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P35411

- CX3C1_RAT

UniProt

P35411 - CX3C1_RAT

Protein

CX3C chemokine receptor 1

Gene

Cx3cr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions.

    GO - Molecular functioni

    1. C-X3-C chemokine receptor activity Source: RGD

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. cellular response to lipopolysaccharide Source: RGD
    3. cellular response to transforming growth factor beta stimulus Source: RGD
    4. cerebral cortex cell migration Source: Ensembl
    5. chemokine-mediated signaling pathway Source: GOC
    6. macrophage chemotaxis Source: Ensembl
    7. microglial cell activation involved in immune response Source: Ensembl
    8. negative regulation of angiogenesis Source: Ensembl
    9. negative regulation of cell migration Source: RGD
    10. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    11. positive regulation of angiogenesis Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CX3C chemokine receptor 1
    Short name:
    C-X3-C CKR-1
    Short name:
    CX3CR1
    Alternative name(s):
    Fractalkine receptor
    RBS11
    Gene namesi
    Name:Cx3cr1
    Synonyms:Rbs11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi620137. Cx3cr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. neuronal cell body membrane Source: RGD
    3. neuron projection Source: RGD
    4. perinuclear region of cytoplasm Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354CX3C chemokine receptor 1PRO_0000069328Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi103 ↔ 176PROSITE-ProRule annotation

    Post-translational modificationi

    This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP35411.

    PTM databases

    PhosphoSiteiP35411.

    Expressioni

    Tissue specificityi

    Most abundant in adult spinal cord, brain, kidney, gut, uterus and testes.

    Gene expression databases

    GenevestigatoriP35411.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025019.

    Structurei

    3D structure databases

    ProteinModelPortaliP35411.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 7010CytoplasmicSequence Analysis
    Topological domaini92 – 10413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 14317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 19628ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 35456CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 6028Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16825Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25725Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29824Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151350.
    GeneTreeiENSGT00700000104407.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP35411.
    KOiK04192.
    OMAiAPQFMFT.
    OrthoDBiEOG7327P9.
    PhylomeDBiP35411.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR005387. Chemokine_CX3CR1.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01562. FRACTALKINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35411-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSIFYS LVFTFGLVGN    50
    LLVVLALTNS RKSKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN 100
    AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI 150
    SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEIWPV LRNSEVNILG 200
    FVLPLLIMSF CYFRIVRTLF SCKNRKKARA IRLILLVVVV FFLFWTPYNI 250
    VIFLETLKFY NFFPSCGMKR DLRWALSVTE TVAFSHCCLN PFIYAFAGEK 300
    FRRYLRHLYN KCLAVLCGRP VHAGFSTESQ RSRQDSILSS LTHYTSEGEG 350
    SLLL 354
    Length:354
    Mass (Da):40,327
    Last modified:June 1, 1994 - v1
    Checksum:iCFC4578095E77376
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04808 mRNA. Translation: AAB87093.1.
    PIRiI58186.
    RefSeqiNP_598218.1. NM_133534.1.
    UniGeneiRn.10482.

    Genome annotation databases

    EnsembliENSRNOT00000025019; ENSRNOP00000025019; ENSRNOG00000018509.
    GeneIDi171056.
    KEGGirno:171056.
    UCSCiRGD:620137. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04808 mRNA. Translation: AAB87093.1 .
    PIRi I58186.
    RefSeqi NP_598218.1. NM_133534.1.
    UniGenei Rn.10482.

    3D structure databases

    ProteinModelPortali P35411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025019.

    Chemistry

    ChEMBLi CHEMBL2346491.
    GuidetoPHARMACOLOGYi 74.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35411.

    Proteomic databases

    PRIDEi P35411.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025019 ; ENSRNOP00000025019 ; ENSRNOG00000018509 .
    GeneIDi 171056.
    KEGGi rno:171056.
    UCSCi RGD:620137. rat.

    Organism-specific databases

    CTDi 1524.
    RGDi 620137. Cx3cr1.

    Phylogenomic databases

    eggNOGi NOG151350.
    GeneTreei ENSGT00700000104407.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P35411.
    KOi K04192.
    OMAi APQFMFT.
    OrthoDBi EOG7327P9.
    PhylomeDBi P35411.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 621621.
    PROi P35411.

    Gene expression databases

    Genevestigatori P35411.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR005387. Chemokine_CX3CR1.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01562. FRACTALKINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors."
      Harrison J.K., Barber C.M., Lynch K.R.
      Neurosci. Lett. 169:85-89(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Spinal cord.

    Entry informationi

    Entry nameiCX3C1_RAT
    AccessioniPrimary (citable) accession number: P35411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3