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Protein

G-protein coupled receptor 3

Gene

Gpr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons (By similarity) and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • regulation of meiotic nuclear division Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 3
Alternative name(s):
GPCR21
Gene namesi
Name:Gpr3
Synonyms:Gpcr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:101908. Gpr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 62Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini63 – 74CytoplasmicSequence analysisAdd BLAST12
Transmembranei75 – 98Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini99 – 110ExtracellularSequence analysisAdd BLAST12
Transmembranei111 – 132Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini133 – 153CytoplasmicSequence analysisAdd BLAST21
Transmembranei154 – 173Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini174 – 198ExtracellularSequence analysisAdd BLAST25
Transmembranei199 – 217Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini218 – 245CytoplasmicSequence analysisAdd BLAST28
Transmembranei246 – 272Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini273 – 277ExtracellularSequence analysis5
Transmembranei278 – 299Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini300 – 330CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are fertile but display progressive reduction in litter size despite a stable age-independent alteration of the meiotic pause, characterized by premature resumption of meiosis in about one-third of antral follicles in mutant females regardless of age. Aging mutant mice had severe reduction of fertility, manifested by an increasing number of nondeveloping early embryos upon spontaneous ovulation and massive amounts of fragmented oocytes after superovulation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695111 – 330G-protein coupled receptor 3Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Lipidationi313S-palmitoyl cysteineBy similarity1
Modified residuei324PhosphoserineSequence analysis1
Modified residuei326PhosphoserineSequence analysis1
Modified residuei328PhosphoserineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP35413.
PRIDEiP35413.

PTM databases

PhosphoSitePlusiP35413.

Expressioni

Tissue specificityi

Expressed in both the forebrain and hindbrain, with the highest level in habenula. Lower level expression in the testis. Highly expressed in regions.2 Publications

Gene expression databases

BgeeiENSMUSG00000049649.
CleanExiMM_GPR3.
ExpressionAtlasiP35413. baseline and differential.
GenevisibleiP35413. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062083.

Structurei

3D structure databases

ProteinModelPortaliP35413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiP35413.
KOiK04311.
OMAiSPRAWDV.
OrthoDBiEOG091G0CNB.
PhylomeDBiP35413.
TreeFamiTF330052.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000984. GPR3.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00648. GPR3ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWGAGSSMA WFSAGSGSVN VSSVDPVEEP TGPATLLPSP RAWDVVLCIS
60 70 80 90 100
GTLVSCENAL VVAIIVGTPA FRAPMFLLVG SLAVADLLAG LGLVLHFAAD
110 120 130 140 150
FCIGSPEMSL MLVGVLAMAF TASIGSLLAI TVDRYLSLYN ALTYYSETTV
160 170 180 190 200
TRTYVMLALV WVGALGLGLV PVLAWNCRDG LTTCGVVYPL SKNHLVVLAI
210 220 230 240 250
AFFMVFGIML QLYAQICRIV CRHAQQIALQ RHLLPASHYV ATRKGIATLA
260 270 280 290 300
VVLGAFAACW LPFTVYCLLG DADSPRLYTY LTLLPATYNS MINPVIYAFR
310 320 330
NQDVQKVLWA ICCCCSTSKI PFRSRSPSDV
Length:330
Mass (Da):35,453
Last modified:June 1, 1994 - v1
Checksum:i89122C57945482B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21062 mRNA. Translation: BAA04641.1.
AK140302 mRNA. Translation: BAE24325.1.
AK140464 mRNA. Translation: BAE24399.1.
AK158917 mRNA. Translation: BAE34727.1.
AL671858 Genomic DNA. Translation: CAM21563.1.
CH466552 Genomic DNA. Translation: EDL30077.1.
BC138248 mRNA. Translation: AAI38249.1.
BC138250 mRNA. Translation: AAI38251.1.
CCDSiCCDS18743.1.
PIRiS40454.
RefSeqiNP_032180.1. NM_008154.3.
UniGeneiMm.4721.

Genome annotation databases

EnsembliENSMUST00000052090; ENSMUSP00000062083; ENSMUSG00000049649.
ENSMUST00000105911; ENSMUSP00000101531; ENSMUSG00000049649.
GeneIDi14748.
KEGGimmu:14748.
UCSCiuc008vci.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21062 mRNA. Translation: BAA04641.1.
AK140302 mRNA. Translation: BAE24325.1.
AK140464 mRNA. Translation: BAE24399.1.
AK158917 mRNA. Translation: BAE34727.1.
AL671858 Genomic DNA. Translation: CAM21563.1.
CH466552 Genomic DNA. Translation: EDL30077.1.
BC138248 mRNA. Translation: AAI38249.1.
BC138250 mRNA. Translation: AAI38251.1.
CCDSiCCDS18743.1.
PIRiS40454.
RefSeqiNP_032180.1. NM_008154.3.
UniGeneiMm.4721.

3D structure databases

ProteinModelPortaliP35413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062083.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP35413.

Proteomic databases

PaxDbiP35413.
PRIDEiP35413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052090; ENSMUSP00000062083; ENSMUSG00000049649.
ENSMUST00000105911; ENSMUSP00000101531; ENSMUSG00000049649.
GeneIDi14748.
KEGGimmu:14748.
UCSCiuc008vci.1. mouse.

Organism-specific databases

CTDi2827.
MGIiMGI:101908. Gpr3.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiP35413.
KOiK04311.
OMAiSPRAWDV.
OrthoDBiEOG091G0CNB.
PhylomeDBiP35413.
TreeFamiTF330052.

Miscellaneous databases

PROiP35413.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049649.
CleanExiMM_GPR3.
ExpressionAtlasiP35413. baseline and differential.
GenevisibleiP35413. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000984. GPR3.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00648. GPR3ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR3_MOUSE
AccessioniPrimary (citable) accession number: P35413
Secondary accession number(s): Q3USD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.