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Protein

ATP synthase subunit delta, mitochondrial

Gene

Atp5f1d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

GO - Molecular functioni

  • ATPase activity Source: RGD
  • protein-containing complex binding Source: RGD
  • proton-transporting ATP synthase activity, rotational mechanism Source: RGD

GO - Biological processi

  • ATP biosynthetic process Source: RGD
  • ATP metabolic process Source: RGD
  • ATP synthesis coupled proton transport Source: RGD

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit delta, mitochondrialCurated
Alternative name(s):
ATP synthase F1 subunit deltaImported
F-ATPase delta subunit
Gene namesi
Name:Atp5f1dImported
Synonyms:Atp5d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621372 Atp5f1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22Mitochondrion1 PublicationAdd BLAST22
ChainiPRO_000000266423 – 168ATP synthase subunit delta, mitochondrialAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136N6-acetyllysine; alternateBy similarity1
Modified residuei136N6-succinyllysine; alternateBy similarity1
Modified residuei165N6-acetyllysine; alternateBy similarity1
Modified residuei165N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP35434
PRIDEiP35434

2D gel databases

UCD-2DPAGEP35434

PTM databases

iPTMnetiP35434
PhosphoSitePlusiP35434

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68.1 Publication

Protein-protein interaction databases

BioGridi251461, 1 interactor
CORUMiP35434
IntActiP35434, 2 interactors
MINTiP35434
STRINGi10116.ENSRNOP00000020670

Structurei

3D structure databases

ProteinModelPortaliP35434
SMRiP35434
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase epsilon chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1758 Eukaryota
COG0355 LUCA
HOGENOMiHOG000216023
HOVERGENiHBG001856
InParanoidiP35434
KOiK02134
PhylomeDBiP35434

Family and domain databases

CDDicd12152 F1-ATPase_delta, 1 hit
Gene3Di2.60.15.10, 1 hit
HAMAPiMF_00530 ATP_synth_epsil_bac, 1 hit
InterProiView protein in InterPro
IPR036794 ATP_F1_dsu/esu_C_sf
IPR001469 ATP_synth_F1_dsu/esu
IPR020546 ATP_synth_F1_dsu/esu_N
IPR036771 ATPsynth_dsu/esu_N
PANTHERiPTHR13822 PTHR13822, 1 hit
PfamiView protein in Pfam
PF02823 ATP-synt_DE_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000944 ATPase_F1-cplx_dsu/esu, 1 hit
SUPFAMiSSF46604 SSF46604, 1 hit
SSF51344 SSF51344, 1 hit
TIGRFAMsiTIGR01216 ATP_synt_epsi, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAALLRHP GLRRLVLQAR TYAQAAASPA PAAGPGQMSF TFASPTQVFF
60 70 80 90 100
DGANVRQVDV PTLTGAFGIL ASHVPTLQVL RPGLVMVHAE DGTTTKYFVS
110 120 130 140 150
SGSVTVNADS SVQLLAEEVV TLDMLDLGAA RANLEKAQSE LSGAADEAAR
160
AEIQIRIEAN EALVKALE
Length:168
Mass (Da):17,595
Last modified:February 1, 1996 - v2
Checksum:iC8628F8BF266F849
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24Q → E AA sequence (Ref. 3) Curated1
Sequence conflicti28S → A AA sequence (Ref. 3) Curated1
Sequence conflicti31P → S AA sequence (Ref. 3) Curated1
Sequence conflicti51D → N AA sequence (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00926 mRNA Translation: AAC28872.1
PIRiB33160
RefSeqiNP_620806.1, NM_139106.1
UniGeneiRn.3879

Genome annotation databases

GeneIDi245965
KEGGirno:245965
UCSCiRGD:621372 rat

Similar proteinsi

Entry informationi

Entry nameiATPD_RAT
AccessioniPrimary (citable) accession number: P35434
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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