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P35414

- APJ_HUMAN

UniProt

P35414 - APJ_HUMAN

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Protein

Apelin receptor

Gene

APLNR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. receptor activity Source: ProtInc

GO - Biological processi

  1. gastrulation Source: UniProtKB-KW
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. heart development Source: UniProtKB
  4. regulation of body fluid levels Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Gastrulation

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Protein family/group databases

TCDBi9.A.14.13.10. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Apelin receptor
Alternative name(s):
Angiotensin receptor-like 1
G-protein coupled receptor APJ
G-protein coupled receptor HG11
Gene namesi
Name:APLNR
Synonyms:AGTRL1, APJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:339. APLNR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 5125Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini52 – 6615CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei67 – 9125Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 1009ExtracellularSequence Analysis
Transmembranei101 – 12525Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini126 – 14419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16622Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini167 – 20034ExtracellularSequence AnalysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini222 – 24423CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 27127Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini272 – 28413ExtracellularSequence AnalysisAdd
BLAST
Transmembranei285 – 30824Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 38072CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376687.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Apelin receptorPRO_0000069173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35414.
PRIDEiP35414.

PTM databases

PhosphoSiteiP35414.

Expressioni

Tissue specificityi

Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.

Gene expression databases

BgeeiP35414.
CleanExiHS_APLNR.
GenevestigatoriP35414.

Organism-specific databases

HPAiCAB025842.

Interactioni

Protein-protein interaction databases

IntActiP35414. 2 interactions.
MINTiMINT-6630838.
STRINGi9606.ENSP00000257254.

Structurei

Secondary structure

1
380
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 124Combined sources
Helixi13 – 164Combined sources
Beta strandi18 – 203Combined sources
Turni21 – 233Combined sources
Helixi24 – 274Combined sources
Beta strandi29 – 313Combined sources
Helixi32 – 376Combined sources
Turni38 – 447Combined sources
Beta strandi45 – 484Combined sources
Helixi49 – 557Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LOTNMR-A1-55[»]
2LOUNMR-A1-55[»]
2LOVNMR-A1-55[»]
2LOWNMR-A1-55[»]
ProteinModelPortaliP35414.
SMRiP35414. Positions 1-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG304842.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP35414.
KOiK04174.
OMAiNVFPYCT.
OrthoDBiEOG7Z0JWM.
PhylomeDBiP35414.
TreeFamiTF330024.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR020279. Apelin_receptor_C.
IPR003904. APJ_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01416. APJRECEPTOR.
PR00237. GPCRRHODOPSN.
ProDomiPD061381. Apelin_receptor_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35414-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL
60 70 80 90 100
WTVFRSSREK RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF
110 120 130 140 150
FCKLSSYLIF VNMYASVFCL TGLSFDRYLA IVRPVANARL RLRVSGAVAT
160 170 180 190 200
AVLWVLAALL AMPVMVLRTT GDLENTTKVQ CYMDYSMVAT VSSEWAWEVG
210 220 230 240 250
LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL RKRRRLLSII
260 270 280 290 300
VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV
310 320 330 340 350
NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH
360 370 380
SQGPGPNMGK GGEQMHEKSI PYSQETLVVD
Length:380
Mass (Da):42,660
Last modified:June 1, 1994 - v1
Checksum:i78DB18BEA6D2B2E4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti300 – 3001V → I.
Corresponds to variant rs7943508 [ dbSNP | Ensembl ].
VAR_049375

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03642 Genomic DNA. Translation: AAA18954.1.
X89271 mRNA. Translation: CAA61546.1.
BC032688 mRNA. Translation: AAH32688.1.
CCDSiCCDS7950.1.
PIRiI38435.
RefSeqiNP_005152.1. NM_005161.4.
UniGeneiHs.438311.

Genome annotation databases

EnsembliENST00000257254; ENSP00000257254; ENSG00000134817.
ENST00000606794; ENSP00000475344; ENSG00000134817.
ENST00000611099; ENSP00000477818; ENSG00000134817.
GeneIDi187.
KEGGihsa:187.
UCSCiuc001njo.3. human.

Polymorphism databases

DMDMi543823.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03642 Genomic DNA. Translation: AAA18954.1 .
X89271 mRNA. Translation: CAA61546.1 .
BC032688 mRNA. Translation: AAH32688.1 .
CCDSi CCDS7950.1.
PIRi I38435.
RefSeqi NP_005152.1. NM_005161.4.
UniGenei Hs.438311.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LOT NMR - A 1-55 [» ]
2LOU NMR - A 1-55 [» ]
2LOV NMR - A 1-55 [» ]
2LOW NMR - A 1-55 [» ]
ProteinModelPortali P35414.
SMRi P35414. Positions 1-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P35414. 2 interactions.
MINTi MINT-6630838.
STRINGi 9606.ENSP00000257254.

Chemistry

BindingDBi P35414.
ChEMBLi CHEMBL1628481.
GuidetoPHARMACOLOGYi 36.

Protein family/group databases

TCDBi 9.A.14.13.10. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei P35414.

Polymorphism databases

DMDMi 543823.

Proteomic databases

PaxDbi P35414.
PRIDEi P35414.

Protocols and materials databases

DNASUi 187.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257254 ; ENSP00000257254 ; ENSG00000134817 .
ENST00000606794 ; ENSP00000475344 ; ENSG00000134817 .
ENST00000611099 ; ENSP00000477818 ; ENSG00000134817 .
GeneIDi 187.
KEGGi hsa:187.
UCSCi uc001njo.3. human.

Organism-specific databases

CTDi 187.
GeneCardsi GC11M057001.
HGNCi HGNC:339. APLNR.
HPAi CAB025842.
MIMi 600052. gene.
neXtProti NX_P35414.
PharmGKBi PA162376687.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304842.
GeneTreei ENSGT00760000119055.
HOGENOMi HOG000234122.
HOVERGENi HBG104998.
InParanoidi P35414.
KOi K04174.
OMAi NVFPYCT.
OrthoDBi EOG7Z0JWM.
PhylomeDBi P35414.
TreeFami TF330024.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi APLNR. human.
GeneWikii Apelin_receptor.
GenomeRNAii 187.
NextBioi 768.
PROi P35414.
SOURCEi Search...

Gene expression databases

Bgeei P35414.
CleanExi HS_APLNR.
Genevestigatori P35414.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR020279. Apelin_receptor_C.
IPR003904. APJ_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01416. APJRECEPTOR.
PR00237. GPCRRHODOPSN.
ProDomi PD061381. Apelin_receptor_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11."
    O'Dowd B.F., Heiber M., Chan A., Heng H.H.Q., Tsui L.-C., Kennedy J.L., Shi X., Petronis A., George S.R., Nguyen T.
    Gene 136:355-360(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning and tissue distribution of a human orphan receptor belonging to the G protein coupled receptors family."
    Eggerickx D., Schurmans S., Vassart G., Parmentier M.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiAPJ_HUMAN
AccessioniPrimary (citable) accession number: P35414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 26, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3