P35455 (NEU2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vasopressin-neurophysin 2-copeptin

Alternative name(s):
AVP-NPII

Cleaved into the following 3 chains:

1. Arg-vasopressin
   Alternative name(s):
   Arginine-vasopressin
2. Neurophysin 2
   Alternative name(s):
   Neurophysin-I
3. Copeptin

Gene names

Name:

Avp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Neurophysin 2 specifically binds vasopressin. Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.
Subcellular location	Secreted.
Sequence similarities	Belongs to the vasopressin/oxytocin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone Vasoactive Vasoconstrictor
PTM	Amidation Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara grooming behavior Inferred from electronic annotation. Source: Compara hyperosmotic salinity response Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara maternal aggressive behavior Inferred from electronic annotation. Source: Compara maternal behavior Inferred from electronic annotation. Source: Compara multicellular organismal water homeostasis Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of female receptivity Inferred from electronic annotation. Source: Compara negative regulation of release of cytochrome c from mitochondria Inferred from electronic annotation. Source: Compara negative regulation of transmission of nerve impulse Inferred from electronic annotation. Source: Compara penile erection Inferred from electronic annotation. Source: Compara positive regulation of cAMP biosynthetic process Inferred from direct assay PubMed 15632412. Source: MGI positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cellular pH reduction Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara positive regulation of glutamate secretion Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of prostaglandin biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of systemic arterial blood pressure Inferred from electronic annotation. Source: Compara positive regulation of vasoconstriction Inferred from electronic annotation. Source: Compara protein kinase C signaling cascade Inferred from electronic annotation. Source: Compara regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to nicotine Inferred from electronic annotation. Source: Compara social behavior Inferred from electronic annotation. Source: Compara vasoconstriction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	dendrite Inferred from electronic annotation. Source: Compara extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: Compara secretory granule Inferred from electronic annotation. Source: Compara
Molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process Inferred from electronic annotation. Source: Compara protein kinase activity Inferred from electronic annotation. Source: Compara signal transducer activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Peptide	24 – 32	9	Arg-vasopressin		PRO_0000020518
	Chain	36 – 128	93	Neurophysin 2		PRO_0000020519
	Peptide	130 – 168	39	Copeptin		PRO_0000020520
Amino acid modifications
	Modified residue	32	1	Glycine amide By similarity
	Glycosylation	135	1	N-linked (GlcNAc...) Potential
	Disulfide bond	24 ↔ 29		By similarity
	Disulfide bond	45 ↔ 89		By similarity
	Disulfide bond	48 ↔ 62		By similarity
	Disulfide bond	56 ↔ 79		By similarity
	Disulfide bond	63 ↔ 69		By similarity
	Disulfide bond	96 ↔ 108		By similarity
	Disulfide bond	102 ↔ 120		By similarity
	Disulfide bond	109 ↔ 114		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35455 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 234F6D826E0BBEE9	FASTA	168	17,900
	10 20 30 40 50 60 MLARMLNTTL SACFLSLLAF SSACYFQNCP RGGKRAISDM ELRQCLPCGP GGKGRCFGPS 70 80 90 100 110 120 ICCADELGCF VGTAEALRCQ EENYLPSPCQ SGQKPCGSGG RCAAVGICCS DESCVAEPEC 130 140 150 160 HDGFFRLTRA REPSNATQLD GPARALLLRL VQLAGTRESV DSAKPRVY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure of mouse vasopressin and oxytocin genes." Hara Y., Battey J., Gainer H. Brain Res. Mol. Brain Res. 8:319-324(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M88354 Genomic DNA. Translation: AAC42027.1. BC051997 mRNA. Translation: AAH51997.1.
IPI	IPI00118471.
PIR	B43755.
RefSeq	NP_033862.1. NM_009732.1.
UniGene	Mm.6190.
3D structure databases
ProteinModelPortal	P35455.
SMR	P35455. Positions 36-120.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000035551.
Proteomic databases
PaxDb	P35455.
PRIDE	P35455.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000046001; ENSMUSP00000035551; ENSMUSG00000037727.
GeneID	11998.
KEGG	mmu:11998.
UCSC	uc008mjh.1. mouse.
Organism-specific databases
CTD	551.
MGI	MGI:88121. Avp.
Phylogenomic databases
eggNOG	NOG44533.
HOGENOM	HOG000113768.
HOVERGEN	HBG004462.
InParanoid	P35455.
KO	K05242.
OMA	PECREGF.
OrthoDB	EOG451DS6.
Enzyme and pathway databases
Reactome	REACT_109335. Circadian Clock. REACT_24972. Circadian Clock (mouse).
Gene expression databases
ArrayExpress	P35455.
Bgee	P35455.
CleanEx	MM_AVP.
Genevestigator	P35455.
GermOnline	ENSMUSG00000037727. Mus musculus.
Family and domain databases
Gene3D	2.60.9.10. 1 hit.
InterPro	IPR000981. Neurhyp_horm. IPR022423. Neurohypophysial_hormone_CS. [Graphical view]
PANTHER	PTHR11681. PTHR11681. 1 hit.
Pfam	PF00220. Hormone_4. 1 hit. PF00184. Hormone_5. 1 hit. [Graphical view]
PIRSF	PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTS	PR00831. NEUROPHYSIN.
ProDom	PD001676. Neurhyp_horm. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00003. NH. 1 hit. [Graphical view]
SUPFAM	SSF49606. Neurhyp_horm. 1 hit.
PROSITE	PS00264. NEUROHYPOPHYS_HORM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280185.
SOURCE	Search...

Entry information

Entry name

NEU2_MOUSE

Accession

Primary (citable) accession number: P35455

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 29, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program