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P35411

- CX3C1_RAT

UniProt

P35411 - CX3C1_RAT

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Protein

CX3C chemokine receptor 1

Gene

Cx3cr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions.

GO - Molecular functioni

  1. C-X3-C chemokine receptor activity Source: RGD

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. cellular response to lipopolysaccharide Source: RGD
  3. cellular response to transforming growth factor beta stimulus Source: RGD
  4. cerebral cortex cell migration Source: Ensembl
  5. chemokine-mediated signaling pathway Source: GOC
  6. macrophage chemotaxis Source: Ensembl
  7. microglial cell activation involved in immune response Source: Ensembl
  8. negative regulation of angiogenesis Source: Ensembl
  9. negative regulation of cell migration Source: RGD
  10. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  11. positive regulation of angiogenesis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
CX3C chemokine receptor 1
Short name:
C-X3-C CKR-1
Short name:
CX3CR1
Alternative name(s):
Fractalkine receptor
RBS11
Gene namesi
Name:Cx3cr1
Synonyms:Rbs11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi620137. Cx3cr1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. neuronal cell body membrane Source: RGD
  3. neuron projection Source: RGD
  4. perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354CX3C chemokine receptor 1PRO_0000069328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi103 ↔ 176PROSITE-ProRule annotation

Post-translational modificationi

This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP35411.

PTM databases

PhosphoSiteiP35411.

Expressioni

Tissue specificityi

Most abundant in adult spinal cord, brain, kidney, gut, uterus and testes.

Gene expression databases

GenevestigatoriP35411.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025019.

Structurei

3D structure databases

ProteinModelPortaliP35411.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Topological domaini61 – 7010CytoplasmicSequence Analysis
Topological domaini92 – 10413ExtracellularSequence AnalysisAdd
BLAST
Topological domaini127 – 14317CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini169 – 19628ExtracellularSequence AnalysisAdd
BLAST
Topological domaini217 – 23216CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini258 – 27417ExtracellularSequence AnalysisAdd
BLAST
Topological domaini299 – 35456CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 6028Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei105 – 12622Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei144 – 16825Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei233 – 25725Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei275 – 29824Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151350.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35411.
KOiK04192.
OMAiAPQFMFT.
OrthoDBiEOG7327P9.
PhylomeDBiP35411.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR005387. Chemokine_CX3CR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35411-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSIFYS LVFTFGLVGN
60 70 80 90 100
LLVVLALTNS RKSKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN
110 120 130 140 150
AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI
160 170 180 190 200
SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEIWPV LRNSEVNILG
210 220 230 240 250
FVLPLLIMSF CYFRIVRTLF SCKNRKKARA IRLILLVVVV FFLFWTPYNI
260 270 280 290 300
VIFLETLKFY NFFPSCGMKR DLRWALSVTE TVAFSHCCLN PFIYAFAGEK
310 320 330 340 350
FRRYLRHLYN KCLAVLCGRP VHAGFSTESQ RSRQDSILSS LTHYTSEGEG

SLLL
Length:354
Mass (Da):40,327
Last modified:June 1, 1994 - v1
Checksum:iCFC4578095E77376
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04808 mRNA. Translation: AAB87093.1.
PIRiI58186.
RefSeqiNP_598218.1. NM_133534.1.
UniGeneiRn.10482.

Genome annotation databases

EnsembliENSRNOT00000025019; ENSRNOP00000025019; ENSRNOG00000018509.
GeneIDi171056.
KEGGirno:171056.
UCSCiRGD:620137. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04808 mRNA. Translation: AAB87093.1 .
PIRi I58186.
RefSeqi NP_598218.1. NM_133534.1.
UniGenei Rn.10482.

3D structure databases

ProteinModelPortali P35411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000025019.

Chemistry

ChEMBLi CHEMBL2346491.
GuidetoPHARMACOLOGYi 74.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35411.

Proteomic databases

PRIDEi P35411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025019 ; ENSRNOP00000025019 ; ENSRNOG00000018509 .
GeneIDi 171056.
KEGGi rno:171056.
UCSCi RGD:620137. rat.

Organism-specific databases

CTDi 1524.
RGDi 620137. Cx3cr1.

Phylogenomic databases

eggNOGi NOG151350.
GeneTreei ENSGT00760000118785.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P35411.
KOi K04192.
OMAi APQFMFT.
OrthoDBi EOG7327P9.
PhylomeDBi P35411.
TreeFami TF330966.

Miscellaneous databases

NextBioi 621621.
PROi P35411.

Gene expression databases

Genevestigatori P35411.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR005387. Chemokine_CX3CR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors."
    Harrison J.K., Barber C.M., Lynch K.R.
    Neurosci. Lett. 169:85-89(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.

Entry informationi

Entry nameiCX3C1_RAT
AccessioniPrimary (citable) accession number: P35411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3