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P35448

- TSP1_XENLA

UniProt

P35448 - TSP1_XENLA

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Protein

Thrombospondin-1

Gene
thbs1, tsp1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3 By similarity. May play a role in ER stress response By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. extracellular matrix binding Source: InterPro
  3. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. inflammatory response Source: InterPro
  3. negative regulation of angiogenesis Source: InterPro
  4. response to unfolded protein Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Unfolded protein response

Keywords - Ligandi

Calcium, Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-1
Gene namesi
Name:thbs1
Synonyms:tsp1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865586. thbs1.

Subcellular locationi

Endoplasmic reticulum By similarity. Sarcoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. extracellular space Source: InterPro
  3. sarcoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 11731155Thrombospondin-1PRO_0000035844Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi174 ↔ 235 By similarity
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi363 – 3631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi394 ↔ 426 By similarity
Disulfide bondi398 ↔ 431 By similarity
Disulfide bondi409 ↔ 416 By similarity
Disulfide bondi450 ↔ 487 By similarity
Disulfide bondi454 ↔ 492 By similarity
Disulfide bondi465 ↔ 477 By similarity
Disulfide bondi507 ↔ 544 By similarity
Disulfide bondi511 ↔ 549 By similarity
Disulfide bondi522 ↔ 534 By similarity
Disulfide bondi554 ↔ 565 By similarity
Disulfide bondi559 ↔ 575 By similarity
Disulfide bondi578 ↔ 589 By similarity
Disulfide bondi595 ↔ 611 By similarity
Disulfide bondi602 ↔ 620 By similarity
Disulfide bondi623 ↔ 647 By similarity
Disulfide bondi653 ↔ 666 By similarity
Disulfide bondi660 ↔ 679 By similarity
Disulfide bondi681 ↔ 692 By similarity
Glycosylationi705 – 7051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi708 ↔ 716 By similarity
Glycosylationi711 – 7111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi721 ↔ 741 By similarity
Disulfide bondi757 ↔ 777 By similarity
Disulfide bondi780 ↔ 800 By similarity
Disulfide bondi816 ↔ 836 By similarity
Disulfide bondi839 ↔ 859 By similarity
Disulfide bondi877 ↔ 897 By similarity
Disulfide bondi913 ↔ 933 By similarity
Disulfide bondi949 ↔ 1170 By similarity
Glycosylationi1070 – 10701N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotrimer; disulfide-linked.

Structurei

3D structure databases

ProteinModelPortaliP35448.
SMRiP35448. Positions 25-235, 552-1172.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 224203Laminin G-likeAdd
BLAST
Domaini319 – 37658VWFCAdd
BLAST
Domaini382 – 43251TSP type-1 1Add
BLAST
Domaini438 – 49356TSP type-1 2Add
BLAST
Domaini495 – 55056TSP type-1 3Add
BLAST
Domaini550 – 59041EGF-like 1Add
BLAST
Domaini649 – 69345EGF-like 2Add
BLAST
Repeati694 – 72936TSP type-3 1Add
BLAST
Repeati730 – 76536TSP type-3 2Add
BLAST
Repeati766 – 78823TSP type-3 3Add
BLAST
Repeati789 – 82436TSP type-3 4Add
BLAST
Repeati825 – 84723TSP type-3 5Add
BLAST
Repeati848 – 88538TSP type-3 6Add
BLAST
Repeati886 – 92136TSP type-3 7Add
BLAST
Repeati922 – 95736TSP type-3 8Add
BLAST
Domaini961 – 1173213TSP C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 9849Heparin-binding By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi929 – 9313Cell attachment site Reviewed prediction

Sequence similaritiesi

Belongs to the thrombospondin family.
Contains 2 EGF-like domains.
Contains 3 TSP type-1 domains.
Contains 8 TSP type-3 repeats.
Contains 1 VWFC domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG018006.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProiIPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR001791. Laminin_G.
IPR028499. Thrombospondin-1.
IPR000884. Thrombospondin_1_rpt.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_C.
[Graphical view]
PANTHERiPTHR10199:SF78. PTHR10199:SF78. 1 hit.
PfamiPF12662. cEGF. 1 hit.
PF12947. EGF_3. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35448-1 [UniParc]FASTAAdd to Basket

