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P35440

- TSP2_CHICK

UniProt

P35440 - TSP2_CHICK

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Protein

Thrombospondin-2

Gene

THBS2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. negative regulation of angiogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_258033. Signaling by PDGF.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-2
Gene namesi
Name:THBS2
Synonyms:TSP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 11781156Thrombospondin-2PRO_0000035848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi272 – 272InterchainBy similarity
Disulfide bondi276 – 276InterchainBy similarity
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi399 ↔ 431By similarity
Disulfide bondi403 ↔ 436By similarity
Disulfide bondi414 ↔ 421By similarity
Disulfide bondi455 ↔ 492By similarity
Disulfide bondi459 ↔ 497By similarity
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi470 ↔ 482By similarity
Disulfide bondi512 ↔ 549By similarity
Disulfide bondi516 ↔ 554By similarity
Disulfide bondi527 ↔ 539By similarity
Disulfide bondi559 ↔ 570By similarity
Disulfide bondi564 ↔ 580By similarity
Disulfide bondi583 ↔ 594By similarity
Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi600 ↔ 616By similarity
Disulfide bondi607 ↔ 625By similarity
Disulfide bondi628 ↔ 652By similarity
Disulfide bondi658 ↔ 671By similarity
Disulfide bondi665 ↔ 684By similarity
Disulfide bondi686 ↔ 697By similarity
Disulfide bondi713 ↔ 721By similarity
Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi726 ↔ 746By similarity
Disulfide bondi762 ↔ 782By similarity
Disulfide bondi785 ↔ 805By similarity
Disulfide bondi821 ↔ 841By similarity
Disulfide bondi844 ↔ 864By similarity
Disulfide bondi882 ↔ 902By similarity
Disulfide bondi918 ↔ 938By similarity
Disulfide bondi954 ↔ 1175By similarity
Glycosylationi1075 – 10751N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35440.
PRIDEiP35440.

Expressioni

Gene expression databases

ExpressionAtlasiP35440. baseline.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036892.

Structurei

3D structure databases

ProteinModelPortaliP35440.
SMRiP35440. Positions 442-554, 557-1177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 221197Laminin G-likeAdd
BLAST
Domaini324 – 38158VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini387 – 43751TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini443 – 49856TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini500 – 55556TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini555 – 59541EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini654 – 69845EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Repeati699 – 73436TSP type-3 1Add
BLAST
Repeati735 – 77036TSP type-3 2Add
BLAST
Repeati771 – 79323TSP type-3 3Add
BLAST
Repeati794 – 82936TSP type-3 4Add
BLAST
Repeati830 – 85223TSP type-3 5Add
BLAST
Repeati853 – 89038TSP type-3 6Add
BLAST
Repeati891 – 92636TSP type-3 7Add
BLAST
Repeati927 – 96236TSP type-3 8Add
BLAST
Domaini966 – 1178213TSP C-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni? – 232Heparin-bindingSequence Analysis

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi934 – 9363Cell attachment siteSequence Analysis

Sequence similaritiesi

Belongs to the thrombospondin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
Contains 3 TSP type-1 domains.PROSITE-ProRule annotation
Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000007542.
HOVERGENiHBG018006.
InParanoidiP35440.
KOiK04659.
PhylomeDBiP35440.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR001791. Laminin_G.
IPR015455. Thrombospondin-2.
IPR000884. Thrombospondin_1_rpt.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_C.
[Graphical view]
PANTHERiPTHR10199:SF10. PTHR10199:SF10. 1 hit.
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35440-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQRSRLLWL AVFITLWVSS DAQDDAKEEE NTFDLLQISN INRKTIGAKL
60 70 80 90 100
FRGPDPAIPA YRFIRFDHIP PFKPEKLKKI VKLIRQNEGF ILSATLRQDR
110 120 130 140 150
QSRGTILALE GPGISERQFE IISNGRANTL DLIYWVDGFQ NVISLEDVDL
160 170 180 190 200
ADSQWKNLTV QVTGENYNLY VGCDLIDSFI LEEPFYEQLK AENSRMYVAK
210 220 230 240 250
GSIRENHFRG LLQNIHLIFD TSIEDVLRKK GCQRSQSTEV NTINESTEIL
260 270 280 290 300
HLSPAVTTEY VGEKTEKKAE FCDRSCEELG TMFTELTGLR IVVNNLADNL
310 320 330 340 350
QKVSEENQIM WELIGPNKTL KNQSVCWQDG RVFADSESWI VDSCTKCTCQ
360 370 380 390 400
DSKIVCHQIT CPPVSCADPS FIEGECCPVC SHSDDSEEGW SPWSDWTKCS
410 420 430 440 450
VTCGSGTQMR GRSCDVTRSA CTGPHIQTRM CSFKKCDHRI RQDGGWSHWS
460 470 480 490 500
PWSSCSVTCG VGNITRIRLC NSPIPQMGGK NCVGNGRETE KCEKAPCPVN
510 520 530 540 550
GQWGPWSPWS ACTVTCGGGI RERSRLCNSP EPQYGGKPCV GDTKQHDMCN
560 570 580 590 600
KRDCPIDGCL SNPCFPGAEC NSYPDGSWSC GPCPAGFLGN GTVCEDLDEC
610 620 630 640 650
IAVSDVCFKV NQVHRCVNTN PGFHCLPCPP RYKGSQPYGV GLEVAKTEKQ
660 670 680 690 700
VCEPENPCKD KTHSCHKSAE CIYLGHFSDP MYKCECRTGY AGDGRICGED
710 720 730 740 750
SDLDGWPNNN LVCAANATYH CVKDNCPLLP NSGQEDFDKD GKGDACDEDD
760 770 780 790 800
DNDGVEDDKD NCPLLFNPRQ FDYDKDEVGD RCDNCPYVHN PAQIDTDNNG
810 820 830 840 850
EGDSCAVDID GDDIFNERDN CPYVYNTDQS DTDGDGVGDQ CDNCPLMHNP
860 870 880 890 900
DQTDADNDLV GDQCDNNEDI DEDGHQNNQD NCPYIPNANQ ADHDKDGKGD
910 920 930 940 950
ACDPDDDNDG IPDDRDNCRL RYNPEQEDSD GDGRGDICKD DFDDDNVPDI
960 970 980 990 1000
FDVCPENNAI SETDFRKFQM VPLDPKGTAQ IDPNWVIRHQ GKELVQTANS
1010 1020 1030 1040 1050
DPGIAVGYDE FSSVDFSGTF YVNTDRDDDY AGFVFGYQSS SRFYVLMWKQ
1060 1070 1080 1090 1100
VTQTYWEDKP TRAYGYSGVS LKVVNSTTGT GEHLRNALWH TGNTPGQVRT
1110 1120 1130 1140 1150
LWHDPKNIGW KDYTAYRWHL IHRPKTGLIK VLVYEGKQVM VDSGPIYDTT
1160 1170
FAGGRLGLFV FSQEMVYFSD LKYECRDA
Length:1,178
Mass (Da):131,817
Last modified:June 1, 1994 - v1
Checksum:iF37E02F42C8717A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60853 mRNA. Translation: AAA51437.1.
PIRiA39804.
RefSeqiNP_001001755.1. NM_001001755.1.
UniGeneiGga.797.

Genome annotation databases

GeneIDi414837.
KEGGigga:414837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60853 mRNA. Translation: AAA51437.1 .
PIRi A39804.
RefSeqi NP_001001755.1. NM_001001755.1.
UniGenei Gga.797.

3D structure databases

ProteinModelPortali P35440.
SMRi P35440. Positions 442-554, 557-1177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000036892.

Proteomic databases

PaxDbi P35440.
PRIDEi P35440.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414837.
KEGGi gga:414837.

Organism-specific databases

CTDi 7058.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000007542.
HOVERGENi HBG018006.
InParanoidi P35440.
KOi K04659.
PhylomeDBi P35440.

Enzyme and pathway databases

Reactomei REACT_258033. Signaling by PDGF.

Miscellaneous databases

NextBioi 20818734.
PROi P35440.

Gene expression databases

ExpressionAtlasi P35440. baseline.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR001791. Laminin_G.
IPR015455. Thrombospondin-2.
IPR000884. Thrombospondin_1_rpt.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_C.
[Graphical view ]
PANTHERi PTHR10199:SF10. PTHR10199:SF10. 1 hit.
Pfami PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEi PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of chicken thrombospondin."
    Lawler J., Duquette M., Ferro P.
    J. Biol. Chem. 266:8039-8043(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTSP2_CHICK
AccessioniPrimary (citable) accession number: P35440
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3