Apelin receptor - Homo sapiens (Human)

Contribute

Send feedback

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P35414 (APJ_HUMAN)

Last modified December 15, 2009. Version 86. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
    Apelin receptor
Alternative name(s):
    G-protein coupled receptor APJ
    Angiotensin receptor-like 1
    HG11

Gene names

Name:	APLNR
Synonyms:	AGTRL1, APJ

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Hide | Top

General annotation (Comments)

Function	Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Hide | Top

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from Experiment. Source: Reactome
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	G-protein coupled receptor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 380

380

Apelin receptor

PRO_0000069173

Regions

Topological domain

1 – 26

Extracellular Potential

Transmembrane

27 – 51

1 Potential

Topological domain

52 – 66

Cytoplasmic Potential

Transmembrane

67 – 91

2 Potential

Topological domain

92 – 100

Extracellular Potential

Transmembrane

101 – 125

3 Potential

Topological domain

126 – 144

Cytoplasmic Potential

Transmembrane

145 – 166

4 Potential

Topological domain

167 – 200

Extracellular Potential

Transmembrane

201 – 221

5 Potential

Topological domain

222 – 244

Cytoplasmic Potential

Transmembrane

245 – 271

6 Potential

Topological domain

272 – 284

Extracellular Potential

Transmembrane

285 – 308

7 Potential

Topological domain

309 – 380

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

175

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

300

V → I: dbSNP rs7943508.

VAR_049375

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

P35414-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 78DB18BEA6D2B2E4
Show »

FASTA

380

42,660

        10         20         30         40         50         60 
MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK 

        70         80         90        100        110        120 
RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL 

       130        140        150        160        170        180 
TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ 

       190        200        210        220        230        240 
CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL 

       250        260        270        280        290        300 
RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 

       310        320        330        340        350        360 
NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK 

       370        380 
GGEQMHEKSI PYSQETLVVD

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11." O'Dowd B.F., Heiber M., Chan A., Heng H.H.Q., Tsui L.-C., Kennedy J.L., Shi X., Petronis A., George S.R., Nguyen T. Gene 136:355-360(1993) [PubMed: 8294032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular cloning and tissue distribution of a human orphan receptor belonging to the G protein coupled receptors family." Eggerickx D., Schurmans S., Vassart G., Parmentier M. Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
	U03642 Genomic DNA. Translation: AAA18954.1. X89271 mRNA. Translation: CAA61546.1. BC032688 mRNA. Translation: AAH32688.1.
IPI	IPI00018672.
PIR	I38435.
RefSeq	NP_005152.1.
UniGene	Hs.438311
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P35414.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P35414.
Genome annotation databases
Ensembl	ENST00000257254; ENSP00000257254; ENSG00000134817; Homo sapiens. [Genome view]
GeneID	187.
KEGG	hsa:187.
UCSC	uc001njo.1. human.
Organism-specific databases
CTD	187.
GeneCards	GC11M056758.
H-InvDB	HIX0009631.
HGNC	HGNC:339. APLNR.
MIM	600052. gene.
PharmGKB	PA24631.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG715940.
HOVERGEN	P35414.
InParanoid	P35414.
OMA	HLVKTLY.
OrthoDB	EOG94N1B8.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P35414.
Bgee	P35414.
CleanEx	HS_APLNR.
Genevestigator	P35414.
GermOnline	ENSG00000134817. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR020279. Apelin_receptor_C. IPR003904. APJ_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01416. APJRECEPTOR. PR00237. GPCRRHODOPSN.
ProDom	PD061381. Apelin_receptor_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	768.
SOURCE	Search...

Hide | Top

Entry information

Entry name

APJ_HUMAN

Accession

Primary (citable) accession number: P35414

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	December 15, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top