Reviewed, UniProtKB/Swiss-Prot P35430 (AHD2_TETPY)

Names and origin

Protein names	Recommended name:     20-alpha-hydroxysteroid dehydrogenase       Short name=20-alpha-HSD     EC=1.1.1.149
Organism	Tetrahymena pyriformis
Taxonomic identifier	5908 [NCBI]
Taxonomic lineage	Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Hymenostomatida › Tetrahymenina › Tetrahymenidae › Tetrahymena

Protein attributes

Sequence length	18 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Specific for the oxidation of the 20-alpha hydroxy group of 17-alpha-hydroxyprogesterone and 17-alpha-hydroxypregnenolone.
Catalytic activity	17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17-alpha-hydroxyprogesterone + NAD(P)H.
Subunit structure	Homodimer.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	20-alpha-hydroxysteroid dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›18	›18	20-alpha-hydroxysteroid dehydrogenase		PRO_0000064503
Experimental info
	Non-terminal residue	18	1

Sequences

	Sequence		Length	Mass (Da)
	P35430-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 16DF6B287E3B0A0D	FASTA	18	1,861
	10 LAKTVPLNDG TNFPIFGG

References

[1]	"Purification and characterization of a novel dimeric 20 alpha-hydroxysteroid dehydrogenase from Tetrahymena pyriformis." Inazu A., Sato K., Nakayama Y., Hara A., Nozawa Y. Biochem. J. 297:195-200(1994) [PubMed: 8280099] [Abstract] Cited for: PROTEIN SEQUENCE, CHARACTERIZATION. Strain: W.

Cross-references

Sequence databases
PIR	S40502.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.149. 258.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

AHD2_TETPY

Accession

Primary (citable) accession number: P35430

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	January 20, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)