Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35413

- GPR3_MOUSE

UniProt

P35413 - GPR3_MOUSE

Protein

G-protein coupled receptor 3

Gene

Gpr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons By similarity and neurite outgrowth By similarity. Maintains also meiotic arrest in oocytes.By similarity2 Publications

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of meiosis Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 3
    Alternative name(s):
    GPCR21
    Gene namesi
    Name:Gpr3
    Synonyms:Gpcr3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:101908. Gpr3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice are fertile but display progressive reduction in litter size despite a stable age-independent alteration of the meiotic pause, characterized by premature resumption of meiosis in about one-third of antral follicles in mutant females regardless of age. Aging mutant mice had severe reduction of fertility, manifested by an increasing number of nondeveloping early embryos upon spontaneous ovulation and massive amounts of fragmented oocytes after superovulation.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330G-protein coupled receptor 3PRO_0000069511Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Lipidationi313 – 3131S-palmitoyl cysteineBy similarity
    Modified residuei324 – 3241PhosphoserineSequence Analysis
    Modified residuei326 – 3261PhosphoserineSequence Analysis
    Modified residuei328 – 3281PhosphoserineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiP35413.

    Expressioni

    Tissue specificityi

    Expressed in both the forebrain and hindbrain, with the highest level in habenula. Lower level expression in the testis. Highly expressed in regions.2 Publications

    Gene expression databases

    BgeeiP35413.
    CleanExiMM_GPR3.
    GenevestigatoriP35413.

    Structurei

    3D structure databases

    ProteinModelPortaliP35413.
    SMRiP35413. Positions 43-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 7412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini99 – 11012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini133 – 15321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini174 – 19825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 24528CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 2775ExtracellularSequence Analysis
    Topological domaini300 – 33031CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6220Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9824Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei111 – 13222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17320Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21719Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei246 – 27227Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29922Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320944.
    GeneTreeiENSGT00750000117639.
    HOGENOMiHOG000294075.
    HOVERGENiHBG079561.
    InParanoidiQ3USD4.
    KOiK04311.
    OMAiLWAICCC.
    OrthoDBiEOG7966H0.
    PhylomeDBiP35413.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000984. GPR3.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00648. GPR3ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35413-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMWGAGSSMA WFSAGSGSVN VSSVDPVEEP TGPATLLPSP RAWDVVLCIS    50
    GTLVSCENAL VVAIIVGTPA FRAPMFLLVG SLAVADLLAG LGLVLHFAAD 100
    FCIGSPEMSL MLVGVLAMAF TASIGSLLAI TVDRYLSLYN ALTYYSETTV 150
    TRTYVMLALV WVGALGLGLV PVLAWNCRDG LTTCGVVYPL SKNHLVVLAI 200
    AFFMVFGIML QLYAQICRIV CRHAQQIALQ RHLLPASHYV ATRKGIATLA 250
    VVLGAFAACW LPFTVYCLLG DADSPRLYTY LTLLPATYNS MINPVIYAFR 300
    NQDVQKVLWA ICCCCSTSKI PFRSRSPSDV 330
    Length:330
    Mass (Da):35,453
    Last modified:June 1, 1994 - v1
    Checksum:i89122C57945482B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21062 mRNA. Translation: BAA04641.1.
    AK140302 mRNA. Translation: BAE24325.1.
    AK140464 mRNA. Translation: BAE24399.1.
    AK158917 mRNA. Translation: BAE34727.1.
    AL671858 Genomic DNA. Translation: CAM21563.1.
    CH466552 Genomic DNA. Translation: EDL30077.1.
    BC138248 mRNA. Translation: AAI38249.1.
    BC138250 mRNA. Translation: AAI38251.1.
    CCDSiCCDS18743.1.
    PIRiS40454.
    RefSeqiNP_032180.1. NM_008154.3.
    UniGeneiMm.4721.

    Genome annotation databases

    EnsembliENSMUST00000052090; ENSMUSP00000062083; ENSMUSG00000049649.
    ENSMUST00000105911; ENSMUSP00000101531; ENSMUSG00000049649.
    GeneIDi14748.
    KEGGimmu:14748.
    UCSCiuc008vci.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21062 mRNA. Translation: BAA04641.1 .
    AK140302 mRNA. Translation: BAE24325.1 .
    AK140464 mRNA. Translation: BAE24399.1 .
    AK158917 mRNA. Translation: BAE34727.1 .
    AL671858 Genomic DNA. Translation: CAM21563.1 .
    CH466552 Genomic DNA. Translation: EDL30077.1 .
    BC138248 mRNA. Translation: AAI38249.1 .
    BC138250 mRNA. Translation: AAI38251.1 .
    CCDSi CCDS18743.1.
    PIRi S40454.
    RefSeqi NP_032180.1. NM_008154.3.
    UniGenei Mm.4721.

    3D structure databases

    ProteinModelPortali P35413.
    SMRi P35413. Positions 43-314.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 83.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P35413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052090 ; ENSMUSP00000062083 ; ENSMUSG00000049649 .
    ENSMUST00000105911 ; ENSMUSP00000101531 ; ENSMUSG00000049649 .
    GeneIDi 14748.
    KEGGi mmu:14748.
    UCSCi uc008vci.1. mouse.

    Organism-specific databases

    CTDi 2827.
    MGIi MGI:101908. Gpr3.

    Phylogenomic databases

    eggNOGi NOG320944.
    GeneTreei ENSGT00750000117639.
    HOGENOMi HOG000294075.
    HOVERGENi HBG079561.
    InParanoidi Q3USD4.
    KOi K04311.
    OMAi LWAICCC.
    OrthoDBi EOG7966H0.
    PhylomeDBi P35413.
    TreeFami TF330052.

    Miscellaneous databases

    NextBioi 286811.
    PROi P35413.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35413.
    CleanExi MM_GPR3.
    Genevestigatori P35413.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000984. GPR3.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00648. GPR3ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system."
      Saeki Y., Ueno S., Mizuno R., Nishimura T., Fujimura H., Nagai Y., Yanagihara T.
      FEBS Lett. 336:317-322(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina, Medulla oblongata and Visual cortex.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Cited for: DISRUPTION PHENOTYPE, FUNCTION.
    7. Cited for: TISSUE SPECIFICITY, FUNCTION.

    Entry informationi

    Entry nameiGPR3_MOUSE
    AccessioniPrimary (citable) accession number: P35413
    Secondary accession number(s): Q3USD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3