Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35452

- HXD12_HUMAN

UniProt

P35452 - HXD12_HUMAN

Protein

Homeobox protein Hox-D12

Gene

HOXD12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (22 Sep 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi202 – 26160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. embryonic digit morphogenesis Source: Ensembl
    2. pattern specification process Source: Ensembl
    3. skeletal system development Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D12
    Alternative name(s):
    Homeobox protein Hox-4H
    Gene namesi
    Name:HOXD12
    Synonyms:HOX4H
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5135. HOXD12.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29409.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Homeobox protein Hox-D12PRO_0000200238Add
    BLAST

    Proteomic databases

    PaxDbiP35452.
    PRIDEiP35452.

    PTM databases

    PhosphoSiteiP35452.

    Expressioni

    Gene expression databases

    ArrayExpressiP35452.
    CleanExiHS_HOXD12.
    GenevestigatoriP35452.

    Interactioni

    Protein-protein interaction databases

    BioGridi109478. 6 interactions.
    STRINGi9606.ENSP00000385586.

    Structurei

    3D structure databases

    ProteinModelPortaliP35452.
    SMRiP35452. Positions 203-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241833.
    HOGENOMiHOG000231177.
    HOVERGENiHBG052050.
    InParanoidiP35452.
    KOiK09297.
    OMAiQAKFYAP.
    OrthoDBiEOG73FQNH.
    PhylomeDBiP35452.
    TreeFamiTF351604.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35452-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCERSLYRAG YVGSLLNLQS PDSFYFSNLR PNGGQLAALP PISYPRGALP    50
    WAATPASCAP AQPAGATAFG GFSQPYLAGS GPLGLQPPTA KDGPEEQAKF 100
    YAPEAAAGPE ERGRTRPSFA PESSLAPAVA ALKAAKYDYA GVGRATPGST 150
    TLLQGAPCAP GFKDDTKGPL NLNMTVQAAG VASCLRPSLP DGLPWGAAPG 200
    RARKKRKPYT KQQIAELENE FLVNEFINRQ KRKELSNRLN LSDQQVKIWF 250
    QNRRMKKKRV VLREQALALY 270
    Length:270
    Mass (Da):29,031
    Last modified:September 22, 2009 - v3
    Checksum:i224D53783405A162
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 4715GGQLA…SYPRG → AASLAFPLSPTRA in AAF79044. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti62 – 643QPA → TC in AAF79044. 1 PublicationCurated
    Sequence conflicti81 – 844GPLG → ASR in AAF79044. 1 PublicationCurated
    Sequence conflicti193 – 2019LPWGAAPGR → KRCPCSPGRPAVGGGPGE in AAF79044. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154915 Genomic DNA. Translation: AAF79044.1.
    AC009336 Genomic DNA. No translation available.
    CH471058 Genomic DNA. Translation: EAX11094.1.
    CCDSiCCDS46456.1.
    PIRiC39065.
    RefSeqiNP_067016.3. NM_021193.3.
    UniGeneiHs.450028.

    Genome annotation databases

    EnsembliENST00000406506; ENSP00000385586; ENSG00000170178.
    GeneIDi3238.
    KEGGihsa:3238.
    UCSCiuc010zev.1. human.

    Polymorphism databases

    DMDMi259016345.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154915 Genomic DNA. Translation: AAF79044.1 .
    AC009336 Genomic DNA. No translation available.
    CH471058 Genomic DNA. Translation: EAX11094.1 .
    CCDSi CCDS46456.1.
    PIRi C39065.
    RefSeqi NP_067016.3. NM_021193.3.
    UniGenei Hs.450028.

    3D structure databases

    ProteinModelPortali P35452.
    SMRi P35452. Positions 203-260.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109478. 6 interactions.
    STRINGi 9606.ENSP00000385586.

    PTM databases

    PhosphoSitei P35452.

    Polymorphism databases

    DMDMi 259016345.

    Proteomic databases

    PaxDbi P35452.
    PRIDEi P35452.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000406506 ; ENSP00000385586 ; ENSG00000170178 .
    GeneIDi 3238.
    KEGGi hsa:3238.
    UCSCi uc010zev.1. human.

    Organism-specific databases

    CTDi 3238.
    GeneCardsi GC02P176930.
    H-InvDB HIX0029976.
    HGNCi HGNC:5135. HOXD12.
    MIMi 142988. gene.
    neXtProti NX_P35452.
    PharmGKBi PA29409.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241833.
    HOGENOMi HOG000231177.
    HOVERGENi HBG052050.
    InParanoidi P35452.
    KOi K09297.
    OMAi QAKFYAP.
    OrthoDBi EOG73FQNH.
    PhylomeDBi P35452.
    TreeFami TF351604.

    Miscellaneous databases

    GeneWikii HOXD12.
    GenomeRNAii 3238.
    NextBioi 12887.
    PROi P35452.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35452.
    CleanExi HS_HOXD12.
    Genevestigatori P35452.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The role of HOXD11 and HOXD12 for the mesomelic dysplasia Kantaptra type."
      Miwa N., Yoshiura K., Kantaputra P.K., Soeda E., Niikawa N.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2."
      D'Esposito M., Morelli F., Acampora D., Migliaccio E., Simeone A., Boncinelli E.
      Genomics 10:43-50(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-267.

    Entry informationi

    Entry nameiHXD12_HUMAN
    AccessioniPrimary (citable) accession number: P35452
    Secondary accession number(s): B5MCP0, Q9NS03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3