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Protein

Vasopressin-neurophysin 2-copeptin

Gene

Avp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-MMU-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-MMU-1368110. Bmal1:Clock,Npas2 activates circadian gene expression.
R-MMU-388479. Vasopressin-like receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-879518. Transport of organic anions.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII
Cleaved into the following 3 chains:
Alternative name(s):
Arginine-vasopressin
Alternative name(s):
Neurophysin-I
Gene namesi
Name:Avp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88121. Avp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
PeptideiPRO_000002051824 – 32Arg-vasopressin9
ChainiPRO_000002051936 – 128Neurophysin 2Add BLAST93
PeptideiPRO_0000020520130 – 168CopeptinAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 29By similarity
Modified residuei32Glycine amideBy similarity1
Disulfide bondi45 ↔ 89By similarity
Disulfide bondi48 ↔ 62By similarity
Disulfide bondi56 ↔ 79By similarity
Disulfide bondi63 ↔ 69By similarity
Disulfide bondi96 ↔ 108By similarity
Disulfide bondi102 ↔ 120By similarity
Disulfide bondi109 ↔ 114By similarity
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35455.
PeptideAtlasiP35455.
PRIDEiP35455.

PTM databases

PhosphoSitePlusiP35455.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037727.
CleanExiMM_AVP.
ExpressionAtlasiP35455. baseline and differential.
GenevisibleiP35455. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035551.

Structurei

3D structure databases

ProteinModelPortaliP35455.
SMRiP35455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP35455.
KOiK05242.
OMAiESCMTEP.
OrthoDBiEOG091G0V8Z.
PhylomeDBiP35455.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARMLNTTL SACFLSLLAF SSACYFQNCP RGGKRAISDM ELRQCLPCGP
60 70 80 90 100
GGKGRCFGPS ICCADELGCF VGTAEALRCQ EENYLPSPCQ SGQKPCGSGG
110 120 130 140 150
RCAAVGICCS DESCVAEPEC HDGFFRLTRA REPSNATQLD GPARALLLRL
160
VQLAGTRESV DSAKPRVY
Length:168
Mass (Da):17,900
Last modified:June 1, 1994 - v1
Checksum:i234F6D826E0BBEE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88354 Genomic DNA. Translation: AAC42027.1.
BC051997 mRNA. Translation: AAH51997.1.
CCDSiCCDS16746.1.
PIRiB43755.
RefSeqiNP_033862.1. NM_009732.2.
UniGeneiMm.6190.

Genome annotation databases

EnsembliENSMUST00000046001; ENSMUSP00000035551; ENSMUSG00000037727.
GeneIDi11998.
KEGGimmu:11998.
UCSCiuc008mjh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88354 Genomic DNA. Translation: AAC42027.1.
BC051997 mRNA. Translation: AAH51997.1.
CCDSiCCDS16746.1.
PIRiB43755.
RefSeqiNP_033862.1. NM_009732.2.
UniGeneiMm.6190.

3D structure databases

ProteinModelPortaliP35455.
SMRiP35455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035551.

PTM databases

PhosphoSitePlusiP35455.

Proteomic databases

PaxDbiP35455.
PeptideAtlasiP35455.
PRIDEiP35455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046001; ENSMUSP00000035551; ENSMUSG00000037727.
GeneIDi11998.
KEGGimmu:11998.
UCSCiuc008mjh.1. mouse.

Organism-specific databases

CTDi551.
MGIiMGI:88121. Avp.

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP35455.
KOiK05242.
OMAiESCMTEP.
OrthoDBiEOG091G0V8Z.
PhylomeDBiP35455.
TreeFamiTF333018.

Enzyme and pathway databases

ReactomeiR-MMU-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-MMU-1368110. Bmal1:Clock,Npas2 activates circadian gene expression.
R-MMU-388479. Vasopressin-like receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-879518. Transport of organic anions.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiP35455.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037727.
CleanExiMM_AVP.
ExpressionAtlasiP35455. baseline and differential.
GenevisibleiP35455. MM.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEU2_MOUSE
AccessioniPrimary (citable) accession number: P35455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.