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P35440

- TSP2_CHICK

UniProt

P35440 - TSP2_CHICK

Protein

Thrombospondin-2

Gene

THBS2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. negative regulation of angiogenesis Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thrombospondin-2
    Gene namesi
    Name:THBS2
    Synonyms:TSP2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 11781156Thrombospondin-2PRO_0000035848Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi272 – 272InterchainBy similarity
    Disulfide bondi276 – 276InterchainBy similarity
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi399 ↔ 431By similarity
    Disulfide bondi403 ↔ 436By similarity
    Disulfide bondi414 ↔ 421By similarity
    Disulfide bondi455 ↔ 492By similarity
    Disulfide bondi459 ↔ 497By similarity
    Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi470 ↔ 482By similarity
    Disulfide bondi512 ↔ 549By similarity
    Disulfide bondi516 ↔ 554By similarity
    Disulfide bondi527 ↔ 539By similarity
    Disulfide bondi559 ↔ 570By similarity
    Disulfide bondi564 ↔ 580By similarity
    Disulfide bondi583 ↔ 594By similarity
    Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi600 ↔ 616By similarity
    Disulfide bondi607 ↔ 625By similarity
    Disulfide bondi628 ↔ 652By similarity
    Disulfide bondi658 ↔ 671By similarity
    Disulfide bondi665 ↔ 684By similarity
    Disulfide bondi686 ↔ 697By similarity
    Disulfide bondi713 ↔ 721By similarity
    Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi726 ↔ 746By similarity
    Disulfide bondi762 ↔ 782By similarity
    Disulfide bondi785 ↔ 805By similarity
    Disulfide bondi821 ↔ 841By similarity
    Disulfide bondi844 ↔ 864By similarity
    Disulfide bondi882 ↔ 902By similarity
    Disulfide bondi918 ↔ 938By similarity
    Disulfide bondi954 ↔ 1175By similarity
    Glycosylationi1075 – 10751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP35440.
    PRIDEiP35440.

    Interactioni

    Subunit structurei

    Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin and type V collagen By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000036892.

    Structurei

    3D structure databases

    ProteinModelPortaliP35440.
    SMRiP35440. Positions 442-554, 557-1177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 221197Laminin G-likeAdd
    BLAST
    Domaini324 – 38158VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini387 – 43751TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini443 – 49856TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini500 – 55556TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini555 – 59541EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini654 – 69845EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati699 – 73436TSP type-3 1Add
    BLAST
    Repeati735 – 77036TSP type-3 2Add
    BLAST
    Repeati771 – 79323TSP type-3 3Add
    BLAST
    Repeati794 – 82936TSP type-3 4Add
    BLAST
    Repeati830 – 85223TSP type-3 5Add
    BLAST
    Repeati853 – 89038TSP type-3 6Add
    BLAST
    Repeati891 – 92636TSP type-3 7Add
    BLAST
    Repeati927 – 96236TSP type-3 8Add
    BLAST
    Domaini966 – 1178213TSP C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni? – 232Heparin-bindingSequence Analysis

