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P35454 (NEU1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxytocin-neurophysin 1

Short name=OT-NPI

Cleaved into the following 2 chains:

  1. Oxytocin
    Alternative name(s):
    Ocytocin
  2. Neurophysin 1
Gene names
Name:Oxt
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Neurophysin 1 specifically binds oxytocin.

Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

Sequence similarities

Belongs to the vasopressin/oxytocin family.

Ontologies

Keywords
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdrinking behavior

Inferred from electronic annotation. Source: Ensembl

eating behavior

Inferred from electronic annotation. Source: Ensembl

female pregnancy

Inferred from electronic annotation. Source: Ensembl

grooming behavior

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from electronic annotation. Source: Ensembl

hyperosmotic salinity response

Inferred from electronic annotation. Source: Ensembl

male mating behavior

Inferred from electronic annotation. Source: Ensembl

maternal aggressive behavior

Inferred from electronic annotation. Source: Ensembl

maternal behavior

Inferred from electronic annotation. Source: Ensembl

memory

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of gastric acid secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of urine volume

Inferred from electronic annotation. Source: Ensembl

positive regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of female receptivity

Inferred from electronic annotation. Source: Ensembl

positive regulation of hindgut contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of norepinephrine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of ossification

Inferred from electronic annotation. Source: Ensembl

positive regulation of penile erection

Inferred from electronic annotation. Source: Ensembl

positive regulation of prostaglandin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of synapse assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission

Inferred from electronic annotation. Source: Ensembl

positive regulation of uterine smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

response to activity

Inferred from electronic annotation. Source: Ensembl

response to amphetamine

Inferred from electronic annotation. Source: Ensembl

response to cAMP

Inferred from electronic annotation. Source: Ensembl

response to cocaine

Inferred from electronic annotation. Source: Ensembl

response to electrical stimulus

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to ether

Inferred from electronic annotation. Source: Ensembl

response to food

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

response to progesterone

Inferred from electronic annotation. Source: Ensembl

response to prostaglandin E

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

response to sucrose

Inferred from electronic annotation. Source: Ensembl

sleep

Inferred from electronic annotation. Source: Ensembl

social behavior

Inferred from electronic annotation. Source: Ensembl

sperm ejaculation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 12383972. Source: MGI

extracellular region

Inferred from direct assay PubMed 12907752. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

secretory granule

Inferred from electronic annotation. Source: Ensembl

terminal bouton

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Peptide20 – 289Oxytocin
PRO_0000020497
Chain32 – 12594Neurophysin 1
PRO_0000020498

Amino acid modifications

Modified residue281Glycine amide By similarity
Disulfide bond20 ↔ 25 By similarity
Disulfide bond41 ↔ 85 By similarity
Disulfide bond44 ↔ 58 By similarity
Disulfide bond52 ↔ 75 By similarity
Disulfide bond59 ↔ 65 By similarity
Disulfide bond92 ↔ 104 By similarity
Disulfide bond98 ↔ 116 By similarity
Disulfide bond105 ↔ 110 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35454 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 96D3135EBBA2436E

FASTA12512,851
        10         20         30         40         50         60 
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG RCFGPSICCA 

        70         80         90        100        110        120 
DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA TGICCSPDGC RTDPACDPES 


AFSER 

« Hide

References

[1]"Structure of mouse vasopressin and oxytocin genes."
Hara Y., Battey J., Gainer H.
Brain Res. Mol. Brain Res. 8:319-324(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ILS and ISS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M88355 Genomic DNA. Translation: AAC42024.1.
AF483508 mRNA. Translation: AAL90782.1.
AF483509 mRNA. Translation: AAL90783.1.
CCDSCCDS16745.1.
PIRA43755.
RefSeqNP_035155.1. NM_011025.4.
UniGeneMm.16745.

3D structure databases

ProteinModelPortalP35454.
SMRP35454. Positions 38-118.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000105894.

Proteomic databases

PaxDbP35454.
PRIDEP35454.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301.
GeneID18429.
KEGGmmu:18429.
UCSCuc008mjg.1. mouse.

Organism-specific databases

CTD5020.
MGIMGI:97453. Oxt.

Phylogenomic databases

eggNOGNOG44533.
HOGENOMHOG000113768.
HOVERGENHBG004462.
KOK05243.
OMAIKEDINC.
OrthoDBEOG7NW6C5.
PhylomeDBP35454.
TreeFamTF333018.

Gene expression databases

ArrayExpressP35454.
BgeeP35454.
CleanExMM_OXT.
GenevestigatorP35454.

Family and domain databases

Gene3D2.60.9.10. 1 hit.
InterProIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERPTHR11681. PTHR11681. 1 hit.
PfamPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSPR00831. NEUROPHYSIN.
ProDomPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00003. NH. 1 hit.
[Graphical view]
SUPFAMSSF49606. SSF49606. 1 hit.
PROSITEPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294090.
PMAP-CutDBP35454.
PROP35454.
SOURCESearch...

Entry information

Entry nameNEU1_MOUSE
AccessionPrimary (citable) accession number: P35454
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot