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Protein

60S ribosomal protein L13a

Gene

Rpl13a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity).By similarity

GO - Molecular functioni

  • structural constituent of ribosome Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13a
Gene namesi
Name:Rpl13a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628697. Rpl13a.

Subcellular locationi

GO - Cellular componenti

  • GAIT complex Source: UniProtKB
  • large ribosomal subunit Source: InterPro
  • ribosome Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity1 Publication
Chaini2 – 20320260S ribosomal protein L13aPRO_0000133773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei59 – 591CitrullineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei140 – 1401CitrullineBy similarity
Modified residuei191 – 1911N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylation at Ser-77 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.By similarity
Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

PaxDbiP35427.
PRIDEiP35427.

PTM databases

PhosphoSiteiP35427.

Expressioni

Gene expression databases

GenevestigatoriP35427.

Interactioni

Subunit structurei

Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 (By similarity).By similarity

Protein-protein interaction databases

IntActiP35427. 1 interaction.
MINTiMINT-4565273.
STRINGi10116.ENSRNOP00000027976.

Structurei

3D structure databases

ProteinModelPortaliP35427.
SMRiP35427. Positions 7-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L13P family.Curated

Phylogenomic databases

eggNOGiCOG0102.
HOGENOMiHOG000225289.
HOVERGENiHBG062176.
InParanoidiP35427.
PhylomeDBiP35427.

Family and domain databases

Gene3Di3.90.1180.10. 1 hit.
HAMAPiMF_01366. Ribosomal_L13.
InterProiIPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR023564. Ribosomal_L13_dom.
IPR005755. Ribosomal_L13_euk/arc.
[Graphical view]
PANTHERiPTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
PfamiPF00572. Ribosomal_L13. 1 hit.
[Graphical view]
SUPFAMiSSF52161. SSF52161. 1 hit.
TIGRFAMsiTIGR01077. L13_A_E. 1 hit.
PROSITEiPS00783. RIBOSOMAL_L13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGQVLVLD GRSHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN
60 70 80 90 100
KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALE
110 120 130 140 150
RLKVLDGIPP PYDKKKRMVV PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ
160 170 180 190 200
AVTATLEEKR KEKAKIHYRK KKQLLRLRKQ AEKNVEKKIC KFTEVLKTNG

LLV
Length:203
Mass (Da):23,476
Last modified:January 23, 2007 - v2
Checksum:i2EEFA27AF6303727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68282 mRNA. Translation: CAA48343.1.
PIRiA53204.
UniGeneiRn.92211.

Genome annotation databases

UCSCiRGD:628697. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68282 mRNA. Translation: CAA48343.1.
PIRiA53204.
UniGeneiRn.92211.

3D structure databases

ProteinModelPortaliP35427.
SMRiP35427. Positions 7-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35427. 1 interaction.
MINTiMINT-4565273.
STRINGi10116.ENSRNOP00000027976.

PTM databases

PhosphoSiteiP35427.

Proteomic databases

PaxDbiP35427.
PRIDEiP35427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:628697. rat.

Organism-specific databases

RGDi628697. Rpl13a.

Phylogenomic databases

eggNOGiCOG0102.
HOGENOMiHOG000225289.
HOVERGENiHBG062176.
InParanoidiP35427.
PhylomeDBiP35427.

Miscellaneous databases

PROiP35427.

Gene expression databases

GenevestigatoriP35427.

Family and domain databases

Gene3Di3.90.1180.10. 1 hit.
HAMAPiMF_01366. Ribosomal_L13.
InterProiIPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR023564. Ribosomal_L13_dom.
IPR005755. Ribosomal_L13_euk/arc.
[Graphical view]
PANTHERiPTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
PfamiPF00572. Ribosomal_L13. 1 hit.
[Graphical view]
SUPFAMiSSF52161. SSF52161. 1 hit.
TIGRFAMsiTIGR01077. L13_A_E. 1 hit.
PROSITEiPS00783. RIBOSOMAL_L13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A leucine zipper-like motif and a basic region-leucine zipper-like element in rat ribosomal protein L13a. Identification of the tum-transplantation antigen P198."
    Chan Y.-L., Olvera J., Glueck A., Wool I.G.
    J. Biol. Chem. 269:5589-5594(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-12.
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiRL13A_RAT
AccessioniPrimary (citable) accession number: P35427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.