true1994-06-012022-12-1468NSP1_ROTSPComparative analysis of the rotavirus NS53 gene: conservation of basic and cysteine-rich regions in the protein and possible stem-loop structures in the RNA.Hua J.J.Mansell E.E.Patton J.T.doi:10.1006/viro.1993.14921993Virology196372-378NUCLEOTIDE SEQUENCE [GENOMIC RNA]ROTA_NSP1Rotavirus_NSP1Rota_NS53Non-structural protein 1NSP1NCVP2Non-structural RNA-binding protein 53NS53Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation. Interacts with host CUL1 and CUL3.The integrity of the zinc-binding domain in NSP1 is important for degradation of host IRF3.The pLxIS motif targets host IRF3 for degradation; however phosphorylation of NSP1 pLxIS motif is not required for its activity.Belongs to the rotavirus NSP1 family.Non-structural protein 1585141495RNA-binding81Zinc-binding domain4279Important for cytoskeleton localization82177Interaction with host IRF3320pLxIS motif4854881994-06-01158514e1d6d5a7d092fbf6eea84be2ad3a8a70MATFKDACFHYRRLTALNRRLCNIGANSIWMPVPDAKIKGWCLECCQIADLTHCYGCSLPHVCKWCVQNRRCFLDNEPHLLKLQQLKHPITKDKLQCIIDLYNIIFPINDKVIRKFERMIKQRECRNQYKIEWYNHKLLPITLNAAAFKFDENNLYYVFGLYEKSVSDIYAPYRIVNFINEFDKLLLDHINFTRMSNLPIELRAITQEYFQLSRLPSSKLKQIYFSDFTKETVIFNTYTKTPGRSIYRNVTEFNWRDELELYTDLKNDKNKLIAAMMTSKYTRFYAHDNNFGRLKMTIFELGHHCQPNYVASNHPGNASDIQYCKWCNIKYFLSKIDWRIRDMYNLLMEFIKDCYKSNVNVGHCSSVENIYPLIKRLIWSLFTNHMDQTIEEVFNHMSPVSVEGTNVIMLILGLNISLYNEIKRTLNVDSIPMVLNLNEFSSIVKSISSKWYNVDELDKLPMSIKSTEELIEMKNSGTLTEEFELLISNSEDDNEtrue