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P35413

- GPR3_MOUSE

UniProt

P35413 - GPR3_MOUSE

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Protein
G-protein coupled receptor 3
Gene
Gpr3, Gpcr3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons By similarity and neurite outgrowth By similarity. Maintains also meiotic arrest in oocytes.2 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of meiosis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 3
Alternative name(s):
GPCR21
Gene namesi
Name:Gpr3
Synonyms:Gpcr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:101908. Gpr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242Extracellular Reviewed prediction
Add
BLAST
Transmembranei43 – 6220Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini63 – 7412Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei75 – 9824Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini99 – 11012Extracellular Reviewed prediction
Add
BLAST
Transmembranei111 – 13222Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini133 – 15321Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei154 – 17320Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini174 – 19825Extracellular Reviewed prediction
Add
BLAST
Transmembranei199 – 21719Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini218 – 24528Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei246 – 27227Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini273 – 2775Extracellular Reviewed prediction
Transmembranei278 – 29922Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini300 – 33031Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are fertile but display progressive reduction in litter size despite a stable age-independent alteration of the meiotic pause, characterized by premature resumption of meiosis in about one-third of antral follicles in mutant females regardless of age. Aging mutant mice had severe reduction of fertility, manifested by an increasing number of nondeveloping early embryos upon spontaneous ovulation and massive amounts of fragmented oocytes after superovulation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330G-protein coupled receptor 3
PRO_0000069511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
Lipidationi313 – 3131S-palmitoyl cysteine By similarity
Modified residuei324 – 3241Phosphoserine Reviewed prediction
Modified residuei326 – 3261Phosphoserine Reviewed prediction
Modified residuei328 – 3281Phosphoserine Reviewed prediction

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP35413.

Expressioni

Tissue specificityi

Expressed in both the forebrain and hindbrain, with the highest level in habenula. Lower level expression in the testis. Highly expressed in regions.2 Publications

Gene expression databases

BgeeiP35413.
CleanExiMM_GPR3.
GenevestigatoriP35413.

Structurei

3D structure databases

ProteinModelPortaliP35413.
SMRiP35413. Positions 43-314.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320944.
GeneTreeiENSGT00750000117639.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiQ3USD4.
KOiK04311.
OMAiLWAICCC.
OrthoDBiEOG7966H0.
PhylomeDBiP35413.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000984. GPR3.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00648. GPR3ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35413-1 [UniParc]FASTAAdd to Basket

« Hide

MMWGAGSSMA WFSAGSGSVN VSSVDPVEEP TGPATLLPSP RAWDVVLCIS    50
GTLVSCENAL VVAIIVGTPA FRAPMFLLVG SLAVADLLAG LGLVLHFAAD 100
FCIGSPEMSL MLVGVLAMAF TASIGSLLAI TVDRYLSLYN ALTYYSETTV 150
TRTYVMLALV WVGALGLGLV PVLAWNCRDG LTTCGVVYPL SKNHLVVLAI 200
AFFMVFGIML QLYAQICRIV CRHAQQIALQ RHLLPASHYV ATRKGIATLA 250
VVLGAFAACW LPFTVYCLLG DADSPRLYTY LTLLPATYNS MINPVIYAFR 300
NQDVQKVLWA ICCCCSTSKI PFRSRSPSDV 330
Length:330
Mass (Da):35,453
Last modified:June 1, 1994 - v1
Checksum:i89122C57945482B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D21062 mRNA. Translation: BAA04641.1.
AK140302 mRNA. Translation: BAE24325.1.
AK140464 mRNA. Translation: BAE24399.1.
AK158917 mRNA. Translation: BAE34727.1.
AL671858 Genomic DNA. Translation: CAM21563.1.
CH466552 Genomic DNA. Translation: EDL30077.1.
BC138248 mRNA. Translation: AAI38249.1.
BC138250 mRNA. Translation: AAI38251.1.
CCDSiCCDS18743.1.
PIRiS40454.
RefSeqiNP_032180.1. NM_008154.3.
UniGeneiMm.4721.

Genome annotation databases

EnsembliENSMUST00000052090; ENSMUSP00000062083; ENSMUSG00000049649.
ENSMUST00000105911; ENSMUSP00000101531; ENSMUSG00000049649.
GeneIDi14748.
KEGGimmu:14748.
UCSCiuc008vci.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D21062 mRNA. Translation: BAA04641.1 .
AK140302 mRNA. Translation: BAE24325.1 .
AK140464 mRNA. Translation: BAE24399.1 .
AK158917 mRNA. Translation: BAE34727.1 .
AL671858 Genomic DNA. Translation: CAM21563.1 .
CH466552 Genomic DNA. Translation: EDL30077.1 .
BC138248 mRNA. Translation: AAI38249.1 .
BC138250 mRNA. Translation: AAI38251.1 .
CCDSi CCDS18743.1.
PIRi S40454.
RefSeqi NP_032180.1. NM_008154.3.
UniGenei Mm.4721.

3D structure databases

ProteinModelPortali P35413.
SMRi P35413. Positions 43-314.
ModBasei Search...

Chemistry

GuidetoPHARMACOLOGYi 83.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P35413.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052090 ; ENSMUSP00000062083 ; ENSMUSG00000049649 .
ENSMUST00000105911 ; ENSMUSP00000101531 ; ENSMUSG00000049649 .
GeneIDi 14748.
KEGGi mmu:14748.
UCSCi uc008vci.1. mouse.

Organism-specific databases

CTDi 2827.
MGIi MGI:101908. Gpr3.

Phylogenomic databases

eggNOGi NOG320944.
GeneTreei ENSGT00750000117639.
HOGENOMi HOG000294075.
HOVERGENi HBG079561.
InParanoidi Q3USD4.
KOi K04311.
OMAi LWAICCC.
OrthoDBi EOG7966H0.
PhylomeDBi P35413.
TreeFami TF330052.

Miscellaneous databases

NextBioi 286811.
PROi P35413.
SOURCEi Search...

Gene expression databases

Bgeei P35413.
CleanExi MM_GPR3.
Genevestigatori P35413.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000984. GPR3.
IPR000723. GPR_3/6/12_orphan.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00648. GPR3ORPHANR.
PR00644. GPRORPHANR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system."
    Saeki Y., Ueno S., Mizuno R., Nishimura T., Fujimura H., Nagai Y., Yanagihara T.
    FEBS Lett. 336:317-322(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina, Medulla oblongata and Visual cortex.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  7. Cited for: TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiGPR3_MOUSE
AccessioniPrimary (citable) accession number: P35413
Secondary accession number(s): Q3USD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi