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Protein

Thrombospondin-2

Gene

THBS2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-2
Gene namesi
Name:THBS2
Synonyms:TSP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003584823 – 1178Thrombospondin-2Add BLAST1156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Glycosylationi244N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi272InterchainBy similarity
Disulfide bondi276InterchainBy similarity
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi399 ↔ 431By similarity
Disulfide bondi403 ↔ 436By similarity
Disulfide bondi414 ↔ 421By similarity
Disulfide bondi455 ↔ 492By similarity
Disulfide bondi459 ↔ 497By similarity
Glycosylationi463N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi470 ↔ 482By similarity
Disulfide bondi512 ↔ 549By similarity
Disulfide bondi516 ↔ 554By similarity
Disulfide bondi527 ↔ 539By similarity
Disulfide bondi559 ↔ 570By similarity
Disulfide bondi564 ↔ 580By similarity
Disulfide bondi583 ↔ 594By similarity
Glycosylationi590N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi600 ↔ 616By similarity
Disulfide bondi607 ↔ 625By similarity
Disulfide bondi628 ↔ 652By similarity
Disulfide bondi658 ↔ 671By similarity
Disulfide bondi665 ↔ 684By similarity
Disulfide bondi686 ↔ 697By similarity
Disulfide bondi713 ↔ 721By similarity
Glycosylationi716N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi726 ↔ 746By similarity
Disulfide bondi762 ↔ 782By similarity
Disulfide bondi785 ↔ 805By similarity
Disulfide bondi821 ↔ 841By similarity
Disulfide bondi844 ↔ 864By similarity
Disulfide bondi882 ↔ 902By similarity
Disulfide bondi918 ↔ 938By similarity
Disulfide bondi954 ↔ 1175By similarity
Glycosylationi1075N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35440.
PRIDEiP35440.

Expressioni

Gene expression databases

BgeeiENSGALG00000011200.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036892.

Structurei

3D structure databases

ProteinModelPortaliP35440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 221Laminin G-likeAdd BLAST197
Domaini324 – 381VWFCPROSITE-ProRule annotationAdd BLAST58
Domaini387 – 437TSP type-1 1PROSITE-ProRule annotationAdd BLAST51
Domaini443 – 498TSP type-1 2PROSITE-ProRule annotationAdd BLAST56
Domaini500 – 555TSP type-1 3PROSITE-ProRule annotationAdd BLAST56
Domaini555 – 595EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini654 – 698EGF-like 2PROSITE-ProRule annotationAdd BLAST45
Repeati699 – 734TSP type-3 1Add BLAST36
Repeati735 – 770TSP type-3 2Add BLAST36
Repeati771 – 793TSP type-3 3Add BLAST23
Repeati794 – 829TSP type-3 4Add BLAST36
Repeati830 – 852TSP type-3 5Add BLAST23
Repeati853 – 890TSP type-3 6Add BLAST38
Repeati891 – 926TSP type-3 7Add BLAST36
Repeati927 – 962TSP type-3 8Add BLAST36
Domaini966 – 1178TSP C-terminalPROSITE-ProRule annotationAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni? – 232Heparin-bindingSequence analysis

