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P35452 (HXD12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D12
Alternative name(s):
Homeobox protein Hox-4H
Gene names
Name:HOXD12
Synonyms:HOX4H
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Homeobox protein Hox-D12
PRO_0000200238

Regions

DNA binding202 – 26160Homeobox

Experimental info

Sequence conflict33 – 4715GGQLA…SYPRG → AASLAFPLSPTRA in AAF79044. Ref.1
Sequence conflict62 – 643QPA → TC in AAF79044. Ref.1
Sequence conflict81 – 844GPLG → ASR in AAF79044. Ref.1
Sequence conflict193 – 2019LPWGAAPGR → KRCPCSPGRPAVGGGPGE in AAF79044. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P35452 [UniParc].

Last modified September 22, 2009. Version 3.
Checksum: 224D53783405A162

FASTA27029,031
        10         20         30         40         50         60 
MCERSLYRAG YVGSLLNLQS PDSFYFSNLR PNGGQLAALP PISYPRGALP WAATPASCAP 

        70         80         90        100        110        120 
AQPAGATAFG GFSQPYLAGS GPLGLQPPTA KDGPEEQAKF YAPEAAAGPE ERGRTRPSFA 

       130        140        150        160        170        180 
PESSLAPAVA ALKAAKYDYA GVGRATPGST TLLQGAPCAP GFKDDTKGPL NLNMTVQAAG 

       190        200        210        220        230        240 
VASCLRPSLP DGLPWGAAPG RARKKRKPYT KQQIAELENE FLVNEFINRQ KRKELSNRLN 

       250        260        270 
LSDQQVKIWF QNRRMKKKRV VLREQALALY 

« Hide

References

« Hide 'large scale' references
[1]"The role of HOXD11 and HOXD12 for the mesomelic dysplasia Kantaptra type."
Miwa N., Yoshiura K., Kantaputra P.K., Soeda E., Niikawa N.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2."
D'Esposito M., Morelli F., Acampora D., Migliaccio E., Simeone A., Boncinelli E.
Genomics 10:43-50(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-267.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF154915 Genomic DNA. Translation: AAF79044.1.
AC009336 Genomic DNA. No translation available.
CH471058 Genomic DNA. Translation: EAX11094.1.
PIRC39065.
RefSeqNP_067016.3. NM_021193.3.
UniGeneHs.450028.

3D structure databases

ProteinModelPortalP35452.
SMRP35452. Positions 203-260.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109478. 6 interactions.
STRING9606.ENSP00000385586.

PTM databases

PhosphoSiteP35452.

Polymorphism databases

DMDM259016345.

Proteomic databases

PaxDbP35452.
PRIDEP35452.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000406506; ENSP00000385586; ENSG00000170178.
GeneID3238.
KEGGhsa:3238.
UCSCuc010zev.1. human.

Organism-specific databases

CTD3238.
GeneCardsGC02P176930.
H-InvDBHIX0029976.
HGNCHGNC:5135. HOXD12.
MIM142988. gene.
neXtProtNX_P35452.
PharmGKBPA29409.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241833.
HOGENOMHOG000231177.
HOVERGENHBG052050.
InParanoidP35452.
KOK09297.
OMALQGAPCA.
OrthoDBEOG73FQNH.
PhylomeDBP35452.
TreeFamTF351604.

Gene expression databases

ArrayExpressP35452.
CleanExHS_HOXD12.
GenevestigatorP35452.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXD12.
GenomeRNAi3238.
NextBio12887.
PROP35452.
SOURCESearch...

Entry information

Entry nameHXD12_HUMAN
AccessionPrimary (citable) accession number: P35452
Secondary accession number(s): B5MCP0, Q9NS03
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 22, 2009
Last modified: April 16, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries