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P35427

- RL13A_RAT

UniProt

P35427 - RL13A_RAT

Protein

60S ribosomal protein L13a

Gene

Rpl13a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex By similarity.By similarity

    GO - Molecular functioni

    1. structural constituent of ribosome Source: RGD

    GO - Biological processi

    1. negative regulation of formation of translation preinitiation complex Source: UniProtKB
    2. negative regulation of translation Source: UniProtKB
    3. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Biological processi

    Translation regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L13a
    Gene namesi
    Name:Rpl13a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628697. Rpl13a.

    Subcellular locationi

    GO - Cellular componenti

    1. GAIT complex Source: UniProtKB
    2. large ribosomal subunit Source: InterPro
    3. ribosome Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 20320260S ribosomal protein L13aPRO_0000133773Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei59 – 591CitrullineBy similarity
    Modified residuei77 – 771PhosphoserineBy similarity
    Modified residuei140 – 1401CitrullineBy similarity
    Modified residuei191 – 1911N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-77 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.By similarity
    Citrullinated by PADI4.By similarity

    Keywords - PTMi

    Acetylation, Citrullination, Phosphoprotein

    Proteomic databases

    PaxDbiP35427.
    PRIDEiP35427.

    PTM databases

    PhosphoSiteiP35427.

    Expressioni

    Gene expression databases

    GenevestigatoriP35427.

    Interactioni

    Subunit structurei

    Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiP35427. 1 interaction.
    MINTiMINT-4565273.
    STRINGi10116.ENSRNOP00000027976.

    Structurei

    3D structure databases

    ProteinModelPortaliP35427.
    SMRiP35427. Positions 7-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L13P family.Curated

    Phylogenomic databases

    eggNOGiCOG0102.
    HOGENOMiHOG000225289.
    HOVERGENiHBG062176.
    InParanoidiP35427.
    PhylomeDBiP35427.

    Family and domain databases

    Gene3Di3.90.1180.10. 1 hit.
    HAMAPiMF_01366. Ribosomal_L13.
    InterProiIPR005822. Ribosomal_L13.
    IPR023563. Ribosomal_L13_CS.
    IPR023564. Ribosomal_L13_dom.
    IPR005755. Ribosomal_L13_euk/arc.
    [Graphical view]
    PANTHERiPTHR11545. PTHR11545. 1 hit.
    PTHR11545:SF3. PTHR11545:SF3. 1 hit.
    PfamiPF00572. Ribosomal_L13. 1 hit.
    [Graphical view]
    SUPFAMiSSF52161. SSF52161. 1 hit.
    TIGRFAMsiTIGR01077. L13_A_E. 1 hit.
    PROSITEiPS00783. RIBOSOMAL_L13. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35427-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEGQVLVLD GRSHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN    50
    KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALE 100
    RLKVLDGIPP PYDKKKRMVV PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ 150
    AVTATLEEKR KEKAKIHYRK KKQLLRLRKQ AEKNVEKKIC KFTEVLKTNG 200
    LLV 203
    Length:203
    Mass (Da):23,476
    Last modified:January 23, 2007 - v2
    Checksum:i2EEFA27AF6303727
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68282 mRNA. Translation: CAA48343.1.
    PIRiA53204.
    UniGeneiRn.92211.

    Genome annotation databases

    UCSCiRGD:628697. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68282 mRNA. Translation: CAA48343.1 .
    PIRi A53204.
    UniGenei Rn.92211.

    3D structure databases

    ProteinModelPortali P35427.
    SMRi P35427. Positions 7-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P35427. 1 interaction.
    MINTi MINT-4565273.
    STRINGi 10116.ENSRNOP00000027976.

    PTM databases

    PhosphoSitei P35427.

    Proteomic databases

    PaxDbi P35427.
    PRIDEi P35427.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:628697. rat.

    Organism-specific databases

    RGDi 628697. Rpl13a.

    Phylogenomic databases

    eggNOGi COG0102.
    HOGENOMi HOG000225289.
    HOVERGENi HBG062176.
    InParanoidi P35427.
    PhylomeDBi P35427.

    Miscellaneous databases

    PROi P35427.

    Gene expression databases

    Genevestigatori P35427.

    Family and domain databases

    Gene3Di 3.90.1180.10. 1 hit.
    HAMAPi MF_01366. Ribosomal_L13.
    InterProi IPR005822. Ribosomal_L13.
    IPR023563. Ribosomal_L13_CS.
    IPR023564. Ribosomal_L13_dom.
    IPR005755. Ribosomal_L13_euk/arc.
    [Graphical view ]
    PANTHERi PTHR11545. PTHR11545. 1 hit.
    PTHR11545:SF3. PTHR11545:SF3. 1 hit.
    Pfami PF00572. Ribosomal_L13. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52161. SSF52161. 1 hit.
    TIGRFAMsi TIGR01077. L13_A_E. 1 hit.
    PROSITEi PS00783. RIBOSOMAL_L13. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A leucine zipper-like motif and a basic region-leucine zipper-like element in rat ribosomal protein L13a. Identification of the tum-transplantation antigen P198."
      Chan Y.-L., Olvera J., Glueck A., Wool I.G.
      J. Biol. Chem. 269:5589-5594(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-12.
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiRL13A_RAT
    AccessioniPrimary (citable) accession number: P35427
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Ribosomal proteins
      Ribosomal proteins families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3