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P35455

- NEU2_MOUSE

UniProt

P35455 - NEU2_MOUSE

Protein

Vasopressin-neurophysin 2-copeptin

Gene

Avp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Neurophysin 2 specifically binds vasopressin.
    Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: Ensembl
    2. protein kinase activity Source: Ensembl
    3. signal transducer activity Source: Ensembl

    GO - Biological processi

    1. ERK1 and ERK2 cascade Source: Ensembl
    2. grooming behavior Source: Ensembl
    3. hyperosmotic salinity response Source: Ensembl
    4. locomotory behavior Source: Ensembl
    5. maternal aggressive behavior Source: Ensembl
    6. maternal behavior Source: Ensembl
    7. multicellular organismal water homeostasis Source: Ensembl
    8. negative regulation of apoptotic process Source: Ensembl
    9. negative regulation of female receptivity Source: Ensembl
    10. negative regulation of release of cytochrome c from mitochondria Source: Ensembl
    11. negative regulation of transmission of nerve impulse Source: Ensembl
    12. penile erection Source: Ensembl
    13. positive regulation of cAMP biosynthetic process Source: MGI
    14. positive regulation of cell growth Source: Ensembl
    15. positive regulation of cell proliferation Source: Ensembl
    16. positive regulation of cellular pH reduction Source: Ensembl
    17. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    18. positive regulation of gene expression Source: Ensembl
    19. positive regulation of glutamate secretion Source: Ensembl
    20. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    21. positive regulation of prostaglandin biosynthetic process Source: Ensembl
    22. positive regulation of systemic arterial blood pressure Source: Ensembl
    23. positive regulation of vasoconstriction Source: Ensembl
    24. protein kinase C signaling Source: Ensembl
    25. regulation of renal sodium excretion Source: Ensembl
    26. response to ethanol Source: Ensembl
    27. response to nicotine Source: Ensembl
    28. response to testosterone Source: Ensembl
    29. social behavior Source: Ensembl
    30. vasoconstriction Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hormone, Vasoactive, Vasoconstrictor

    Enzyme and pathway databases

    ReactomeiREACT_115781. Bmal1:Clock,Npas2 activates circadian gene expression.
    REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_207651. G alpha (q) signalling events.
    REACT_210189. Transport of organic anions.
    REACT_213947. Regulation of water balance by renal Aquaporins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasopressin-neurophysin 2-copeptin
    Alternative name(s):
    AVP-NPII
    Cleaved into the following 3 chains:
    Alternative name(s):
    Arginine-vasopressin
    Alternative name(s):
    Neurophysin-I
    Gene namesi
    Name:Avp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:88121. Avp.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. extracellular region Source: Reactome
    3. extracellular space Source: Ensembl
    4. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Peptidei24 – 329Arg-vasopressinPRO_0000020518
    Chaini36 – 12893Neurophysin 2PRO_0000020519Add
    BLAST
    Peptidei130 – 16839CopeptinPRO_0000020520Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 29By similarity
    Modified residuei32 – 321Glycine amideBy similarity
    Disulfide bondi45 ↔ 89By similarity
    Disulfide bondi48 ↔ 62By similarity
    Disulfide bondi56 ↔ 79By similarity
    Disulfide bondi63 ↔ 69By similarity
    Disulfide bondi96 ↔ 108By similarity
    Disulfide bondi102 ↔ 120By similarity
    Disulfide bondi109 ↔ 114By similarity
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP35455.
    PRIDEiP35455.

    Expressioni

    Gene expression databases

    ArrayExpressiP35455.
    BgeeiP35455.
    CleanExiMM_AVP.
    GenevestigatoriP35455.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000035551.

    Structurei

    3D structure databases

    ProteinModelPortaliP35455.
    SMRiP35455. Positions 36-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vasopressin/oxytocin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44533.
    HOGENOMiHOG000113768.
    HOVERGENiHBG004462.
    InParanoidiP35455.
    KOiK05242.
    OMAiPECREGF.
    OrthoDBiEOG7NW6C5.
    PhylomeDBiP35455.
    TreeFamiTF333018.

