P35454 (NEU1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oxytocin-neurophysin 1
Short name=OT-NPI

Cleaved into the following 2 chains:

1. Oxytocin
   Alternative name(s):
   Ocytocin
2. Neurophysin 1

Gene names

Name:

Oxt

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
Sequence similarities	Belongs to the vasopressin/oxytocin family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	drinking behavior Inferred from electronic annotation. Source: Compara eating behavior Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara female pregnancy Inferred from electronic annotation. Source: Compara grooming behavior Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara hyperosmotic salinity response Inferred from electronic annotation. Source: Compara male mating behavior Inferred from electronic annotation. Source: Compara maternal aggressive behavior Inferred from electronic annotation. Source: Compara maternal behavior Inferred from electronic annotation. Source: Compara memory Inferred from electronic annotation. Source: Compara negative regulation of blood pressure Inferred from electronic annotation. Source: Compara negative regulation of gastric acid secretion Inferred from electronic annotation. Source: Compara negative regulation of urine volume Inferred from electronic annotation. Source: Compara positive regulation of blood pressure Inferred from electronic annotation. Source: Compara positive regulation of female receptivity Inferred from electronic annotation. Source: Compara positive regulation of hindgut contraction Inferred from electronic annotation. Source: Compara positive regulation of norepinephrine secretion Inferred from electronic annotation. Source: Compara positive regulation of ossification Inferred from electronic annotation. Source: Compara positive regulation of penile erection Inferred from electronic annotation. Source: Compara positive regulation of prostaglandin secretion Inferred from electronic annotation. Source: Compara positive regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara positive regulation of synapse assembly Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission Inferred from electronic annotation. Source: Compara positive regulation of uterine smooth muscle contraction Inferred from electronic annotation. Source: Compara regulation of heart rate Inferred from electronic annotation. Source: Compara regulation of sensory perception of pain Inferred from electronic annotation. Source: Compara response to activity Inferred from electronic annotation. Source: Compara response to amphetamine Inferred from electronic annotation. Source: Compara response to cAMP Inferred from electronic annotation. Source: Compara response to cocaine Inferred from electronic annotation. Source: Compara response to electrical stimulus Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to ether Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara response to progesterone stimulus Inferred from electronic annotation. Source: Compara response to prostaglandin E stimulus Inferred from electronic annotation. Source: Compara response to retinoic acid Inferred from electronic annotation. Source: Compara response to sucrose stimulus Inferred from electronic annotation. Source: Compara sleep Inferred from electronic annotation. Source: Compara social behavior Inferred from electronic annotation. Source: Compara sperm ejaculation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay PubMed 12383972. Source: MGI extracellular region Inferred from direct assay PubMed 12907752. Source: MGI extracellular space Inferred from electronic annotation. Source: Compara secretory granule Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Peptide	20 – 28	9	Oxytocin		PRO_0000020497
	Chain	32 – 125	94	Neurophysin 1		PRO_0000020498
Amino acid modifications
	Modified residue	28	1	Glycine amide By similarity
	Disulfide bond	20 ↔ 25		By similarity
	Disulfide bond	41 ↔ 85		By similarity
	Disulfide bond	44 ↔ 58		By similarity
	Disulfide bond	52 ↔ 75		By similarity
	Disulfide bond	59 ↔ 65		By similarity
	Disulfide bond	92 ↔ 104		By similarity
	Disulfide bond	98 ↔ 116		By similarity
	Disulfide bond	105 ↔ 110		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35454 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 96D3135EBBA2436E	FASTA	125	12,851
	10 20 30 40 50 60 MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG RCFGPSICCA 70 80 90 100 110 120 DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA TGICCSPDGC RTDPACDPES AFSER

References

[1]	"Structure of mouse vasopressin and oxytocin genes." Hara Y., Battey J., Gainer H. Brain Res. Mol. Brain Res. 8:319-324(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"High-throughput sequence identification of gene coding variants within alcohol-related QTLs." Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M. Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ILS and ISS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M88355 Genomic DNA. Translation: AAC42024.1. AF483508 mRNA. Translation: AAL90782.1. AF483509 mRNA. Translation: AAL90783.1.
IPI	IPI00118469.
PIR	A43755.
RefSeq	NP_035155.1. NM_011025.3.
UniGene	Mm.16745.
3D structure databases
ProteinModelPortal	P35454.
SMR	P35454. Positions 38-118.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000105894.
Proteomic databases
PaxDb	P35454.
PRIDE	P35454.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301.
GeneID	18429.
KEGG	mmu:18429.
UCSC	uc008mjg.1. mouse.
Organism-specific databases
CTD	5020.
MGI	MGI:97453. Oxt.
Phylogenomic databases
eggNOG	NOG44533.
HOGENOM	HOG000113768.
HOVERGEN	HBG004462.
KO	K05243.
OMA	DGCRTDP.
OrthoDB	EOG451DS6.
Gene expression databases
ArrayExpress	P35454.
Bgee	P35454.
CleanEx	MM_OXT.
Genevestigator	P35454.
GermOnline	ENSMUSG00000027301. Mus musculus.
Family and domain databases
Gene3D	2.60.9.10. 1 hit.
InterPro	IPR000981. Neurhyp_horm. IPR022423. Neurohypophysial_hormone_CS. [Graphical view]
PANTHER	PTHR11681. PTHR11681. 1 hit.
Pfam	PF00220. Hormone_4. 1 hit. PF00184. Hormone_5. 1 hit. [Graphical view]
PIRSF	PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTS	PR00831. NEUROPHYSIN.
ProDom	PD001676. Neurhyp_horm. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00003. NH. 1 hit. [Graphical view]
SUPFAM	SSF49606. Neurhyp_horm. 1 hit.
PROSITE	PS00264. NEUROHYPOPHYS_HORM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	294090.
PMAP-CutDB	P35454.
SOURCE	Search...

Entry information

Entry name

NEU1_MOUSE

Accession

Primary (citable) accession number: P35454

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 29, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program