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Protein

Mas-related G-protein coupled receptor MRG

Gene

MAS1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor MRG
Short name:
MAS-R
Alternative name(s):
MAS1-like
Gene namesi
Name:MAS1L
Synonyms:MRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13961. MAS1L.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 77ExtracellularSequence analysisAdd BLAST77
Transmembranei78 – 101Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini102 – 109CytoplasmicSequence analysis8
Transmembranei110 – 136Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini137 – 154ExtracellularSequence analysisAdd BLAST18
Transmembranei155 – 169Helical; Name=3Sequence analysisAdd BLAST15
Topological domaini170 – 191CytoplasmicSequence analysisAdd BLAST22
Transmembranei192 – 207Helical; Name=4Sequence analysisAdd BLAST16
Topological domaini208 – 221ExtracellularSequence analysisAdd BLAST14
Transmembranei222 – 248Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini249 – 264CytoplasmicSequence analysisAdd BLAST16
Transmembranei265 – 286Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini287 – 297ExtracellularSequence analysisAdd BLAST11
Transmembranei298 – 317Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini318 – 378CytoplasmicSequence analysisAdd BLAST61

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116511.
OpenTargetsiENSG00000204687.
ENSG00000206470.
ENSG00000206515.
ENSG00000228377.
ENSG00000228515.
ENSG00000233141.
ENSG00000234954.
ENSG00000237284.
PharmGKBiPA134912067.

Polymorphism and mutation databases

BioMutaiMAS1L.
DMDMi547920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697171 – 378Mas-related G-protein coupled receptor MRGAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35410.
PRIDEiP35410.

Expressioni

Gene expression databases

CleanExiHS_MAS1L.
ExpressionAtlasiP35410. baseline and differential.
GenevisibleiP35410. HS.

Organism-specific databases

HPAiHPA017983.

Structurei

3D structure databases

ProteinModelPortaliP35410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000204130.
HOVERGENiHBG052413.
InParanoidiP35410.
KOiK04324.
OMAiFCINIVK.
OrthoDBiEOG091G09C0.
PhylomeDBiP35410.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWGKICWFS QRAGWTVFAE SQISLSCSLC LHSGDQEAQN PNLVSQLCGV
60 70 80 90 100
FLQNETNETI HMQMSMAVGQ QALPLNIIAP KAVLVSLCGV LLNGTVFWLL
110 120 130 140 150
CCGATNPYMV YILHLVAADV IYLCCSAVGF LQVTLLTYHG VVFFIPDFLA
160 170 180 190 200
ILSPFSFEVC LCLLVAISTE RCVCVLFPIW YRCHRPKYTS NVVCTLIWGL
210 220 230 240 250
PFCINIVKSL FLTYWKHVKA CVIFLKLSGL FHAILSLVMC VSSLTLLIRF
260 270 280 290 300
LCCSQQQKAT RVYAVVQISA PMFLLWALPL SVAPLITDFK MFVTTSYLIS
310 320 330 340 350
LFLIINSSAN PIIYFFVGSL RKKRLKESLR VILQRALADK PEVGRNKKAA
360 370
GIDPMEQPHS TQHVENLLPR EHRVDVET
Length:378
Mass (Da):42,411
Last modified:June 1, 1994 - v1
Checksum:iE08A606294B61474
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049416288D → E.Corresponds to variant rs17184100dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78653 Genomic DNA. Translation: AAB21255.1.
AL035542 Genomic DNA. Translation: CAB44503.1.
BX000531 Genomic DNA. Translation: CAI18459.1.
BX247947 Genomic DNA. Translation: CAM26164.1.
CR759956 Genomic DNA. Translation: CAQ06741.1.
CR759768 Genomic DNA. Translation: CAQ09891.1.
BX927133 Genomic DNA. Translation: CAQ10419.1.
CR388393 Genomic DNA. Translation: CAQ10827.1.
CH471081 Genomic DNA. Translation: EAX03197.1.
BC069127 mRNA. Translation: AAH69127.1.
BC069345 mRNA. Translation: AAH69345.1.
BC101176 mRNA. Translation: AAI01177.1.
BC101177 mRNA. Translation: AAI01178.1.
CCDSiCCDS4661.1.
PIRiA39485.
RefSeqiNP_443199.1. NM_052967.2.
UniGeneiHs.533297.