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi934 – 936Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the thrombospondin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
Contains 3 TSP type-1 domains.PROSITE-ProRule annotation
Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFQQ. Eukaryota.
ENOG410XQKE. LUCA.
HOGENOMiHOG000007542.
HOVERGENiHBG018006.
InParanoidiP35440.
KOiK04659.
OrthoDBiEOG091G00TV.
PhylomeDBiP35440.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024731. EGF_dom.
IPR001791. Laminin_G.
IPR015455. Thrombospondin-2.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR000884. TSP1_rpt.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR10199:SF10. PTHR10199:SF10. 1 hit.
PfamiPF12947. EGF_3. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQRSRLLWL AVFITLWVSS DAQDDAKEEE NTFDLLQISN INRKTIGAKL
60 70 80 90 100
FRGPDPAIPA YRFIRFDHIP PFKPEKLKKI VKLIRQNEGF ILSATLRQDR
110 120 130 140 150
QSRGTILALE GPGISERQFE IISNGRANTL DLIYWVDGFQ NVISLEDVDL
160 170 180 190 200
ADSQWKNLTV QVTGENYNLY VGCDLIDSFI LEEPFYEQLK AENSRMYVAK
210 220 230 240 250
GSIRENHFRG LLQNIHLIFD TSIEDVLRKK GCQRSQSTEV NTINESTEIL
260 270 280 290 300
HLSPAVTTEY VGEKTEKKAE FCDRSCEELG TMFTELTGLR IVVNNLADNL
310 320 330 340 350
QKVSEENQIM WELIGPNKTL KNQSVCWQDG RVFADSESWI VDSCTKCTCQ
360 370 380 390 400
DSKIVCHQIT CPPVSCADPS FIEGECCPVC SHSDDSEEGW SPWSDWTKCS
410 420 430 440 450
VTCGSGTQMR GRSCDVTRSA CTGPHIQTRM CSFKKCDHRI RQDGGWSHWS
460 470 480 490 500
PWSSCSVTCG VGNITRIRLC NSPIPQMGGK NCVGNGRETE KCEKAPCPVN
510 520 530 540 550
GQWGPWSPWS ACTVTCGGGI RERSRLCNSP EPQYGGKPCV GDTKQHDMCN
560 570 580 590 600
KRDCPIDGCL SNPCFPGAEC NSYPDGSWSC GPCPAGFLGN GTVCEDLDEC
610 620 630 640 650
IAVSDVCFKV NQVHRCVNTN PGFHCLPCPP RYKGSQPYGV GLEVAKTEKQ
660 670 680 690 700
VCEPENPCKD KTHSCHKSAE CIYLGHFSDP MYKCECRTGY AGDGRICGED
710 720 730 740 750
SDLDGWPNNN LVCAANATYH CVKDNCPLLP NSGQEDFDKD GKGDACDEDD
760 770 780 790 800
DNDGVEDDKD NCPLLFNPRQ FDYDKDEVGD RCDNCPYVHN PAQIDTDNNG
810 820 830 840 850
EGDSCAVDID GDDIFNERDN CPYVYNTDQS DTDGDGVGDQ CDNCPLMHNP
860 870 880 890 900
DQTDADNDLV GDQCDNNEDI DEDGHQNNQD NCPYIPNANQ ADHDKDGKGD
910 920 930 940 950
ACDPDDDNDG IPDDRDNCRL RYNPEQEDSD GDGRGDICKD DFDDDNVPDI
960 970 980 990 1000
FDVCPENNAI SETDFRKFQM VPLDPKGTAQ IDPNWVIRHQ GKELVQTANS
1010 1020 1030 1040 1050
DPGIAVGYDE FSSVDFSGTF YVNTDRDDDY AGFVFGYQSS SRFYVLMWKQ
1060 1070 1080 1090 1100
VTQTYWEDKP TRAYGYSGVS LKVVNSTTGT GEHLRNALWH TGNTPGQVRT
1110 1120 1130 1140 1150
LWHDPKNIGW KDYTAYRWHL IHRPKTGLIK VLVYEGKQVM VDSGPIYDTT
1160 1170
FAGGRLGLFV FSQEMVYFSD LKYECRDA
Length:1,178
Mass (Da):131,817
Last modified:June 1, 1994 - v1
Checksum:iF37E02F42C8717A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60853 mRNA. Translation: AAA51437.1.
PIRiA39804.
RefSeqiNP_001001755.1. NM_001001755.1.
XP_015139539.1. XM_015284053.1.
UniGeneiGga.797.

Genome annotation databases

GeneIDi414837.
KEGGigga:414837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60853 mRNA. Translation: AAA51437.1.
PIRiA39804.
RefSeqiNP_001001755.1. NM_001001755.1.
XP_015139539.1. XM_015284053.1.
UniGeneiGga.797.

3D structure databases

ProteinModelPortaliP35440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036892.

Proteomic databases

PaxDbiP35440.
PRIDEiP35440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414837.
KEGGigga:414837.

Organism-specific databases

CTDi7058.

Phylogenomic databases

eggNOGiENOG410IFQQ. Eukaryota.
ENOG410XQKE. LUCA.
HOGENOMiHOG000007542.
HOVERGENiHBG018006.
InParanoidiP35440.
KOiK04659.
OrthoDBiEOG091G00TV.
PhylomeDBiP35440.

Miscellaneous databases

PROiP35440.

Gene expression databases

BgeeiENSGALG00000011200.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024731. EGF_dom.
IPR001791. Laminin_G.
IPR015455. Thrombospondin-2.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR000884. TSP1_rpt.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR10199:SF10. PTHR10199:SF10. 1 hit.
PfamiPF12947. EGF_3. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSP2_CHICK
AccessioniPrimary (citable) accession number: P35440
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.