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Protein

Transcription factor HES-2

Gene

Hes2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription.

GO - Molecular functioni

  • double-stranded DNA binding Source: RGD
  • protein dimerization activity Source: InterPro
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-2
Alternative name(s):
Hairy and enhancer of split 2
Gene namesi
Name:Hes2
Synonyms:Hes-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi62082. Hes2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272081 – 157Transcription factor HES-2Add BLAST157

Proteomic databases

PaxDbiP35429.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010490.
GenevisibleiP35429. RN.

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

Protein-protein interaction databases

ELMiP35429.
STRINGi10116.ENSRNOP00000014035.

Structurei

3D structure databases

ProteinModelPortaliP35429.
SMRiP35429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 70bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini86 – 119OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi154 – 157WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 148Pro-rich10

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiKOG4304. Eukaryota.
ENOG4111F0X. LUCA.
GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiP35429.
KOiK09087.
OMAiEGYSACV.
OrthoDBiEOG091G0GBN.
PhylomeDBiP35429.
TreeFamiTF351373.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR003650. Orange_dom.
PfamiView protein in Pfam
PF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.

Sequencei

Sequence statusi: Complete.

P35429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPRGVGDA AELRKSLKPL LEKRRRARIN ESLSQLKGLV LPLLGAETSR
60 70 80 90 100
YSKLEKADIL EMTVRFLREQ PASVCSTEAP GSLDSYLEGY RACLARLARV
110 120 130 140 150
LPACSVLEPA VSARLLEHLR QRTVSGGPPS LTPASASAPA PSPPVPPPSS

LGLWRPW
Length:157
Mass (Da):17,028
Last modified:June 1, 1994 - v1
Checksum:iB5D621E814AE0369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14029 mRNA. Translation: BAA03118.1.
PIRiS35037.
RefSeqiNP_062109.1. NM_019236.1.
UniGeneiRn.44655.

Genome annotation databases

EnsembliENSRNOT00000014035; ENSRNOP00000014035; ENSRNOG00000010490.
GeneIDi29567.
KEGGirno:29567.
UCSCiRGD:62082. rat.

Similar proteinsi

Entry informationi

Entry nameiHES2_RAT
AccessioniPrimary (citable) accession number: P35429
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: August 30, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome