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Protein

Mas-related G-protein coupled receptor MRG

Gene

MAS1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor MRG
Short name:
MAS-R
Alternative name(s):
MAS1-like
Gene namesi
Name:MAS1L
Synonyms:MRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13961. MAS1L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7777ExtracellularSequence analysisAdd
BLAST
Transmembranei78 – 10124Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini102 – 1098CytoplasmicSequence analysis
Transmembranei110 – 13627Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini137 – 15418ExtracellularSequence analysisAdd
BLAST
Transmembranei155 – 16915Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini170 – 19122CytoplasmicSequence analysisAdd
BLAST
Transmembranei192 – 20716Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini208 – 22114ExtracellularSequence analysisAdd
BLAST
Transmembranei222 – 24827Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini249 – 26416CytoplasmicSequence analysisAdd
BLAST
Transmembranei265 – 28622Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini287 – 29711ExtracellularSequence analysisAdd
BLAST
Transmembranei298 – 31720Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini318 – 37861CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134912067.

Polymorphism and mutation databases

BioMutaiMAS1L.
DMDMi547920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Mas-related G-protein coupled receptor MRGPRO_0000069717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence analysis
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35410.
PRIDEiP35410.

Expressioni

Gene expression databases

CleanExiHS_MAS1L.
ExpressionAtlasiP35410. baseline and differential.
GenevisibleiP35410. HS.

Organism-specific databases

HPAiHPA017983.

Structurei

3D structure databases

ProteinModelPortaliP35410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
HOGENOMiHOG000204130.
HOVERGENiHBG052413.
InParanoidiP35410.
KOiK04324.
OMAiFCINIVK.
OrthoDBiEOG769ZJN.
PhylomeDBiP35410.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWGKICWFS QRAGWTVFAE SQISLSCSLC LHSGDQEAQN PNLVSQLCGV
60 70 80 90 100
FLQNETNETI HMQMSMAVGQ QALPLNIIAP KAVLVSLCGV LLNGTVFWLL
110 120 130 140 150
CCGATNPYMV YILHLVAADV IYLCCSAVGF LQVTLLTYHG VVFFIPDFLA
160 170 180 190 200
ILSPFSFEVC LCLLVAISTE RCVCVLFPIW YRCHRPKYTS NVVCTLIWGL
210 220 230 240 250
PFCINIVKSL FLTYWKHVKA CVIFLKLSGL FHAILSLVMC VSSLTLLIRF
260 270 280 290 300
LCCSQQQKAT RVYAVVQISA PMFLLWALPL SVAPLITDFK MFVTTSYLIS
310 320 330 340 350
LFLIINSSAN PIIYFFVGSL RKKRLKESLR VILQRALADK PEVGRNKKAA
360 370
GIDPMEQPHS TQHVENLLPR EHRVDVET
Length:378
Mass (Da):42,411
Last modified:June 1, 1994 - v1
Checksum:iE08A606294B61474
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti288 – 2881D → E.
Corresponds to variant rs17184100 [ dbSNP | Ensembl ].
VAR_049416

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78653 Genomic DNA. Translation: AAB21255.1.
AL035542 Genomic DNA. Translation: CAB44503.1.
BX000531 Genomic DNA. Translation: CAI18459.1.
BX247947 Genomic DNA. Translation: CAM26164.1.
CR759956 Genomic DNA. Translation: CAQ06741.1.
CR759768 Genomic DNA. Translation: CAQ09891.1.
BX927133 Genomic DNA. Translation: CAQ10419.1.
CR388393 Genomic DNA. Translation: CAQ10827.1.
CH471081 Genomic DNA. Translation: EAX03197.1.
BC069127 mRNA. Translation: AAH69127.1.
BC069345 mRNA. Translation: AAH69345.1.
BC101176 mRNA. Translation: AAI01177.1.
BC101177 mRNA. Translation: AAI01178.1.
CCDSiCCDS4661.1.
PIRiA39485.
RefSeqiNP_443199.1. NM_052967.1.
UniGeneiHs.533297.

Genome annotation databases

EnsembliENST00000377127; ENSP00000366331; ENSG00000204687.
ENST00000383549; ENSP00000373041; ENSG00000206470.
ENST00000383643; ENSP00000373139; ENSG00000206515.
ENST00000415802; ENSP00000405164; ENSG00000233141.
ENST00000418003; ENSP00000410649; ENSG00000234954.
ENST00000420035; ENSP00000405030; ENSG00000228377.
ENST00000449044; ENSP00000399042; ENSG00000228515.
ENST00000451019; ENSP00000392071; ENSG00000237284.
GeneIDi116511.
KEGGihsa:116511.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78653 Genomic DNA. Translation: AAB21255.1.
AL035542 Genomic DNA. Translation: CAB44503.1.
BX000531 Genomic DNA. Translation: CAI18459.1.
BX247947 Genomic DNA. Translation: CAM26164.1.
CR759956 Genomic DNA. Translation: CAQ06741.1.
CR759768 Genomic DNA. Translation: CAQ09891.1.
BX927133 Genomic DNA. Translation: CAQ10419.1.
CR388393 Genomic DNA. Translation: CAQ10827.1.
CH471081 Genomic DNA. Translation: EAX03197.1.
BC069127 mRNA. Translation: AAH69127.1.
BC069345 mRNA. Translation: AAH69345.1.
BC101176 mRNA. Translation: AAI01177.1.
BC101177 mRNA. Translation: AAI01178.1.
CCDSiCCDS4661.1.
PIRiA39485.
RefSeqiNP_443199.1. NM_052967.1.
UniGeneiHs.533297.

3D structure databases

ProteinModelPortaliP35410.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiMAS1L.
DMDMi547920.

Proteomic databases

PaxDbiP35410.
PRIDEiP35410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377127; ENSP00000366331; ENSG00000204687.
ENST00000383549; ENSP00000373041; ENSG00000206470.
ENST00000383643; ENSP00000373139; ENSG00000206515.
ENST00000415802; ENSP00000405164; ENSG00000233141.
ENST00000418003; ENSP00000410649; ENSG00000234954.
ENST00000420035; ENSP00000405030; ENSG00000228377.
ENST00000449044; ENSP00000399042; ENSG00000228515.
ENST00000451019; ENSP00000392071; ENSG00000237284.
GeneIDi116511.
KEGGihsa:116511.

Organism-specific databases

CTDi116511.
GeneCardsiMAS1L.
HGNCiHGNC:13961. MAS1L.
HPAiHPA017983.
MIMi607235. gene.
neXtProtiNX_P35410.
PharmGKBiPA134912067.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
HOGENOMiHOG000204130.
HOVERGENiHBG052413.
InParanoidiP35410.
KOiK04324.
OMAiFCINIVK.
OrthoDBiEOG769ZJN.
PhylomeDBiP35410.
TreeFamiTF336336.

Miscellaneous databases

GeneWikiiMAS1L.
GenomeRNAii116511.
PROiP35410.
SOURCEiSearch...

Gene expression databases

CleanExiHS_MAS1L.
ExpressionAtlasiP35410. baseline and differential.
GenevisibleiP35410. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions."
    Monnot C., Weber V., Stinnakre J., Bihoreau C., Teutsch B., Corvol P., Clauser E.
    Mol. Endocrinol. 5:1477-1487(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMAS1L_HUMAN
AccessioniPrimary (citable) accession number: P35410
Secondary accession number(s): Q5SUN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 8, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.