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P35455

- NEU2_MOUSE

UniProt

P35455 - NEU2_MOUSE

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Protein
Vasopressin-neurophysin 2-copeptin
Gene
Avp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: Ensembl
  2. protein kinase activity Source: Ensembl
  3. signal transducer activity Source: Ensembl

GO - Biological processi

  1. ERK1 and ERK2 cascade Source: Ensembl
  2. grooming behavior Source: Ensembl
  3. hyperosmotic salinity response Source: Ensembl
  4. locomotory behavior Source: Ensembl
  5. maternal aggressive behavior Source: Ensembl
  6. maternal behavior Source: Ensembl
  7. multicellular organismal water homeostasis Source: Ensembl
  8. negative regulation of apoptotic process Source: Ensembl
  9. negative regulation of female receptivity Source: Ensembl
  10. negative regulation of release of cytochrome c from mitochondria Source: Ensembl
  11. negative regulation of transmission of nerve impulse Source: Ensembl
  12. penile erection Source: Ensembl
  13. positive regulation of cAMP biosynthetic process Source: MGI
  14. positive regulation of cell growth Source: Ensembl
  15. positive regulation of cell proliferation Source: Ensembl
  16. positive regulation of cellular pH reduction Source: Ensembl
  17. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  18. positive regulation of gene expression Source: Ensembl
  19. positive regulation of glutamate secretion Source: Ensembl
  20. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  21. positive regulation of prostaglandin biosynthetic process Source: Ensembl
  22. positive regulation of systemic arterial blood pressure Source: Ensembl
  23. positive regulation of vasoconstriction Source: Ensembl
  24. protein kinase C signaling Source: Ensembl
  25. regulation of renal sodium excretion Source: Ensembl
  26. response to ethanol Source: Ensembl
  27. response to nicotine Source: Ensembl
  28. response to testosterone Source: Ensembl
  29. social behavior Source: Ensembl
  30. vasoconstriction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_115781. Bmal1:Clock,Npas2 activates circadian gene expression.
REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_207651. G alpha (q) signalling events.
REACT_210189. Transport of organic anions.
REACT_213947. Regulation of water balance by renal Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII
Cleaved into the following 3 chains:
Alternative name(s):
Arginine-vasopressin
Alternative name(s):
Neurophysin-I
Gene namesi
Name:Avp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:88121. Avp.

Subcellular locationi

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. extracellular region Source: Reactome
  3. extracellular space Source: Ensembl
  4. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Peptidei24 – 329Arg-vasopressin
PRO_0000020518
Chaini36 – 12893Neurophysin 2
PRO_0000020519Add
BLAST
Peptidei130 – 16839Copeptin
PRO_0000020520Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 29 By similarity
Modified residuei32 – 321Glycine amide By similarity
Disulfide bondi45 ↔ 89 By similarity
Disulfide bondi48 ↔ 62 By similarity
Disulfide bondi56 ↔ 79 By similarity
Disulfide bondi63 ↔ 69 By similarity
Disulfide bondi96 ↔ 108 By similarity
Disulfide bondi102 ↔ 120 By similarity
Disulfide bondi109 ↔ 114 By similarity
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35455.
PRIDEiP35455.

Expressioni

Gene expression databases

ArrayExpressiP35455.
BgeeiP35455.
CleanExiMM_AVP.
GenevestigatoriP35455.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035551.

Structurei

3D structure databases

ProteinModelPortaliP35455.
SMRiP35455. Positions 36-120.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44533.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP35455.
KOiK05242.
OMAiPECREGF.
OrthoDBiEOG7NW6C5.
PhylomeDBiP35455.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35455-1 [UniParc]FASTAAdd to Basket

« Hide

MLARMLNTTL SACFLSLLAF SSACYFQNCP RGGKRAISDM ELRQCLPCGP    50
GGKGRCFGPS ICCADELGCF VGTAEALRCQ EENYLPSPCQ SGQKPCGSGG 100
RCAAVGICCS DESCVAEPEC HDGFFRLTRA REPSNATQLD GPARALLLRL 150
VQLAGTRESV DSAKPRVY 168
Length:168
Mass (Da):17,900
Last modified:June 1, 1994 - v1
Checksum:i234F6D826E0BBEE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88354 Genomic DNA. Translation: AAC42027.1.
BC051997 mRNA. Translation: AAH51997.1.
CCDSiCCDS16746.1.
PIRiB43755.
RefSeqiNP_033862.1. NM_009732.1.
UniGeneiMm.6190.

Genome annotation databases

EnsembliENSMUST00000046001; ENSMUSP00000035551; ENSMUSG00000037727.
GeneIDi11998.
KEGGimmu:11998.
UCSCiuc008mjh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88354 Genomic DNA. Translation: AAC42027.1 .
BC051997 mRNA. Translation: AAH51997.1 .
CCDSi CCDS16746.1.
PIRi B43755.
RefSeqi NP_033862.1. NM_009732.1.
UniGenei Mm.6190.

3D structure databases

ProteinModelPortali P35455.
SMRi P35455. Positions 36-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000035551.

Proteomic databases

PaxDbi P35455.
PRIDEi P35455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046001 ; ENSMUSP00000035551 ; ENSMUSG00000037727 .
GeneIDi 11998.
KEGGi mmu:11998.
UCSCi uc008mjh.1. mouse.

Organism-specific databases

CTDi 551.
MGIi MGI:88121. Avp.

Phylogenomic databases

eggNOGi NOG44533.
HOGENOMi HOG000113768.
HOVERGENi HBG004462.
InParanoidi P35455.
KOi K05242.
OMAi PECREGF.
OrthoDBi EOG7NW6C5.
PhylomeDBi P35455.
TreeFami TF333018.

Enzyme and pathway databases

Reactomei REACT_115781. Bmal1:Clock,Npas2 activates circadian gene expression.
REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_207651. G alpha (q) signalling events.
REACT_210189. Transport of organic anions.
REACT_213947. Regulation of water balance by renal Aquaporins.

Miscellaneous databases

NextBioi 280185.
PROi P35455.
SOURCEi Search...

Gene expression databases

ArrayExpressi P35455.
Bgeei P35455.
CleanExi MM_AVP.
Genevestigatori P35455.

Family and domain databases

Gene3Di 2.60.9.10. 1 hit.
InterProi IPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view ]
PANTHERi PTHR11681. PTHR11681. 1 hit.
Pfami PF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSi PR00831. NEUROPHYSIN.
ProDomi PD001676. Neurhyp_horm. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00003. NH. 1 hit.
[Graphical view ]
SUPFAMi SSF49606. SSF49606. 1 hit.
PROSITEi PS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of mouse vasopressin and oxytocin genes."
    Hara Y., Battey J., Gainer H.
    Brain Res. Mol. Brain Res. 8:319-324(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiNEU2_MOUSE
AccessioniPrimary (citable) accession number: P35455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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