    Family and domain databases

    Gene3Di2.60.9.10. 1 hit.
    InterProiIPR000981. Neurhyp_horm.
    IPR022423. Neurohypophysial_hormone_CS.
    [Graphical view]
    PANTHERiPTHR11681. PTHR11681. 1 hit.
    PfamiPF00220. Hormone_4. 1 hit.
    PF00184. Hormone_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
    PRINTSiPR00831. NEUROPHYSIN.
    ProDomiPD001676. Neurhyp_horm. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00003. NH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49606. SSF49606. 1 hit.
    PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35455-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLARMLNTTL SACFLSLLAF SSACYFQNCP RGGKRAISDM ELRQCLPCGP    50
    GGKGRCFGPS ICCADELGCF VGTAEALRCQ EENYLPSPCQ SGQKPCGSGG 100
    RCAAVGICCS DESCVAEPEC HDGFFRLTRA REPSNATQLD GPARALLLRL 150
    VQLAGTRESV DSAKPRVY 168
    Length:168
    Mass (Da):17,900
    Last modified:June 1, 1994 - v1
    Checksum:i234F6D826E0BBEE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88354 Genomic DNA. Translation: AAC42027.1.
    BC051997 mRNA. Translation: AAH51997.1.
    CCDSiCCDS16746.1.
    PIRiB43755.
    RefSeqiNP_033862.1. NM_009732.1.
    UniGeneiMm.6190.

    Genome annotation databases

    EnsembliENSMUST00000046001; ENSMUSP00000035551; ENSMUSG00000037727.
    GeneIDi11998.
    KEGGimmu:11998.
    UCSCiuc008mjh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88354 Genomic DNA. Translation: AAC42027.1 .
    BC051997 mRNA. Translation: AAH51997.1 .
    CCDSi CCDS16746.1.
    PIRi B43755.
    RefSeqi NP_033862.1. NM_009732.1.
    UniGenei Mm.6190.

    3D structure databases

    ProteinModelPortali P35455.
    SMRi P35455. Positions 36-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000035551.

    Proteomic databases

    PaxDbi P35455.
    PRIDEi P35455.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046001 ; ENSMUSP00000035551 ; ENSMUSG00000037727 .
    GeneIDi 11998.
    KEGGi mmu:11998.
    UCSCi uc008mjh.1. mouse.

    Organism-specific databases

    CTDi 551.
    MGIi MGI:88121. Avp.

    Phylogenomic databases

    eggNOGi NOG44533.
    HOGENOMi HOG000113768.
    HOVERGENi HBG004462.
    InParanoidi P35455.
    KOi K05242.
    OMAi PECREGF.
    OrthoDBi EOG7NW6C5.
    PhylomeDBi P35455.
    TreeFami TF333018.

    Enzyme and pathway databases

    Reactomei REACT_115781. Bmal1:Clock,Npas2 activates circadian gene expression.
    REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_207651. G alpha (q) signalling events.
    REACT_210189. Transport of organic anions.
    REACT_213947. Regulation of water balance by renal Aquaporins.

    Miscellaneous databases

    NextBioi 280185.
    PROi P35455.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35455.
    Bgeei P35455.
    CleanExi MM_AVP.
    Genevestigatori P35455.

    Family and domain databases

    Gene3Di 2.60.9.10. 1 hit.
    InterProi IPR000981. Neurhyp_horm.
    IPR022423. Neurohypophysial_hormone_CS.
    [Graphical view ]
    PANTHERi PTHR11681. PTHR11681. 1 hit.
    Pfami PF00220. Hormone_4. 1 hit.
    PF00184. Hormone_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
    PRINTSi PR00831. NEUROPHYSIN.
    ProDomi PD001676. Neurhyp_horm. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00003. NH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49606. SSF49606. 1 hit.
    PROSITEi PS00264. NEUROHYPOPHYS_HORM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of mouse vasopressin and oxytocin genes."
      Hara Y., Battey J., Gainer H.
      Brain Res. Mol. Brain Res. 8:319-324(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiNEU2_MOUSE
    AccessioniPrimary (citable) accession number: P35455
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3