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Protein

Oxytocin-neurophysin 1

Gene

Oxt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

GO - Biological processi

  1. drinking behavior Source: Ensembl
  2. eating behavior Source: Ensembl
  3. female pregnancy Source: Ensembl
  4. grooming behavior Source: Ensembl
  5. heart development Source: Ensembl
  6. hyperosmotic salinity response Source: Ensembl
  7. male mating behavior Source: Ensembl
  8. maternal aggressive behavior Source: Ensembl
  9. maternal behavior Source: Ensembl
  10. memory Source: Ensembl
  11. negative regulation of blood pressure Source: Ensembl
  12. negative regulation of gastric acid secretion Source: Ensembl
  13. negative regulation of urine volume Source: Ensembl
  14. positive regulation of blood pressure Source: Ensembl
  15. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  16. positive regulation of female receptivity Source: Ensembl
  17. positive regulation of hindgut contraction Source: Ensembl
  18. positive regulation of norepinephrine secretion Source: Ensembl
  19. positive regulation of ossification Source: Ensembl
  20. positive regulation of penile erection Source: Ensembl
  21. positive regulation of prostaglandin secretion Source: Ensembl
  22. positive regulation of renal sodium excretion Source: Ensembl
  23. positive regulation of synapse assembly Source: Ensembl
  24. positive regulation of synaptic transmission Source: Ensembl
  25. positive regulation of uterine smooth muscle contraction Source: Ensembl
  26. regulation of heart rate Source: Ensembl
  27. regulation of sensory perception of pain Source: Ensembl
  28. response to activity Source: Ensembl
  29. response to amphetamine Source: Ensembl
  30. response to cAMP Source: Ensembl
  31. response to cocaine Source: Ensembl
  32. response to electrical stimulus Source: Ensembl
  33. response to estradiol Source: Ensembl
  34. response to ether Source: Ensembl
  35. response to external biotic stimulus Source: AgBase
  36. response to food Source: AgBase
  37. response to glucocorticoid Source: Ensembl
  38. response to mechanical stimulus Source: AgBase
  39. response to peptide hormone Source: Ensembl
  40. response to progesterone Source: Ensembl
  41. response to prostaglandin E Source: Ensembl
  42. response to retinoic acid Source: Ensembl
  43. response to sucrose Source: Ensembl
  44. sleep Source: Ensembl
  45. social behavior Source: Ensembl
  46. sperm ejaculation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_310308. Vasopressin-like receptors.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin-neurophysin 1
Short name:
OT-NPI
Cleaved into the following 2 chains:
Alternative name(s):
Ocytocin
Gene namesi
Name:Oxt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97453. Oxt.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular region Source: MGI
  3. extracellular space Source: AgBase
  4. secretory granule Source: Ensembl
  5. terminal bouton Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Peptidei20 – 289OxytocinPRO_0000020497
Chaini32 – 12594Neurophysin 1PRO_0000020498Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 25By similarity
Modified residuei28 – 281Glycine amideBy similarity
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP35454.
PRIDEiP35454.

Miscellaneous databases

PMAP-CutDBP35454.

Expressioni

Gene expression databases

BgeeiP35454.
CleanExiMM_OXT.
ExpressionAtlasiP35454. baseline and differential.
GenevestigatoriP35454.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105894.

Structurei

3D structure databases

ProteinModelPortaliP35454.
SMRiP35454. Positions 38-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44533.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP35454.
KOiK05243.
OMAiDGCRTDP.
OrthoDBiEOG7NW6C5.
PhylomeDBiP35454.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35454-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA
110 120
TGICCSPDGC RTDPACDPES AFSER
Length:125
Mass (Da):12,851
Last modified:May 31, 1994 - v1
Checksum:i96D3135EBBA2436E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88355 Genomic DNA. Translation: AAC42024.1.
AF483508 mRNA. Translation: AAL90782.1.
AF483509 mRNA. Translation: AAL90783.1.
CCDSiCCDS16745.1.
PIRiA43755.
RefSeqiNP_035155.1. NM_011025.4.
UniGeneiMm.16745.

Genome annotation databases

EnsembliENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301.
GeneIDi18429.
KEGGimmu:18429.
UCSCiuc008mjg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88355 Genomic DNA. Translation: AAC42024.1.
AF483508 mRNA. Translation: AAL90782.1.
AF483509 mRNA. Translation: AAL90783.1.
CCDSiCCDS16745.1.
PIRiA43755.
RefSeqiNP_035155.1. NM_011025.4.
UniGeneiMm.16745.

3D structure databases

ProteinModelPortaliP35454.
SMRiP35454. Positions 38-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105894.

Proteomic databases

PaxDbiP35454.
PRIDEiP35454.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301.
GeneIDi18429.
KEGGimmu:18429.
UCSCiuc008mjg.1. mouse.

Organism-specific databases

CTDi5020.
MGIiMGI:97453. Oxt.

Phylogenomic databases

eggNOGiNOG44533.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP35454.
KOiK05243.
OMAiDGCRTDP.
OrthoDBiEOG7NW6C5.
PhylomeDBiP35454.
TreeFamiTF333018.

Enzyme and pathway databases

ReactomeiREACT_310308. Vasopressin-like receptors.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi294090.
PMAP-CutDBP35454.
PROiP35454.
SOURCEiSearch...

Gene expression databases

BgeeiP35454.
CleanExiMM_OXT.
ExpressionAtlasiP35454. baseline and differential.
GenevestigatoriP35454.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of mouse vasopressin and oxytocin genes."
    Hara Y., Battey J., Gainer H.
    Brain Res. Mol. Brain Res. 8:319-324(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
    Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Mamm. Genome 12:657-663(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ILS and ISS.

Entry informationi

Entry nameiNEU1_MOUSE
AccessioniPrimary (citable) accession number: P35454
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 1994
Last sequence update: May 31, 1994
Last modified: March 31, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.