Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P35427 (RL13A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L13a
Gene names
Name:Rpl13a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex By similarity. HAMAP-Rule MF_01366

Subunit structure

Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 By similarity.

Post-translational modification

Phosphorylation at Ser-77 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition By similarity. HAMAP-Rule MF_01366

Citrullinated by PADI4 By similarity. HAMAP-Rule MF_01366

Sequence similarities

Belongs to the ribosomal protein L13P family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 20320260S ribosomal protein L13a HAMAP-Rule MF_01366
PRO_0000133773

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue591Citrulline By similarity
Modified residue771Phosphoserine By similarity
Modified residue1401Citrulline By similarity
Modified residue1911N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P35427 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 2EEFA27AF6303727

FASTA20323,476
        10         20         30         40         50         60 
MAEGQVLVLD GRSHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN KLKYLAFLRK 

        70         80         90        100        110        120 
RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALE RLKVLDGIPP PYDKKKRMVV 

       130        140        150        160        170        180 
PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ AVTATLEEKR KEKAKIHYRK KKQLLRLRKQ 

       190        200 
AEKNVEKKIC KFTEVLKTNG LLV 

« Hide

References

[1]"A leucine zipper-like motif and a basic region-leucine zipper-like element in rat ribosomal protein L13a. Identification of the tum-transplantation antigen P198."
Chan Y.-L., Olvera J., Glueck A., Wool I.G.
J. Biol. Chem. 269:5589-5594(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-12.
Strain: Sprague-Dawley.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68282 mRNA. Translation: CAA48343.1.
PIRA53204.
UniGeneRn.92211.

3D structure databases

ProteinModelPortalP35427.
SMRP35427. Positions 7-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP35427. 1 interaction.
MINTMINT-4565273.
STRING10116.ENSRNOP00000027976.

PTM databases

PhosphoSiteP35427.

Proteomic databases

PaxDbP35427.
PRIDEP35427.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:628697. rat.

Organism-specific databases

RGD628697. Rpl13a.

Phylogenomic databases

eggNOGCOG0102.
HOGENOMHOG000225289.
HOVERGENHBG062176.
InParanoidP35427.
PhylomeDBP35427.

Gene expression databases

GenevestigatorP35427.

Family and domain databases

Gene3D3.90.1180.10. 1 hit.
HAMAPMF_01366. Ribosomal_L13.
InterProIPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR023564. Ribosomal_L13_dom.
IPR005755. Ribosomal_L13_euk/arc.
[Graphical view]
PANTHERPTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
PfamPF00572. Ribosomal_L13. 1 hit.
[Graphical view]
SUPFAMSSF52161. SSF52161. 1 hit.
TIGRFAMsTIGR01077. L13_A_E. 1 hit.
PROSITEPS00783. RIBOSOMAL_L13. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP35427.

Entry information

Entry nameRL13A_RAT
AccessionPrimary (citable) accession number: P35427
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries