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P35443

- TSP4_HUMAN

UniProt

P35443 - TSP4_HUMAN

Protein

Thrombospondin-4

Gene

THBS4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. heparin binding Source: UniProtKB
    3. integrin binding Source: UniProtKB
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. behavioral response to pain Source: UniProtKB
    2. endothelial cell-cell adhesion Source: UniProtKB
    3. myoblast migration Source: UniProtKB
    4. negative regulation of angiogenesis Source: UniProtKB
    5. positive regulation of cell division Source: UniProtKB-KW
    6. positive regulation of endothelial cell proliferation Source: UniProtKB
    7. positive regulation of neutrophil chemotaxis Source: UniProtKB
    8. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    9. regulation of tissue remodeling Source: UniProtKB
    10. response to endoplasmic reticulum stress Source: UniProtKB
    11. response to unfolded protein Source: UniProtKB-KW
    12. tissue remodeling Source: UniProtKB-KW

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Keywords - Biological processi

    Cell adhesion, Tissue remodeling, Unfolded protein response

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_16888. Signaling by PDGF.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thrombospondin-4
    Gene namesi
    Name:THBS4
    Synonyms:TSP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:11788. THBS4.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: UniProtKB
    2. endoplasmic reticulum Source: UniProtKB
    3. extracellular matrix Source: UniProtKB
    4. extracellular region Source: Reactome
    5. extracellular space Source: UniProtKB
    6. sarcoplasmic reticulum Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36500.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 961935Thrombospondin-4PRO_0000035852Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi258 – 258InterchainCurated
    Disulfide bondi261 – 261InterchainCurated
    Disulfide bondi290 ↔ 301PROSITE-ProRule annotation
    Disulfide bondi295 ↔ 310PROSITE-ProRule annotation
    Disulfide bondi313 ↔ 324PROSITE-ProRule annotation
    Disulfide bondi330 ↔ 341PROSITE-ProRule annotation
    Disulfide bondi335 ↔ 350PROSITE-ProRule annotation
    Disulfide bondi353 ↔ 377PROSITE-ProRule annotation
    Disulfide bondi383 ↔ 394PROSITE-ProRule annotation
    Disulfide bondi388 ↔ 403PROSITE-ProRule annotation
    Disulfide bondi406 ↔ 418PROSITE-ProRule annotation
    Disulfide bondi424 ↔ 438PROSITE-ProRule annotation
    Disulfide bondi432 ↔ 448PROSITE-ProRule annotation
    Disulfide bondi450 ↔ 461PROSITE-ProRule annotation
    Disulfide bondi477 ↔ 482PROSITE-ProRule annotation
    Disulfide bondi487 ↔ 507PROSITE-ProRule annotation
    Disulfide bondi523 ↔ 543PROSITE-ProRule annotation
    Disulfide bondi546 ↔ 566PROSITE-ProRule annotation
    Disulfide bondi582 ↔ 602PROSITE-ProRule annotation
    Disulfide bondi605 ↔ 625PROSITE-ProRule annotation
    Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi643 ↔ 663PROSITE-ProRule annotation
    Disulfide bondi683 ↔ 703PROSITE-ProRule annotation
    Disulfide bondi719 ↔ 940PROSITE-ProRule annotation
    Glycosylationi941 – 9411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP35443.
    PaxDbiP35443.
    PeptideAtlasiP35443.
    PRIDEiP35443.

    PTM databases

    PhosphoSiteiP35443.

    Expressioni

    Gene expression databases

    ArrayExpressiP35443.
    BgeeiP35443.
    CleanExiHS_THBS4.
    GenevestigatoriP35443.

    Organism-specific databases

    HPAiCAB004597.

    Interactioni

    Subunit structurei

    Homopentamer; disulfide-linked. Interacts with PTBP3. Interacts with NOTCH1 By similarity. Interacts (via EGF-like 3; calcium-binding domain) with ATF6 and facilitates its processing, activation and nuclear translocation.By similarity3 Publications

    Protein-protein interaction databases

    IntActiP35443. 1 interaction.
    STRINGi9606.ENSP00000339730.

    Structurei

    3D structure databases

    ProteinModelPortaliP35443.
    SMRiP35443. Positions 218-262, 290-952.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 192166Laminin G-likeAdd
    BLAST
    Domaini286 – 32540EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini326 – 36338EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini379 – 41941EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini420 – 46243EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Repeati463 – 49533TSP type-3 1Add
    BLAST
    Repeati496 – 53136TSP type-3 2Add
    BLAST
    Repeati532 – 55423TSP type-3 3Add
    BLAST
    Repeati555 – 59036TSP type-3 4Add
    BLAST
    Repeati591 – 61323TSP type-3 5Add
    BLAST
    Repeati614 – 65138TSP type-3 6Add
    BLAST
    Repeati652 – 69140TSP type-3 7Add
    BLAST
    Repeati692 – 72736TSP type-3 8Add
    BLAST
    Domaini731 – 945215TSP C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi562 – 5643Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 4 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
    Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000007542.
    HOVERGENiHBG000636.
    InParanoidiP35443.
    KOiK04659.
    OMAiAECQACG.
    OrthoDBiEOG76QFGD.
    PhylomeDBiP35443.
    TreeFamiTF324917.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    4.10.1080.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    IPR024665. Thbs/COMP_coiled-coil.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    [Graphical view]
    PfamiPF11598. COMP. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02412. TSP_3. 6 hits.
    PF05735. TSP_C. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00179. EGF_CA. 2 hits.
    SM00210. TSPN. 1 hit.
    [Graphical view]
    SUPFAMiSSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEiPS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 2 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35443-1 [UniParc]FASTAAdd to Basket

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    MLAPRGAAVL LLHLVLQRWL AAGAQATPQV FDLLPSSSQR LNPGALLPVL    50
    TDPALNDLYV ISTFKLQTKS SATIFGLYSS TDNSKYFEFT VMGRLNKAIL 100
    RYLKNDGKVH LVVFNNLQLA DGRRHRILLR LSNLQRGAGS LELYLDCIQV 150
    DSVHNLPRAF AGPSQKPETI ELRTFQRKPQ DFLEELKLVV RGSLFQVASL 200
    QDCFLQQSEP LAATGTGDFN RQFLGQMTQL NQLLGEVKDL LRQQVKETSF 250
    LRNTIAECQA CGPLKFQSPT PSTVVPPAPP APPTRPPRRC DSNPCFRGVQ 300
    CTDSRDGFQC GPCPEGYTGN GITCIDVDEC KYHPCYPGVH CINLSPGFRC 350
    DACPVGFTGP MVQGVGISFA KSNKQVCTDI DECRNGACVP NSICVNTLGS 400
    YRCGPCKPGY TGDQIRGCKA ERNCRNPELN PCSVNAQCIE ERQGDVTCVC 450
    GVGWAGDGYI CGKDVDIDSY PDEELPCSAR NCKKDNCKYV PNSGQEDADR 500
    DGIGDACDED ADGDGILNEQ DNCVLIHNVD QRNSDKDIFG DACDNCLSVL 550
    NNDQKDTDGD GRGDACDDDM DGDGIKNILD NCPKFPNRDQ RDKDGDGVGD 600
    ACDSCPDVSN PNQSDVDNDL VGDSCDTNQD SDGDGHQDST DNCPTVINSA 650
    QLDTDKDGIG DECDDDDDND GIPDLVPPGP DNCRLVPNPA QEDSNSDGVG 700
    DICESDFDQD QVIDRIDVCP ENAEVTLTDF RAYQTVVLDP EGDAQIDPNW 750
    VVLNQGMEIV QTMNSDPGLA VGYTAFNGVD FEGTFHVNTQ TDDDYAGFIF 800
    GYQDSSSFYV VMWKQTEQTY WQATPFRAVA EPGIQLKAVK SKTGPGEHLR 850
    NSLWHTGDTS DQVRLLWKDS RNVGWKDKVS YRWFLQHRPQ VGYIRVRFYE 900
    GSELVADSGV TIDTTMRGGR LGVFCFSQEN IIWSNLKYRC NDTIPEDFQE 950
    FQTQNFDRFD N 961
    Length:961
    Mass (Da):105,869
    Last modified:November 23, 2004 - v2
    Checksum:i18F867AA5FFDA54B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961N → S no nucleotide entry (PubMed:8350346)Curated
    Sequence conflicti96 – 961N → S in CAA79635. (PubMed:7852353)Curated
    Sequence conflicti276 – 2761P → A no nucleotide entry (PubMed:8350346)Curated
    Sequence conflicti276 – 2761P → A in CAA79635. (PubMed:7852353)Curated
    Sequence conflicti737 – 7371V → G no nucleotide entry (PubMed:8350346)Curated
    Sequence conflicti737 – 7371V → G in CAA79635. (PubMed:7852353)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551L → Q.1 Publication
    Corresponds to variant rs17881847 [ dbSNP | Ensembl ].
    VAR_019951
    Natural varianti387 – 3871A → P Gain of function mutation; resulting in a pro-atherogenic phenotype. 2 Publications
    Corresponds to variant rs1866389 [ dbSNP | Ensembl ].
    VAR_019952
    Natural varianti420 – 4201A → V.3 Publications
    Corresponds to variant rs17882372 [ dbSNP | Ensembl ].
    VAR_019953
    Natural varianti646 – 6461V → I.1 Publication
    Corresponds to variant rs2229396 [ dbSNP | Ensembl ].
    VAR_019954
    Natural varianti737 – 7371V → I.
    Corresponds to variant rs2229398 [ dbSNP | Ensembl ].
    VAR_052659

