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P35454

- NEU1_MOUSE

UniProt

P35454 - NEU1_MOUSE

Protein

Oxytocin-neurophysin 1

Gene

Oxt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Neurophysin 1 specifically binds oxytocin.
    Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

    GO - Biological processi

    1. drinking behavior Source: Ensembl
    2. eating behavior Source: Ensembl
    3. female pregnancy Source: Ensembl
    4. grooming behavior Source: Ensembl
    5. heart development Source: Ensembl
    6. hyperosmotic salinity response Source: Ensembl
    7. male mating behavior Source: Ensembl
    8. maternal aggressive behavior Source: Ensembl
    9. maternal behavior Source: Ensembl
    10. memory Source: Ensembl
    11. negative regulation of blood pressure Source: Ensembl
    12. negative regulation of gastric acid secretion Source: Ensembl
    13. negative regulation of urine volume Source: Ensembl
    14. positive regulation of blood pressure Source: Ensembl
    15. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    16. positive regulation of female receptivity Source: Ensembl
    17. positive regulation of hindgut contraction Source: Ensembl
    18. positive regulation of norepinephrine secretion Source: Ensembl
    19. positive regulation of ossification Source: Ensembl
    20. positive regulation of penile erection Source: Ensembl
    21. positive regulation of prostaglandin secretion Source: Ensembl
    22. positive regulation of renal sodium excretion Source: Ensembl
    23. positive regulation of synapse assembly Source: Ensembl
    24. positive regulation of synaptic transmission Source: Ensembl
    25. positive regulation of uterine smooth muscle contraction Source: Ensembl
    26. regulation of heart rate Source: Ensembl
    27. regulation of sensory perception of pain Source: Ensembl
    28. response to activity Source: Ensembl
    29. response to amphetamine Source: Ensembl
    30. response to cAMP Source: Ensembl
    31. response to cocaine Source: Ensembl
    32. response to electrical stimulus Source: Ensembl
    33. response to estradiol Source: Ensembl
    34. response to ether Source: Ensembl
    35. response to food Source: Ensembl
    36. response to glucocorticoid Source: Ensembl
    37. response to peptide hormone Source: Ensembl
    38. response to progesterone Source: Ensembl
    39. response to prostaglandin E Source: Ensembl
    40. response to retinoic acid Source: Ensembl
    41. response to sucrose Source: Ensembl
    42. sleep Source: Ensembl
    43. social behavior Source: Ensembl
    44. sperm ejaculation Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxytocin-neurophysin 1
    Short name:
    OT-NPI
    Cleaved into the following 2 chains:
    Alternative name(s):
    Ocytocin
    Gene namesi
    Name:Oxt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:97453. Oxt.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular region Source: MGI
    3. extracellular space Source: Ensembl
    4. secretory granule Source: Ensembl
    5. terminal bouton Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Peptidei20 – 289OxytocinPRO_0000020497
    Chaini32 – 12594Neurophysin 1PRO_0000020498Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi20 ↔ 25By similarity
    Modified residuei28 – 281Glycine amideBy similarity
    Disulfide bondi41 ↔ 85By similarity
    Disulfide bondi44 ↔ 58By similarity
    Disulfide bondi52 ↔ 75By similarity
    Disulfide bondi59 ↔ 65By similarity
    Disulfide bondi92 ↔ 104By similarity
    Disulfide bondi98 ↔ 116By similarity
    Disulfide bondi105 ↔ 110By similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiP35454.
    PRIDEiP35454.

    Miscellaneous databases

    PMAP-CutDBP35454.

    Expressioni

    Gene expression databases

    ArrayExpressiP35454.
    BgeeiP35454.
    CleanExiMM_OXT.
    GenevestigatoriP35454.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000105894.

    Structurei

    3D structure databases

    ProteinModelPortaliP35454.
    SMRiP35454. Positions 38-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vasopressin/oxytocin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44533.
    HOGENOMiHOG000113768.
    HOVERGENiHBG004462.
    KOiK05243.
    OMAiIKEDINC.
    OrthoDBiEOG7NW6C5.
    PhylomeDBiP35454.
    TreeFamiTF333018.

    Family and domain databases

    Gene3Di2.60.9.10. 1 hit.
    InterProiIPR000981. Neurhyp_horm.
    IPR022423. Neurohypophysial_hormone_CS.
    [Graphical view]
    PANTHERiPTHR11681. PTHR11681. 1 hit.
    PfamiPF00220. Hormone_4. 1 hit.
    PF00184. Hormone_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
    PRINTSiPR00831. NEUROPHYSIN.
    ProDomiPD001676. Neurhyp_horm. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00003. NH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49606. SSF49606. 1 hit.
    PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35454-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG    50
    RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA 100
    TGICCSPDGC RTDPACDPES AFSER 125
    Length:125
    Mass (Da):12,851
    Last modified:June 1, 1994 - v1
    Checksum:i96D3135EBBA2436E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88355 Genomic DNA. Translation: AAC42024.1.
    AF483508 mRNA. Translation: AAL90782.1.
    AF483509 mRNA. Translation: AAL90783.1.
    CCDSiCCDS16745.1.
    PIRiA43755.
    RefSeqiNP_035155.1. NM_011025.4.
    UniGeneiMm.16745.

    Genome annotation databases

    EnsembliENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301.
    GeneIDi18429.
    KEGGimmu:18429.
    UCSCiuc008mjg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88355 Genomic DNA. Translation: AAC42024.1 .
    AF483508 mRNA. Translation: AAL90782.1 .
    AF483509 mRNA. Translation: AAL90783.1 .
    CCDSi CCDS16745.1.
    PIRi A43755.
    RefSeqi NP_035155.1. NM_011025.4.
    UniGenei Mm.16745.

    3D structure databases

    ProteinModelPortali P35454.
    SMRi P35454. Positions 38-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000105894.

    Proteomic databases

    PaxDbi P35454.
    PRIDEi P35454.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028764 ; ENSMUSP00000028764 ; ENSMUSG00000027301 .
    GeneIDi 18429.
    KEGGi mmu:18429.
    UCSCi uc008mjg.1. mouse.

    Organism-specific databases

    CTDi 5020.
    MGIi MGI:97453. Oxt.

    Phylogenomic databases

    eggNOGi NOG44533.
    HOGENOMi HOG000113768.
    HOVERGENi HBG004462.
    KOi K05243.
    OMAi IKEDINC.
    OrthoDBi EOG7NW6C5.
    PhylomeDBi P35454.
    TreeFami TF333018.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 294090.
    PMAP-CutDB P35454.
    PROi P35454.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35454.
    Bgeei P35454.
    CleanExi MM_OXT.
    Genevestigatori P35454.

    Family and domain databases

    Gene3Di 2.60.9.10. 1 hit.
    InterProi IPR000981. Neurhyp_horm.
    IPR022423. Neurohypophysial_hormone_CS.
    [Graphical view ]
    PANTHERi PTHR11681. PTHR11681. 1 hit.
    Pfami PF00220. Hormone_4. 1 hit.
    PF00184. Hormone_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
    PRINTSi PR00831. NEUROPHYSIN.
    ProDomi PD001676. Neurhyp_horm. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00003. NH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49606. SSF49606. 1 hit.
    PROSITEi PS00264. NEUROHYPOPHYS_HORM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of mouse vasopressin and oxytocin genes."
      Hara Y., Battey J., Gainer H.
      Brain Res. Mol. Brain Res. 8:319-324(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
      Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
      Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ILS and ISS.

    Entry informationi

    Entry nameiNEU1_MOUSE
    AccessioniPrimary (citable) accession number: P35454
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3