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P35414

- APJ_HUMAN

UniProt

P35414 - APJ_HUMAN

Protein

Apelin receptor

Gene

APLNR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. receptor activity Source: ProtInc

    GO - Biological processi

    1. gastrulation Source: UniProtKB-KW
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. heart development Source: UniProtKB
    4. regulation of body fluid levels Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Gastrulation

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Protein family/group databases

    TCDBi9.A.14.13.10. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apelin receptor
    Alternative name(s):
    Angiotensin receptor-like 1
    G-protein coupled receptor APJ
    G-protein coupled receptor HG11
    Gene namesi
    Name:APLNR
    Synonyms:AGTRL1, APJ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:339. APLNR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162376687.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Apelin receptorPRO_0000069173Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP35414.
    PRIDEiP35414.

    PTM databases

    PhosphoSiteiP35414.

    Expressioni

    Tissue specificityi

    Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.

    Gene expression databases

    BgeeiP35414.
    CleanExiHS_APLNR.
    GenevestigatoriP35414.

    Organism-specific databases

    HPAiCAB025842.

    Interactioni

    Protein-protein interaction databases

    IntActiP35414. 2 interactions.
    MINTiMINT-6630838.
    STRINGi9606.ENSP00000257254.

    Structurei

    Secondary structure

    1
    380
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi9 – 124
    Helixi13 – 164
    Beta strandi18 – 203
    Turni21 – 233
    Helixi24 – 274
    Beta strandi29 – 313
    Helixi32 – 376
    Turni38 – 447
    Beta strandi45 – 484
    Helixi49 – 557

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LOTNMR-A1-55[»]
    2LOUNMR-A1-55[»]
    2LOVNMR-A1-55[»]
    2LOWNMR-A1-55[»]
    ProteinModelPortaliP35414.
    SMRiP35414. Positions 1-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 6615CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini92 – 1009ExtracellularSequence Analysis
    Topological domaini126 – 14419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini167 – 20034ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini222 – 24423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini272 – 28413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 38072CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 5125Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei67 – 9125Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12525Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16622Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 27127Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30824Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG304842.
    HOGENOMiHOG000234122.
    HOVERGENiHBG104998.
    InParanoidiP35414.
    KOiK04174.
    OMAiNVFPYCT.
    OrthoDBiEOG7Z0JWM.
    PhylomeDBiP35414.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR020279. Apelin_receptor_C.
    IPR003904. APJ_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01416. APJRECEPTOR.
    PR00237. GPCRRHODOPSN.
    ProDomiPD061381. Apelin_receptor_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35414-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL    50
    WTVFRSSREK RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF 100
    FCKLSSYLIF VNMYASVFCL TGLSFDRYLA IVRPVANARL RLRVSGAVAT 150
    AVLWVLAALL AMPVMVLRTT GDLENTTKVQ CYMDYSMVAT VSSEWAWEVG 200
    LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL RKRRRLLSII 250
    VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 300
    NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH 350
    SQGPGPNMGK GGEQMHEKSI PYSQETLVVD 380
    Length:380
    Mass (Da):42,660
    Last modified:June 1, 1994 - v1
    Checksum:i78DB18BEA6D2B2E4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti300 – 3001V → I.
    Corresponds to variant rs7943508 [ dbSNP | Ensembl ].
    VAR_049375

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03642 Genomic DNA. Translation: AAA18954.1.
    X89271 mRNA. Translation: CAA61546.1.
    BC032688 mRNA. Translation: AAH32688.1.
    CCDSiCCDS7950.1.
    PIRiI38435.
    RefSeqiNP_005152.1. NM_005161.4.
    UniGeneiHs.438311.

    Genome annotation databases

    EnsembliENST00000257254; ENSP00000257254; ENSG00000134817.
    ENST00000606794; ENSP00000475344; ENSG00000134817.
    GeneIDi187.
    KEGGihsa:187.
    UCSCiuc001njo.3. human.

    Polymorphism databases

    DMDMi543823.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03642 Genomic DNA. Translation: AAA18954.1 .
    X89271 mRNA. Translation: CAA61546.1 .
    BC032688 mRNA. Translation: AAH32688.1 .
    CCDSi CCDS7950.1.
    PIRi I38435.
    RefSeqi NP_005152.1. NM_005161.4.
    UniGenei Hs.438311.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LOT NMR - A 1-55 [» ]
    2LOU NMR - A 1-55 [» ]
    2LOV NMR - A 1-55 [» ]
    2LOW NMR - A 1-55 [» ]
    ProteinModelPortali P35414.
    SMRi P35414. Positions 1-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P35414. 2 interactions.
    MINTi MINT-6630838.
    STRINGi 9606.ENSP00000257254.

    Chemistry

    BindingDBi P35414.
    ChEMBLi CHEMBL1628481.
    GuidetoPHARMACOLOGYi 36.

    Protein family/group databases

    TCDBi 9.A.14.13.10. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35414.

    Polymorphism databases

    DMDMi 543823.

    Proteomic databases

    PaxDbi P35414.
    PRIDEi P35414.

    Protocols and materials databases

    DNASUi 187.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257254 ; ENSP00000257254 ; ENSG00000134817 .
    ENST00000606794 ; ENSP00000475344 ; ENSG00000134817 .
    GeneIDi 187.
    KEGGi hsa:187.
    UCSCi uc001njo.3. human.

    Organism-specific databases

    CTDi 187.
    GeneCardsi GC11M057001.
    HGNCi HGNC:339. APLNR.
    HPAi CAB025842.
    MIMi 600052. gene.
    neXtProti NX_P35414.
    PharmGKBi PA162376687.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304842.
    HOGENOMi HOG000234122.
    HOVERGENi HBG104998.
    InParanoidi P35414.
    KOi K04174.
    OMAi NVFPYCT.
    OrthoDBi EOG7Z0JWM.
    PhylomeDBi P35414.
    TreeFami TF330024.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi APLNR. human.
    GeneWikii Apelin_receptor.
    GenomeRNAii 187.
    NextBioi 768.
    PROi P35414.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35414.
    CleanExi HS_APLNR.
    Genevestigatori P35414.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR020279. Apelin_receptor_C.
    IPR003904. APJ_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01416. APJRECEPTOR.
    PR00237. GPCRRHODOPSN.
    ProDomi PD061381. Apelin_receptor_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11."
      O'Dowd B.F., Heiber M., Chan A., Heng H.H.Q., Tsui L.-C., Kennedy J.L., Shi X., Petronis A., George S.R., Nguyen T.
      Gene 136:355-360(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular cloning and tissue distribution of a human orphan receptor belonging to the G protein coupled receptors family."
      Eggerickx D., Schurmans S., Vassart G., Parmentier M.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiAPJ_HUMAN
    AccessioniPrimary (citable) accession number: P35414
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3