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi934 – 9363Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 2 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
    Contains 3 TSP type-1 domains.PROSITE-ProRule annotation
    Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000007542.
    HOVERGENiHBG018006.
    InParanoidiP35440.
    KOiK04659.
    PhylomeDBiP35440.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    4.10.1080.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR001791. Laminin_G.
    IPR015455. Thrombospondin-2.
    IPR000884. Thrombospondin_1_rpt.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PANTHERiPTHR10199:SF10. PTHR10199:SF10. 1 hit.
    PfamiPF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF00090. TSP_1. 3 hits.
    PF02412. TSP_3. 7 hits.
    PF05735. TSP_C. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00209. TSP1. 3 hits.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    SSF82895. SSF82895. 3 hits.
    PROSITEiPS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 2 hits.
    PS50092. TSP1. 3 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35440-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQRSRLLWL AVFITLWVSS DAQDDAKEEE NTFDLLQISN INRKTIGAKL     50
    FRGPDPAIPA YRFIRFDHIP PFKPEKLKKI VKLIRQNEGF ILSATLRQDR 100
    QSRGTILALE GPGISERQFE IISNGRANTL DLIYWVDGFQ NVISLEDVDL 150
    ADSQWKNLTV QVTGENYNLY VGCDLIDSFI LEEPFYEQLK AENSRMYVAK 200
    GSIRENHFRG LLQNIHLIFD TSIEDVLRKK GCQRSQSTEV NTINESTEIL 250
    HLSPAVTTEY VGEKTEKKAE FCDRSCEELG TMFTELTGLR IVVNNLADNL 300
    QKVSEENQIM WELIGPNKTL KNQSVCWQDG RVFADSESWI VDSCTKCTCQ 350
    DSKIVCHQIT CPPVSCADPS FIEGECCPVC SHSDDSEEGW SPWSDWTKCS 400
    VTCGSGTQMR GRSCDVTRSA CTGPHIQTRM CSFKKCDHRI RQDGGWSHWS 450
    PWSSCSVTCG VGNITRIRLC NSPIPQMGGK NCVGNGRETE KCEKAPCPVN 500
    GQWGPWSPWS ACTVTCGGGI RERSRLCNSP EPQYGGKPCV GDTKQHDMCN 550
    KRDCPIDGCL SNPCFPGAEC NSYPDGSWSC GPCPAGFLGN GTVCEDLDEC 600
    IAVSDVCFKV NQVHRCVNTN PGFHCLPCPP RYKGSQPYGV GLEVAKTEKQ 650
    VCEPENPCKD KTHSCHKSAE CIYLGHFSDP MYKCECRTGY AGDGRICGED 700
    SDLDGWPNNN LVCAANATYH CVKDNCPLLP NSGQEDFDKD GKGDACDEDD 750
    DNDGVEDDKD NCPLLFNPRQ FDYDKDEVGD RCDNCPYVHN PAQIDTDNNG 800
    EGDSCAVDID GDDIFNERDN CPYVYNTDQS DTDGDGVGDQ CDNCPLMHNP 850
    DQTDADNDLV GDQCDNNEDI DEDGHQNNQD NCPYIPNANQ ADHDKDGKGD 900
    ACDPDDDNDG IPDDRDNCRL RYNPEQEDSD GDGRGDICKD DFDDDNVPDI 950
    FDVCPENNAI SETDFRKFQM VPLDPKGTAQ IDPNWVIRHQ GKELVQTANS 1000
    DPGIAVGYDE FSSVDFSGTF YVNTDRDDDY AGFVFGYQSS SRFYVLMWKQ 1050
    VTQTYWEDKP TRAYGYSGVS LKVVNSTTGT GEHLRNALWH TGNTPGQVRT 1100
    LWHDPKNIGW KDYTAYRWHL IHRPKTGLIK VLVYEGKQVM VDSGPIYDTT 1150
    FAGGRLGLFV FSQEMVYFSD LKYECRDA 1178
    Length:1,178
    Mass (Da):131,817
    Last modified:June 1, 1994 - v1
    Checksum:iF37E02F42C8717A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60853 mRNA. Translation: AAA51437.1.
    PIRiA39804.
    RefSeqiNP_001001755.1. NM_001001755.1.
    UniGeneiGga.797.

    Genome annotation databases

    GeneIDi414837.
    KEGGigga:414837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60853 mRNA. Translation: AAA51437.1 .
    PIRi A39804.
    RefSeqi NP_001001755.1. NM_001001755.1.
    UniGenei Gga.797.

    3D structure databases

    ProteinModelPortali P35440.
    SMRi P35440. Positions 442-554, 557-1177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000036892.

    Proteomic databases

    PaxDbi P35440.
    PRIDEi P35440.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 414837.
    KEGGi gga:414837.

    Organism-specific databases

    CTDi 7058.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000007542.
    HOVERGENi HBG018006.
    InParanoidi P35440.
    KOi K04659.
    PhylomeDBi P35440.

    Miscellaneous databases

    NextBioi 20818734.
    PROi P35440.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    4.10.1080.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR001791. Laminin_G.
    IPR015455. Thrombospondin-2.
    IPR000884. Thrombospondin_1_rpt.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    PANTHERi PTHR10199:SF10. PTHR10199:SF10. 1 hit.
    Pfami PF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF00090. TSP_1. 3 hits.
    PF02412. TSP_3. 7 hits.
    PF05735. TSP_C. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00209. TSP1. 3 hits.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    SSF82895. SSF82895. 3 hits.
    PROSITEi PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 2 hits.
    PS50092. TSP1. 3 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of chicken thrombospondin."
      Lawler J., Duquette M., Ferro P.
      J. Biol. Chem. 266:8039-8043(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTSP2_CHICK
    AccessioniPrimary (citable) accession number: P35440
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3