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P35411

- CX3C1_RAT

UniProt

P35411 - CX3C1_RAT

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Protein
CX3C chemokine receptor 1
Gene
Cx3cr1, Rbs11
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions.

GO - Molecular functioni

  1. C-X3-C chemokine receptor activity Source: RGD

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. cellular response to lipopolysaccharide Source: RGD
  3. cellular response to transforming growth factor beta stimulus Source: RGD
  4. cerebral cortex cell migration Source: Ensembl
  5. chemokine-mediated signaling pathway Source: GOC
  6. macrophage chemotaxis Source: Ensembl
  7. microglial cell activation involved in immune response Source: Ensembl
  8. negative regulation of angiogenesis Source: Ensembl
  9. negative regulation of cell migration Source: RGD
  10. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  11. positive regulation of angiogenesis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
CX3C chemokine receptor 1
Short name:
C-X3-C CKR-1
Short name:
CX3CR1
Alternative name(s):
Fractalkine receptor
RBS11
Gene namesi
Name:Cx3cr1
Synonyms:Rbs11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi620137. Cx3cr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Extracellular Reviewed prediction
Add
BLAST
Transmembranei33 – 6028Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini61 – 7010Cytoplasmic Reviewed prediction
Transmembranei71 – 9121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini92 – 10413Extracellular Reviewed prediction
Add
BLAST
Transmembranei105 – 12622Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini127 – 14317Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei144 – 16825Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini169 – 19628Extracellular Reviewed prediction
Add
BLAST
Transmembranei197 – 21620Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini217 – 23216Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei233 – 25725Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini258 – 27417Extracellular Reviewed prediction
Add
BLAST
Transmembranei275 – 29824Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini299 – 35456Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. neuron projection Source: RGD
  3. neuronal cell body membrane Source: RGD
  4. perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354CX3C chemokine receptor 1
PRO_0000069328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi103 ↔ 176 By similarity

Post-translational modificationi

This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP35411.

PTM databases

PhosphoSiteiP35411.

Expressioni

Tissue specificityi

Most abundant in adult spinal cord, brain, kidney, gut, uterus and testes.

Gene expression databases

GenevestigatoriP35411.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025019.

Structurei

3D structure databases

ProteinModelPortaliP35411.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151350.
GeneTreeiENSGT00700000104407.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35411.
KOiK04192.
OMAiAPQFMFT.
OrthoDBiEOG7327P9.
PhylomeDBiP35411.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR005387. Chemokine_CX3CR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35411-1 [UniParc]FASTAAdd to Basket

« Hide

MPTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSIFYS LVFTFGLVGN    50
LLVVLALTNS RKSKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN 100
AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI 150
SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEIWPV LRNSEVNILG 200
FVLPLLIMSF CYFRIVRTLF SCKNRKKARA IRLILLVVVV FFLFWTPYNI 250
VIFLETLKFY NFFPSCGMKR DLRWALSVTE TVAFSHCCLN PFIYAFAGEK 300
FRRYLRHLYN KCLAVLCGRP VHAGFSTESQ RSRQDSILSS LTHYTSEGEG 350
SLLL 354
Length:354
Mass (Da):40,327
Last modified:June 1, 1994 - v1
Checksum:iCFC4578095E77376
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04808 mRNA. Translation: AAB87093.1.
PIRiI58186.
RefSeqiNP_598218.1. NM_133534.1.
UniGeneiRn.10482.

Genome annotation databases

EnsembliENSRNOT00000025019; ENSRNOP00000025019; ENSRNOG00000018509.
GeneIDi171056.
KEGGirno:171056.
UCSCiRGD:620137. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04808 mRNA. Translation: AAB87093.1 .
PIRi I58186.
RefSeqi NP_598218.1. NM_133534.1.
UniGenei Rn.10482.

3D structure databases

ProteinModelPortali P35411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000025019.

Chemistry

ChEMBLi CHEMBL2346491.
GuidetoPHARMACOLOGYi 74.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35411.

Proteomic databases

PRIDEi P35411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025019 ; ENSRNOP00000025019 ; ENSRNOG00000018509 .
GeneIDi 171056.
KEGGi rno:171056.
UCSCi RGD:620137. rat.

Organism-specific databases

CTDi 1524.
RGDi 620137. Cx3cr1.

Phylogenomic databases

eggNOGi NOG151350.
GeneTreei ENSGT00700000104407.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P35411.
KOi K04192.
OMAi APQFMFT.
OrthoDBi EOG7327P9.
PhylomeDBi P35411.
TreeFami TF330966.

Miscellaneous databases

NextBioi 621621.
PROi P35411.

Gene expression databases

Genevestigatori P35411.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR005387. Chemokine_CX3CR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors."
    Harrison J.K., Barber C.M., Lynch K.R.
    Neurosci. Lett. 169:85-89(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.

Entry informationi

Entry nameiCX3C1_RAT
AccessioniPrimary (citable) accession number: P35411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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