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P35411 (CX3C1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CX3C chemokine receptor 1

Short name=C-X3-C CKR-1
Short name=CX3CR1
Alternative name(s):
Fractalkine receptor
RBS11
Gene names
Name:Cx3cr1
Synonyms:Rbs11
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Most abundant in adult spinal cord, brain, kidney, gut, uterus and testes.

Post-translational modification

This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: InterPro

cellular response to lipopolysaccharide

Inferred from expression pattern PubMed 10422773. Source: RGD

cellular response to transforming growth factor beta stimulus

Inferred from expression pattern PubMed 12446007. Source: RGD

cerebral cortex cell migration

Inferred from electronic annotation. Source: Ensembl

chemokine-mediated signaling pathway

Inferred from direct assay PubMed 11278650. Source: GOC

macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

microglial cell activation involved in immune response

Inferred from electronic annotation. Source: Ensembl

negative regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell migration

Inferred from mutant phenotype PubMed 17114429. Source: RGD

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from mutant phenotype PubMed 18006432. Source: RGD

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuron projection

Inferred from direct assay PubMed 10869418. Source: RGD

neuronal cell body membrane

Inferred from direct assay PubMed 10869418. Source: RGD

perinuclear region of cytoplasm

Inferred from direct assay PubMed 11870871PubMed 19748551. Source: RGD

   Molecular_functionC-X3-C chemokine receptor activity

Inferred from direct assay PubMed 11278650. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354CX3C chemokine receptor 1
PRO_0000069328

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 6028Helical; Name=1; Potential
Topological domain61 – 7010Cytoplasmic Potential
Transmembrane71 – 9121Helical; Name=2; Potential
Topological domain92 – 10413Extracellular Potential
Transmembrane105 – 12622Helical; Name=3; Potential
Topological domain127 – 14317Cytoplasmic Potential
Transmembrane144 – 16825Helical; Name=4; Potential
Topological domain169 – 19628Extracellular Potential
Transmembrane197 – 21620Helical; Name=5; Potential
Topological domain217 – 23216Cytoplasmic Potential
Transmembrane233 – 25725Helical; Name=6; Potential
Topological domain258 – 27417Extracellular Potential
Transmembrane275 – 29824Helical; Name=7; Potential
Topological domain299 – 35456Cytoplasmic Potential

Amino acid modifications

Disulfide bond103 ↔ 176 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35411 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: CFC4578095E77376

FASTA35440,327
        10         20         30         40         50         60 
MPTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSIFYS LVFTFGLVGN LLVVLALTNS 

        70         80         90        100        110        120 
RKSKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN AMCKLTTAFF FIGFFGGIFF 

       130        140        150        160        170        180 
ITVISIDRYL AIVLAANSMN NRTVQHGVTI SLGVWAAAIL VASPQFMFTK RKDNECLGDY 

       190        200        210        220        230        240 
PEVLQEIWPV LRNSEVNILG FVLPLLIMSF CYFRIVRTLF SCKNRKKARA IRLILLVVVV 

       250        260        270        280        290        300 
FFLFWTPYNI VIFLETLKFY NFFPSCGMKR DLRWALSVTE TVAFSHCCLN PFIYAFAGEK 

       310        320        330        340        350 
FRRYLRHLYN KCLAVLCGRP VHAGFSTESQ RSRQDSILSS LTHYTSEGEG SLLL 

« Hide

References

[1]"cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors."
Harrison J.K., Barber C.M., Lynch K.R.
Neurosci. Lett. 169:85-89(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Spinal cord.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U04808 mRNA. Translation: AAB87093.1.
PIRI58186.
RefSeqNP_598218.1. NM_133534.1.
UniGeneRn.10482.

3D structure databases

ProteinModelPortalP35411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000025019.

Chemistry

ChEMBLCHEMBL2346491.
GuidetoPHARMACOLOGY74.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP35411.

Proteomic databases

PRIDEP35411.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000025019; ENSRNOP00000025019; ENSRNOG00000018509.
GeneID171056.
KEGGrno:171056.
UCSCRGD:620137. rat.

Organism-specific databases

CTD1524.
RGD620137. Cx3cr1.

Phylogenomic databases

eggNOGNOG151350.
GeneTreeENSGT00700000104407.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP35411.
KOK04192.
OMAAPQFMFT.
OrthoDBEOG7327P9.
PhylomeDBP35411.
TreeFamTF330966.

Gene expression databases

GenevestigatorP35411.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR005387. Chemokine_CX3CR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio621621.
PROP35411.

Entry information

Entry nameCX3C1_RAT
AccessionPrimary (citable) accession number: P35411
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries