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Reviewed, UniProtKB/Swiss-Prot P35414 (APJ_HUMAN)

Last modified December 15, 2009. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Apelin receptor
Alternative name(s):
    G-protein coupled receptor APJ
    Angiotensin receptor-like 1
    HG11
Gene names
Name: APLNR
Synonyms: AGTRL1, APJ
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processG-protein coupled receptor protein signaling pathway

Inferred from Experiment. Source: Reactome

   Cellular componentintegral to plasma membrane Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionG-protein coupled receptor activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Apelin receptor
PRO_0000069173

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 51251 Potential
Topological domain52 – 6615Cytoplasmic Potential
Transmembrane67 – 91252 Potential
Topological domain92 – 1009Extracellular Potential
Transmembrane101 – 125253 Potential
Topological domain126 – 14419Cytoplasmic Potential
Transmembrane145 – 166224 Potential
Topological domain167 – 20034Extracellular Potential
Transmembrane201 – 221215 Potential
Topological domain222 – 24423Cytoplasmic Potential
Transmembrane245 – 271276 Potential
Topological domain272 – 28413Extracellular Potential
Transmembrane285 – 308247 Potential
Topological domain309 – 38072Cytoplasmic Potential

Amino acid modifications

Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation1751N-linked (GlcNAc...) Potential

Natural variations

Natural variant3001V → I: dbSNP rs7943508.
VAR_049375

Sequences

Sequence LengthMass (Da)Tools
P35414-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 78DB18BEA6D2B2E4

FASTA38042,660
        10         20         30         40         50         60 
MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK 

        70         80         90        100        110        120 
RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL 

       130        140        150        160        170        180 
TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ 

       190        200        210        220        230        240 
CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL 

       250        260        270        280        290        300 
RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 

       310        320        330        340        350        360 
NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK 

       370        380 
GGEQMHEKSI PYSQETLVVD 

« Hide

References

« Hide 'large scale' references
[1]"A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11."
O'Dowd B.F., Heiber M., Chan A., Heng H.H.Q., Tsui L.-C., Kennedy J.L., Shi X., Petronis A., George S.R., Nguyen T.
Gene 136:355-360(1993) [PubMed: 8294032] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning and tissue distribution of a human orphan receptor belonging to the G protein coupled receptors family."
Eggerickx D., Schurmans S., Vassart G., Parmentier M.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

U03642 Genomic DNA. Translation: AAA18954.1.
X89271 mRNA. Translation: CAA61546.1.
BC032688 mRNA. Translation: AAH32688.1.
IPIIPI00018672.
PIRI38435.
RefSeqNP_005152.1.
UniGeneHs.438311

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP35414.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP35414.

Genome annotation databases

EnsemblENST00000257254; ENSP00000257254; ENSG00000134817; Homo sapiens. [Genome view]
GeneID187.
KEGGhsa:187.
UCSCuc001njo.1. human.

Organism-specific databases

CTD187.
GeneCardsGC11M056758.
H-InvDBHIX0009631.
HGNCHGNC:339. APLNR.
MIM600052. gene.
PharmGKBPA24631.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG715940.
HOVERGENP35414.
InParanoidP35414.
OMAHLVKTLY.
OrthoDBEOG94N1B8.

Enzyme and pathway databases

ReactomeREACT_14797. Signaling by GPCR.

Gene expression databases

ArrayExpressP35414.
BgeeP35414.
CleanExHS_APLNR.
GenevestigatorP35414.
GermOnlineENSG00000134817. Homo sapiens.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR020279. Apelin_receptor_C.
IPR003904. APJ_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01416. APJRECEPTOR.
PR00237. GPCRRHODOPSN.
ProDomPD061381. Apelin_receptor_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio768.
SOURCESearch...

Entry information

Entry nameAPJ_HUMAN
AccessionPrimary (citable) accession number: P35414
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 15, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents