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Protein

CX3C chemokine receptor 1

Gene

Cx3cr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions.

GO - Molecular functioni

  1. C-X3-C chemokine receptor activity Source: RGD

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. cellular response to lipopolysaccharide Source: RGD
  3. cellular response to transforming growth factor beta stimulus Source: RGD
  4. cerebral cortex cell migration Source: Ensembl
  5. chemokine-mediated signaling pathway Source: GOC
  6. macrophage chemotaxis Source: Ensembl
  7. memory Source: RGD
  8. microglial cell activation Source: RGD
  9. microglial cell activation involved in immune response Source: Ensembl
  10. negative regulation of angiogenesis Source: Ensembl
  11. negative regulation of cell migration Source: RGD
  12. negative regulation of chronic inflammatory response to non-antigenic stimulus Source: RGD
  13. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  14. negative regulation of long-term synaptic potentiation Source: RGD
  15. positive regulation of angiogenesis Source: RGD
  16. positive regulation of neuroblast proliferation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_263785. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
CX3C chemokine receptor 1
Short name:
C-X3-C CKR-1
Short name:
CX3CR1
Alternative name(s):
Fractalkine receptor
RBS11
Gene namesi
Name:Cx3cr1
Synonyms:Rbs11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi620137. Cx3cr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 6028Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 7010CytoplasmicSequence Analysis
Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 10413ExtracellularSequence AnalysisAdd
BLAST
Transmembranei105 – 12622Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini127 – 14317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16825Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini169 – 19628ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 23216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei233 – 25725Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27417ExtracellularSequence AnalysisAdd
BLAST
Transmembranei275 – 29824Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini299 – 35456CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. neuronal cell body membrane Source: RGD
  3. neuron projection Source: RGD
  4. perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354CX3C chemokine receptor 1PRO_0000069328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi103 ↔ 176PROSITE-ProRule annotation

Post-translational modificationi

This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP35411.

PTM databases

PhosphoSiteiP35411.

Expressioni

Tissue specificityi

Most abundant in adult spinal cord, brain, kidney, gut, uterus and testes.

Gene expression databases

GenevestigatoriP35411.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025019.

Structurei

3D structure databases

ProteinModelPortaliP35411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151350.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35411.
KOiK04192.
OMAiAPQFMFT.
OrthoDBiEOG7327P9.
PhylomeDBiP35411.
TreeFamiTF330966.

Family and domain databases

InterProiIPR005387. Chemokine_CX3CR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35411-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSIFYS LVFTFGLVGN
60 70 80 90 100
LLVVLALTNS RKSKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN
110 120 130 140 150
AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI
160 170 180 190 200
SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEIWPV LRNSEVNILG
210 220 230 240 250
FVLPLLIMSF CYFRIVRTLF SCKNRKKARA IRLILLVVVV FFLFWTPYNI
260 270 280 290 300
VIFLETLKFY NFFPSCGMKR DLRWALSVTE TVAFSHCCLN PFIYAFAGEK
310 320 330 340 350
FRRYLRHLYN KCLAVLCGRP VHAGFSTESQ RSRQDSILSS LTHYTSEGEG

SLLL
Length:354
Mass (Da):40,327
Last modified:June 1, 1994 - v1
Checksum:iCFC4578095E77376
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04808 mRNA. Translation: AAB87093.1.
PIRiI58186.
RefSeqiNP_598218.1. NM_133534.1.
XP_008764890.1. XM_008766668.1.
UniGeneiRn.10482.

Genome annotation databases

EnsembliENSRNOT00000025019; ENSRNOP00000025019; ENSRNOG00000018509.
GeneIDi171056.
KEGGirno:171056.
UCSCiRGD:620137. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04808 mRNA. Translation: AAB87093.1.
PIRiI58186.
RefSeqiNP_598218.1. NM_133534.1.
XP_008764890.1. XM_008766668.1.
UniGeneiRn.10482.

3D structure databases

ProteinModelPortaliP35411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025019.

Chemistry

ChEMBLiCHEMBL2346491.
GuidetoPHARMACOLOGYi74.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP35411.

Proteomic databases

PRIDEiP35411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025019; ENSRNOP00000025019; ENSRNOG00000018509.
GeneIDi171056.
KEGGirno:171056.
UCSCiRGD:620137. rat.

Organism-specific databases

CTDi1524.
RGDi620137. Cx3cr1.

Phylogenomic databases

eggNOGiNOG151350.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35411.
KOiK04192.
OMAiAPQFMFT.
OrthoDBiEOG7327P9.
PhylomeDBiP35411.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_263785. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi621621.
PROiP35411.

Gene expression databases

GenevestigatoriP35411.

Family and domain databases

InterProiIPR005387. Chemokine_CX3CR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors."
    Harrison J.K., Barber C.M., Lynch K.R.
    Neurosci. Lett. 169:85-89(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.

Entry informationi

Entry nameiCX3C1_RAT
AccessioniPrimary (citable) accession number: P35411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 7, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.