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Protein

Apelin receptor

Gene

APLNR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure by acting as a receptor for APLN hormone (PubMed:25639753, PubMed:28137936).By similarity2 Publications
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:11090199).1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • receptor activity Source: ProtInc

GO - Biological processi

  • gastrulation Source: UniProtKB-KW
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • heart development Source: UniProtKB
  • negative regulation of cAMP-mediated signaling Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of inhibitory G-protein coupled receptor phosphorylation Source: UniProtKB
  • positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  • regulation of body fluid levels Source: Ensembl

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processGastrulation

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Protein family/group databases

TCDBi9.A.14.13.10. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Apelin receptor
Alternative name(s):
Angiotensin receptor-like 1
G-protein coupled receptor APJ
G-protein coupled receptor HG11
Gene namesi
Name:APLNR
Synonyms:AGTRL1, APJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000134817.10.
HGNCiHGNC:339. APLNR.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 51Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini52 – 66CytoplasmicSequence analysisAdd BLAST15
Transmembranei67 – 91Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini92 – 100ExtracellularSequence analysis9
Transmembranei101 – 125Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini126 – 144CytoplasmicSequence analysisAdd BLAST19
Transmembranei145 – 166Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini167 – 200ExtracellularSequence analysisAdd BLAST34
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 244CytoplasmicSequence analysisAdd BLAST23
Transmembranei245 – 271Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini272 – 284ExtracellularSequence analysisAdd BLAST13
Transmembranei285 – 308Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini309 – 380CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi187.
OpenTargetsiENSG00000134817.
PharmGKBiPA162376687.

Chemistry databases

ChEMBLiCHEMBL1628481.
GuidetoPHARMACOLOGYi36.

Polymorphism and mutation databases

BioMutaiAPLNR.
DMDMi543823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691731 – 380Apelin receptorAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35414.
PeptideAtlasiP35414.
PRIDEiP35414.

PTM databases

iPTMnetiP35414.
PhosphoSitePlusiP35414.

Expressioni

Tissue specificityi

Expressed in heart, brain, kidney, stomach, spleen, thymus, lung, ovary, small intestine and colon, adipose tissues and pancreas (PubMed:8294032, PubMed:25639753). Expressed in glial cells, astrocytes and neuronal subpopulations (PubMed:8294032). Expressed in embryonic (ESCs) and induced (iPSCs) pluripotent stem cells (PubMed:25639753).2 Publications

Gene expression databases

BgeeiENSG00000134817.
CleanExiHS_APLNR.
GenevisibleiP35414. HS.

Organism-specific databases

HPAiCAB025842.

Interactioni

Protein-protein interaction databases

BioGridi106693. 117 interactors.
IntActiP35414. 2 interactors.
MINTiMINT-6630838.
STRINGi9606.ENSP00000257254.

Chemistry databases

BindingDBiP35414.

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 12Combined sources4
Helixi13 – 16Combined sources4
Beta strandi18 – 20Combined sources3
Turni21 – 23Combined sources3
Helixi24 – 27Combined sources4
Beta strandi29 – 31Combined sources3
Helixi32 – 37Combined sources6
Turni38 – 44Combined sources7
Beta strandi45 – 48Combined sources4
Helixi49 – 55Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LOTNMR-A1-55[»]
2LOUNMR-A1-55[»]
2LOVNMR-A1-55[»]
2LOWNMR-A1-55[»]
5VBLX-ray2.60B7-229[»]
B243-330[»]
ProteinModelPortaliP35414.
SMRiP35414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP35414.
KOiK04174.
OMAiVMVFRST.
OrthoDBiEOG091G0BIX.
PhylomeDBiP35414.
TreeFamiTF330024.

Family and domain databases

InterProiView protein in InterPro
IPR020279. Apelin_receptor_C.
IPR003904. APJ_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR01416. APJRECEPTOR.
PR00237. GPCRRHODOPSN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD061381. Apelin_receptor_C. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P35414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL
60 70 80 90 100
WTVFRSSREK RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF
110 120 130 140 150
FCKLSSYLIF VNMYASVFCL TGLSFDRYLA IVRPVANARL RLRVSGAVAT
160 170 180 190 200
AVLWVLAALL AMPVMVLRTT GDLENTTKVQ CYMDYSMVAT VSSEWAWEVG
210 220 230 240 250
LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL RKRRRLLSII
260 270 280 290 300
VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV
310 320 330 340 350
NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH
360 370 380
SQGPGPNMGK GGEQMHEKSI PYSQETLVVD
Length:380
Mass (Da):42,660
Last modified:June 1, 1994 - v1
Checksum:i78DB18BEA6D2B2E4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049375300V → I. Corresponds to variant dbSNP:rs7943508Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03642 Genomic DNA. Translation: AAA18954.1.
X89271 mRNA. Translation: CAA61546.1.
BC032688 mRNA. Translation: AAH32688.1.
CCDSiCCDS7950.1.
PIRiI38435.
RefSeqiNP_005152.1. NM_005161.4.
UniGeneiHs.438311.

Genome annotation databases

EnsembliENST00000257254; ENSP00000257254; ENSG00000134817.
ENST00000606794; ENSP00000475344; ENSG00000134817.
ENST00000611099; ENSP00000477818; ENSG00000134817.
GeneIDi187.
KEGGihsa:187.
UCSCiuc001njo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAPJ_HUMAN
AccessioniPrimary (citable) accession number: P35414
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 27, 2017
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families