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Protein

Thrombospondin-2

Gene

THBS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.1 Publication

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • heparin binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32728-MONOMER.
ReactomeiR-HSA-186797. Signaling by PDGF.
R-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.
SIGNORiP35442.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-2
Gene namesi
Name:THBS2
Synonyms:TSP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11786. THBS2.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: Ensembl
  • extracellular region Source: Reactome
  • platelet alpha granule Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Intervertebral disc disease (IDD)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.
See also OMIM:603932

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi702N → S: Alters protein stability. 1 Publication1

Organism-specific databases

DisGeNETi7058.
MalaCardsiTHBS2.
MIMi603932. phenotype.
OpenTargetsiENSG00000186340.
PharmGKBiPA36498.

Polymorphism and mutation databases

BioMutaiTHBS2.
DMDMi215273908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003584619 – 1172Thrombospondin-2Add BLAST1154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi266InterchainCurated
Disulfide bondi270InterchainCurated
Glycosylationi316N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi393 ↔ 425By similarity
Disulfide bondi397 ↔ 430By similarity
Disulfide bondi408 ↔ 415By similarity
Disulfide bondi449 ↔ 486By similarity
Disulfide bondi453 ↔ 491By similarity
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi464 ↔ 476By similarity
Disulfide bondi506 ↔ 543By similarity
Disulfide bondi510 ↔ 548By similarity
Disulfide bondi521 ↔ 533By similarity
Disulfide bondi553 ↔ 564Combined sources2 Publications
Disulfide bondi558 ↔ 574Combined sources2 Publications
Disulfide bondi577 ↔ 588Combined sources2 Publications
Glycosylationi584N-linked (GlcNAc...)1 Publication1
Disulfide bondi594 ↔ 610Combined sources2 Publications
Disulfide bondi601 ↔ 619Combined sources2 Publications
Disulfide bondi622 ↔ 646Combined sources2 Publications
Disulfide bondi652 ↔ 665Combined sources2 Publications
Disulfide bondi659 ↔ 678Combined sources2 Publications
Disulfide bondi680 ↔ 691Combined sources2 Publications
Disulfide bondi707 ↔ 715Combined sources2 Publications
Glycosylationi710N-linked (GlcNAc...)1 Publication1
Disulfide bondi720 ↔ 740Combined sources2 Publications
Disulfide bondi756 ↔ 776Combined sources2 Publications
Disulfide bondi779 ↔ 799Combined sources2 Publications
Disulfide bondi815 ↔ 835Combined sources2 Publications
Disulfide bondi838 ↔ 858Combined sources2 Publications
Disulfide bondi876 ↔ 896Combined sources2 Publications
Disulfide bondi912 ↔ 932Combined sources2 Publications
Disulfide bondi948 ↔ 1169Combined sources2 Publications
Glycosylationi1069N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP35442.
MaxQBiP35442.
PaxDbiP35442.
PeptideAtlasiP35442.
PRIDEiP35442.

PTM databases

iPTMnetiP35442.
PhosphoSitePlusiP35442.

Miscellaneous databases

PMAP-CutDBQ5RI52.

Expressioni

Tissue specificityi

High expression in invertebral disk tissue.1 Publication

Gene expression databases

BgeeiENSG00000186340.
CleanExiHS_THBS2.
ExpressionAtlasiP35442. baseline and differential.
GenevisibleiP35442. HS.

Organism-specific databases

HPAiCAB017716.
HPA044304.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cacna2d1P542902EBI-2466249,EBI-2466294From a different organism.

Protein-protein interaction databases

BioGridi112916. 13 interactors.
IntActiP35442. 1 interactor.
STRINGi9606.ENSP00000355751.

Structurei

Secondary structure

11172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi552 – 555Combined sources4
Beta strandi564 – 566Combined sources3
Beta strandi572 – 574Combined sources3
Beta strandi585 – 587Combined sources3
Turni593 – 596Combined sources4
Beta strandi605 – 607Combined sources3
Beta strandi610 – 612Combined sources3
Beta strandi614 – 619Combined sources6
Beta strandi626 – 628Combined sources3
Beta strandi632 – 636Combined sources5
Helixi637 – 640Combined sources4
Beta strandi646 – 648Combined sources3
Turni651 – 655Combined sources5
Beta strandi663 – 667Combined sources5
Beta strandi673 – 680Combined sources8
Beta strandi684 – 693Combined sources10
Beta strandi697 – 700Combined sources4
Turni706 – 710Combined sources5
Beta strandi712 – 714Combined sources3
Beta strandi734 – 736Combined sources3
Turni738 – 740Combined sources3
Beta strandi746 – 749Combined sources4
Turni751 – 753Combined sources3
Turni755 – 758Combined sources4
Beta strandi767 – 772Combined sources6
Helixi774 – 776Combined sources3
Beta strandi793 – 795Combined sources3
Helixi797 – 799Combined sources3
Beta strandi805 – 808Combined sources4
Turni810 – 812Combined sources3
Beta strandi829 – 831Combined sources3
Helixi833 – 835Combined sources3
Beta strandi851 – 854Combined sources4
Turni856 – 858Combined sources3
Beta strandi866 – 869Combined sources4
Helixi871 – 873Combined sources3
Beta strandi890 – 892Combined sources3
Turni894 – 896Combined sources3
Beta strandi903 – 905Combined sources3
Helixi907 – 909Combined sources3
Turni911 – 914Combined sources4
Beta strandi926 – 928Combined sources3
Helixi930 – 932Combined sources3
Beta strandi939 – 941Combined sources3
Helixi943 – 945Combined sources3
Beta strandi960 – 968Combined sources9
Beta strandi971 – 973Combined sources3
Beta strandi979 – 982Combined sources4
Helixi983 – 985Combined sources3
Beta strandi987 – 990Combined sources4
Beta strandi995 – 1016Combined sources22
Beta strandi1024 – 1033Combined sources10
Beta strandi1036 – 1045Combined sources10
Beta strandi1053 – 1055Combined sources3
Beta strandi1061 – 1069Combined sources9
Helixi1076 – 1083Combined sources8
Beta strandi1084 – 1086Combined sources3
Turni1089 – 1091Combined sources3
Beta strandi1092 – 1097Combined sources6
Beta strandi1110 – 1116Combined sources7
Turni1118 – 1120Combined sources3
Beta strandi1122 – 1129Combined sources8
Beta strandi1132 – 1136Combined sources5
Beta strandi1139 – 1141Combined sources3
Beta strandi1148 – 1156Combined sources9
Beta strandi1159 – 1169Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YO8X-ray2.60A551-1172[»]
2RHPX-ray2.90A551-1172[»]
ProteinModelPortaliP35442.
SMRiP35442.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35442.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 215Laminin G-likeAdd BLAST197
Domaini318 – 375VWFCPROSITE-ProRule annotationAdd BLAST58
Domaini381 – 431TSP type-1 1PROSITE-ProRule annotationAdd BLAST51
Domaini437 – 492TSP type-1 2PROSITE-ProRule annotationAdd BLAST56
Domaini494 – 549TSP type-1 3PROSITE-ProRule annotationAdd BLAST56
Domaini549 – 589EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini648 – 692EGF-like 2PROSITE-ProRule annotationAdd BLAST45
Repeati693 – 728TSP type-3 1Add BLAST36
Repeati729 – 764TSP type-3 2Add BLAST36
Repeati765 – 787TSP type-3 3Add BLAST23
Repeati788 – 823TSP type-3 4Add BLAST36
Repeati824 – 846TSP type-3 5Add BLAST23
Repeati847 – 884TSP type-3 6Add BLAST38
Repeati885 – 920TSP type-3 7Add BLAST36
Repeati921 – 956TSP type-3 8Add BLAST36
Domaini960 – 1172TSP C-terminalPROSITE-ProRule annotationAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 232Heparin-bindingSequence analysisAdd BLAST214

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi928 – 930Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the thrombospondin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
Contains 3 TSP type-1 domains.PROSITE-ProRule annotation
Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFQQ. Eukaryota.
ENOG410XQKE. LUCA.
GeneTreeiENSGT00850000132273.
HOGENOMiHOG000007542.
HOVERGENiHBG018006.
InParanoidiP35442.
KOiK04659.
OMAiTEKQVCE.
OrthoDBiEOG091G00TV.
PhylomeDBiP35442.
TreeFamiTF324917.

Family and domain databases

Gene3Di2.60.120.200. 3 hits.
4.10.1080.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024731. EGF_dom.
IPR001791. Laminin_G.
IPR015455. Thrombospondin-2.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR000884. TSP1_rpt.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR10199:SF10. PTHR10199:SF10. 1 hit.
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWRLVLLAL WVWPSTQAGH QDKDTTFDLF SISNINRKTI GAKQFRGPDP
60 70 80 90 100
GVPAYRFVRF DYIPPVNADD LSKITKIMRQ KEGFFLTAQL KQDGKSRGTL
110 120 130 140 150
LALEGPGLSQ RQFEIVSNGP ADTLDLTYWI DGTRHVVSLE DVGLADSQWK
160 170 180 190 200
NVTVQVAGET YSLHVGCDLI DSFALDEPFY EHLQAEKSRM YVAKGSARES
210 220 230 240 250
HFRGLLQNVH LVFENSVEDI LSKKGCQQGQ GAEINAISEN TETLRLGPHV
260 270 280 290 300
TTEYVGPSSE RRPEVCERSC EELGNMVQEL SGLHVLVNQL SENLKRVSND
310 320 330 340 350
NQFLWELIGG PPKTRNMSAC WQDGRFFAEN ETWVVDSCTT CTCKKFKTIC
360 370 380 390 400
HQITCPPATC ASPSFVEGEC CPSCLHSVDG EEGWSPWAEW TQCSVTCGSG
410 420 430 440 450
TQQRGRSCDV TSNTCLGPSI QTRACSLSKC DTRIRQDGGW SHWSPWSSCS
460 470 480 490 500
VTCGVGNITR IRLCNSPVPQ MGGKNCKGSG RETKACQGAP CPIDGRWSPW
510 520 530 540 550
SPWSACTVTC AGGIRERTRV CNSPEPQYGG KACVGDVQER QMCNKRSCPV
560 570 580 590 600
DGCLSNPCFP GAQCSSFPDG SWSCGSCPVG FLGNGTHCED LDECALVPDI
610 620 630 640 650
CFSTSKVPRC VNTQPGFHCL PCPPRYRGNQ PVGVGLEAAK TEKQVCEPEN
660 670 680 690 700
PCKDKTHNCH KHAECIYLGH FSDPMYKCEC QTGYAGDGLI CGEDSDLDGW
710 720 730 740 750
PNLNLVCATN ATYHCIKDNC PHLPNSGQED FDKDGIGDAC DDDDDNDGVT
760 770 780 790 800
DEKDNCQLLF NPRQADYDKD EVGDRCDNCP YVHNPAQIDT DNNGEGDACS
810 820 830 840 850
VDIDGDDVFN ERDNCPYVYN TDQRDTDGDG VGDHCDNCPL VHNPDQTDVD
860 870 880 890 900
NDLVGDQCDN NEDIDDDGHQ NNQDNCPYIS NANQADHDRD GQGDACDPDD
910 920 930 940 950
DNDGVPDDRD NCRLVFNPDQ EDLDGDGRGD ICKDDFDNDN IPDIDDVCPE
960 970 980 990 1000
NNAISETDFR NFQMVPLDPK GTTQIDPNWV IRHQGKELVQ TANSDPGIAV
1010 1020 1030 1040 1050
GFDEFGSVDF SGTFYVNTDR DDDYAGFVFG YQSSSRFYVV MWKQVTQTYW
1060 1070 1080 1090 1100
EDQPTRAYGY SGVSLKVVNS TTGTGEHLRN ALWHTGNTPG QVRTLWHDPR
1110 1120 1130 1140 1150
NIGWKDYTAY RWHLTHRPKT GYIRVLVHEG KQVMADSGPI YDQTYAGGRL
1160 1170
GLFVFSQEMV YFSDLKYECR DI
Length:1,172
Mass (Da):129,991
Last modified:November 25, 2008 - v2
Checksum:i415BF376F4669F6A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2V → A in AAI50176 (PubMed:15489334).Curated1
Sequence conflicti171 – 173DSF → GPV in AAA03703 (PubMed:8406456).Curated3
Sequence conflicti576S → F in AAA03703 (PubMed:8406456).Curated1
Sequence conflicti1111R → G in AAI46677 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045842133T → S.Corresponds to variant rs36088849dbSNPEnsembl.1
Natural variantiVAR_045843375L → F.Corresponds to variant rs35404985dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12350 mRNA. Translation: AAA03703.1.
M81339 mRNA. No translation available.
AK292429 mRNA. Translation: BAF85118.1.
BX322234 Genomic DNA. Translation: CAI23645.1.
CH471051 Genomic DNA. Translation: EAW47455.1.
BC146676 mRNA. Translation: AAI46677.1.
BC150175 mRNA. Translation: AAI50176.1.
CCDSiCCDS34574.1.
PIRiA47379. TSHUP2.
RefSeqiNP_003238.2. NM_003247.3.
UniGeneiHs.371147.

Genome annotation databases

EnsembliENST00000366787; ENSP00000355751; ENSG00000186340.
ENST00000617924; ENSP00000482784; ENSG00000186340.
GeneIDi7058.
KEGGihsa:7058.
UCSCiuc003qwt.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12350 mRNA. Translation: AAA03703.1.
M81339 mRNA. No translation available.
AK292429 mRNA. Translation: BAF85118.1.
BX322234 Genomic DNA. Translation: CAI23645.1.
CH471051 Genomic DNA. Translation: EAW47455.1.
BC146676 mRNA. Translation: AAI46677.1.
BC150175 mRNA. Translation: AAI50176.1.
CCDSiCCDS34574.1.
PIRiA47379. TSHUP2.
RefSeqiNP_003238.2. NM_003247.3.
UniGeneiHs.371147.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YO8X-ray2.60A551-1172[»]
2RHPX-ray2.90A551-1172[»]
ProteinModelPortaliP35442.
SMRiP35442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112916. 13 interactors.
IntActiP35442. 1 interactor.
STRINGi9606.ENSP00000355751.

PTM databases

iPTMnetiP35442.
PhosphoSitePlusiP35442.

Polymorphism and mutation databases

BioMutaiTHBS2.
DMDMi215273908.

Proteomic databases

EPDiP35442.
MaxQBiP35442.
PaxDbiP35442.
PeptideAtlasiP35442.
PRIDEiP35442.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366787; ENSP00000355751; ENSG00000186340.
ENST00000617924; ENSP00000482784; ENSG00000186340.
GeneIDi7058.
KEGGihsa:7058.
UCSCiuc003qwt.5. human.

Organism-specific databases

CTDi7058.
DisGeNETi7058.
GeneCardsiTHBS2.
H-InvDBHIX0025092.
HIX0165050.
HGNCiHGNC:11786. THBS2.
HPAiCAB017716.
HPA044304.
MalaCardsiTHBS2.
MIMi188061. gene.
603932. phenotype.
neXtProtiNX_P35442.
OpenTargetsiENSG00000186340.
PharmGKBiPA36498.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFQQ. Eukaryota.
ENOG410XQKE. LUCA.
GeneTreeiENSGT00850000132273.
HOGENOMiHOG000007542.
HOVERGENiHBG018006.
InParanoidiP35442.
KOiK04659.
OMAiTEKQVCE.
OrthoDBiEOG091G00TV.
PhylomeDBiP35442.
TreeFamiTF324917.

Enzyme and pathway databases

BioCyciZFISH:G66-32728-MONOMER.
ReactomeiR-HSA-186797. Signaling by PDGF.
R-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.
SIGNORiP35442.

Miscellaneous databases

ChiTaRSiTHBS2. human.
EvolutionaryTraceiP35442.
GeneWikiiTHBS2.
GenomeRNAii7058.
PMAP-CutDBQ5RI52.
PROiP35442.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186340.
CleanExiHS_THBS2.
ExpressionAtlasiP35442. baseline and differential.
GenevisibleiP35442. HS.

Family and domain databases

Gene3Di2.60.120.200. 3 hits.
4.10.1080.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024731. EGF_dom.
IPR001791. Laminin_G.
IPR015455. Thrombospondin-2.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR000884. TSP1_rpt.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR10199:SF10. PTHR10199:SF10. 1 hit.
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSP2_HUMAN
AccessioniPrimary (citable) accession number: P35442
Secondary accession number(s): A6H8N1, A7E232, Q5RI52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.