Genome annotation databases

EnsembliENST00000377127; ENSP00000366331; ENSG00000204687.
ENST00000383549; ENSP00000373041; ENSG00000206470.
ENST00000383643; ENSP00000373139; ENSG00000206515.
ENST00000415802; ENSP00000405164; ENSG00000233141.
ENST00000418003; ENSP00000410649; ENSG00000234954.
ENST00000420035; ENSP00000405030; ENSG00000228377.
ENST00000449044; ENSP00000399042; ENSG00000228515.
ENST00000451019; ENSP00000392071; ENSG00000237284.
GeneIDi116511.
KEGGihsa:116511.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78653 Genomic DNA. Translation: AAB21255.1.
AL035542 Genomic DNA. Translation: CAB44503.1.
BX000531 Genomic DNA. Translation: CAI18459.1.
BX247947 Genomic DNA. Translation: CAM26164.1.
CR759956 Genomic DNA. Translation: CAQ06741.1.
CR759768 Genomic DNA. Translation: CAQ09891.1.
BX927133 Genomic DNA. Translation: CAQ10419.1.
CR388393 Genomic DNA. Translation: CAQ10827.1.
CH471081 Genomic DNA. Translation: EAX03197.1.
BC069127 mRNA. Translation: AAH69127.1.
BC069345 mRNA. Translation: AAH69345.1.
BC101176 mRNA. Translation: AAI01177.1.
BC101177 mRNA. Translation: AAI01178.1.
CCDSiCCDS4661.1.
PIRiA39485.
RefSeqiNP_443199.1. NM_052967.2.
UniGeneiHs.533297.

3D structure databases

ProteinModelPortaliP35410.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiMAS1L.
DMDMi547920.

Proteomic databases

PaxDbiP35410.
PRIDEiP35410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377127; ENSP00000366331; ENSG00000204687.
ENST00000383549; ENSP00000373041; ENSG00000206470.
ENST00000383643; ENSP00000373139; ENSG00000206515.
ENST00000415802; ENSP00000405164; ENSG00000233141.
ENST00000418003; ENSP00000410649; ENSG00000234954.
ENST00000420035; ENSP00000405030; ENSG00000228377.
ENST00000449044; ENSP00000399042; ENSG00000228515.
ENST00000451019; ENSP00000392071; ENSG00000237284.
GeneIDi116511.
KEGGihsa:116511.

Organism-specific databases

CTDi116511.
DisGeNETi116511.
GeneCardsiMAS1L.
HGNCiHGNC:13961. MAS1L.
HPAiHPA017983.
MIMi607235. gene.
neXtProtiNX_P35410.
OpenTargetsiENSG00000204687.
ENSG00000206470.
ENSG00000206515.
ENSG00000228377.
ENSG00000228515.
ENSG00000233141.
ENSG00000234954.
ENSG00000237284.
PharmGKBiPA134912067.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000204130.
HOVERGENiHBG052413.
InParanoidiP35410.
KOiK04324.
OMAiFCINIVK.
OrthoDBiEOG091G09C0.
PhylomeDBiP35410.
TreeFamiTF336336.

Miscellaneous databases

GeneWikiiMAS1L.
GenomeRNAii116511.
PROiP35410.
SOURCEiSearch...

Gene expression databases

CleanExiHS_MAS1L.
ExpressionAtlasiP35410. baseline and differential.
GenevisibleiP35410. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAS1L_HUMAN
AccessioniPrimary (citable) accession number: P35410
Secondary accession number(s): Q5SUN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.