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z19585 mRNA. Translation: CAA79635.1.
    AK313587 mRNA. Translation: BAG36356.1.
    AY566253 Genomic DNA. Translation: AAS66982.1.
    BC050456 mRNA. Translation: AAH50456.1.
    CCDSiCCDS4049.1.
    PIRiA55710. TSHUP4.
    RefSeqiNP_003239.2. NM_003248.4.
    UniGeneiHs.211426.

    Genome annotation databases

    EnsembliENST00000350881; ENSP00000339730; ENSG00000113296.
    GeneIDi7060.
    KEGGihsa:7060.
    UCSCiuc021yaw.1. human.

    Polymorphism databases

    DMDMi55977790.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z19585 mRNA. Translation: CAA79635.1 .
    AK313587 mRNA. Translation: BAG36356.1 .
    AY566253 Genomic DNA. Translation: AAS66982.1 .
    BC050456 mRNA. Translation: AAH50456.1 .
    CCDSi CCDS4049.1.
    PIRi A55710. TSHUP4.
    RefSeqi NP_003239.2. NM_003248.4.
    UniGenei Hs.211426.

    3D structure databases

    ProteinModelPortali P35443.
    SMRi P35443. Positions 218-262, 290-952.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P35443. 1 interaction.
    STRINGi 9606.ENSP00000339730.

    PTM databases

    PhosphoSitei P35443.

    Polymorphism databases

    DMDMi 55977790.

    Proteomic databases

    MaxQBi P35443.
    PaxDbi P35443.
    PeptideAtlasi P35443.
    PRIDEi P35443.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000350881 ; ENSP00000339730 ; ENSG00000113296 .
    GeneIDi 7060.
    KEGGi hsa:7060.
    UCSCi uc021yaw.1. human.

    Organism-specific databases

    CTDi 7060.
    GeneCardsi GC05P079287.
    HGNCi HGNC:11788. THBS4.
    HPAi CAB004597.
    MIMi 600715. gene.
    neXtProti NX_P35443.
    PharmGKBi PA36500.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000007542.
    HOVERGENi HBG000636.
    InParanoidi P35443.
    KOi K04659.
    OMAi AECQACG.
    OrthoDBi EOG76QFGD.
    PhylomeDBi P35443.
    TreeFami TF324917.

    Enzyme and pathway databases

    Reactomei REACT_16888. Signaling by PDGF.

    Miscellaneous databases

    GeneWikii THBS4.
    GenomeRNAii 7060.
    NextBioi 27609.
    PROi P35443.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35443.
    Bgeei P35443.
    CleanExi HS_THBS4.
    Genevestigatori P35443.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    4.10.1080.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    IPR024665. Thbs/COMP_coiled-coil.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    [Graphical view ]
    Pfami PF11598. COMP. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02412. TSP_3. 6 hits.
    PF05735. TSP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 2 hits.
    SM00210. TSPN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEi PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 2 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-420.
      Tissue: Heart.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-420, SUBUNIT.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-387.
      Tissue: Synovium.
    4. SeattleSNPs variation discovery resource
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-55; PRO-387; VAL-420 AND ILE-646.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PNS.
    6. "Regulator of differentiation 1 (ROD1) binds to the amphipathic C-terminal peptide of thrombospondin-4 and is involved in its mitogenic activity."
      Sadvakassova G., Dobocan M.C., Difalco M.R., Congote L.F.
      J. Cell. Physiol. 220:672-679(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CELL PROLIFERATION, INTERACTION WITH PTBP3.
    7. Cited for: INTERACTION WITH ATF6.
    8. "ATF6 [corrected] and thrombospondin 4: the dynamic duo of the adaptive endoplasmic reticulum stress response."
      Doroudgar S., Glembotski C.C.
      Circ. Res. 112:9-12(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. Cited for: REVIEW.
    10. "Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels."
      Corsetti J.P., Ryan D., Moss A.J., McCarthy J., Goldenberg I., Zareba W., Sparks C.E.
      Thromb. Haemost. 106:1170-1178(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANT PRO-387.

    Entry informationi

    Entry nameiTSP4_HUMAN
    AccessioniPrimary (citable) accession number: P35443
    Secondary accession number(s): B2R909, Q86TG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3