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MKGIFLLLML VMPQTHQAAE SGNDDNSVFD LFELTGYNRK AGSRKPQGLH     50
LVKGPDPSSP AYRIEDADLI PPLPEDKFQD LLDAIRADRG FILLATLRQA 100
KKSRGALLSV ERKDGGGHIF SLISNGRART LDLSLSGERK QQVVSVEDAV 150
LATGNWTNIT LFVQEDRAQL YVGCNKMENA ELDVPIQKIF TENLASTAHL 200
RVAKGGVKDN FQGVLQNVRF VFGTTLEAIL RNKGCLSMTN SVITLDNPVN 250
GSSPAIRTNY IGHKTKDLQA VCGFSCDDLS KLFAEMKGLR TLVTTLKDQV 300
TKETEKNELI AQIVTRTPGV CLHNGVLHKN RDEWTVDSCT ECTCQNSATI 350
CRKVSCPLMP CTNATIPDGE CCPRCWPSDS ADDDWSPWSD WTPCSVTCGH 400
GIQQRGRSCD SLNNPCEGSS VQTRSCQIQD CDKRFKQDGG WSHWSPWSSC 450
SVTCGSGQIT RIRLCNSPVP QLNGKQCEGE GRENKPCQKD PCPINGQWGP 500
WSLWDTCTVT CGGGMQKRER LCNNPKPQYE GKDCIGEPTD SQICNKQDCP 550
IDGCLSNPCF AGVKCTSFID GSWKCGSCPP GYRGNGITCK DIDECKEVPD 600
ACFTLNGVHR CENTEPGYNC LPCPPRFTGT QPFGKGIEEA KANKQVCKPR 650
NPCADGTHDC HKNARCIYLG HYSDPMFRCE CRPGYAGNGI ICGEDTDLDG 700
WPNENLTCVD NATYHCLKDN CPNLPNSGQE DYDKDGMGDA CDKDDDNDGI 750
LDDRDNCQFV YNPAQYDYDR DDVGDRCDNC PYNHNPDQAD TDRNGEGDAC 800
SVDIDGDGIL NERDNCAYVY NVDQKDTDKD GVGDQCDNCP LEHNPEQTDS 850
DSDLIGDKCD NNQDIDEDGH QNNLDNCPYI PNANQADHDK DGKGDACDHD 900
DDNDGVPDDK DNCRLVPNPD QTDTNGDGRG DACQYDFDDD SIPDAEDVCP 950
ENVEISTTDF RKFQMVPLDP KGTSQIDPNW VVRHQGKELV QTVNCDPGIA 1000
VGFDEFSAVD FSGTFFINTE RDDDYAGFVF GYQSSSRFYV VMWKQITQTY 1050
WDTTPTVAQG YSGLSIKVVN STSGPGEHLR NALWHTGNTP GQVRTLWHDP 1100
HQKGWKDFTA YRWHLTHRPK TGFIRVVMYE GKRVMADSGP IYDKTYAGGR 1150
LGLFVFSQEM VFFSDLKYEC RDS 1173
Length:1,173
Mass (Da):130,020
Last modified:June 1, 1994 - v1
Checksum:iA9F036D6516C0F24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04278 mRNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04278 mRNA. No translation available.

3D structure databases

ProteinModelPortali P35448.
SMRi P35448. Positions 25-235, 552-1172.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-865586. thbs1.

Phylogenomic databases

HOVERGENi HBG018006.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProi IPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR001791. Laminin_G.
IPR028499. Thrombospondin-1.
IPR000884. Thrombospondin_1_rpt.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_C.
[Graphical view ]
PANTHERi PTHR10199:SF78. PTHR10199:SF78. 1 hit.
Pfami PF12662. cEGF. 1 hit.
PF12947. EGF_3. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEi PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, characterization and expression of thrombospondin-1 in Xenopus laevis embryos."
    Urry L.A., Ramos J., Duquette M., Desimone D.W., Lawler J.
    Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTSP1_XENLA
AccessioniPrimary (citable) accession number: P35448
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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