENSMUSP00000002284; ENSMUSG00000046223. [P35456-1]
GeneID18793.
KEGGmmu:18793.
UCSCuc009fpr.1. mouse. [P35456-1]

Organism-specific databases

CTD5329.
MGIMGI:97612. Plaur.

Phylogenomic databases

eggNOGNOG41870.
HOGENOMHOG000136855.
HOVERGENHBG000245.
InParanoidP35456.
KOK03985.
OMATNRTMSY.
OrthoDBEOG7QRQVG.
PhylomeDBP35456.
TreeFamTF338662.

Gene expression databases

ArrayExpressP35456.
BgeeP35456.
CleanExMM_PLAUR.
GenevestigatorP35456.

Family and domain databases

InterProIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
[Graphical view]
PfamPF00021. UPAR_LY6. 3 hits.
[Graphical view]
SMARTSM00134. LU. 3 hits.
[Graphical view]
PROSITEPS00983. LY6_UPAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP35456.
NextBio295076.
PMAP-CutDBP35456.
PROP35456.
SOURCESearch...

Entry information

Entry nameUPAR_MOUSE
AccessionPrimary (citable) accession number: P35456
Secondary accession number(s): P35457
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot