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P35414 (APJ_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apelin receptor
Alternative name(s):
Angiotensin receptor-like 1
G-protein coupled receptor APJ
G-protein coupled receptor HG11
Gene names
Name:APLNR
Synonyms:AGTRL1, APJ
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Apelin receptor
PRO_0000069173

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 5125Helical; Name=1; Potential
Topological domain52 – 6615Cytoplasmic Potential
Transmembrane67 – 9125Helical; Name=2; Potential
Topological domain92 – 1009Extracellular Potential
Transmembrane101 – 12525Helical; Name=3; Potential
Topological domain126 – 14419Cytoplasmic Potential
Transmembrane145 – 16622Helical; Name=4; Potential
Topological domain167 – 20034Extracellular Potential
Transmembrane201 – 22121Helical; Name=5; Potential
Topological domain222 – 24423Cytoplasmic Potential
Transmembrane245 – 27127Helical; Name=6; Potential
Topological domain272 – 28413Extracellular Potential
Transmembrane285 – 30824Helical; Name=7; Potential
Topological domain309 – 38072Cytoplasmic Potential

Amino acid modifications

Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation1751N-linked (GlcNAc...) Potential

Natural variations

Natural variant3001V → I.
Corresponds to variant rs7943508 [ dbSNP | Ensembl ].
VAR_049375

Secondary structure

.............. 380
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P35414 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 78DB18BEA6D2B2E4

FASTA38042,660
        10         20         30         40         50         60 
MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK 

        70         80         90        100        110        120 
RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL 

       130        140        150        160        170        180 
TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ 

       190        200        210        220        230        240 
CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL 

       250        260        270        280        290        300 
RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 

       310        320        330        340        350        360 
NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK 

       370        380 
GGEQMHEKSI PYSQETLVVD 

« Hide

References

« Hide 'large scale' references
[1]"A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11."
O'Dowd B.F., Heiber M., Chan A., Heng H.H.Q., Tsui L.-C., Kennedy J.L., Shi X., Petronis A., George S.R., Nguyen T.
Gene 136:355-360(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning and tissue distribution of a human orphan receptor belonging to the G protein coupled receptors family."
Eggerickx D., Schurmans S., Vassart G., Parmentier M.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U03642 Genomic DNA. Translation: AAA18954.1.
X89271 mRNA. Translation: CAA61546.1.
BC032688 mRNA. Translation: AAH32688.1.
PIRI38435.
RefSeqNP_005152.1. NM_005161.4.
UniGeneHs.438311.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2LOTNMR-A1-55[»]
2LOUNMR-A1-55[»]
2LOVNMR-A1-55[»]
2LOWNMR-A1-55[»]
ProteinModelPortalP35414.
SMRP35414. Positions 1-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP35414. 2 interactions.
MINTMINT-6630838.
STRING9606.ENSP00000257254.

Chemistry

BindingDBP35414.
ChEMBLCHEMBL1628481.
GuidetoPHARMACOLOGY36.

Protein family/group databases

TCDB9.A.14.13.10. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteP35414.

Polymorphism databases

DMDM543823.

Proteomic databases

PaxDbP35414.
PRIDEP35414.

Protocols and materials databases

DNASU187.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257254; ENSP00000257254; ENSG00000134817.
ENST00000606794; ENSP00000475344; ENSG00000134817.
GeneID187.
KEGGhsa:187.
UCSCuc001njo.3. human.

Organism-specific databases

CTD187.
GeneCardsGC11M057001.
HGNCHGNC:339. APLNR.
HPACAB025842.
MIM600052. gene.
neXtProtNX_P35414.
PharmGKBPA162376687.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304842.
HOGENOMHOG000234122.
HOVERGENHBG104998.
InParanoidP35414.
KOK04174.
OMANVFPYCT.
OrthoDBEOG7Z0JWM.
PhylomeDBP35414.
TreeFamTF330024.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP35414.
CleanExHS_APLNR.
GenevestigatorP35414.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR020279. Apelin_receptor_C.
IPR003904. APJ_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01416. APJRECEPTOR.
PR00237. GPCRRHODOPSN.
ProDomPD061381. Apelin_receptor_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPLNR. human.
GeneWikiApelin_receptor.
GenomeRNAi187.
NextBio768.
PROP35414.
SOURCESearch...

Entry information

Entry nameAPJ_HUMAN
AccessionPrimary (citable) accession number: P35414
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries