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P35440 (TSP2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thrombospondin-2
Gene names
Name:THBS2
Synonyms:TSP2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions By similarity.

Subunit structure

Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin and type V collagen By similarity.

Sequence similarities

Belongs to the thrombospondin family.

Contains 2 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 1 TSP C-terminal (TSPC) domain.

Contains 3 TSP type-1 domains.

Contains 8 TSP type-3 repeats.

Contains 1 VWFC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 11781156Thrombospondin-2
PRO_0000035848

Regions

Domain25 – 221197Laminin G-like
Domain324 – 38158VWFC
Domain387 – 43751TSP type-1 1
Domain443 – 49856TSP type-1 2
Domain500 – 55556TSP type-1 3
Domain555 – 59541EGF-like 1
Domain654 – 69845EGF-like 2
Repeat699 – 73436TSP type-3 1
Repeat735 – 77036TSP type-3 2
Repeat771 – 79323TSP type-3 3
Repeat794 – 82936TSP type-3 4
Repeat830 – 85223TSP type-3 5
Repeat853 – 89038TSP type-3 6
Repeat891 – 92636TSP type-3 7
Repeat927 – 96236TSP type-3 8
Domain966 – 1178213TSP C-terminal
Region? – 232Heparin-binding Potential
Motif934 – 9363Cell attachment site Potential

Amino acid modifications

Glycosylation1571N-linked (GlcNAc...) Potential
Glycosylation2441N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential
Glycosylation4631N-linked (GlcNAc...) Potential
Glycosylation5901N-linked (GlcNAc...) Potential
Glycosylation7161N-linked (GlcNAc...) Potential
Glycosylation10751N-linked (GlcNAc...) Potential
Disulfide bond272Interchain By similarity
Disulfide bond276Interchain By similarity
Disulfide bond399 ↔ 431 By similarity
Disulfide bond403 ↔ 436 By similarity
Disulfide bond414 ↔ 421 By similarity
Disulfide bond455 ↔ 492 By similarity
Disulfide bond459 ↔ 497 By similarity
Disulfide bond470 ↔ 482 By similarity
Disulfide bond512 ↔ 549 By similarity
Disulfide bond516 ↔ 554 By similarity
Disulfide bond527 ↔ 539 By similarity
Disulfide bond559 ↔ 570 By similarity
Disulfide bond564 ↔ 580 By similarity
Disulfide bond583 ↔ 594 By similarity
Disulfide bond600 ↔ 616 By similarity
Disulfide bond607 ↔ 625 By similarity
Disulfide bond628 ↔ 652 By similarity
Disulfide bond658 ↔ 671 By similarity
Disulfide bond665 ↔ 684 By similarity
Disulfide bond686 ↔ 697 By similarity
Disulfide bond713 ↔ 721 By similarity
Disulfide bond726 ↔ 746 By similarity
Disulfide bond762 ↔ 782 By similarity
Disulfide bond785 ↔ 805 By similarity
Disulfide bond821 ↔ 841 By similarity
Disulfide bond844 ↔ 864 By similarity
Disulfide bond882 ↔ 902 By similarity
Disulfide bond918 ↔ 938 By similarity
Disulfide bond954 ↔ 1175 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35440 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: F37E02F42C8717A2

FASTA1,178131,817
        10         20         30         40         50         60 
MLQRSRLLWL AVFITLWVSS DAQDDAKEEE NTFDLLQISN INRKTIGAKL FRGPDPAIPA 

        70         80         90        100        110        120 
YRFIRFDHIP PFKPEKLKKI VKLIRQNEGF ILSATLRQDR QSRGTILALE GPGISERQFE 

       130        140        150        160        170        180 
IISNGRANTL DLIYWVDGFQ NVISLEDVDL ADSQWKNLTV QVTGENYNLY VGCDLIDSFI 

       190        200        210        220        230        240 
LEEPFYEQLK AENSRMYVAK GSIRENHFRG LLQNIHLIFD TSIEDVLRKK GCQRSQSTEV 

       250        260        270        280        290        300 
NTINESTEIL HLSPAVTTEY VGEKTEKKAE FCDRSCEELG TMFTELTGLR IVVNNLADNL 

       310        320        330        340        350        360 
QKVSEENQIM WELIGPNKTL KNQSVCWQDG RVFADSESWI VDSCTKCTCQ DSKIVCHQIT 

       370        380        390        400        410        420 
CPPVSCADPS FIEGECCPVC SHSDDSEEGW SPWSDWTKCS VTCGSGTQMR GRSCDVTRSA 

       430        440        450        460        470        480 
CTGPHIQTRM CSFKKCDHRI RQDGGWSHWS PWSSCSVTCG VGNITRIRLC NSPIPQMGGK 

       490        500        510        520        530        540 
NCVGNGRETE KCEKAPCPVN GQWGPWSPWS ACTVTCGGGI RERSRLCNSP EPQYGGKPCV 

       550        560        570        580        590        600 
GDTKQHDMCN KRDCPIDGCL SNPCFPGAEC NSYPDGSWSC GPCPAGFLGN GTVCEDLDEC 

       610        620        630        640        650        660 
IAVSDVCFKV NQVHRCVNTN PGFHCLPCPP RYKGSQPYGV GLEVAKTEKQ VCEPENPCKD 

       670        680        690        700        710        720 
KTHSCHKSAE CIYLGHFSDP MYKCECRTGY AGDGRICGED SDLDGWPNNN LVCAANATYH 

       730        740        750        760        770        780 
CVKDNCPLLP NSGQEDFDKD GKGDACDEDD DNDGVEDDKD NCPLLFNPRQ FDYDKDEVGD 

       790        800        810        820        830        840 
RCDNCPYVHN PAQIDTDNNG EGDSCAVDID GDDIFNERDN CPYVYNTDQS DTDGDGVGDQ 

       850        860        870        880        890        900 
CDNCPLMHNP DQTDADNDLV GDQCDNNEDI DEDGHQNNQD NCPYIPNANQ ADHDKDGKGD 

       910        920        930        940        950        960 
ACDPDDDNDG IPDDRDNCRL RYNPEQEDSD GDGRGDICKD DFDDDNVPDI FDVCPENNAI 

       970        980        990       1000       1010       1020 
SETDFRKFQM VPLDPKGTAQ IDPNWVIRHQ GKELVQTANS DPGIAVGYDE FSSVDFSGTF 

      1030       1040       1050       1060       1070       1080 
YVNTDRDDDY AGFVFGYQSS SRFYVLMWKQ VTQTYWEDKP TRAYGYSGVS LKVVNSTTGT 

      1090       1100       1110       1120       1130       1140 
GEHLRNALWH TGNTPGQVRT LWHDPKNIGW KDYTAYRWHL IHRPKTGLIK VLVYEGKQVM 

      1150       1160       1170 
VDSGPIYDTT FAGGRLGLFV FSQEMVYFSD LKYECRDA 

« Hide

References

[1]"Cloning and sequencing of chicken thrombospondin."
Lawler J., Duquette M., Ferro P.
J. Biol. Chem. 266:8039-8043(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M60853 mRNA. Translation: AAA51437.1.
PIRA39804.
RefSeqNP_001001755.1. NM_001001755.1.
UniGeneGga.797.

3D structure databases

ProteinModelPortalP35440.
SMRP35440. Positions 442-554, 557-1177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000036892.

Proteomic databases

PaxDbP35440.
PRIDEP35440.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID414837.
KEGGgga:414837.

Organism-specific databases

CTD7058.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000007542.
HOVERGENHBG018006.
InParanoidP35440.
KOK04659.
PhylomeDBP35440.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR001791. Laminin_G.
IPR015455. Thrombospondin-2.
IPR000884. Thrombospondin_1_rpt.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR001007. VWF_C.
[Graphical view]
PANTHERPTHR10199:SF10. PTHR10199:SF10. 1 hit.
PfamPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818734.
PROP35440.

Entry information

Entry nameTSP2_CHICK
AccessionPrimary (citable) accession number: P35440
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families