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P35455

- NEU2_MOUSE

UniProt

P35455 - NEU2_MOUSE

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Protein

Vasopressin-neurophysin 2-copeptin

Gene

Avp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: Ensembl
  2. protein kinase activity Source: Ensembl
  3. signal transducer activity Source: Ensembl

GO - Biological processi

  1. ERK1 and ERK2 cascade Source: Ensembl
  2. grooming behavior Source: Ensembl
  3. hyperosmotic salinity response Source: Ensembl
  4. locomotory behavior Source: Ensembl
  5. maternal aggressive behavior Source: Ensembl
  6. maternal behavior Source: Ensembl
  7. multicellular organismal water homeostasis Source: Ensembl
  8. negative regulation of apoptotic process Source: Ensembl
  9. negative regulation of female receptivity Source: Ensembl
  10. negative regulation of release of cytochrome c from mitochondria Source: Ensembl
  11. negative regulation of transmission of nerve impulse Source: Ensembl
  12. penile erection Source: Ensembl
  13. positive regulation of cAMP biosynthetic process Source: MGI
  14. positive regulation of cell growth Source: Ensembl
  15. positive regulation of cell proliferation Source: Ensembl
  16. positive regulation of cellular pH reduction Source: Ensembl
  17. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  18. positive regulation of gene expression Source: Ensembl
  19. positive regulation of glutamate secretion Source: Ensembl
  20. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  21. positive regulation of prostaglandin biosynthetic process Source: Ensembl
  22. positive regulation of systemic arterial blood pressure Source: Ensembl
  23. positive regulation of vasoconstriction Source: Ensembl
  24. protein kinase C signaling Source: Ensembl
  25. regulation of renal sodium excretion Source: Ensembl
  26. response to ethanol Source: Ensembl
  27. response to nicotine Source: Ensembl
  28. response to testosterone Source: Ensembl
  29. social behavior Source: Ensembl
  30. vasoconstriction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_115781. Bmal1:Clock,Npas2 activates circadian gene expression.
REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_207651. G alpha (q) signalling events.
REACT_210189. Transport of organic anions.
REACT_213947. Regulation of water balance by renal Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII
Cleaved into the following 3 chains:
Alternative name(s):
Arginine-vasopressin
Alternative name(s):
Neurophysin-I
Gene namesi
Name:Avp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:88121. Avp.

Subcellular locationi

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. extracellular region Source: Reactome
  3. extracellular space Source: Ensembl
  4. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Peptidei24 – 329Arg-vasopressinPRO_0000020518
Chaini36 – 12893Neurophysin 2PRO_0000020519Add
BLAST
Peptidei130 – 16839CopeptinPRO_0000020520Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 29By similarity
Modified residuei32 – 321Glycine amideBy similarity
Disulfide bondi45 ↔ 89By similarity
Disulfide bondi48 ↔ 62By similarity
Disulfide bondi56 ↔ 79By similarity
Disulfide bondi63 ↔ 69By similarity
Disulfide bondi96 ↔ 108By similarity
Disulfide bondi102 ↔ 120By similarity
Disulfide bondi109 ↔ 114By similarity
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35455.
PRIDEiP35455.

Expressioni

Gene expression databases

BgeeiP35455.
CleanExiMM_AVP.
ExpressionAtlasiP35455. baseline.
GenevestigatoriP35455.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035551.

Structurei

3D structure databases

ProteinModelPortaliP35455.
SMRiP35455. Positions 36-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44533.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP35455.
KOiK05242.
OMAiPECREGF.
OrthoDBiEOG7NW6C5.
PhylomeDBiP35455.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35455-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLARMLNTTL SACFLSLLAF SSACYFQNCP RGGKRAISDM ELRQCLPCGP
60 70 80 90 100
GGKGRCFGPS ICCADELGCF VGTAEALRCQ EENYLPSPCQ SGQKPCGSGG
110 120 130 140 150
RCAAVGICCS DESCVAEPEC HDGFFRLTRA REPSNATQLD GPARALLLRL
160
VQLAGTRESV DSAKPRVY
Length:168
Mass (Da):17,900
Last modified:June 1, 1994 - v1
Checksum:i234F6D826E0BBEE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88354 Genomic DNA. Translation: AAC42027.1.
BC051997 mRNA. Translation: AAH51997.1.
CCDSiCCDS16746.1.
PIRiB43755.
RefSeqiNP_033862.1. NM_009732.1.
UniGeneiMm.6190.

Genome annotation databases

EnsembliENSMUST00000046001; ENSMUSP00000035551; ENSMUSG00000037727.
GeneIDi11998.
KEGGimmu:11998.
UCSCiuc008mjh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88354 Genomic DNA. Translation: AAC42027.1 .
BC051997 mRNA. Translation: AAH51997.1 .
CCDSi CCDS16746.1.
PIRi B43755.
RefSeqi NP_033862.1. NM_009732.1.
UniGenei Mm.6190.

3D structure databases

ProteinModelPortali P35455.
SMRi P35455. Positions 36-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000035551.

Proteomic databases

PaxDbi P35455.
PRIDEi P35455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046001 ; ENSMUSP00000035551 ; ENSMUSG00000037727 .
GeneIDi 11998.
KEGGi mmu:11998.
UCSCi uc008mjh.1. mouse.

Organism-specific databases

CTDi 551.
MGIi MGI:88121. Avp.

Phylogenomic databases

eggNOGi NOG44533.
HOGENOMi HOG000113768.
HOVERGENi HBG004462.
InParanoidi P35455.
KOi K05242.
OMAi PECREGF.
OrthoDBi EOG7NW6C5.
PhylomeDBi P35455.
TreeFami TF333018.

Enzyme and pathway databases

Reactomei REACT_115781. Bmal1:Clock,Npas2 activates circadian gene expression.
REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_207651. G alpha (q) signalling events.
REACT_210189. Transport of organic anions.
REACT_213947. Regulation of water balance by renal Aquaporins.

Miscellaneous databases

NextBioi 280185.
PROi P35455.
SOURCEi Search...

Gene expression databases

Bgeei P35455.
CleanExi MM_AVP.
ExpressionAtlasi P35455. baseline.
Genevestigatori P35455.

Family and domain databases

Gene3Di 2.60.9.10. 1 hit.
InterProi IPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view ]
PANTHERi PTHR11681. PTHR11681. 1 hit.
Pfami PF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSi PR00831. NEUROPHYSIN.
ProDomi PD001676. Neurhyp_horm. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00003. NH. 1 hit.
[Graphical view ]
SUPFAMi SSF49606. SSF49606. 1 hit.
PROSITEi PS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of mouse vasopressin and oxytocin genes."
    Hara Y., Battey J., Gainer H.
    Brain Res. Mol. Brain Res. 8:319-324(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiNEU2_MOUSE
AccessioniPrimary (citable) accession number: P35455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3