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P35454 (NEU1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oxytocin-neurophysin 1
Short name=OT-NPI

Cleaved into the following 2 chains:

  1. Oxytocin
    Alternative name(s):
    Ocytocin
  2. Neurophysin 1
Gene names
Name:Oxt
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Neurophysin 1 specifically binds oxytocin.

Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

Sequence similarities

Belongs to the vasopressin/oxytocin family.

Ontologies

Keywords
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionneurohypophyseal hormone activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Peptide20 – 289Oxytocin
PRO_0000020497
Chain32 – 12594Neurophysin 1
PRO_0000020498

Amino acid modifications

Modified residue281Glycine amide By similarity
Disulfide bond20 ↔ 25 By similarity
Disulfide bond41 ↔ 85 By similarity
Disulfide bond44 ↔ 58 By similarity
Disulfide bond52 ↔ 75 By similarity
Disulfide bond59 ↔ 65 By similarity
Disulfide bond92 ↔ 104 By similarity
Disulfide bond98 ↔ 116 By similarity
Disulfide bond105 ↔ 110 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35454 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 96D3135EBBA2436E

FASTA12512,851
        10         20         30         40         50         60 
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG RCFGPSICCA 

        70         80         90        100        110        120 
DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA TGICCSPDGC RTDPACDPES 


AFSER

« Hide

References

[1]"Structure of mouse vasopressin and oxytocin genes."
Hara Y., Battey J., Gainer H.
Brain Res. Mol. Brain Res. 8:319-324(1990) [PubMed: 2176709] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
Mamm. Genome 12:657-663(2001) [PubMed: 11471062] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ILS and ISS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M88355 Genomic DNA. Translation: AAC42024.1.
AF483508 mRNA. Translation: AAL90782.1.
AF483509 mRNA. Translation: AAL90783.1.
IPIIPI00118469.
PIRA43755.
RefSeqNP_035155.1. NM_011025.3.
UniGeneMm.16745.

3D structure databases

ProteinModelPortalP35454.
SMRP35454. Positions 38-118.
ModBaseSearch...

Protein-protein interaction databases

STRINGP35454.

Proteomic databases

PRIDEP35454.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301.
GeneID18429.
KEGGmmu:18429.

Organism-specific databases

CTD5020.
MGIMGI:97453. Oxt.

Phylogenomic databases

eggNOGroNOG16235.
HOVERGENHBG004462.
OrthoDBEOG451DS6.

Gene expression databases

ArrayExpressP35454.
BgeeP35454.
CleanExMM_OXT.
GenevestigatorP35454.
GermOnlineENSMUSG00000027301. Mus musculus.

Family and domain databases

InterProIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
Gene3DG3DSA:2.60.9.10. Neurhyp_horm. 1 hit.
KOK05243.
PANTHERPTHR11681. PTHR11681. 1 hit.
PfamPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSPR00831. NEUROPHYSIN.
ProDomPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00003. NH. 1 hit.
[Graphical view]
SUPFAMSSF49606. Neurhyp_horm. 1 hit.
PROSITEPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294090.
PMAP-CutDBP35454.
SOURCESearch...

Entry information

Entry nameNEU1_MOUSE
AccessionPrimary (citable) accession number: P35454
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 16, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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