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P35455 (NEU2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII

Cleaved into the following 3 chains:

  1. Arg-vasopressin
    Alternative name(s):
    Arginine-vasopressin
  2. Neurophysin 2
    Alternative name(s):
    Neurophysin-I
  3. Copeptin
Gene names
Name:Avp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length168 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Neurophysin 2 specifically binds vasopressin.

Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.

Subcellular location

Secreted.

Sequence similarities

Belongs to the vasopressin/oxytocin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
Vasoactive
Vasoconstrictor
   PTMAmidation
Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

grooming behavior

Inferred from electronic annotation. Source: Ensembl

hyperosmotic salinity response

Inferred from electronic annotation. Source: Ensembl

locomotory behavior

Inferred from electronic annotation. Source: Ensembl

maternal aggressive behavior

Inferred from electronic annotation. Source: Ensembl

maternal behavior

Inferred from electronic annotation. Source: Ensembl

multicellular organismal water homeostasis

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of female receptivity

Inferred from electronic annotation. Source: Ensembl

negative regulation of release of cytochrome c from mitochondria

Inferred from electronic annotation. Source: Ensembl

negative regulation of transmission of nerve impulse

Inferred from electronic annotation. Source: Ensembl

penile erection

Inferred from electronic annotation. Source: Ensembl

positive regulation of cAMP biosynthetic process

Inferred from direct assay PubMed 15632412. Source: MGI

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cellular pH reduction

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of glutamate secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of prostaglandin biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of systemic arterial blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasoconstriction

Inferred from electronic annotation. Source: Ensembl

protein kinase C signaling

Inferred from electronic annotation. Source: Ensembl

regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to nicotine

Inferred from electronic annotation. Source: Ensembl

response to testosterone

Inferred from electronic annotation. Source: Ensembl

social behavior

Inferred from electronic annotation. Source: Ensembl

vasoconstriction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentdendrite

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: Ensembl

secretory granule

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

protein kinase activity

Inferred from electronic annotation. Source: Ensembl

signal transducer activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Peptide24 – 329Arg-vasopressin
PRO_0000020518
Chain36 – 12893Neurophysin 2
PRO_0000020519
Peptide130 – 16839Copeptin
PRO_0000020520

Amino acid modifications

Modified residue321Glycine amide By similarity
Glycosylation1351N-linked (GlcNAc...) Potential
Disulfide bond24 ↔ 29 By similarity
Disulfide bond45 ↔ 89 By similarity
Disulfide bond48 ↔ 62 By similarity
Disulfide bond56 ↔ 79 By similarity
Disulfide bond63 ↔ 69 By similarity
Disulfide bond96 ↔ 108 By similarity
Disulfide bond102 ↔ 120 By similarity
Disulfide bond109 ↔ 114 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35455 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 234F6D826E0BBEE9

FASTA16817,900
        10         20         30         40         50         60 
MLARMLNTTL SACFLSLLAF SSACYFQNCP RGGKRAISDM ELRQCLPCGP GGKGRCFGPS 

        70         80         90        100        110        120 
ICCADELGCF VGTAEALRCQ EENYLPSPCQ SGQKPCGSGG RCAAVGICCS DESCVAEPEC 

       130        140        150        160 
HDGFFRLTRA REPSNATQLD GPARALLLRL VQLAGTRESV DSAKPRVY 

« Hide

References

« Hide 'large scale' references
[1]"Structure of mouse vasopressin and oxytocin genes."
Hara Y., Battey J., Gainer H.
Brain Res. Mol. Brain Res. 8:319-324(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M88354 Genomic DNA. Translation: AAC42027.1.
BC051997 mRNA. Translation: AAH51997.1.
PIRB43755.
RefSeqNP_033862.1. NM_009732.1.
UniGeneMm.6190.

3D structure databases

ProteinModelPortalP35455.
SMRP35455. Positions 36-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000035551.

Proteomic databases

PaxDbP35455.
PRIDEP35455.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046001; ENSMUSP00000035551; ENSMUSG00000037727.
GeneID11998.
KEGGmmu:11998.
UCSCuc008mjh.1. mouse.

Organism-specific databases

CTD551.
MGIMGI:88121. Avp.

Phylogenomic databases

eggNOGNOG44533.
HOGENOMHOG000113768.
HOVERGENHBG004462.
InParanoidP35455.
KOK05242.
OMAPECREGF.
OrthoDBEOG7NW6C5.
PhylomeDBP35455.
TreeFamTF333018.

Enzyme and pathway databases

ReactomeREACT_109335. Circadian Clock.
REACT_24972. Circadian Clock.

Gene expression databases

ArrayExpressP35455.
BgeeP35455.
CleanExMM_AVP.
GenevestigatorP35455.

Family and domain databases

Gene3D2.60.9.10. 1 hit.
InterProIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERPTHR11681. PTHR11681. 1 hit.
PfamPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSPR00831. NEUROPHYSIN.
ProDomPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00003. NH. 1 hit.
[Graphical view]
SUPFAMSSF49606. SSF49606. 1 hit.
PROSITEPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280185.
PROP35455.
SOURCESearch...

Entry information

Entry nameNEU2_MOUSE
AccessionPrimary (citable) accession number: P35455
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot