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P35427

- RL13A_RAT

UniProt

P35427 - RL13A_RAT

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Protein

60S ribosomal protein L13a

Gene
Rpl13a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex By similarity.UniRule annotation

GO - Molecular functioni

  1. structural constituent of ribosome Source: RGD

GO - Biological processi

  1. negative regulation of formation of translation preinitiation complex Source: UniProtKB
  2. negative regulation of translation Source: UniProtKB
  3. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13a
Gene namesi
Name:Rpl13a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628697. Rpl13a.

Subcellular locationi

GO - Cellular componenti

  1. GAIT complex Source: UniProtKB
  2. large ribosomal subunit Source: InterPro
  3. ribosome Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 20320260S ribosomal protein L13aUniRule annotationPRO_0000133773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei59 – 591Citrulline By similarity
Modified residuei77 – 771Phosphoserine By similarity
Modified residuei140 – 1401Citrulline By similarity
Modified residuei191 – 1911N6-acetyllysine By similarity

Post-translational modificationi

Phosphorylation at Ser-77 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition By similarity.UniRule annotation
Citrullinated by PADI4 By similarity.UniRule annotation

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

PaxDbiP35427.
PRIDEiP35427.

PTM databases

PhosphoSiteiP35427.

Expressioni

Gene expression databases

GenevestigatoriP35427.

Interactioni

Subunit structurei

Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 By similarity.

Protein-protein interaction databases

IntActiP35427. 1 interaction.
MINTiMINT-4565273.
STRINGi10116.ENSRNOP00000027976.

Structurei

3D structure databases

ProteinModelPortaliP35427.
SMRiP35427. Positions 7-142.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0102.
HOGENOMiHOG000225289.
HOVERGENiHBG062176.
InParanoidiP35427.
PhylomeDBiP35427.

Family and domain databases

Gene3Di3.90.1180.10. 1 hit.
HAMAPiMF_01366. Ribosomal_L13.
InterProiIPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR023564. Ribosomal_L13_dom.
IPR005755. Ribosomal_L13_euk/arc.
[Graphical view]
PANTHERiPTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
PfamiPF00572. Ribosomal_L13. 1 hit.
[Graphical view]
SUPFAMiSSF52161. SSF52161. 1 hit.
TIGRFAMsiTIGR01077. L13_A_E. 1 hit.
PROSITEiPS00783. RIBOSOMAL_L13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35427-1 [UniParc]FASTAAdd to Basket

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MAEGQVLVLD GRSHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN    50
KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALE 100
RLKVLDGIPP PYDKKKRMVV PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ 150
AVTATLEEKR KEKAKIHYRK KKQLLRLRKQ AEKNVEKKIC KFTEVLKTNG 200
LLV 203
Length:203
Mass (Da):23,476
Last modified:January 23, 2007 - v2
Checksum:i2EEFA27AF6303727
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68282 mRNA. Translation: CAA48343.1.
PIRiA53204.
UniGeneiRn.92211.

Genome annotation databases

UCSCiRGD:628697. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68282 mRNA. Translation: CAA48343.1 .
PIRi A53204.
UniGenei Rn.92211.

3D structure databases

ProteinModelPortali P35427.
SMRi P35427. Positions 7-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P35427. 1 interaction.
MINTi MINT-4565273.
STRINGi 10116.ENSRNOP00000027976.

PTM databases

PhosphoSitei P35427.

Proteomic databases

PaxDbi P35427.
PRIDEi P35427.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:628697. rat.

Organism-specific databases

RGDi 628697. Rpl13a.

Phylogenomic databases

eggNOGi COG0102.
HOGENOMi HOG000225289.
HOVERGENi HBG062176.
InParanoidi P35427.
PhylomeDBi P35427.

Miscellaneous databases

PROi P35427.

Gene expression databases

Genevestigatori P35427.

Family and domain databases

Gene3Di 3.90.1180.10. 1 hit.
HAMAPi MF_01366. Ribosomal_L13.
InterProi IPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR023564. Ribosomal_L13_dom.
IPR005755. Ribosomal_L13_euk/arc.
[Graphical view ]
PANTHERi PTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
Pfami PF00572. Ribosomal_L13. 1 hit.
[Graphical view ]
SUPFAMi SSF52161. SSF52161. 1 hit.
TIGRFAMsi TIGR01077. L13_A_E. 1 hit.
PROSITEi PS00783. RIBOSOMAL_L13. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A leucine zipper-like motif and a basic region-leucine zipper-like element in rat ribosomal protein L13a. Identification of the tum-transplantation antigen P198."
    Chan Y.-L., Olvera J., Glueck A., Wool I.G.
    J. Biol. Chem. 269:5589-5594(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-12.
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiRL13A_RAT
AccessioniPrimary (citable) accession number: P35427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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